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1.
Artigo em Inglês | WPRIM | ID: wpr-982279

RESUMO

OBJECTIVE@#To derive the Chinese medicine (CM) syndrome classification and subgroup syndrome characteristics of ischemic stroke patients.@*METHODS@#By extracting the CM clinical electronic medical records (EMRs) of 7,170 hospitalized patients with ischemic stroke from 2016 to 2018 at Weifang Hospital of Traditional Chinese Medicine, Shandong Province, China, a patient similarity network (PSN) was constructed based on the symptomatic phenotype of the patients. Thereafter the efficient community detection method BGLL was used to identify subgroups of patients. Finally, subgroups with a large number of cases were selected to analyze the specific manifestations of clinical symptoms and CM syndromes in each subgroup.@*RESULTS@#Seven main subgroups of patients with specific symptom characteristics were identified, including M3, M2, M1, M5, M0, M29 and M4. M3 and M0 subgroups had prominent posterior circulatory symptoms, while M3 was associated with autonomic disorders, and M4 manifested as anxiety; M2 and M4 had motor and motor coordination disorders; M1 had sensory disorders; M5 had more obvious lung infections; M29 had a disorder of consciousness. The specificity of CM syndromes of each subgroup was as follows. M3, M2, M1, M0, M29 and M4 all had the same syndrome as wind phlegm pattern; M3 and M0 both showed hyperactivity of Gan (Liver) yang pattern; M2 and M29 had similar syndromes, which corresponded to intertwined phlegm and blood stasis pattern and phlegm-stasis obstructing meridians pattern, respectively. The manifestations of CM syndromes often appeared in a combination of 2 or more syndrome elements. The most common combination of these 7 subgroups was wind-phlegm. The 7 subgroups of CM syndrome elements were specifically manifested as pathogenic wind, pathogenic phlegm, and deficiency pathogens.@*CONCLUSIONS@#There were 7 main symptom similarity-based subgroups in ischemic stroke patients, and their specific characteristics were obvious. The main syndromes were wind phlegm pattern and hyperactivity of Gan yang pattern.


Assuntos
Humanos , Síndrome , AVC Isquêmico , Medicina Tradicional Chinesa , Fígado , Fenótipo
2.
J Oncol ; 2022: 6093216, 2022.
Artigo em Inglês | MEDLINE | ID: mdl-36618071

RESUMO

Background: Paeoniflorin is an active component of a widely used traditional Chinese medicine with antitumor activity through ferroptosis induction. It has been reported recently that ferroptosis is emerging in certain types of cancer; however, its relevance in glioma is still not well studied. Methods: CCK8 assay was performed for cell proliferation. Expression of mRNA and protein was tested by qPCR and western blot, respectively. Clinical section samples were detected by IHC. The relationship between NEDD4L and STAT3 was validated by a coimmunoprecipitation assay. Apoptosis was identified by TUNEL assay. A xenograft mouse model was utilized to validate the potential of paeoniflorin toward glioma cancer cells. Results: The data suggested that paeoniflorin could increase NEDD4L expression in glioma cells. The NEDD4L expression level was lower in glioma cancer tissues compared to adjacent normal tissues, and it correlates with poor prognosis. Meanwhile, NEDD4L mediates the ubiquitination of STAT3. Furthermore, increased NEDD4L significantly inhibited cell viability and induced accumulation of intracellular ROS levels, accompanied by decreased expression of key ferroptosis factors Nrl2 and GPX4, while NEDD4L knockdown had a reverse effect, suggesting that ferroptosis could be involved. NEDD4L-induced ferroptosis could be rescued by forced expression of STAT3. A xenograft nude mouse model showed that paeoniflorin inhibits tumor growth and further sensitizes glioma cells to RSL3, another well-known ferroptosis inducer. Conclusions: In summary, this study demonstrated that paeoniflorin might function as an effective drug for glioma by inducing ferroptosis via upregulation of NEDD4L and repression of Nrl2, GPX4, and STAT3.

