RESUMO
BACKGROUND: Nasal hyperkeratosis may cause discomfort in dogs by predisposing them to fissures and secondary bacterial infection. Approaches to treatment have been described anecdotally; the effectiveness of such therapies remains unproven. HYPOTHESIS/OBJECTIVES: To investigate the efficacy of a balm containing essential oils and essential fatty acids in dogs with idiopathic nasal hyperkeratosis. ANIMALS: Client-owned dogs with noncomplicated nasal hyperkeratosis. METHODS: The study was conducted as a randomized, double-blind, placebo-controlled clinical trial with parallel group design and two month follow-up period. Dogs received daily topical application of a commercial balm product (group DBB) or placebo (aqueous gelling agent with preservatives, group PB). The main outcome variables were lichenification, dryness, suppleness and extent of lesions. Subjective owner satisfaction index score was a secondary variable. Evaluation was performed on days (D)0, 30 and 60. Response to treatment was assessed as the change from baseline to each examination day for each criterion. RESULTS: Forty eight dogs, principally French (26 of 48) and English (seven of 48) bulldogs, were included and 39 completed the study. No major adverse events were reported. On D60, changes from baseline for lichenification, lesion extent, suppleness and total score were -31.2%, -18.3%, -72.8% and -36.8% in group DBB (23 dogs) and -11.9%, 2.3%, -42.1% and -14% in group PB (16 dogs), respectively. The total score was significantly improved on D60 in group DBB compared to PB (Wilcoxon-Mann-Whitney U-test, P = 0.0016). CONCLUSIONS AND CLINICAL IMPORTANCE: The balm proved safe and helpful in managing canine idiopathic noncomplicated nasal hyperkeratosis.
Assuntos
Ácidos Graxos Essenciais/uso terapêutico , Ceratose/veterinária , Nariz/patologia , Óleos Voláteis/uso terapêutico , Animais , Dermatite Atópica/veterinária , Cães , Método Duplo-Cego , Ácidos Graxos Essenciais/administração & dosagem , Ácidos Graxos Essenciais/efeitos adversos , Feminino , Ceratose/tratamento farmacológico , Masculino , Nariz/efeitos dos fármacos , Óleos Voláteis/administração & dosagem , Óleos Voláteis/efeitos adversos , Prurido/veterináriaAssuntos
Bovinos/fisiologia , Fenômenos Fisiológicos da Nutrição Animal , Animais , Apoptose , Doenças dos Bovinos/história , Corpo Lúteo/fisiologia , Desenvolvimento Embrionário , Sincronização do Estro , Feminino , História do Século XX , História do Século XXI , Hipotálamo/fisiologia , Ceratose/história , Ceratose/veterinária , Luteólise/fisiologia , Masculino , Neoplasias Hormônio-Dependentes/tratamento farmacológico , Ovulação/fisiologia , Gravidez , Reprodução/fisiologia , Pesquisa/históriaRESUMO
In a colony of 18 green anoles (Anolis carolinensis), 3 animals experienced focally thickened lips, ulcerative cheilitis, lethargy, depression, and weight loss over a 5-month period. In addition to crickets fed fresh fruit and leafy green vegetables, the diet of the green anoles consisted of a supply of mealworms that had been dusted with a commercial liquid vitamin supplement. The history, clinical findings, and histopathologic lesions were suggestive of hypovitaminosis A, which is known to cause squamous metaplasia of the mucus secreting glands and epithelial surfaces in many species.
Assuntos
Queilite/veterinária , Doenças da Túnica Conjuntiva/veterinária , Ceratose/veterinária , Lagartos , Mucosa Bucal/patologia , Deficiência de Vitamina A/veterinária , Animais , Doenças da Túnica Conjuntiva/etiologia , Doenças da Túnica Conjuntiva/patologia , Depressão/etiologia , Ceratose/etiologia , Ceratose/patologia , Lábio/patologia , Metaplasia/etiologia , Metaplasia/patologia , Metaplasia/veterinária , Fases do Sono , Deficiência de Vitamina A/etiologia , Deficiência de Vitamina A/patologia , Redução de PesoRESUMO
Zinc deficiency was diagnosed in 2 flocks of sheep and a herd of goats. Alopecia and eating of wool were observed. Skin lesions were hyperkeratosis and parakeratosis. Abnormal hoof growth and a closed stance with arched back and bowed hindlimbs were seen. Anorexia, depression, and foot soreness diminished quickly after zinc supplementation. Skin lesions healed and hair and wool growth resumed. A cause for the deficiency could not be established.