Absolute pitch: neurophysiological evidence for early brain activity in prefrontal cortex.

Absolute pitch (AP) is the ability to rapidly label pitch without an external reference. The speed of AP labeling may be related to faster sensory processing. We compared time needed for auditory processing in AP musicians, non-AP musicians, and nonmusicians (NM) using high-density electroencephalographic recording. Participants responded to pure tones and sung voice. Stimuli evoked a negative deflection peaking at ~100 ms (N1) post-stimulus onset, followed by a positive deflection peaking at ~200 ms (P2). N1 latency was shortest in AP, intermediate in non-AP musicians, and longest in NM. Source analyses showed decreased auditory cortex and increased frontal cortex contributions to N1 for complex tones compared with pure tones. Compared with NM, AP musicians had weaker source currents in left auditory cortex but stronger currents in left inferior frontal gyrus (IFG) during N1, and stronger currents in left IFG during P2. Compared with non-AP musicians, AP musicians exhibited stronger source currents in right insula and left IFG during N1, and stronger currents in left IFG during P2. Non-AP musicians had stronger N1 currents in right auditory cortex than nonmusicians. Currents in left IFG and left auditory cortex were correlated to response times exclusively in AP. Findings suggest a left frontotemporal network supports rapid pitch labeling in AP.

The relationship between acoustic and musical pitch processing in adolescents.

Amusia is defined as a difficulty processing the tonal pitch structure of music such that an individual cannot tell the difference between notes that are in-key and out-of-key. A fine-grained pitch discrimination deficit is often observed in people with amusia. It is possible that an intervention, early in development, could mitigate amusia; however, one challenge identifying amusia early in development is that identifying in- and out-of-key notes is a metacognitive task. Given the common co-occurrence of difficulties with pitch discrimination, it would be easier to identify amusia in developing children by using a pitch change detection task. The goal of this study was to explore the behavioural and neurophysiological profiles of adolescents with poor pitch processing (Poor PP) abilities compared with those with normal pitch processing (Normal PP) abilities. Neurophysiologically, the Poor PPs exhibited a similar event-related potential (ERP) profile to adult amusics during both acoustic and musical pitch discrimination tasks. That is, early ERPs (ERAN, MMN) were similar in Poor PPs compared with Normal PPs, whereas late positivities (P300, P600) were absent in Poor PPs, but present in Normal PPs. At the same time, behavioural data revealed a double dissociation between the abilities to detect a pitch deviant in acoustic and musical context, suggesting that about a third of the children would be missed by selecting a fine-grained acoustic pitch discrimination task to identify the presence of amusia in early childhood.

Distinct Representations of Tonotopy and Pitch in Human Auditory Cortex.

Frequency-to-place mapping, or tonotopy, is a fundamental organizing principle throughout the auditory system, from the earliest stages of auditory processing in the cochlea to subcortical and cortical regions. Although cortical maps are referred to as tonotopic, it is unclear whether they simply reflect a mapping of physical frequency inherited from the cochlea, a computation of pitch based on the fundamental frequency, or a mixture of these two features. We used high-resolution functional magnetic resonance imaging (fMRI) to measure BOLD responses as male and female human participants listened to pure tones that varied in frequency or complex tones that varied in either spectral content (brightness) or fundamental frequency (pitch). Our results reveal evidence for pitch tuning in bilateral regions that partially overlap with the traditional tonotopic maps of spectral content. In general, primary regions within Heschl's gyri (HGs) exhibited more tuning to spectral content, whereas areas surrounding HGs exhibited more tuning to pitch.SIGNIFICANCE STATEMENT Tonotopy, an orderly mapping of frequency, is observed throughout the auditory system. However, it is not known whether the tonotopy observed in the cortex simply reflects the frequency spectrum (as in the ear) or instead represents the higher-level feature of fundamental frequency, or pitch. Using carefully controlled stimuli and high-resolution functional magnetic resonance imaging (fMRI), we separated these features to study their cortical representations. Our results suggest that tonotopy in primary cortical regions is driven predominantly by frequency, but also reveal evidence for tuning to pitch in regions that partially overlap with the tonotopic gradients but extend into nonprimary cortical areas. In addition to resolving ambiguities surrounding cortical tonotopy, our findings provide evidence that selectivity for pitch is distributed bilaterally throughout auditory cortex.

