RESUMO
Objective:To investigate the distribution of allergens in patients with allergic rhinitis ï¼ARï¼ in Ningxia, and provide theoretical data for the prevention and treatment of AR in this region. Methods:A total of 1664 patients diagnosed with AR in the Otorhinolaryngology Head and Neck Surgery Department of Yinchuan First People's Hospital Outpatient Clinic from January 2018 to December 2021 were retrospectively collected. Use the allergen sIgE antibody detection kit ï¼immunoblotting methodï¼ to detect inhalation and ingestion allergens in patients.Results: â Among all AR patients, 1 158 cases were detected positive, resulting in the detection rate was 69.59%; â¡The detection rate of inhalation allergen was 65.87%, and the detection rate of ingestion allergen was 19.83%; â¢Mugwort was the most sensitive allergen, and 76.32% of the patients having a positive grade ≥3; â£Out of the patients, 294 cases ï¼25.39%ï¼ were allergic to only one allergen, 244 cases ï¼21.07%ï¼ were allergic to two allergens, and 620 cases ï¼53.54%ï¼ were allergic to three or more allergens; â¤During different seasons, the highest number of positive allergens detected was in the summer, with 968 cases ï¼83.59%ï¼. Mugwort was the main allergen during this season ï¼69.01%ï¼. After the COVID-19 epidemic, the total positive rate of sIgE tests in AR patients decreased compared to before, and the difference was statistically significant ï¼P<0.001ï¼; â¥Mugwort, dog epithelium, mold combination, egg, peanut, soybean, Marine fish combination and fruit combination all showed statistically significant differences between different gender groups ï¼P<0.05ï¼; â¦Common ragweed, mugwort, dust mite combination, cockroach, egg, milk, Marine fish combination, shrimp, fruit combination and nut combination all showed statistically significant differences among different age groups ï¼P<0.05ï¼; â§There were statistically significant differences in hay dust among different ethnic groups ï¼P<0.05ï¼. Conclusion:Artemisia argyi is the main allergen in Ningxia, and the distribution characteristics of different allergens are influenced by treatment season, the COVID-19 epidemic, gender, age, ethnicity, and other factors, showing certain distribution patterns and rules.
Assuntos
Artemisia , COVID-19 , Rinite Alérgica , Alérgenos , Estudos Retrospectivos , Testes Cutâneos , Humanos , Masculino , FemininoRESUMO
Papaveris pericarpium, a natural source of morphine and codeine, is the principal active component in many antitussive traditional Chinese medicines. We herein report the first PK study of papaveris pericarpium in human plasma and urine following oral administration of single (15, 30, 60 mL) and multiple dose (15 mL) of Qiangli Pipa Syrup (MOR 0.1 mg/mL, COD 0.028 mg/mL) by monitoring morphine and codeine using a HPLC-MS/MS method. Their Tmax and t1/2 values are independent of dosages, while the AUC0-t linearly increased with higher dosages, indicating linear PK characteristics. AUC0-t increased obviously after multiple doses, indicating possible risk of accumulative toxicity. Urine studies suggested risks of positive opiate drug tests with a cutoff of 300 ng/mL, which lasted 6-14 h at different doses. These results provide important information for clinical safety, efficacy and rational drug use of Qiangli Pipa Syrup and also guide the related judicial expertise of its administration.
Assuntos
Antitussígenos/administração & dosagem , Codeína/farmacocinética , Medicamentos de Ervas Chinesas/administração & dosagem , Morfina/farmacocinética , Administração Oral , Adulto , Antitussígenos/química , China , Cromatografia Líquida de Alta Pressão , Codeína/análise , Estudos Cross-Over , Relação Dose-Resposta a Droga , Medicamentos de Ervas Chinesas/química , Humanos , Masculino , Medicina Tradicional Chinesa , Morfina/análise , Distribuição Aleatória , Espectrometria de Massas em Tandem , Adulto JovemRESUMO
Shenfu Injection (SFI) is a well-defined Chinese herbal formulation that is obtained from red ginseng and processed aconite root. The main active constituents in SFI are ginsenosides and aconitum alkaloids. In this work, ginsenosides (ginsenoside Rg1, ginsenoside Rb1 and ginsenoside Rc) and aconitum alkaloids (benzoylmesaconine and fuziline) were used as the index components to explore the pharmacokinetic behavior of SFI. A selective and sensitive HPLC-MS/MS method was developed for the quantification of ginsenosides and aconitum alkaloids in dog plasma and was used to characterize the pharmacokinetics of the five index components after intravenous drip of three different dosages of SFI in beagle dogs. The pharmacokinetic properties of the index components were linear over the dose range of 2-8 mL/kg.