1.
Phytomedicine
; 7(1): 49-54, 2000 Mar.
Artigo
em Inglês
| MEDLINE
| ID: mdl-10782490
RESUMO
In this study we investigated inhibition of Arylamine N-acetyltransferase (NAT) activity in rat blood and liver tissue cytosols by luteolin. Using high-performance liquid chromatography, NAT activity for acetylation of 2-aminofluorene and remaining unacetylated 2-aminofluorene were examined. The NAT activity in rat blood and liver tissue was inhibited by luteolin in a dose-dependent manner: higher concentrations of luteolin in the reaction resulted in greater inhibition of NAT activities in both examined tissues. The data also indicated that luteolin decreased apparent Km and Vmax of NAT enzymes from rat blood and liver tissue cytosols. This report is the first demonstration that luteolin can affect rat blood and liver tissue NAT activity.
Assuntos
Arilamina N-Acetiltransferase/antagonistas & inibidores , Arilamina N-Acetiltransferase/efeitos dos fármacos , Inibidores Enzimáticos/farmacologia , Flavonoides/farmacologia , Fígado/efeitos dos fármacos , Plantas Medicinais , Animais , Arilamina N-Acetiltransferase/sangue , Arilamina N-Acetiltransferase/metabolismo , Cromatografia Líquida de Alta Pressão , Relação Dose-Resposta a Droga , Fígado/enzimologia , Luteolina , Masculino , Ratos , Ratos Sprague-Dawley
2.
Pharmacogenetics
; 3(4): 209-12, 1993 Aug.
Artigo
em Inglês
| MEDLINE
| ID: mdl-8220441