Acoustically Enriched Environment during the Critical Period of Postnatal Development Positively Modulates Gap Detection and Frequency Discrimination Abilities in Adult Rats.

Throughout life, sensory systems adapt to the sensory environment to provide optimal responses to relevant tasks. In the case of a developing system, sensory inputs induce changes that are permanent and detectable up to adulthood. Previously, we have shown that rearing rat pups in a complex acoustic environment (spectrally and temporally modulated sound) from postnatal day 14 (P14) to P28 permanently improves the response characteristics of neurons in the inferior colliculus and auditory cortex, influencing tonotopical arrangement, response thresholds and strength, and frequency selectivity, along with stochasticity and the reproducibility of neuronal spiking patterns. In this study, we used a set of behavioral tests based on a recording of the acoustic startle response (ASR) and its prepulse inhibition (PPI), with the aim to extend the evidence of the persistent beneficial effects of the developmental acoustical enrichment. The enriched animals were generally not more sensitive to startling sounds, and also, their PPI of ASR, induced by noise or pure tone pulses, was comparable to the controls. They did, however, exhibit a more pronounced PPI when the prepulse stimulus was represented either by a change in the frequency of a background tone or by a silent gap in background noise. The differences in the PPI of ASR between the enriched and control animals were significant at lower (55 dB SPL), but not at higher (65-75 dB SPL), intensities of background sound. Thus, rearing pups in the acoustically enriched environment led to an improvement of the frequency resolution and gap detection ability under more difficult testing conditions, i.e., with a worsened stimulus clarity. We confirmed, using behavioral tests, that an acoustically enriched environment during the critical period of development influences the frequency and temporal processing in the auditory system, and these changes persist until adulthood.

Low fundamental and formant frequencies predict fighting ability among male mixed martial arts fighters.

Human voice pitch is highly sexually dimorphic and eminently quantifiable, making it an ideal phenotype for studying the influence of sexual selection. In both traditional and industrial populations, lower pitch in men predicts mating success, reproductive success, and social status and shapes social perceptions, especially those related to physical formidability. Due to practical and ethical constraints however, scant evidence tests the central question of whether male voice pitch and other acoustic measures indicate actual fighting ability in humans. To address this, we examined pitch, pitch variability, and formant position of 475 mixed martial arts (MMA) fighters from an elite fighting league, with each fighter's acoustic measures assessed from multiple voice recordings extracted from audio or video interviews available online (YouTube, Google Video, podcasts), totaling 1312 voice recording samples. In four regression models each predicting a separate measure of fighting ability (win percentages, number of fights, Elo ratings, and retirement status), no acoustic measure significantly predicted fighting ability above and beyond covariates. However, after fight statistics, fight history, height, weight, and age were used to extract underlying dimensions of fighting ability via factor analysis, pitch and formant position negatively predicted "Fighting Experience" and "Size" factor scores in a multivariate regression model, explaining 3-8% of the variance. Our findings suggest that lower male pitch and formants may be valid cues of some components of fighting ability in men.

Auditory local-global temporal processing: evidence for perceptual reorganization with musical expertise.

The way the visual system processes different scales of spatial information has been widely studied, highlighting the dominant role of global over local processing. Recent studies addressing how the auditory system deals with local-global temporal information suggest a comparable processing scheme, but little is known about how this organization is modulated by long-term musical training, in particular regarding musical sequences. Here, we investigate how non-musicians and expert musicians detect local and global pitch changes in short hierarchical tone sequences structured across temporally-segregated triplets made of musical intervals (local scale) forming a melodic contour (global scale) varying either in one direction (monotonic) or both (non-monotonic). Our data reveal a clearly distinct organization between both groups. Non-musicians show global advantage (enhanced performance to detect global over local modifications) and global-to-local interference effects (interference of global over local processing) only for monotonic sequences, while musicians exhibit the reversed pattern for non-monotonic sequences. These results suggest that the local-global processing scheme depends on the complexity of the melodic contour, and that long-term musical training induces a prominent perceptual reorganization that reshapes its initial global dominance to favour local information processing. This latter result supports the theory of "analytic" processing acquisition in musicians.

A Neurophysiological Study of Musical Pitch Identification in Mandarin-Speaking Cochlear Implant Users.

