RESUMO
Patients with inflammatory bowel disease (IBD) do not receive routine preventative care at the same rate as general medical patients. This patient population is at increased risk of vaccine preventable illness such as influenza and pneumococcal pneumonia. This review will discuss health maintenance needs and preventative care issues in patients with IBD.
Assuntos
Neoplasias Colorretais/diagnóstico , Imunossupressores/efeitos adversos , Doenças Inflamatórias Intestinais/terapia , Medicina Preventiva/métodos , Vacinação/métodos , Conservadores da Densidade Óssea/uso terapêutico , Varicela/etiologia , Varicela/imunologia , Varicela/prevenção & controle , Vacina contra Varicela/uso terapêutico , Depressão/diagnóstico , Depressão/terapia , Gerenciamento Clínico , Detecção Precoce de Câncer/métodos , Hepatite Viral Humana/etiologia , Hepatite Viral Humana/imunologia , Hepatite Viral Humana/prevenção & controle , Herpes Zoster/etiologia , Herpes Zoster/imunologia , Herpes Zoster/prevenção & controle , Vacina contra Herpes Zoster/uso terapêutico , Humanos , Hospedeiro Imunocomprometido , Vacinas contra Influenza/uso terapêutico , Influenza Humana/etiologia , Influenza Humana/imunologia , Influenza Humana/prevenção & controle , Sarampo/etiologia , Sarampo/imunologia , Sarampo/prevenção & controle , Vacina contra Sarampo-Caxumba-Rubéola/uso terapêutico , Meningite Meningocócica/etiologia , Meningite Meningocócica/imunologia , Meningite Meningocócica/prevenção & controle , Vacinas Meningocócicas/uso terapêutico , Caxumba/etiologia , Caxumba/imunologia , Caxumba/prevenção & controle , Osteoporose/diagnóstico por imagem , Osteoporose/tratamento farmacológico , Infecções por Papillomavirus/etiologia , Infecções por Papillomavirus/imunologia , Infecções por Papillomavirus/prevenção & controle , Vacinas contra Papillomavirus/uso terapêutico , Vacinas Pneumocócicas/uso terapêutico , Pneumonia Pneumocócica/etiologia , Pneumonia Pneumocócica/imunologia , Pneumonia Pneumocócica/prevenção & controle , Rubéola (Sarampo Alemão)/etiologia , Rubéola (Sarampo Alemão)/imunologia , Rubéola (Sarampo Alemão)/prevenção & controle , Abandono do Hábito de Fumar , Vacinas contra Hepatite Viral/uso terapêutico , Vitamina D/uso terapêutico , Deficiência de Vitamina D/diagnósticoRESUMO
Combined application of mumps and measles vaccine strains in equal doses results in significant decrease of immune response to the former component in humans. It is possible that this phenomenon is related with well-known immunodepressive effect of measles virus, which was demonstrated both in vivo and in vitro. It was previously shown that myelopeptide-2 (MP-2) partially neutralizes suppressive effect of measles vaccine on blast transformation of activated human lymphocytes in vitro. Partial supression of immune response to mumps vaccine by live measles vaccine was reproduced in laboratory animals. It was shown that in experiment MP-2 partially neutralized suppressive effect of measles vaccine.