3.
Artigo em Chinês | WPRIM | ID: wpr-887506
4.
Artigo em Inglês | WPRIM | ID: wpr-888678

RESUMO

OBJECTIVE@#To obtain the subtypes of the clinical hypertension population based on symptoms and to explore the relationship between hypertension and comorbidities.@*METHODS@#The data set was collected from the Chinese medicine (CM) electronic medical records of 33,458 hypertension inpatients in the Affiliated Hospital of Shandong University of Traditional Chinese Medicine between July 2014 and May 2017. Then, a hypertension disease comorbidity network (HDCN) was built to investigate the complicated associations between hypertension and their comorbidities. Moreover, a hypertension patient similarity network (HPSN) was constructed with patients' shared symptoms, and 7 main hypertension patient subgroups were identified from HPSN with a community detection method to exhibit the characteristics of clinical phenotypes and molecular mechanisms. In addition, the significant symptoms, diseases, CM syndromes and pathways of each main patient subgroup were obtained by enrichment analysis.@*RESULTS@#The significant symptoms and diseases of these patient subgroups were associated with different damaged target organs of hypertension. Additionally, the specific phenotypic features (symptoms, diseases, and CM syndromes) were consistent with specific molecular features (pathways) in the same patient subgroup.@*CONCLUSION@#The utility and comprehensiveness of disease classification based on community detection of patient networks using shared CM symptom phenotypes showed the importance of hypertension patient subgroups.

5.
Journal of Integrative Medicine ; (12): 530-534, 2020.
Artigo em Inglês | WPRIM | ID: wpr-880982

RESUMO

Adult-onset Still's disease (AOSD) is a rare but clinically well-known, polygenic, and systemic autoinflammatory disease, which is characterized by spiking fever, evanescent skin rash, arthralgia, and sore throat. The application of non-steroidal anti-inflammatory drugs and glucocorticoids, which are first-line therapies of AOSD, is limited due to their side effects such as liver injury or disorder of blood glucose. Therefore, patients who suffer from systemic diseases in China prefer to seek help from Chinese herbal medicine (CHM), which is an important part of complementary and alternative medicine. In this case, we report a 28-year-old male badminton coach presenting with a 15-day history of fever and skin rash, accompanied by sore throat, fatigue, myalgia and chills. Additionally, hepatosplenomegaly, multiple lymphadenopathies, aminotransferase abnormality, and elevated inflammatory factor levels were observed during hospitalization. Infectious diseases, solid tumors, hematological diseases, and common autoimmune diseases were excluded. Not benefitting from antibiotic therapy, the patient was finally diagnosed with AOSD, after a careful examination, then showed rapid remission after a six-week treatment with CHM granules based on Xiaochaihu Decoction and Yinqiao Powder. After stopping the treatment, there was no relapse within a 15-month follow-up period. To the best of our knowledge, this is the first well-documented case of this successful treatment. The present case report suggests that CHM is a reliable choice for complementary and alternative therapy for AOSD, but confirming the utility of CHM for AOSD requires further support from prospective studies.

6.
World J Gastroenterol ; 23(47): 8432-8436, 2017 Dec 21.
Artigo em Inglês | MEDLINE | ID: mdl-29308003

RESUMO

Wernicke encephalopathy (WE) is an acute neurological disorder resulting from vitamin B1 deficiency, which is common in chronic alcoholism and is rare in acute liver failure. So far, there are 2 cases of WE reported after liver transplantation. Here, we report a case of a 45-year-old nonalcoholic male patient who developed psychiatric and neurological disturbance 15 d after receiving orthotopic liver transplantation because of hepatitis B-related cirrhosis and portal hypertension. Brain magnetic resonance imaging (MRI) showed symmetric high-signal intensities in the periaqueductal area. The patient was diagnosed with WE and given intravenous high-dose vitamin B1 immediately. His neurological disturbance resolved in 7 d after receiving the vitamin B1. Brain MRI after 5 mo showed nearly complete recovery. Most WE cases may be misdiagnosed in patients after liver transplantation, and we should pay more attention to its onset.