Music perception in cochlear implant (CI) users is far from satisfactory, not only because of the technological limitations of current CI devices but also due to the neurophysiological alterations that generally accompany deafness. Early behavioral studies revealed that similar mechanisms underlie musical and lexical pitch perception in CI-based electric hearing. Although neurophysiological studies of the musical pitch perception of English-speaking CI users are actively ongoing, little such research has been conducted with Mandarin-speaking CI users; as Mandarin is a tonal language, these individuals require pitch information to understand speech. The aim of this work was to study the neurophysiological mechanisms accounting for the musical pitch identification abilities of Mandarin-speaking CI users and normal-hearing (NH) listeners. Behavioral and mismatch negativity (MMN) data were analyzed to examine musical pitch processing performance. Moreover, neurophysiological results from CI users with good and bad pitch discrimination performance (according to the just-noticeable differences (JND) and pitch-direction discrimination (PDD) tasks) were compared to identify cortical responses associated with musical pitch perception differences. The MMN experiment was conducted using a passive oddball paradigm, with musical tone C4 (262 Hz) presented as the standard and tones D4 (294 Hz), E4 (330 Hz), G#4 (415 Hz), and C5 (523 Hz) presented as deviants. CI users demonstrated worse musical pitch discrimination ability than did NH listeners, as reflected by larger JND and PDD thresholds for pitch identification, and significantly increased latencies and reduced amplitudes in MMN responses. Good CI performers had better MMN results than did bad performers. Consistent with findings for English-speaking CI users, the results of this work suggest that MMN is a viable marker of cortical pitch perception in Mandarin-speaking CI users.

Enhanced Pitch Discrimination for Cochlear Implant Users with a New Haptic Neuroprosthetic.

The cochlear implant (CI) is the most widely used neuroprosthesis, recovering hearing for more than half a million severely-to-profoundly hearing-impaired people. However, CIs still have significant limitations, with users having severely impaired pitch perception. Pitch is critical to speech understanding (particularly in noise), to separating different sounds in complex acoustic environments, and to music enjoyment. In recent decades, researchers have attempted to overcome shortcomings in CIs by improving implant technology and surgical techniques, but with limited success. In the current study, we take a new approach of providing missing pitch information through haptic stimulation on the forearm, using our new mosaicOne_B device. The mosaicOne_B extracts pitch information in real-time and presents it via 12 motors that are arranged in ascending pitch along the forearm, with each motor representing a different pitch. In normal-hearing subjects listening to CI simulated audio, we showed that participants were able to discriminate pitch differences at a similar performance level to that achieved by normal-hearing listeners. Furthermore, the device was shown to be highly robust to background noise. This enhanced pitch discrimination has the potential to significantly improve music perception, speech recognition, and speech prosody perception in CI users.

How musical experience affects tone perception efficiency by musicians of tonal and non-tonal speakers?

PURPOSE: To investigate if, regardless of language background (tonal or non-tonal), musicians may show stronger CP than non-musicians; To examine if native speakers of English (English or non-tonal musicians henceforth) or Mandarin Chinese (Mandarin or tonal musicians henceforth) can better accommodate multiple functions of the same acoustic cue and if musicians' sensitivity to pitch of lexical tones comes at the cost of slower processing. METHOD: English and Mandarin Musicians and non-musicians performed a categorical identification and a discrimination task on rising and falling continua of fundamental frequency on two vowels with 9 duration values. RESULTS: Non-tonal musicians exhibited significantly stronger categorical perception of pitch contour than non-tonal non-musicians. However, tonal musicians did not consistently perceive the two types of pitch directions more categorically than tonal non-musicians. Both tonal and non-tonal musicians also benefited more from increasing stimulus duration in processing pitch changes than non-musicians and they generally require less time for pitch processing. Musicians were also more sensitive to intrinsic F0 in pitch perception and differences of pitch types. CONCLUSION: The effect of musical training strengthens categorical perception more consistently in non-tonal speakers than tonal speakers. Overall, musicians benefit more from increased stimulus duration, due perhaps to their greater sensitivity to temporal information, thus allowing them to be better at forming a more robust auditory representation and matching sounds to internalized memory templates. Musicians also attended more to acoustic details such as intrinsic F0 and pitch types in pitch processing, and yet, overall, their categorization of pitch was not compromised by traces of these acoustic details from their auditory short-term working memory. These findings may lead to a better understanding of pitch perception deficits in special populations, particularly among individuals diagnosed with autism spectrum disorder (ASD).

