Attention-deficit/hyperactivity disorder is characterized by a delay in subcortical maturation.

Although previous studies have found that ADHD is characterized by a delay in cortical maturation, it is not clear whether this phenomenon was secondary to developmental trajectories in subcortical regions (caudate, putamen, pallidum, thalamus, hippocampus and amygdala). Using the ADHD-200 dataset, we estimated subcortical volumes in 339 individuals with ADHD and 568 typically developing controls. We defined the growth trajectory of each subcortical structure, delineating a phase of childhood increase followed by an adolescent decrease in subcortical volumes using a quadratic growth model. From these trajectories, the age of attaining peak subcortical volumes was derived and used as an index of subcortical maturation. We found that subcortical structures (caudate, putamen, pallidum, thalamus, hippocampus and amygdala) followed curvilinear trajectories similar to those reported in previous studies. The volumes of these subcortical structures in ADHD were also delayed in the developmental trajectory, which suggested that ADHD may be characterized by a delay in subcortical maturation. This delay may lead to a shift in which individuals with ADHD go through the process of pruning the nerve connections that is part of the normal maturation process during adolescence. Further, we also found that the asymmetric development of subcortical structures was abnormal in ADHD, which resulted from the imbalance of the maturation delay of bilateral subcortical structures. The subcortical maturation delay may play an important role in the pathophysiology of ADHD. Our findings provide new potential targets to investigate the pathophysiology of ADHD.

Reduced Thalamus Volume and Enhanced Thalamus and Fronto-Parietal Network Integration in the Chess Experts.

The ability of chess experts depends to a large extent on spatial visual processing, attention, and working memory, all of which are thought to be mediated by the thalamus. This study explored whether continued practice and rehearsal over a long period of time results in structural changes in the thalamic region. We found smaller gray matter volume regions in the thalami of expert Chinese chess players in comparison with novice players. We then used these regions as seeds for resting-state functional connectivity analysis and observed significantly strengthened integration between the thalamus and fronto-parietal network in expert Chinese chess players. This strengthened integration that includes a group of brain regions showing an increase in activation to external stimulation, particularly during tasks relying on working memory and attention. Our findings demonstrate structural changes in the thalamus caused by a wide range of engagement in chess problem solving, and that this strengthened functional integration with widely distributed circuitry better supports high-level cognitive control of behavior.

Changes in the development of subcortical structures in autism spectrum disorder.

Many studies have reported abnormalities in the volume of subcortical structures in individuals with autism spectrum disorder (ASD), and many of these change with age. However, most studies that have investigated subcortical structures were cross-sectional and did not accurately segment the subcortical structures. In this study, we used volBrain, an automatic and reliable quantitative analysis tool, and a longitudinal design to examine developmental changes in the volume of subcortical structures in ASD, and quantified the relation between subcortical volume development and clinical correlates. Nineteen individuals with ASD (16 males; age: 12.53 ± 2.34 years at baseline; interval: 2.33 years) and 14 typically developing controls (TDC; 12 males; age: 13.50 ± 1.77 years at baseline; interval: 2.31 years) underwent T1-weighted MRI at two time points. Bilaterally, hippocampus volume increased from baseline to follow-up in both ASD and TDC, with no difference between groups. Left caudate and right thalamus volume decreased in ASD, but did not change in TDC. The decreases in left caudate and right thalamus volume were related to ASD social score. Right amygdala volume was larger in ASD than in TDC at baseline but not at follow-up. These results confirm previous cross-sectional findings regarding the development of subcortical structures in ASD. The association between developmental changes in left caudate and right thalamus volume and ASD social score offers an explanation for the social deficits in ASD. Results also captured the different abnormality of amygdala volume between childhood and late adolescence.

Gender differences in anomalous subcortical morphology for children with ADHD.

Although studies showed subtle reductions in brain volume in fronto-striatial regions in children with ADHD, there have been limited investigations of volume and lateralizaton in subcortical structures and a paucity of exploration of the influence of gender on these findings. This study aims to examine morphology of subcortical structures and their association with ADHD symptoms in boys and girls as compared to their typically-developing (TD) peers. One hundred and eighty five children aged 7-14 years with and without ADHD were included from ADHD-200 Consortium. Results showed that compared to TD boys, boys with ADHD had reduced accumbens, amygdala and hippocampus volumes. There were no volumetric differences in any structure between ADHD and TD girls. Asymmetry analysis revealed right lateralization compressions within the thalamus in ADHD boys relative to TD boys. The findings suggest a gender dimorphic pattern of differences in subcortical structures in children with ADHD, and a possible neurobiological mechanism where boys with ADHD demonstrate increasing difficulties with hyperactivity/impulsivity.