Assuntos
Doença Hepática Terminal/cirurgia , Transplante de Fígado/efeitos adversos , Complicações Pós-Operatórias/etiologia , Complexo Vitamínico B/uso terapêutico , Encefalopatia de Wernicke/etiologia , Administração Intravenosa , Encéfalo/diagnóstico por imagem , Humanos , Testes de Função Hepática , Imageamento por Ressonância Magnética , Masculino , Pessoa de Meia-Idade , Complicações Pós-Operatórias/sangue , Complicações Pós-Operatórias/diagnóstico , Complicações Pós-Operatórias/tratamento farmacológico , Tiamina/uso terapêutico , Deficiência de Tiamina/sangue , Deficiência de Tiamina/diagnóstico , Deficiência de Tiamina/tratamento farmacológico , Deficiência de Tiamina/etiologia , Encefalopatia de Wernicke/sangue , Encefalopatia de Wernicke/diagnóstico , Encefalopatia de Wernicke/tratamento farmacológico
7.
Chinese Medical Journal ; (24): 3219-3230, 2015.
Artigo em Inglês | WPRIM | ID: wpr-275534

RESUMO

<p><b>BACKGROUND</b>Malnutrition and tuberculosis (TB) tend to interact with each other. TB may lead to nutrition deficiencies that will conversely delay recovery by depressing immune functions. Nutrition support can promote recovery in the subject being treated for TB. The aim of this study was to evaluate the effectiveness of nutrition support on promoting the recovery of adult pulmonary TB patients with anti-TB drug therapy.</p><p><b>METHODS</b>English database of the Cochrane Controlled Trials Register, PubMed, EMBASE, and Chinese database of CBM, CNKI, VIP, and WANFANG were searched. Randomized controlled trials comparing nutrition support (given for more than 2 weeks) with no nutrition intervention, nutrition advice only, or placebo-control for TB patients being anti-TB treated were included. Two reviewers conducted data extraction, assessed the quality of the studies independently, and any discrepancies were solved by the third reviewer. Data were entered and analyzed by RevMan 5.2 software, and meta-analysis was done using risk ratios (RR s) for dichotomous variables and mean differences (MDs) for continuous variables with 95% confidence intervals (CI s).</p><p><b>RESULTS</b>A total of 19 studies (3681 participants) were included. In nutritional support for TB patients, pooled RR and its 95% CI of sputum smears- or culture-negative conversion rate and chest X-ray (CXR) absorption rate were 1.10 (1.04, 1.17) and 1.22 (1.08, 1.39), respectively, the pooled MD and its 95% CI of body mass index (BMI) and time of sputum smears or culture negativity were 0.59 (0.16, 1.2) and - 5.42 (-7.93, -2.92), respectively, compared with the control group. The differences in outcomes of CXR zone affected, TB score, serum albumin, and hemoglobin were not statistically significant (P = 0.76, 0.24, 0.28, and 0.20, respectively) between the intervention group and the control group. No systemic adverse events were recorded.</p><p><b>CONCLUSIONS</b>During anti-TB course, nutrition support may be helpful in treatment of TB patients by improving both sputum smears- or culture-negative conversion rate and BMI, shortening the time of sputum conversion negative. Whether it can improve the final clinical effect, there still needs high-level quality studies to confirm in the future.</p>


Assuntos
Animais , Humanos , Antituberculosos , Usos Terapêuticos , Desnutrição , Terapêutica , Apoio Nutricional , Escarro , Microbiologia , Tuberculose Pulmonar , Tratamento Farmacológico , Terapêutica
8.
J Sep Sci ; 37(11): 1308-14, 2014 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-24648272

RESUMO

A green, simple, and effective method for the extraction of sugarcane lipids from sugarcane rind was investigated by response surface methodology. The optimum conditions of technological progress obtained through response surface methodology were as follows: liquid-to-solid ratio 7.94: 1 mL/g, extraction temperature 50°C and extraction time 5.98 h. The practical sugarcane lipids extraction yield was 6.55 ± 0.28%, which was in good consistence with the predicted extraction yield of 6.47%. The results showed that the sugarcane lipids extraction yield obtained in optimum conditions increased by 1.16∼7.28-fold compared to the yields obtained in single-factor experiments. After saponification and SPE steps, the nonsaponifiable fraction of sugarcane lipids was analyzed by gas chromatography with mass spectrometry and high-performance liquid chromatography. ß-Sitosterol, stigmasterol, and campesterol were the prevailing phytosterols in the sample, while fucosterol, gramisterol, stigmast-7-en-3-ol, (3ß,5α,24S)-, stigmasta-4,6,22-trien-3α-ol, and cholest-8(14)-en-3ß-ol acetate were also identified as minor steroids. Furthermore, the content of ß-sitosterol and a mixture of campesterol and stigmasterol (quantified by high-performance liquid chromatography) was 44.18 mg/100 g dry weight and 43.20 mg stigmasterol/100 g dry weight, respectively. Our results indicate that sugarcane rind is a good source of phytosterol.


