Efectos del extracto de té verde sobre los daños oxidativos inducidos por cisplatino en riñones y testículos de ratas / Effect of green tea extract on cisplatin induced oxidative damage on kidney and testes of rats

Se administró extracto de té verde (Camellia sinensis) por vía oral a las ratas en dosis de 25, 50 y 100 mg/kg para investigar sus efectos sobre la nefrotoxicidad y la toxicidad testicular inducida por cisplatino (3mg/kg). El extracto de té verde restauró el nivel de creatinina, urea, nitrógeno ureico en sangre (NUS) y ácido úrico en el suero de animales tratados con cisplatino en comparación con los animales tratados sólo con cisplatino. Además, se observó que la administración de extracto de té verde restauró los niveles de enzimas antioxidantes como superóxido dismutasa (SOD), catalasa (CAT) y glutatión reducido (GSH), y enzimas ligadas a la membrana como Na Na+K+ATPasa, Ca Ca2+ 2+ ATPasa y Mg Mg2+ 2+ ATPasa y redujo la peroxidación lipídica (MDA) en los riñones y en los testículos de animales con alteraciones tras el tratamiento crónico con cisplatino. Por tanto, se puede concluir que el extracto de té verde posee actividad antioxidante y que, en virtud de esta acción, puede proteger los riñones y los testículos frente a los daños oxidativos inducidos por el cisplatino

Green tea extract (Camellia sinensis) was administered orally to rats at the dose levels of 25, 50,100 mg/kg to investigate its effect on cisplatin (3mg/kg) induced nephrotoxicity and testicular toxicity. Green tea extract restored the level of creatinine, urea, blood urea nitrogen (BUN) and uric acid in serum of animals treated with cisplatin as compared to the animals treated with cisplatin alone. It was further found that administration of green tea extract restored the level of antioxidant enzymes such as, superoxide dismutase (SOD), catalase (CAT) and reduced glutathione (GSH), and membrane bound enzymes like Na Na+K+ ATPase, Ca Ca2+ 2+ ATPase and Mg Mg2+ 2+ ATPase and decreased lipid peroxidation (MDA) in kidney and in testes of animals which were altered after chronic treatment with cisplatin. Thus it can be concluded that green tea extract possesses antioxidant activity and by virtue of this action it can protect the kidney and testes from cisplatin induced oxidative damage

Radioimmunotherapy: recent results and future directions.

PURPOSE: To review antibody structure, function, and production; suitable radioisotopes for radioimmunotherapy; challenges facing the field; recent clinical results; toxicity; and future directions. DESIGN: The radioimmunotherapy literature was reviewed, with an emphasis on clinical results and future directions. RESULTS: The highest complete response rates (overall, approximately 50%) have been achieved in patients with B-cell non-Hodgkin's lymphoma. Challenges that currently face radioimmunotherapy include circulating free antigen, binding of antibodies to nonspecific Fc receptors, insufficient tumor penetration, antigenic heterogeneity and insufficient antigen expression, antigenic modulation, and development of human antimouse antibodies. Possible approaches to these challenges, including high-dose radioimmunotherapy and chemotherapy followed by autologous bone marrow transplantation, the use of radionuclides such as yttrium 90 (90Y) and copper 67 (67Cu), and the development of humanized and bifunctional antibodies, are under investigation. CONCLUSION: Although radioimmunotherapy is a relatively new field, substantial progress has been made. Additional research will ultimately resolve many of the challenges that currently face radioimmunotherapy and hopefully lead to the cure of some currently incurable malignancies.