RESUMO
The present study aimed to investigate the possible effects and underlying molecular mechanism of BushenYizhi formula (BSYZ), a traditional Chinese medicine, on agerelated degeneration of brain physiology in senescenceaccelerated mouse prone 8 (SAMP8) mice. SAMP8 mice (age, 6 months) were administered BSYZ (1.46, 2.92 and 5.84 g/kg/day) for 30 days. Morris water maze and stepdown tests demonstrated that BSYZ significantly improved memory impairments in SAMP8 mice. In addition, BSYZ significantly enhanced the expression levels of peroxisome proliferatoractivated receptorγ and Bcell lymphoma extralarge, and downregulated the expression levels of inflammatory mediators, glial fibrillary acidic protein, cyclooxygenase2, nuclear factorκB and interleukin1ß in the brain compared with untreated SAMP8 mice. Furthermore, BSYZ reversed disordered superoxide dismutase activity, malondialdehyde content and glutathione peroxidase activity, and ameliorated apoptosis and histological alterations. The present study indicated that BSYZ may attenuate cognitive impairment in SAMP8 mice, and modulate inflammation, oxidative stress and neuronal apoptosis. These results suggested that BSYZ may have the potential to be further developed into a therapeutic agent for protection against agerelated neurodegenerative diseases.
Assuntos
Senilidade Prematura/complicações , Senilidade Prematura/tratamento farmacológico , Medicamentos de Ervas Chinesas/farmacologia , Inflamação/tratamento farmacológico , Memória/efeitos dos fármacos , Fármacos Neuroprotetores/farmacologia , Estresse Oxidativo/efeitos dos fármacos , Animais , Apoptose/efeitos dos fármacos , Encéfalo/citologia , Encéfalo/efeitos dos fármacos , Encéfalo/fisiologia , Química Encefálica/efeitos dos fármacos , Ciclo-Oxigenase 2/análise , Proteína Glial Fibrilar Ácida/análise , Inflamação/etiologia , Masculino , Aprendizagem em Labirinto/efeitos dos fármacos , Camundongos , PPAR gama/análiseRESUMO
Ulcerative colitis is one of the most common types of inflammatory bowel disease and is multifactorial and relapsing. 6-Gingerol, a component of gingerols extracted from ginger (Zingiber officinale), has been reported to improve ulcerative colitis. The present study aims to investigate the therapeutic efficacy of two analogous forms of 6-gingerol, 8-gingerol, and 10-gingerol, on ulcerative colitis. Colitis was induced in rats through consumption of 5% (w/v) dextran sulfate sodium drinking water for 7 consecutive days. 6-Gingerol, 8-gingerol, and 10-gingerol were then given intraperitoneally at doses of 30 mg kg-1 d-1 for another 7 days, respectively. Body weight change, disease activity index, inflammatory cytokines, and oxidative stress indices were measured, and the colonic tissue injuries were assessed macroscopically and histopathologically. Results showed that all three gingerols attenuated colitic symptoms evoked by dextran sulfate sodium, significantly elevated superoxide dismutase activity, decreased malondialdehyde levels and myeloperoxidase activity in the colon tissue, and markedly reduced the content of tumor necrosis factor alpha and Interleukin 1 beta in the serum. Histological observations showed that all three gingerols obviously accelerated mucosal damage healing. It is concluded that 6-gingerol, 8-gingerol, and 10-gingerol, the three analogues, have a strong and relatively equal efficacy in the treatment of colitis. Copyright © 2017 John Wiley & Sons, Ltd.
Assuntos
Catecóis/farmacologia , Colite Ulcerativa/tratamento farmacológico , Álcoois Graxos/farmacologia , Animais , Colite Ulcerativa/induzido quimicamente , Colo/efeitos dos fármacos , Colo/patologia , Sulfato de Dextrana , Modelos Animais de Doenças , Interleucina-1beta/sangue , Mucosa Intestinal/efeitos dos fármacos , Mucosa Intestinal/patologia , Masculino , Malondialdeído/metabolismo , Estresse Oxidativo/efeitos dos fármacos , Peroxidase/metabolismo , Ratos , Ratos Sprague-Dawley , Superóxido Dismutase/metabolismo , Fator de Necrose Tumoral alfa/sangueRESUMO
OBJECTIVE: To analyze the status of vitamin A deficiency among children under 5 years old in poor rural areas of 6 Western Chinese provinces in 2009. METHODS: The study subjects involved 2091 children from a program - 'Appropriate measurements in improving children under-nutrition in poor rural areas'. RESULTS: In 2009, prevalence of vitamin A deficiency among children under 5 years old from the poor rural areas of 6 western Chinese provinces was 20.2%, with boys as 20.6% and girls as 19.7%. Prevalence rates of vitamin A deficiency among children under 5 years old in the highest and lowest areas were seen in Gansu (25.5%) and Guangxi (12.2%) provinces, respectively. The peak of vitamin A deficiency prevalence fell in the 6 - 11 months age group. The prevalence of vitamin A deficiency declined along with the increase of age. RESULTS: from this study demonstrated that vitamin A deficiency among children under 5 years old appeared to be a serious public health problem in the poor rural areas of 6 Western Chinese provinces. Education on reasonable ways of feeding and provision of complementary nutrients to children with vitamin A deficiency, should be the key points in the prevention and control programs on this problem.