Assuntos
Fitosteróis/química , Fitosteróis/isolamento & purificação , Extratos Vegetais/química , Extratos Vegetais/isolamento & purificação , Saccharum/química , Extração em Fase Sólida/métodos , Cromatografia Gasosa-Espectrometria de Massas , Estrutura Molecular , Extração em Fase Sólida/instrumentação
9.
Food Chem ; 151: 452-8, 2014 May 15.
Artigo em Inglês | MEDLINE | ID: mdl-24423556

RESUMO

Antioxidant capacities and phytochemicals such as phenolics, flavonoids, triterpenoids, phytosterols of four parts of two sugarcane cultivars have been characterised. The total triterpenoid content (TTC), total phenolic content (TPC), total flavonoid content (TFC) and total sterol content (TSC) were different among parts and cultivars of sugarcane. The node of both cultivars contained the highest TTC (2096.02 and 1779.66 mg ursolic acid/100g DW for green-rind and red-rind sugarcane, respectively). However, the highest TPC, TFC and TSC were found in the rind. Green-rind sugarcane cultivars contained higher TSC than the red-rind sugarcane cultivars in most parts, while opposite trend were found in TPC and TFC. Stigmasterol and ß-sitosterol were found as two main phytosterols. Furthermore, TPC and TFC revealed good correlations with DPPH and FRAP. As cultivars and parts could affect phytochemical content, present result may provide a theoretical basis for further exploitation of the health beneficial resources of sugarcane.


Assuntos
Antioxidantes/química , Fenóis/química , Compostos Fitoquímicos/química , Extratos Vegetais/química , Saccharum/química , Flavonoides
10.
Artigo em Chinês | WPRIM | ID: wpr-318490

RESUMO

<p><b>OBJECTIVE</b>To observe the impacts on the recovery of swallowing function in patients of dysphagia after acute stroke treated with acupuncture and functional electric stimulation.</p><p><b>METHODS</b>Seventy-four patients were randomized into an acupuncture plus electric stimulation group (38 cases) and an electric stimulation group (36 cases). The functional electric stimulator was used in the two groups. The electric pads were placed on the hyoid bone, the upper part of thyroid cartilage, the masseter muscle and the mandibular joint. The treatment lasted for 30 mm each time. In the acupuncture plus electric stimulation group, acupuncture was supplemented at motor area of Jiao's scalp acupuncture, lower 2/5 of sensory area, Baihui (CV 20), Lianquan (CV 23), Jinjin (EX-HN 12) and Yuye (EX-HN 13), 30 mm each time. The treatment was given once a day, 6 treatments for one session and there was 1 day at interval between the sessions, 4 sessions were required totally in the two groups. The dysphagia scale was adopted for efficacy evaluation before treatment and after 4 sessions of treatment in the two groups. The removal rate of nasal feeding tube was observed after treatment.</p><p><b>RESULTS</b>The dysphagia score was increased apparently after treatment compared with that before treatment in the two groups (both P < 0.05). After treatment, in the acupuncture plus electric stimulation group, the dysphagia score was increased much more apparently than that in the electric stimulation group (8.01 +/- 1.25 vs 6.73 +/- 1.36, P < 0.05). The remarkably effective rate was 84.2% (32/38) in the acupuncture plus electric stimulation group, better than 58.3% (21/36) in the electric stimulation group (P < 0.05). The removal rate of nasal feeding tube was 89.5% (34/38) in the acupuncture plus electric stimulation group, which was higher than 50. 0% (18/36) in the electric stimulation group (P < 0.05).</p><p><b>CONCLUSION</b>Acupuncture combined with electric stimulation achieves the much better efficacy on dysphagia after acute stroke and promotes the early removal of nasal feeding tube. The efficacy is better than that of the simple electric stimulation therapy.</p>


