RESUMO
OBJECTIVES: To determine whether the oxidative stress transmitted to newly grown hair from an unhealthy scalp has physical consequences to the cuticular condition and function. METHODS: A uniquely designed 24-week clinical study included 8 weeks of pretreatment with a cosmetic shampoo and 16 weeks of treatment with either a potentiated zinc pyrithione (ZPT) antidandruff shampoo or a placebo cosmetic shampoo. This clinical design allowed the growth and acquisition of hair samples under conditions of varying but known scalp health as a result of treating a dandruff/seborrheic dermatitis (D/SD) population. Two complementary methods were used to characterize the integrity of the cuticular surface. Hair surface hydrophobicity was assessed by quantifying water wetting force using a Wilhelmy balance method. Surface structure and porosity were assessed using dynamic vapor sorption (DVS) to gravimetrically quantify water sorption. RESULTS: Chemical oxidative stress to pre-emergent hair has been shown to have negative consequences to hair surface structure. Compared to a placebo shampoo control, use of a potentiated ZPT shampoo improved scalp health and significantly improved the following attributes associated with healthy hair: hair surface hydrophobicity (surface energy) and cuticular moisture barrier effectiveness (dynamic vapor sorption). CONCLUSIONS: Pre-emergent hair can be negatively impacted by the oxidative stress that occurs with an unhealthy scalp, possibly due to metabolic activity of resident microbes. Manifestations of the oxidative stress include altered cuticle surface properties that are responsible for its protective function; these effects are similar in type to those observed by bleaching post-emergent hair. These alterations have the potential to make the hair, once emerged from the scalp, more susceptible to the cumulative physical and chemical insults responsible for hair feel and look, fiber integrity, and overall retention.
Assuntos
Caspa/terapia , Dermatite Seborreica/terapia , Preparações para Cabelo/uso terapêutico , Compostos Organometálicos/uso terapêutico , Estresse Oxidativo/fisiologia , Piridinas/uso terapêutico , Dermatoses do Couro Cabeludo/terapia , Adolescente , Adulto , Idoso , Canadá , Dermatite Seborreica/fisiopatologia , Método Duplo-Cego , Feminino , Folículo Piloso/efeitos dos fármacos , Preparações para Cabelo/química , Humanos , Masculino , Pessoa de Meia-Idade , Valores de Referência , Medição de Risco , Dermatoses do Couro Cabeludo/fisiopatologia , Índice de Gravidade de Doença , Resultado do Tratamento , Adulto JovemRESUMO
We present a case where alopecia occurred with severe seborrhoeic dermatitis associated with the commencement of combination antiretroviral therapy for acute retroviral syndrome. We postulate that the eruption could represent a novel manifestation in association with immunological response to antiretroviral therapy.
Assuntos
Alopecia/induzido quimicamente , Terapia Antirretroviral de Alta Atividade/efeitos adversos , Dermatite Seborreica/induzido quimicamente , Infecções por HIV/tratamento farmacológico , Administração Tópica , Adulto , Alopecia/tratamento farmacológico , Alopecia/fisiopatologia , Terapia Antirretroviral de Alta Atividade/métodos , Betametasona/uso terapêutico , Óleo de Coco , Dermatite Seborreica/tratamento farmacológico , Dermatite Seborreica/fisiopatologia , Quimioterapia Combinada , Seguimentos , Infecções por HIV/diagnóstico , Humanos , Masculino , Óleos de Plantas/uso terapêutico , Medição de Risco , Ácido Salicílico/uso terapêutico , Índice de Gravidade de Doença , Resultado do TratamentoRESUMO
Thirty-seven patients with clinically diagnosed infantile seborrhoeic dermatitis (ISD) were studied in an attempt to establish the significance of transepidermal water loss (TEWL) and water content in the stratum corneum, in active disease and after recovery. All the patients were treated daily with topically applied borage oil (containing 24% gamma-linolenic acid). With this regimen they were completely free from all skin symptoms within 3-4 weeks. Analyses of essential fatty acids in serum showed aberrations as previously described, with elevated levels of 18:1w9 and 20:2w6. TEWL and water content were recorded at the time of diagnosis and after treatment from the right forearm in skin that was free from symptoms and not treated with borage oil. Twenty-five healthy children in an age-matched group without skin disorders were used as controls. Significant differences in TEWL between patients and controls were found before treatment. After treatment no significant differences were found. There were no significant differences between controls and patients regarding water content in the stratum corneum. Gamma-linolenic acid is suggested to be of importance in maintaining normal TEWL and also in promoting recovery in patients suffering from ISD.
Assuntos
Dermatite Seborreica/metabolismo , Ácidos Linolênicos/uso terapêutico , Perda Insensível de Água , Dermatite Seborreica/tratamento farmacológico , Dermatite Seborreica/fisiopatologia , Epiderme/efeitos dos fármacos , Epiderme/metabolismo , Epiderme/fisiopatologia , Espaço Extracelular/metabolismo , Ácidos Graxos Essenciais/sangue , Feminino , Humanos , Lactente , Recém-Nascido , Ácidos Linolênicos/administração & dosagem , Ácidos Linolênicos/fisiologia , Masculino , Óleos/uso terapêutico , Permeabilidade/efeitos dos fármacos , Perda Insensível de Água/efeitos dos fármacos , Ácido gama-LinolênicoRESUMO
Al considerara el grave problema estético y social que constituye la caspa, así como su elevada frecuencia entre la población, se decidió estudiar cuatro principios activos anticaspa, contra placebo. Se consideraron los parámetros clínicos más importantes: número de corneocitos, estudio micológico directo, cultivo, cutirreacción, prurito, irritación del cuero cabelludo y caida del cabello. Los resultados mostraron claramente que el disulfuro de selenio solo y en su presentación con acondicionador, fueron las sustancias más eficaces para combatir el problema