Modifying the Adult Rat Tonotopic Map with Sound Exposure Produces Frequency Discrimination Deficits That Are Recovered with Training.

Frequency discrimination learning is often accompanied by an expansion of the functional region corresponding to the target frequency within the auditory cortex. Although the perceptual significance of this plastic functional reorganization remains debated, greater cortical representation is generally thought to improve perception for a stimulus. Recently, the ability to expand functional representations through passive sound experience has been demonstrated in adult rats, suggesting that it may be possible to design passive sound exposures to enhance specific perceptual abilities in adulthood. To test this hypothesis, we exposed adult female Long-Evans rats to 2 weeks of moderate-intensity broadband white noise followed by 1 week of 7 kHz tone pips, a paradigm that results in the functional over-representation of 7 kHz within the adult tonotopic map. We then tested the ability of exposed rats to identify 7 kHz among distractor tones on an adaptive tone discrimination task. Contrary to our expectations, we found that map expansion impaired frequency discrimination and delayed perceptual learning. Rats exposed to noise followed by 15 kHz tone pips were not impaired at the same task. Exposed rats also exhibited changes in auditory cortical responses consistent with reduced discriminability of the exposure tone. Encouragingly, these deficits were completely recovered with training. Our results provide strong evidence that map expansion alone does not imply improved perception. Rather, plastic changes in frequency representation induced by bottom-up processes can worsen perceptual faculties, but because of the very nature of plasticity these changes are inherently reversible.SIGNIFICANCE STATEMENT The potent ability of our acoustic environment to shape cortical sensory representations throughout life has led to a growing interest in harnessing both passive sound experience and operant perceptual learning to enhance mature cortical function. We use sound exposure to induce targeted expansions in the adult rat tonotopic map and find that these bottom-up changes unexpectedly impair performance on an adaptive tone discrimination task. Encouragingly, however, we also show that training promotes the recovery of electrophysiological measures of reduced neural discriminability following sound exposure. These results provide support for future neuroplasticity-based treatments that take into account both the sensory statistics of our external environment and perceptual training strategies to improve learning and memory in the adult auditory system.

Vowel and Tone Identification for Mandarin Congenital Amusics: Effects of Vowel Type and Semantic Content.

Purpose This study aimed to explore the effects of Mandarin congenital amusia with or without lexical tone deficit (i.e., tone agnosia and pure amusia) on Mandarin vowel and tone identification in different types of vowels (e.g., monophthong, diphthongs, and triphthongs) embedded in consonant-vowel contexts with and without semantic content. Method Thirteen pure amusics (i.e., amusics with normal lexical processing), 5 tone agnosics (i.e., with lexical tone deficit), and 12 controls were screened with Montreal Battery of Evaluation of Amusia and lexical tone tests (Nan et al., 2010; Peretz et al., 2003). Vowel-plus-tone identification tasks with the factors of vowel type and syllables with and without semantic content (e.g., real and nonsense words) were examined among the 3 groups, and identification scores were calculated in 3 formats: vowel-plus-tone identification, vowel identification, and tone identification. Results Tone agnosics showed significantly poorer performances on identifications of vowel, tone, and vowel plus tone across monophthongs, diphthongs, and triphthongs in both real and nonsense words compared to pure amusics and controls. Their deficits were similar across the 3 types of vowels, while the deficit on vowel-plus-tone identification was more severe in nonsense words than in real words. On the other hand, pure amusics performed similarly with controls across all these conditions. Conclusions Tone agnosia might affect both musical pitch and phonological processing, resulting in deficits in lexical tone and vowel perception. On the contrary, pure amusics's effect is primarily on musical pitch perception but not on lexical tone or phonemic deficit. Vowel type did not affect speech deficits for tone agnosics, while they relied more on semantic content as a compensation.

Alpha Oscillations in the Human Brain Implement Distractor Suppression Independent of Target Selection.