Assuntos
Adulto , Idoso , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Pontos de Acupuntura , Terapia por Acupuntura , Deglutição , Transtornos de Deglutição , Terapêutica , Estimulação Elétrica , Acidente Vascular Cerebral , Resultado do Tratamento
11.
Artigo em Chinês | WPRIM | ID: wpr-313008

RESUMO

<p><b>OBJECTIVE</b>To explore combination rules of Chinese herbal prescriptions from effective cases for treatment of unstable angina (UA).</p><p><b>METHODS</b>Prescription data from 156 UA patients effectively treated at Cardiovascular Diseases Centre of Xiyuan Hospital were analyzed using complex network method.</p><p><b>RESULTS</b>According to multi-scale analysis of backbone network and pointwise mutual information analysis, core prescriptions from the 156 UA patients were presented as follows: Rhizoma Ligustici wallichii, Radix Paeoniae rubra, Radix Codonopsis, Rhizoma Pinelliae, poria, and Angelica sinensis. Meanwhile, core couplet medicines for these patients covered Rhizoma Ligustici wallichii and Radix paeoniaerubra, Angelica sinensis and Rhizoma Ligustici wallichii, Radix Codonopsis and Rhizoma Ligustici wallichii, Rhizoma Ligustici wallichii and Rhizoma Pinelliae, Rhizoma Atractylodis Macrocephalae and poriacocos, Bulbus Alli Macrostemi and Rhizoma Pinelliae. Among different primary symptoms, there was slightly difference in core prescriptions.</p><p><b>CONCLUSION</b>The core prescriptions for the treatment of UA include blood-activating drug, phlem-resolving drugs. As an exploration of combination rules of Chinese herbal prescriptions in treating UA based on complex network, it can be used as a reference for further researches.</p>


Assuntos
Humanos , Angelica sinensis , Angina Instável , Tratamento Farmacológico , Medicamentos de Ervas Chinesas , Padrões de Referência , Usos Terapêuticos , Pinellia , Raízes de Plantas , Guias de Prática Clínica como Assunto , Prescrições , Padrões de Referência
12.
Artigo em Chinês | WPRIM | ID: wpr-359323

RESUMO

<p><b>OBJECTIVE</b>To initially optimize comprehensive treatment program for treating and preventing unstable angina (UA) by integrative medicine (IM).</p><p><b>METHODS</b>Based on partially observable Markov decision process model (POMDP), we chose 3 syndrome elements, i.e., qi deficiency, blood stasis, and phlegm turbidity from UA inpatients. The efficacy of treating UA by IM was objectively assessed by in-depth data mining and analyses.</p><p><b>RESULTS</b>The treatment programs for UA patients of qi deficiency syndrome, blood stasis syndrome, and phlegm turbidity syndrome were recommended as follows: nitrates +statins +clopidogrel +angiotensin II receptor blockers +heparins +Astragalus membranaceus +Condonopsis + poria and large-head atractylodes rhizome (ADR = 0.85077869); nitrates + aspirin + clopidogrel + statins + heparins + Astragalus membranaceus + safflower + peach seed + red peony root (ADR = 0.70773000); nitrates + aspirin + statins + angiotensin-converting inhibitors + snakegourd fruit + onion bulb + ternate pinellia + tangerine peel (ADR = 0.72509600).</p><p><b>CONCLUSION</b>As a POMDP based optimized treatment programs for UA, it can be used as a reference for further standardization and formulation of UA program by integrative medicine.</p>


Assuntos
Humanos , Angina Instável , Terapêutica , Tomada de Decisões , Sistemas de Apoio a Decisões Clínicas , Medicina Integrativa , Cadeias de Markov
13.
Artigo em Chinês | WPRIM | ID: wpr-353037

