RESUMO
Since the successful clinical trial of AuroShell for photothermal therapy, there is currently intense interest in developing gold-based core-shell structures with near-infrared (NIR) absorption ranging from NIR-I (650-900 nm) to NIR-II (900-1700 nm). Here, we propose a seed-mediated successive growth approach to produce gold nanoshells on the surface of the nanoscale metal-organic framework (NMOF) of UiO-66-NH2 (UiO = the University of Oslo) in one pot. The key to this strategy is to modulate the proportion of the formaldehyde (reductant) and its regulator / oxidative product of formic acid to harness the particle nucleation and growth rate within the same system. The gold nanoshells propagate through a well-oriented and controllable diffusion growth pattern (points â facets â octahedron), which has not been identified. Most strikingly, the gold nanoshells prepared hereby exhibit an exceedingly broad and strong absorption in NIR-II with a peak beyond 1300 nm and outstanding photothermal conversion efficiency of 74.0%. Owing to such superior performance, these gold nanoshells show promising outcomes in photoacoustic (PA), computed tomography (CT), and photothermal imaging-guided photothermal therapy (PTT) for breast cancer, as demonstrated both in vitro and in vivo.
Assuntos
Nanoconchas , Nanoconchas/química , Terapia Fototérmica , Ouro/química , Imagem Multimodal , FototerapiaRESUMO
"Shengdeng" is its Tibetan transliteration referring to many medicines. Tibetan doctors and pharmacists in different areas use different drugs in formulation and clinical application, which are easily confused. In order to grasp the formula and clinical application accurately, we conduct a literature survey on history and current state of botanical origin and clinical application of "Shengdeng", making clear the application of various herbs named "Shengdeng" and providing reference to all Tibetan researchers and clinical workers in formulation and clinical application.
Assuntos
Tratamento Farmacológico , Medicamentos de Ervas Chinesas/uso terapêutico , Medicina Tradicional Tibetana , Plantas Medicinais/química , Tratamento Farmacológico/história , Medicamentos de Ervas Chinesas/análise , Medicamentos de Ervas Chinesas/história , História Antiga , Humanos , Medicina Tradicional Tibetana/históriaRESUMO
OBJECTIVE: To study the alkaloid constituents of Corydalis adunca. METHOD: The constituents were isolated on silica gel column and their structures were elucidated by IR, NMR, MS data. RESULT: Eight alkaloid compounds were isolated from alcohol extracts of the herb of C. adunca, and identified as dihydrosanguinarine (I), tetrahydrocolumbamine (II), 1,2,3,4-tetrahydro-7-methoxy-1-[(4-methoxy)phenyl]methyl-8-quinolinol (III), protopine (IV) and 6-acetonyl-5,6-dihydrosanguinarine (V). CONCLUSION: Five compounds were isolated from C. adunca for the first time.
Assuntos
Alcaloides/isolamento & purificação , Alcaloides de Berberina/isolamento & purificação , Corydalis/química , Fenantridinas/isolamento & purificação , Plantas Medicinais/química , Alcaloides/química , Benzofenantridinas , Alcaloides de Berberina/química , Isoquinolinas , Estrutura Molecular , Fenantridinas/químicaRESUMO
OBJECTIVE: To study the identification method of Pterocephalus hookeri. METHOD: The microscopical, Physicochemical and TLC methods were used. RESULT AND CONCLUSION: The convenient and effective identification methods for P. hookeri were established, which provide basis for its quality standard and development.