Assuntos
Adjuvantes Imunológicos/farmacologia , Imunização , Vacina contra Sarampo/administração & dosagem , Sarampo/imunologia , Morbillivirus/imunologia , Vacina contra Caxumba/administração & dosagem , Vacina contra Caxumba/imunologia , Vírus da Caxumba/imunologia , Caxumba/imunologia , Oligopeptídeos/farmacologia , Adjuvantes Imunológicos/administração & dosagem , Animais , Anticorpos Antivirais/sangue , Avaliação Pré-Clínica de Medicamentos , Feminino , Cobaias , Esquemas de Imunização , Terapia de Imunossupressão , Injeções Intramusculares , Sarampo/sangue , Caxumba/sangue , Oligopeptídeos/administração & dosagem , Ratos , Vacinas Combinadas/imunologiaRESUMO
The immunity to vaccine-preventable diseases included in the Dutch immunisation programme in the general population and among orthodox reformed individuals who refuse vaccination was assessed. The programme induces good protection. However, a large proportion of adults lacks diphtheria and tetanus immunity. Measles, mumps and rubella seroprevalence was somewhat lower among vaccinated compared to unvaccinated cohorts. The prevalence of HibPS antibodies declined during 2.5 years after the fourth vaccination. However, protection occurs also by memory immunity. Herd immunity is sufficient among the general population, but not among orthodox reformed individuals. Immunosurveillance is an efficient way to evaluate the effects of immunisation programmes and identify risk groups for infection.
Assuntos
Doenças Transmissíveis/imunologia , Programas de Imunização/estatística & dados numéricos , Adolescente , Adulto , Idoso , Criança , Pré-Escolar , Controle de Doenças Transmissíveis/estatística & dados numéricos , Difteria/imunologia , Difteria/prevenção & controle , Infecções por Haemophilus/imunologia , Infecções por Haemophilus/prevenção & controle , Haemophilus influenzae tipo b/imunologia , Humanos , Lactente , Recém-Nascido , Vacinação em Massa/métodos , Vacinação em Massa/estatística & dados numéricos , Sarampo/imunologia , Sarampo/prevenção & controle , Pessoa de Meia-Idade , Caxumba/imunologia , Caxumba/prevenção & controle , Programas Nacionais de Saúde , Países Baixos/epidemiologia , Poliomielite/imunologia , Poliomielite/prevenção & controle , Avaliação de Programas e Projetos de Saúde , Rubéola (Sarampo Alemão)/imunologia , Rubéola (Sarampo Alemão)/prevenção & controle , Tétano/imunologia , Tétano/prevenção & controleRESUMO
OBJECTIVE: We investigated the assertion that past childhood diseases, acute and febrile infections as well as allergies have a preventive effect on cancer. Former studies on this topic show controversial results and methodical deficits. PATIENTS AND METHODS The investigation was conducted as a retrospective case control study with 111 cancer patients and a group of 109 control persons from 3 hospitals in Berlin. RESULTS: A significant change in the risk of developing cancer could only be observed for mumps (OR = 2.6; increased risk), whooping cough (OR = 2.7; increased risk), and colds in the recent past (OR = 0.7; decreased risk). Fever within the last 5 years showed no association with the development of malign tumors. CONCLUSION: We could not confirm the results of former studies which assumed a preventive effect of childhood diseases and fever on the cancer risk. On the contrary, on the basis of this investigation one might postulate a 2- to 3-fold rise of the cancer risk by mumps or whooping cough. Because of divergent study results, deficits in the study designs, and a low evidence of the present findings no final statement on the association between childhood diseases or fever and cancer should be made.
Assuntos
Doenças Transmissíveis/imunologia , Febre/imunologia , Neoplasias/epidemiologia , Adulto , Idoso , Idoso de 80 Anos ou mais , Estudos de Casos e Controles , Feminino , Alemanha/epidemiologia , Humanos , Hipersensibilidade/imunologia , Masculino , Pessoa de Meia-Idade , Caxumba/imunologia , Neoplasias/etiologia , Razão de Chances , Estudos Retrospectivos , Fatores de Risco , Coqueluche/imunologiaRESUMO
In this study we investigated asymptomatic mumps as a possible cause of sudden deafness. We studied 131 sudden deafness patients by measuring their serum mumps antibody values. Positive IgM antibody results, which strongly suggest recent mumps infection, were revealed in 9 of the 130 patients tested (6.9%). Asymptomatic mumps infections are apparently closely related to sudden deafness. Further studies will provide more definite diagnoses of mumps deafness and might be applicable to the treatment of such hearing loss.