RESUMO

<p><b>OBJECTIVE</b>To evaluate therapeutic effect of the needle-knife closed solution combined with minor adjusting of spine for treatment of neck-shoulder syndrome.</p><p><b>METHODS</b>From April 2010 to August 2011,120 patients with neck-shoulder syndrome were treated with the needle-knife closed solution combined with minor adjusting of spine, and included 45 males and 75 females and aged from 40 to 68 years old. The disease course was from 3 days to 10 years. After the operation, all patients taken the medicine of activating blood circulation herbs. At the 3rd, 7th, 10th day after operation, spinal rotation massage was performed on these patients. After the healing of the needle points, traditional Chinese medicine herb fumigation was applied on the needle points, and the patients were directed to do the cervical spine exercise. Therapeutic effect of the patients was evaluated by the neck disability index (NDI).</p><p><b>RESULTS</b>All patients were followed up after 3 weeks' treatment. The pain of neck-shoulder was relieved, and the range of motion was improved,the NDI score lowered from 49.30 +/- 1.35 before treatment to 10.15 +/- 1.18 at 3 weeks after treatment (t = 2.116, P < 0.05).</p><p><b>CONCLUSION</b>The needle-knife closed solution combined with minor adjusting of spine for the treatment of neck-shoulder syndrome can relieve the pain in the neck-shoulder and improved the motion of the neck. The key for the effect is accurate location before operation, sufficient adhesion solution during the operation and spinal minor adjusting after operation.</p>


Assuntos
Adulto , Idoso , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Manipulação da Coluna , Métodos , Síndromes da Dor Miofascial , Terapêutica , Cervicalgia , Terapêutica , Dor de Ombro , Terapêutica
14.
Artigo em Inglês | WPRIM | ID: wpr-289743

RESUMO

Chinese medicine (CM) is a discipline with its own distinct methodologies and philosophical principles. The main method of treatment in CM is to use herbal prescriptions. Typically, a number of herbs are combined to form a formula and different formulae are prescribed for different patients. Regularities in the mixture of herbs in the prescriptions are important for both clinical treatment and novel patent medicine development. In this study, we analyze CM formula data using latent tree (LT) models. Interesting regularities are discovered. Those regularities are of interest to students of CM as well as pharmaceutical companies that manufacture medicine using Chinese herbs.


Assuntos
Humanos , Química Farmacêutica , Padrões de Referência , Composição de Medicamentos , Padrões de Referência , Medicamentos de Ervas Chinesas , Usos Terapêuticos , Medicina Tradicional Chinesa , Modelos Biológicos , Medicamentos sob Prescrição , Usos Terapêuticos
15.
Artigo em Inglês | WPRIM | ID: wpr-328513

RESUMO

Induction of common knowledge or regularities from large-scale clinical data is a vital task for Chinese medicine (CM). In this paper, we propose a data mining method, called the Symptom-Herb-Diagnosis topic (SHDT) model, to automatically extract the common relationships among symptoms, herb combinations and diagnoses from large-scale CM clinical data. The SHDT model is one of the multi-relational extensions of the latent topic model, which can acquire topic structure from discrete corpora (such as document collection) by capturing the semantic relations among words. We applied the SHDT model to discover the common CM diagnosis and treatment knowledge for type 2 diabetes mellitus (T2DM) using 3 238 inpatient cases. We obtained meaningful diagnosis and treatment topics (clusters) from the data, which clinically indicated some important medical groups corresponding to comorbidity diseases (e.g., heart disease and diabetic kidney diseases in T2DM inpatients). The results show that manifestation sub-categories actually exist in T2DM patients that need specific, individualised CM therapies. Furthermore, the results demonstrate that this method is helpful for generating CM clinical guidelines for T2DM based on structured collected clinical data.


Assuntos
Humanos , Diabetes Mellitus Tipo 2 , Diagnóstico , Terapêutica , Diagnóstico Diferencial , Medicina Tradicional Chinesa , Modelos Teóricos
16.
Artigo em Inglês | WPRIM | ID: wpr-328437