In principle, selective attention is the net result of target selection and distractor suppression. The way in which both mechanisms are implemented neurally has remained contested. Neural oscillatory power in the alpha frequency band (∼10 Hz) has been implicated in the selection of to-be-attended targets, but there is lack of empirical evidence for its involvement in the suppression of to-be-ignored distractors. Here, we use electroencephalography recordings of N = 33 human participants (males and females) to test the preregistered hypothesis that alpha power directly relates to distractor suppression and thus operates independently from target selection. In an auditory spatial pitch discrimination task, we modulated the location (left vs right) of either a target or a distractor tone sequence, while fixing the other in the front. When the distractor was fixed in the front, alpha power relatively decreased contralaterally to the target and increased ipsilaterally. Most importantly, when the target was fixed in the front, alpha lateralization reversed in direction for the suppression of distractors on the left versus right. These data show that target-selection-independent alpha power modulation is involved in distractor suppression. Although both lateralized alpha responses for selection and for suppression proved reliable, they were uncorrelated and distractor-related alpha power emerged from more anterior, frontal cortical regions. Lending functional significance to suppression-related alpha oscillations, alpha lateralization at the individual, single-trial level was predictive of behavioral accuracy. These results fuel a renewed look at neurobiological accounts of selection-independent suppressive filtering in attention.SIGNIFICANCE STATEMENT Although well established models of attention rest on the assumption that irrelevant sensory information is filtered out, the neural implementation of such a filter mechanism is unclear. Using an auditory attention task that decouples target selection from distractor suppression, we demonstrate that two sign-reversed lateralized alpha responses reflect target selection versus distractor suppression. Critically, these alpha responses are reliable, independent of each other, and generated in more anterior, frontal regions for suppression versus selection. Prediction of single-trial task performance from alpha modulation after stimulus onset agrees with the view that alpha modulation bears direct functional relevance as a neural implementation of attention. Results demonstrate that the neurobiological foundation of attention implies a selection-independent alpha oscillatory mechanism to suppress distraction.

Implicit temporal predictability enhances pitch discrimination sensitivity and biases the phase of delta oscillations in auditory cortex.

Can human listeners use implicit temporal contingencies in auditory input to form temporal predictions, and if so, how are these predictions represented endogenously? To assess this question, we implicitly manipulated temporal predictability in an auditory pitch discrimination task: unbeknownst to participants, the pitch of the standard tone could either be deterministically predictive of the temporal onset of the target tone, or convey no predictive information. Predictive and non-predictive conditions were presented interleaved in one stream, and separated by variable inter-stimulus intervals such that there was no dominant stimulus rhythm throughout. Even though participants were unaware of the implicit temporal contingencies, pitch discrimination sensitivity (the slope of the psychometric function) increased when the onset of the target tone was predictable in time (N = 49, 28 female, 21 male). Concurrently recorded EEG data (N = 24) revealed that standard tones that conveyed temporal predictions evoked a more negative N1 component than non-predictive standards. We observed no significant differences in oscillatory power or phase coherence between conditions during the foreperiod. Importantly, the phase angle of delta oscillations (1-3 Hz) in auditory areas in the post-standard and pre-target time windows predicted behavioral pitch discrimination sensitivity. This suggests that temporal predictions are encoded in delta oscillatory phase during the foreperiod interval. In sum, we show that auditory perception benefits from implicit temporal contingencies, and provide evidence for a role of slow neural oscillations in the endogenous representation of temporal predictions, in absence of exogenously driven entrainment to rhythmic input.

Pitch-specific contributions of auditory imagery and auditory memory in vocal pitch imitation.

Vocal imitation guides both music and language development. Despite the developmental significance of this behavior, a sizable minority of individuals are inaccurate at vocal pitch imitation. Although previous research suggested that inaccurate pitch imitation results from deficient sensorimotor associations between pitch perception and vocal motor planning, the cognitive processes involved in sensorimotor translation are not clearly defined. In the present research, we investigated the roles of basic cognitive processes in the vocal imitation of pitch, as well as the degree to which these processes rely on pitch-specific resources. In the present study, participants completed a battery of pitch and verbal tasks to measure pitch perception, pitch and verbal auditory imagery, pitch and verbal auditory short-term memory, and pitch imitation ability. Information on participants' music background was collected, as well. Pitch imagery, pitch short-term memory, pitch discrimination ability, and musical experience were unique predictors of pitch imitation ability. Furthermore, pitch imagery was a partial mediator of the relationship between pitch short-term memory and pitch imitation ability. These results indicate that vocal imitation recruits cognitive processes that rely on at least partially separate neural resources for pitch and verbal representations.

