RESUMO
<p><b>OBJECTIVE</b>To investigate the effects of curcumin on the expressions of TNF-alpha, IL-6 and IL-8 in rats with chronic nonbacterial prostatitis.</p><p><b>METHODS</b>Sixty healthy adult male SD rats with the body weight of 200 -220 g were equally and randomly divided into a normal control, a positive control, a model, an oral curcumin and an intraperitoneal curcumin group. The rat models of chronic nonbacterial prostatitis were made by hypodermic injection of estradiol benzoate at the dose of 0.25 mg/(kg x d) for 30 days after castration, and then treated with curcumin at 200 mg/(kg x d) by gavage or intraperitoneal injection. The positive controls received oral celebrex at 250 mg/(kg x d), while the normal control and model groups were given saline by gavage. After a week of treatment, the levels of TNF-alpha, IL-6 and IL-8 in the serum and prostate tissues of the rats were detected by ELISA assay.</p><p><b>RESULTS</b>The levels of TNF-alpha and IL-8 in the serum and prostate tissues were significantly lower in the intraperitoneal curcumin than in the positive control group (P < 0.05), but the expression of IL-6 showed no significant difference between the two groups (P > 0.01).</p><p><b>CONCLUSION</b>Curcumin is efficacious for chronic nonbacterial prostatitis in rats, and the action mechanism may be associated with its decreasing effect on the proinflammatory cytokines IL-8 and TNF-alpha in the blood and tissues.</p>
Assuntos
Animais , Masculino , Ratos , Doença Crônica , Curcumina , Farmacologia , Usos Terapêuticos , Medicamentos de Ervas Chinesas , Usos Terapêuticos , Interleucina-6 , Metabolismo , Interleucina-8 , Metabolismo , Fitoterapia , Prostatite , Tratamento Farmacológico , Metabolismo , Ratos Sprague-Dawley , Fator de Necrose Tumoral alfa , MetabolismoRESUMO
The use of turmeric, derived from the root of the plant curcuma longa, for the treatment of various diseases has been described in Ayurveda and in Traditional Chinese Medicine for thousands of years. The active component of turmeric responsible for this activity, curcumin, was identified almost two centuries ago. Extensive research over the last decade has indicated that this polyphenol can both prevent and treat prostatic diseases.