RESUMO
Objective To investigate the therapeutic effect of total saponins of ginseng (GFS)combined with serotonin re-uptake inhibitor(SSRIs)fluoxetine on rats with myocardial infarction(MI)and depression.Methods Left thoracotomy and per-manent ligation of left atrial appendage were performed to establish MI model in SD rats ,and depression model was established by chronic uncontrollable mild stress.SD rats were randomly divided into control group ,MI depression group(MI+ D group) (intragastric perfusion with 2 mL saline) ,fluoxetine group(F group)(intragastric perfusion with 0.2% fluoxetine at 10 mL/kg) and ginseng fruit saponins+ fluoxetine group(GFS+ F group)(intragastric perfusion of 20 mL/kg ginsenoside + 10 mL/kg 0.2% fluoxetine). The depression degree ,survival rate ,cardiac function ,electrophysiological parameters and histological chan-ges were evaluated after 28 days of intervention.Results Compared with the control group ,the consumption of sugar water in MI+D group was significantly decreased ,and the frequency of climbing ,crawling distance and crawling speed were significantly lower than those of the control group.GFS+fluoxetine and fluoxetine significantly increased the consumption of sugar water , increased the frequency of climbing and crawling distance ,but the treatment of GFS+fluoxetine was better than fluoxetine ,and could also improve the crawl speed. There was no significant difference in survival rate between MI +D group ,F group and GFS+F group(P＝0.24).Compared with the control group ,LVEDD ,LVESD and LVWT were significantly increased ,LVEF and FS significantly reduced in the MI+D group.GFS+fluoxetine and fluoxetine significantly reduced LVEDD in MI+D group and increased LVEF ,but GFS+ fluoxetine was superior to fluoxetine ,and also decreased LVESD and LVWT.Compared with the control group ,VERP and APD90 in MI+D group were significantly prolonged and VFT was significantly decreased.GFS+flu-oxetine and fluoxetine significantly improved the VFT of MI+D rats ,and the effect of GFS+fluoxetine was better than that of fluoxetine ,and they could shorten VERP and APD90 in model group. There was no significant difference in myocardial infarct size between MI+ D group ,F group and GFS+ F group(P＝ 0.076).Fluoxetine intervention did not improve the myocardial thickness and collagen content in the myocardial infarction area ,but GFS+ fluoxetine did.Conclusion Fluoxetine and GFS+fluoxetine can improve depression ,cardiac function and electrophysiological parameters of the rats with MI and depression ,but the effect of GFS+fluoxetine is better than that of fluoxetine ,and the myocardial thickness and collagen expression also have been improved by GFS+fluoxetine.