Speech perception is similar for musicians and non-musicians across a wide range of conditions.

It remains unclear whether musical training is associated with improved speech understanding in a noisy environment, with different studies reaching differing conclusions. Even in those studies that have reported an advantage for highly trained musicians, it is not known whether the benefits measured in laboratory tests extend to more ecologically valid situations. This study aimed to establish whether musicians are better than non-musicians at understanding speech in a background of competing speakers or speech-shaped noise under more realistic conditions, involving sounds presented in space via a spherical array of 64 loudspeakers, rather than over headphones, with and without simulated room reverberation. The study also included experiments testing fundamental frequency discrimination limens (F0DLs), interaural time differences limens (ITDLs), and attentive tracking. Sixty-four participants (32 non-musicians and 32 musicians) were tested, with the two groups matched in age, sex, and IQ as assessed with Raven's Advanced Progressive matrices. There was a significant benefit of musicianship for F0DLs, ITDLs, and attentive tracking. However, speech scores were not significantly different between the two groups. The results suggest no musician advantage for understanding speech in background noise or talkers under a variety of conditions.

A lateral inhibition mechanism explains the dissociation between mismatch negativity and behavioral pitch discrimination.

Although mismatch negativity (MMN), a change-specific component of auditory event-related potential, is considered to be an index of sound discrimination accuracy, the amplitude of the MMN responses elicited by pitch height deviations in musicians and tone language speakers with superior pitch discrimination is usually not enhanced compared to that elicited in individuals with inferior pitch discrimination. We hypothesized that superior pitch discrimination is accompanied by enhanced lateral inhibition, a critical neural mechanism that sharpens the tuning curves of the auditory neurons in the tonotopy. Forty Mandarin-speaking healthy adults completed an auditory EEG experiment in which MMN was elicited by pitch height deviations in both pure and harmonic tones. Their behavioral pitch discrimination was indexed by the difference limens measured using pure and harmonic tones. Behavioral pitch discrimination correlated significantly with the MMN elicited by pure tones, but not by harmonic tones; this could be due to lateral inhibition strongly influencing the MMN elicited by harmonic tones but having less effect on the MMN elicited by pure tones. As lateral inhibition is a neural mechanism for attenuating the amplitude of MMN, our results support the notion that an enhanced lateral inhibition mechanism underlies superior pitch discrimination.

Mismatch negativity reveals plasticity in cortical dynamics after 1-hour of auditory training exercises.

BACKGROUND: Impaired sensory processing contributes to deficits in cognitive and psychosocial functioning in individuals with schizophrenia (SZ). Mismatch Negativity (MMN), an event-related potential (ERP) index of sensory discrimination associated with cognitive and psychosocial functioning, is a candidate biomarker of auditory discrimination and thus possibly of changes following auditory-based Targeted Cognitive Training (TCT). Here we evaluated the acute effect of TCT on cortical processes supporting auditory discrimination. METHODS: MMN was assessed in 28 SZ outpatients before and after a single 1-hour (hr) session of "Sound Sweeps," a pitch discrimination task that is a component of the TCT suite of exercises. Independent component (IC) analysis was applied to decompose 64-channel scalp-recorded electroencephalogram (EEG) activity into spatiotemporally stationary sources and their activities. ICs from all patients were pooled to find commonalities in their cortical locations. IC cluster-mean ERPs were evaluated to determine the clusters contributing to the (140-200 ms) MMN difference between responses to deviant and standard tone stimuli respectively. RESULTS: Two frontal IC clusters centered in orbitofrontal cortex (OFC) and anterior cingulate cortex (ACC) accounted for >77% of MMN variance across all scalp channels. After 1-hr auditory training, significant suppression of ACC cluster contributions was detected, whereas the OFC cluster contribution was unchanged. CONCLUSIONS: Prior to TCT, the MMN response was dominated by EEG effective sources in or near OFC and ACC. However, after 1-hr of auditory-based TCT, a significant attenuation of ACC was observed, whereas OFC contribution to MMN persisted. The present findings support further trials designed to test whether training-related MMN plasticity in the ACC after 1-hr may predict individual patient response to a full course of TCT.