RESUMO

<p><b>OBJECTIVE</b>To explore the most effective herbal combinations commonly used by highly experienced Chinese medicine (CM) physicians for the treatment of insomnia.</p><p><b>METHODS</b>We collected and analyzed data related to insomnia treatment from the clinics of 7 highly experienced CM physicians in Beijing. The sample included 162 patients and 460 consultations in total. Patient outcomes, such as sleep quality and sleep time per day, were manually collected from the medical records by trained CM clinicians. Three data mining methods, support vector machine (SVM), logistic regression and decision tree, and multifactor dimensionality reduction (MDR), were used to determine and confirm the herbal combinations that resulted in positive outcomes in patients suffering from insomnia.</p><p><b>RESULTS</b>Results show that MDR is the most efficient method to predict the effective herbal combinations. Using the MDR model, we identified several combinations of herbs with 100% positive outcomes, such as stir-fried spine date seed, Szechwan lovage rhizome, and prepared thinleaf milkwort root; white peony root, golden thread, and stir-fried spine date seed; and Asiatic cornelian cherry fruit with fresh rehmannia.</p><p><b>CONCLUSIONS</b>Results indicate that herbal combinations are effective treatments for patients with insomnia compared with individual herbs. It is also shown that MDR is a potent data mining method to identify the herbal combination with high rates of positive outcome.</p>


Assuntos
Adolescente , Adulto , Idoso , Idoso de 80 Anos ou mais , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Adulto Jovem , Competência Clínica , Mineração de Dados , Quimioterapia Combinada , Medicamentos de Ervas Chinesas , Usos Terapêuticos , Medicina Tradicional Chinesa , Pacientes Ambulatoriais , Médicos , Distúrbios do Início e da Manutenção do Sono , Tratamento Farmacológico , Resultado do Tratamento
17.
Artigo em Inglês | WPRIM | ID: wpr-345000

RESUMO

<p><b>OBJECTIVE</b>To investigate the impacts of Xuezhikang (XZK) or pravastatin combined with antihypertensive drugs on circulating endothelial progenitor cells (CEPCs) in essential hypertensive (EH) patients.</p><p><b>METHODS</b>Eighty-eight EH patients were enrolled into the study and randomly assigned to the antihypertensive drug treatment group (ATH group, 29 cases), the pravastatin treatment group (PRA group, 29 cases) and the Xuezhikang treatment group (XZK group, 30 cases). Patients in the 3 groups were treated with routine antihypertensive drugs. In addition, pravastatin and Xuezhikang were given to the patients in the PRA group and XZK group, respectively. After an eight-week treatment, CEPCs were counted using a laser scanning confocal microscope, and their proliferation function was evaluated by the MTT colorimetric assay and the adherent cell number was counted to estimate the adhesion function.</p><p><b>RESULTS</b>After the treatment, CEPCs in the PRA group (116.60+/-5.70) and XZK group (114.40+/-6.55) was significantly higher than that in the ATH group (88.00+/-6.32, P<0.01). CEPCs proliferation capability and the adhesion function in the PRA group (0.406+/-0.016, 33.60+/-4.26) and XZK group (0.415+/-0.018, 34.30+/-3.77) were obviously superior to those in the ATH group (0.333+/-0.021, P<0.01; 23.30+/-3.19, P<0.01). No significant difference was found between the pravastatin group and the XZK group.</p><p><b>CONCLUSIONS</b>Combined use of XZK or pravastatin with the anti-hypertensive therapy could increase the CEPCs number and improve their function in EH patients with the blood pressure controlled by antihypertensive drugs, leading to benefits independent of pressure-lowering effects.</p>


Assuntos
Idoso , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Anticolesterolemiantes , Antidiuréticos , Anti-Hipertensivos , Contagem de Células Sanguíneas , Bloqueadores dos Canais de Cálcio , Adesão Celular , Proliferação de Células , Células Cultivadas , Quimioterapia Combinada , Medicamentos de Ervas Chinesas , Células Endoteliais , Patologia , Fisiologia , Hipertensão , Sangue , Tratamento Farmacológico , Patologia , Medicina Integrativa , Métodos , Pravastatina , Células-Tronco , Patologia , Fisiologia
18.
Guang Pu Xue Yu Guang Pu Fen Xi ; 28(11): 2699-702, 2008 Nov.
Artigo em Chinês | MEDLINE | ID: mdl-19271521

