[Effects of water drinking regimens on crystallization intensity in experimental nephrolithiasis].

We studied effects of water regimens on crystallization efficacy in experimental nephrolithiasis on 3 groups of Wistar male rats with initial experimental nephrolithiasis (ethylene glycol model). The animals were on free, limited and supernormal liquid intake regimen. For 3 weeks each 3-4 days we estimated 24-h diuresis, urine concentration of calcium, phosphate and oxalate ions. After 3 weeks we made a morphological examination of the kidneys. We found that limited drinking leads to an increase in urinary concentrations of oxalate- and phosphate ions which stimulate enhanced formation of calcium-containing concrements. More water intake considerably reduces oxalate and phosphate concentrations in the urine resulting in reduction of the number and size of calcium deposits in renal tissue. Thus, low liquid intake leads to intensification of urine oversaturation causing formation of renal concrements. Much liquid intake weakens oversaturation and reduces the number and size of calcium deposits in the kidneys.

[The chemico-pharmacological patterns in the action of plants from the family of Pyrolaceae]. / Khimiko-farmakologicheskie zakonomernosti v deistvii semeistva grushankovykh.

The effect of leaf decoctions of three plants of the Pyrolaceae family, namely, umbrella wintergreen, one-side ortilia, and round-leaf Pyrola was studied in rat experiments. All plants under study were found to contain approximately equal amounts of tannins and arbutin glycoside. Their concentration was comparable though rather lower than in common bearberry, a well-known plant with diuretic and antiseptic activity. When given for a long time, all Pyrolaceae increased urination and sodium excretion. Besides, their decoctions caused an antimicrobial effect. Only round-leaf Pyrola weakened the development of experimental inflammation. Its anti-inflammatory effect was probably due the presence of flavonoids the content of which in Pyrola was maximum.

[The effect of calcium antagonists on the development of inflammatory edema in rats]. / Vliianie antagonistov kal'tsiia na razvitie vospalitel'nogo oteka u krys.

The calcium antagonists verapamil and nifedipine were shown to attenuate the development of carrageenin-induced rat paw inflammatory edema. Oral nifedipine exerted more pronounced antiedematous dose-dependent effects.

[Comparative effectiveness of the anti-inflammatory action of diuretics and butadione in an experiment]. / Sravnitel'naia éffektivnost' protivovospalitel'nogo deistviia diuretikov i butadiona v éksperimente.

Dichlothiazide and butadione were shown to attenuate equally the development of the rat paw inflammatory edema induced by subplantar dextran administration. Ethacrynic acid produced more pronounced antiedematous effect. Also, ethacrynic acid reduced to the highest degree the damp and dry mass of the inflammatory granuloma. Oxadoline and butadione considerably inhibit the formation of granuloma as well. The combined use of diuretics and butadione did not lead to a mutual potentiation of the antiinflammatory effect in exudative and proliferative inflammation.

[Effect of diuretics on vascular permeability and proliferative inflammation in rats]. / Vliianie diuretikov na sosudistuiu pronitsaemost' i proliferativnoe vospalenie u krys.

It is shown that ethacrynic acid and dichlothiazide in 50 mg/kg dose reduce the dextran-induced increase of rat skin vascular permeability. Besides, durable administration of furosemide, dichlothiazide and ethacrynic acid in 50-80 mg/kg doses decreases the dry mass of inflammatory granuloma. This fact shows the ability of diuretics to suppress the development of proliferative inflammation.

[Effect of diuretics on the development of experimental inflammatory edema in rats]. / Vliianie diuretikov na razvitie éksperimental'nogo vospalitel'nogo oteka u krys.

Experiments on rats have shown that administration of furosemide, dichlothiazide and etacrinic acid (50 mg/kg intraperitoneally) reduced the development of experimental inflammatory edema caused by subplantar administration of 0.1 ml of 6% dextran or 10% ovalbumin. The antiedematous effect of the diuretics was preserved under the conditions of bilateral nephrectomy, which points to the presence of extrarenal mechanisms in the action of the drugs in experimental inflammation.