RESUMO
Using an immunological method (immunoblot), we have established that hemoglobin (or hemoglobin fragments) can be quantitatively determined in old and ancient bones, some of them dating back 4500 years. It is shown that the total recovery decreases with time, but it is still effective in the older specimens. Thus, the immunological assay may prove useful to solve problems relevant to paleontology and paleopathology.
Assuntos
Hemoglobinometria/métodos , Hemoglobinas/análise , Vértebras Lombares/análise , Paleontologia , Anticorpos Anti-Idiotípicos/imunologia , Hemoglobinas/imunologia , Hemoglobinas Anormais/análise , História Antiga , Humanos , Itália , Paleopatologia , Cidade de Roma , Talassemia/sangue , Talassemia/históriaRESUMO
Sudden hemodynamic collapse in the perioperative period following myocardial revascularization may be due to coronary artery spasm. Nitroglycerin has been the standard treatment for this; however, it is not always effective, and the resultant morbidity and mortality are high. We present the case of a patient in whom sudden hemodynamic collapse due to coronary artery spasm was refractory to intravenously administered nitroglycerin but was relieved quickly with sublingually administered nifedipine. In certain selected patients in whom coronary artery spasm is responsible for myocardial collapse, the drug nifedipine may be effective in relieving this spasm and allowing for myocardial recovery.
Assuntos
Vasoespasmo Coronário/tratamento farmacológico , Complicações Intraoperatórias , Revascularização Miocárdica , Nifedipino/uso terapêutico , Piridinas/uso terapêutico , Vasoespasmo Coronário/complicações , Parada Cardíaca/tratamento farmacológico , Parada Cardíaca/etiologia , Frequência Cardíaca , Hemodinâmica , Humanos , Hipotensão/tratamento farmacológico , Hipotensão/etiologia , Masculino , Pessoa de Meia-IdadeRESUMO
1. The amino acid composition of highly purified aspartate aminotransferase from ox heart was determined. 2. Alanine is the only N-terminal residue. 3. Leucine was identified as the only C-terminal residue. 4. No disulphide bridges are present in the enzyme molecule. 5. The thiol groups are not equally accessible, the accessibility being comparatively easier in the apoenzyme molecule.