RESUMO

In the present paper, the authors prepared all the samples by the same method, and optimized the work conditions for flame qtomic absorption spectrometry. FAAS was applied to determine the trace elements, such as Pb, Cr, Cd, Cu, Zn, Hg, Se etc, in Elsholtzia bodineri Vaniot. from Mengzi, Shiping, Mile and Jianshui located in Honghe state. The method is simple, rapid and accurate, and allows simultaneous determination of many elements. The recoveries were in the range of 98.7%-116.4%, and RSD was 0.07%-1.69%. The contents of Pb, Cd and Hg were 53.47, 6.03 and 7.68 microg x g(-1), respectively, in the sample from Jianshui, and were higher than those from other areas. The content of Mn was the highest, and was higher in Mengzi than in other areas, and the average content in the four samples was 913.48 microg x g(-1), which was higher than the content in the soil. Fe is the semi-microelement whose average content in Elsholtzia bodineri Vaniot. from Honghe was 688.46 microg x g(-1), the high-to-low content sequence of Fe in terms of location was Mengzi, Mile, Shiping and Jianshui. The average content of Zn was 116.64 microg x g(-1), and the highest one was from Shiping. But we did not obtain the data of Se in the Elsholtzia bodineri Vaniot. from Honghe state by AAS, and did not detect Hg in samples from Shiping and Mile. The content of the detected elements in Mengzi's sample had the sequence as follows; Mn > Fe > Zn > Pb > Cu > Cr > Cd > Hg>Se, while the sequence was Mn > Fe > Zn > Pb > Cu > Hg > Cd > Cr > Se in the sample of Jianshui, Mn > Fe > Z n >Pb > Cu > Cd > Cr > Hg > Se in Shiping, and Fe > Mn > Zn > Pb > Cu > Cd > Cr > Hg > Se in Mile. The results show that the content of the trace elements is high, especially, Mn, Fe and Zn, in Elsholtzia bodineri Vaniot. in Honghe. Therefore, Elsholtzia bodineri Vaniot., which can be used as drug or beverage, is worth exploitation.


Assuntos
Lamiaceae/química , Oligoelementos/análise , Cádmio/análise , Cromo/análise , Cobre/análise , Chumbo/análise , Mercúrio/análise , Selênio/análise , Espectrofotometria Atômica , Zinco/análise
19.
Artigo em Chinês | WPRIM | ID: wpr-287893

RESUMO

<p><b>OBJECTIVE</b>To analyze the law that famous old doctor of traditional Chinese medicine (TCM) treat angina pectoris using Chinese drugs, explore the method that well-known doctor's experience was arranged.</p><p><b>METHOD</b>Typical medicine case 115 of angina pectoris were collected and well-known doctor coronary heart disease database making a diagnosis was set up, then used association rules to analyze well-known doctor's prescription compatibility law curing coronary heart disease.</p><p><b>RESULT</b>In 175 kinds of traditional Chinese medicinal used, the compatibility among blood-activating drug, phlegm-resolving drug and tonic was the most frequently used medicinal groups, Gualou Xiebai decoction, Huoxue decoction and Shengmai powder were the basic formula that well-known doctor treat coronary heart disease, matching and employing between the three form the universal law that the well-known doctor used medicine.</p><p><b>CONCLUSION</b>Drug groups drew with association rules that well-known doctor treat coronary heart disease reacted well-known doctor's therapeutic thought of curing, would provide the method reference to research in the hereafter.</p>


Assuntos
Adulto , Idoso , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Angina Pectoris , Tratamento Farmacológico , Doença das Coronárias , Tratamento Farmacológico , Bases de Dados Factuais , Combinação de Medicamentos , Medicamentos de Ervas Chinesas , Usos Terapêuticos , Medicina Tradicional Chinesa , Métodos , Fitoterapia , Plantas Medicinais , Química
20.
Artigo em Chinês | WPRIM | ID: wpr-262093

RESUMO

Clinically, professor TIAN Cong-huo pays attention to treatment based on syndrome differentiation, with acupoint selection based on syndrome differentiation. In this present paper, clinically commonly-used 19 acupoint prescriptions, and relatively fixed indication ranges, manipulation methods, modified acupoint prescriptions, and professor TIAN's experience in application of these acupoints are summarized and introduced.


Assuntos
Humanos , Pontos de Acupuntura , Terapia por Acupuntura , Métodos , Diagnóstico Diferencial , Medicina Tradicional Chinesa
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