RESUMO
A pronounced antianemic effect of water-soluble Na,Ca,Fe-polygalacturonate is demonstrated. The drug in solution is more effective than in the solid form; it promotes absorption of nutrient calcium and iron. During this treatment, consumed calcium does not impair iron absorption.
Assuntos
Anemia/tratamento farmacológico , Cálcio/metabolismo , Ferro/metabolismo , Pectinas/química , Pectinas/uso terapêutico , Sódio/metabolismo , Água/química , Animais , Contagem de Eritrócitos , Feminino , Hemoglobinas/metabolismo , Ratos , SolubilidadeRESUMO
We have investigated effect of a representative of the novel class of selective acetylcholinesterase inhibitors A 1,3-bis[5(diethyl-o-nitrobenzyl ammonio) penthyl]-6-methyluracildibromide (compound 547) on duration and rhythm of sequence of right atrial action potential (AP) as well as on kinetics of acetylcholinesterase catalyzed reaction in homogenates of skeletal muscle (m. extensor digitorum longus) and cardiac muscle in the rat. We have shown that contrary to classical acetylcholinesterase inhibitors armin and proserin none of studied concentrations (1, 10 and 100 nM) of compound 547 exerted significant effect on AP configuration and rate of sinus rhythm. Compound 547 belongs to noncompetitive type with K1(heart)=3.6 x 10(-4) M and K1(EDL)=1.3 x 10(-8) M. Proserin exerts comparable inhibitory action on reaction in the heart and skeletal muscle, its K1(heart)=0.73 x 10(-5) M and K1(EDL) = 0.4 x 10(-5) M. Thus low sensitivity of myocardium to compound 547 in electrophysiological experiments is not related to lesser availability of synaptic acetylcholinesterase in the heart compared with acetylcholinesterase in skeletal muscles but reaction catalyzed by cardiac acetylcholinesterase is actually to a substantial degree less prone to inhibition by compound 547.
Assuntos
Inibidores da Colinesterase/farmacologia , Sistema de Condução Cardíaco/efeitos dos fármacos , Frequência Cardíaca/efeitos dos fármacos , Coração/efeitos dos fármacos , Animais , Combinação de Medicamentos , Técnicas Eletrofisiológicas Cardíacas/métodos , Coração/inervação , Coração/fisiologia , Átrios do Coração/efeitos dos fármacos , Átrios do Coração/inervação , Sistema de Condução Cardíaco/fisiologia , Masculino , Potenciais da Membrana/efeitos dos fármacos , Potenciais da Membrana/fisiologia , Músculo Esquelético/efeitos dos fármacos , Músculo Esquelético/fisiologia , Neostigmina/farmacologia , RatosRESUMO
We studied the effects of peptides from Amaranthus cruentus L., Rauwolfia serpentina Benth., and citrus plants on contractile activity of the uterine myometrium in rats. Pectin substances inhibited spontaneous contractile activity of uterine muscles and abolished the stimulatory effect of oxytocin. Pectins had a synergistic effect with epinephrine and acetylcholine.
Assuntos
Contração Muscular/efeitos dos fármacos , Miométrio/efeitos dos fármacos , Pectinas/química , Extratos Vegetais/farmacologia , Útero/efeitos dos fármacos , Amaranthus , Animais , Citrus , Feminino , Ocitocina/metabolismo , Pectinas/farmacologia , Peptídeos/química , RatosRESUMO
The anti-inflammatory and analgesic action of diucifon, methyluracil and 4,4'-diaminodiphenylsulfone (DDS) was studied in comparison with some nonsteroid preparations. In three traditional models of agar, kaolin and carrageenan paw edema and in the models of analgesia (convulsions, induced by intraabdominal administration of acetic acid to mice and hyperalgesia according to Randall-Selitto's test in rats), diucifon proved more active than its precursors. In Randall-Selitto's test the efficiency of diucifon was 1.5 times less than that of butadione but 24 times higher than that of methyluracil; DDS had no analgetic activity. Diucifon, methyluracil and DDS did not exert any ulcerogenic action.