RESUMO
PURPOSE: To explore the feasibility of spray dried smectite clay particles fabricated from montmorillonite or laponite materials for adsorbing dietary lipids and reducing rodent weight gain in vivo. METHODS: Spray dried montmorillonite (SD-MMT) and spray dried laponite (SD-LAP) particles were prepared via spray drying. Particle morphology, surface area and redispersion/aggregation properties in aqueous media were characterized. The ability of SD-MMT and SD-LAP particles to inhibit lipid digestion kinetics and adsorb lipid species from solution was assessed during in vitro lipolysis using proton nuclear magnetic resonance analysis. SD-MMT and SD-LAP particles were dosed to rodents fed a high-fat diet and their effect on body weight gain was evaluated. RESULTS: Both SD-MMT and SD-LAP particles adsorbed significant quantities of medium chain triglycerides and lipolytic products from solution during in vitro lipolysis. At a concentration of 50% w/w relative to lipid content, SD-MMT and SD-LAP particles adsorbed 42% and 94% of all lipid species, respectively. SD-MMT and SD-LAP particles also reduced the extent of rodent weight gain relative to the negative control treatment group and performed similarly to orlistat via an alternate mechanism of action. CONCLUSIONS: Spray dried smectite clay particles (SD-MMT and SD-LAP) with significant adsorptive capacities for dietary lipids and digestion products were successfully fabricated. These particles may be developed as novel anti-obesity treatments with fewer adverse effects than currently marketed treatment options.
Assuntos
Bentonita/farmacologia , Obesidade/tratamento farmacológico , Silicatos/farmacologia , Adsorção/efeitos dos fármacos , Animais , Bentonita/química , Bentonita/farmacocinética , Peso Corporal/efeitos dos fármacos , Lipase/metabolismo , Metabolismo dos Lipídeos/efeitos dos fármacos , Lipólise/efeitos dos fármacos , Masculino , Nanopartículas/uso terapêutico , Obesidade/metabolismo , Tamanho da Partícula , Ratos , Ratos Sprague-Dawley , Silicatos/química , Silicatos/farmacocinética , Triglicerídeos/metabolismoRESUMO
La farmacopea de las culturas nativas bolivianas contienen productos con actividad farmacologica, como es el caso de la Montmorillonita-bentonita (Phasa), arcilla que a traves de analisis quimicos se ha demostrado que contiene silicatos, hidroxido y carbonatos, principalmente de aluminio y calcio analoga a los tradicionales antiacidos del arsenal terapeutico facultativo.