The time course of auditory recognition measured with rapid sequences of short natural sounds.

Human listeners are able to recognize accurately an impressive range of complex sounds, such as musical instruments or voices. The underlying mechanisms are still poorly understood. Here, we aimed to characterize the processing time needed to recognize a natural sound. To do so, by analogy with the "rapid visual sequential presentation paradigm", we embedded short target sounds within rapid sequences of distractor sounds. The core hypothesis is that any correct report of the target implies that sufficient processing for recognition had been completed before the time of occurrence of the subsequent distractor sound. We conducted four behavioral experiments using short natural sounds (voices and instruments) as targets or distractors. We report the effects on performance, as measured by the fastest presentation rate for recognition, of sound duration, number of sounds in a sequence, the relative pitch between target and distractors and target position in the sequence. Results showed a very rapid auditory recognition of natural sounds in all cases. Targets could be recognized at rates up to 30 sounds per second. In addition, the best performance was observed for voices in sequences of instruments. These results give new insights about the remarkable efficiency of timbre processing in humans, using an original behavioral paradigm to provide strong constraints on future neural models of sound recognition.

Rhythmicity facilitates pitch discrimination: Differential roles of low and high frequency neural oscillations.

Previous studies indicate that temporal predictability can enhance timing and intensity perception, but it is not known whether it also enhances pitch perception, despite pitch being a fundamental perceptual attribute of sound. Here we investigate this in the context of rhythmic regularity, a form of predictable temporal structure common in sound streams, including music and speech. It is known that neural oscillations in low (delta: 1-3 Hz) and high (beta: 15-25 Hz) frequency bands entrain to rhythms in phase and power, respectively, but it is not clear why both low and high frequency bands entrain to external rhythms, and whether they and their coupling serve different perceptual functions. Participants discriminated near-threshold pitch deviations (targets) embedded in either rhythmic (regular/isochronous) or arrhythmic (irregular/non-isochronous) tone sequences. Psychophysically, we found superior pitch discrimination performance for target tones in rhythmic compared to arrhythmic sequences. Electroencephalography recordings from auditory cortex showed that delta phase, beta power modulation, and delta-beta coupling were all modulated by rhythmic regularity. Importantly, trial-by-trial neural-behavioural correlational analyses showed that, prior to a target, the depth of U-shaped beta power modulation predicted pitch discrimination sensitivity whereas cross-frequency coupling strength predicted reaction time. These novel findings suggest that delta phase might reflect rhythmic temporal expectation, beta power temporal attention, and delta-beta coupling auditory-motor communication. Together, low and high frequency auditory neural oscillations reflect different perceptual functions that work in concert for tracking rhythmic regularity and proactively facilitate pitch perception.

Frequency change detection and speech perception in cochlear implant users.

Dynamic frequency changes in sound provide critical cues for speech perception. Most previous studies examining frequency discrimination in cochlear implant (CI) users have employed behavioral tasks in which target and reference tones (differing in frequency) are presented statically in separate time intervals. Participants are required to identify the target frequency by comparing stimuli across these time intervals. However, perceiving dynamic frequency changes in speech requires detection of within-interval frequency change. This study explored the relationship between detection of within-interval frequency changes and speech perception performance of CI users. Frequency change detection thresholds (FCDTs) were measured in 20 adult CI users using a 3-alternative forced-choice (3AFC) procedure. Stimuli were 1-sec pure tones (base frequencies at 0.25, 1, 4 kHz) with frequency changes occurring 0.5 s after the tone onset. Speech tests were 1) Consonant-Nucleus-Consonant (CNC) monosyllabic word recognition, 2) Arizona Biomedical Sentence Recognition (AzBio) in Quiet, 3) AzBio in Noise (AzBio-N, +10 dB signal-to-noise/SNR ratio), and 4) Digits-in-noise (DIN). Participants' subjective satisfaction with the CI was obtained. Results showed that correlations between FCDTs and speech perception were all statistically significant. The satisfaction level of CI use was not related to FCDTs, after controlling for major demographic factors. DIN speech reception thresholds were significantly correlated to AzBio-N scores. The current findings suggest that the ability to detect within-interval frequency changes may play an important role in speech perception performance of CI users. FCDT and DIN can serve as simple and rapid tests that require no or minimal linguistic background for the prediction of CI speech outcomes.