RESUMO
Fu's subcutaneous needling (FSN) is a new acupuncture therapy developed from acupuncture and Traditional Chinese Medicine models. The aim of this study was to investigate the effect of FSN on shoulder pain. In this retrospective comparative study, patient case files with shoulder pain (Group A) treated with FSN were analyzed and compared with the same number of patients with shoulder pain (Group B) treated with conventional acupuncture and physical therapy. Motion-related pain (MRP), pain under pressure (PUP), and Range of motion (ROM) were collected before and after intervention. In the 68 patients, there were 39 males and 29 females, aged 21-53 years old (mean ± SD = 36.4 ± 8.15) with onset time ranging from 1 day to 7 days (mean ± SD = 3.15 ± 1.73). MRP, PUP, and ROM scores were improved after FSN intervention (p < .05). There were significant differences between group A and group B in MRP, PUP, and ROM scores after FSN intervention and 1 week follow-up (p < .05). No adverse events, such as fainting and sharp pain, occurred during the treatment process. FSN can be an effective rehabilitation intervention for improving shoulder pain and shoulder range of motion.
Assuntos
Terapia por Acupuntura , Dor de Ombro , Adulto , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Projetos Piloto , Amplitude de Movimento Articular , Estudos Retrospectivos , Dor de Ombro/terapia , Resultado do Tratamento , Adulto JovemRESUMO
Although previous studies have demonstrated that triterpenoids, such as betulinic acid (BA), can inhibit tumor cell growth, their potential targets in colorectal cancer (CRC) metabolism have not been systematically investigated. In the present study, BAloaded nanoliposomes (BANLs) were prepared, and their effects on CRC cell lines were evaluated. The aim of the present study was to determine the anticancer mechanisms of action of BANLs in fatty acid metabolismmediated glycolysis, and investigate the role of key targets, such as acylCoA synthetase (ACSL), carnitine palmitoyltransferase (CPT) and acetyl CoA, in promoting glycolysis, which is activated by inducing hexokinase (HK), phosphofructokinase1 (PFK1), phosphoenolpyruvate (PEP) and pyruvate kinase (PK) expression. The results demonstrated that BANLs significantly suppressed the proliferation and glucose uptake of CRC cells by regulating potential glycolysis and fatty acid metabolism targets and pathways, which forms the basis of the antiCRC function of BANLs. Moreover, the effects of BANLs were further validated by demonstrating that the key targets of HK2, PFK1, PEP and PK isoenzyme M2 (PKM2) in glycolysis, and of ACSL1, CPT1a and PEP in fatty acid metabolism, were blocked by BANLs, which play key roles in the inhibition of glycolysis and fatty acidmediated production of pyruvate and lactate. The results of the present study may provide a deeper understanding supporting the hypothesis that liposomal BA may regulate alternative metabolic pathways implicated in CRC adjuvant therapy.
Assuntos
Antineoplásicos Fitogênicos/administração & dosagem , Neoplasias Colorretais/tratamento farmacológico , Nanopartículas/química , Triterpenos Pentacíclicos/administração & dosagem , Efeito Warburg em Oncologia/efeitos dos fármacos , Carnitina O-Palmitoiltransferase/antagonistas & inibidores , Carnitina O-Palmitoiltransferase/metabolismo , Proteínas de Transporte/antagonistas & inibidores , Proteínas de Transporte/metabolismo , Coenzima A Ligases/antagonistas & inibidores , Coenzima A Ligases/metabolismo , Neoplasias Colorretais/patologia , Ácidos Graxos/metabolismo , Células HCT116 , Humanos , Lipossomos , Proteínas de Membrana/antagonistas & inibidores , Proteínas de Membrana/metabolismo , Transdução de Sinais/efeitos dos fármacos , Hormônios Tireóideos/metabolismo , Ácido Betulínico , Proteínas de Ligação a Hormônio da TireoideRESUMO
OBJECTIVE: The aim of the study was to compare the efficacy of radial extracorporeal shock wave therapy and dry needling in the treatment of myofascial trigger points in the upper trapezius muscle. DESIGN: A total of 65 patients with myofascial trigger points were randomly divided into extracorporeal shock wave therapy group (n = 32) and dry needling group (n = 33). Patients received 3 wks of treatment at 1-wk intervals (in both groups). Visual analog scale, pressure pain threshold, Neck Disability Index, and shear modulus were evaluated before treatment, immediately after the first therapy, 1 mo, and 3 mos after the completion of the third therapy. RESULTS: Significant improvements of visual analog scale, pressure pain threshold, and Neck Disability Index scores were observed at all time points after treatment (P < 0.01) in both treatment groups. The shear modulus of myofascial trigger points was reduced in both dry needling group (P < 0.05) and extracorporeal shock wave therapy group (P < 0.01) immediately after the first treatment. Significant reductions in shear modulus were maintained up to 3-mo posttreatment in both groups (P < 0.01). There were no significant differences between the radial extracorporeal shock wave therapy group and dry needling group. CONCLUSIONS: The extracorporeal shock wave therapy is as effective as dry needling for relieving pain, improving function, and reducing shear modulus for patients with myofascial trigger points after a series of three treatments.
Assuntos
Agulhamento Seco , Tratamento por Ondas de Choque Extracorpóreas , Síndromes da Dor Miofascial/terapia , Músculos Superficiais do Dorso , Pontos-Gatilho , Adulto , Técnicas de Imagem por Elasticidade , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Síndromes da Dor Miofascial/diagnóstico , Medição da Dor , Projetos Piloto , Resultado do Tratamento , Adulto JovemRESUMO
OBJECTIVE: This study was to test the feasibility of permanent maxillary tooth removal using articaine without a second palatal injection. METHODS: Of 104 patients, 38 patients had bilateral extraction and 66 patients had unilateral extraction of maxillary tooth. In the test group, 1.7 mL articaine with 1:100000 epinephrine was injected into the buccal vestibule of the tooth and the tooth were extracted after 5 minutes. In the control group, the patients were subjected to both palatal injection with 2% lidocaine hydrochloride and buccal injection with articaine. All patients completed visual analog scales (VAS) after extraction. RESULTS: The achievement ratio of permanent maxillary tooth anesthesia of test group was 96.2%. The achievement ratio of permanent maxillary tooth anesthesia of control group was 97.1%. There was no statistical significance between achievement ratio of test group and control group(P > 0.05). CONCLUSION: Permanent maxillary tooth removal without palatal injection is possible by articaine injection to the buccal vestibule of the tooth.