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1.
J Neurosurg ; 139(5): 1386-1395, 2023 11 01.
Artigo em Inglês | MEDLINE | ID: mdl-37119096

RESUMO

OBJECTIVE: The authors of this study aimed to define the microanatomy of the interthalamic adhesion (ITA) using microfiber dissection, magnetic resonance (MR) tractography, and histological analysis. METHODS: Sagittal, coronal, and axial MR images from 160 healthy individuals 2-82 years of age were examined. The relationships between age range and ITA morphology as well as between gender and ITA morphology were evaluated statistically. Among these 160 individuals, 100 who had undergone MR tractography were examined. In this group, the presence of fiber tracts in the ITA and the relationship with ITA morphological types were examined. Thirty formalin-fixed human cadaveric brains were also examined endoscopically, and 6 hemispheres were dissected from the medial to lateral and superior to inferior directions under the microscope. Sections taken from one of the brains with an ITA type 2 with both thalami were examined histologically. Anti-neurofilament antibody was used in the histological examination. RESULTS: Four morphological types of ITA were observed. Type 1 had an adhesion/adherent appearance, type 2 had a bridge/commissure appearance, type 3 showed no adhesion, and type 4 had a double bridge. Tractographic examination revealed that 28% had no fiber tract transition in the ITA, 21% had a significant transition, and 51% had an indistinct transition. Statistically, the presence of the ITA was significantly higher in the pediatric (age) and female (gender) groups. In specimens with ITAs of a bridge/commissure appearance (type 2), fiber tracts showed clear transitions between thalami. In type 1 (adherent/adhesive appearance), fiber tracts were observed within the ITA, but a reciprocal transition was unclear. Dissection showed that these fiber tracts in the ITA reach the nucleus accumbens, caudate nucleus, and frontoorbital region anteriorly and the lateral habenula and posterior commissure posteriorly. Some fibers also joined the ansa peduncularis. In histological studies, axonal fibers moving in the ITA were observed with anti-neurofilament antibody staining. CONCLUSIONS: This is the first study to demonstrate fiber tracts of the ITA through fiber dissection and transillumination techniques as well as radiological and histological study. Statistical data were obtained by comparing the morphological group with age and gender groups. The anatomy of this structure, which has been neglected for many years, was reexamined. This study showed that the ITA has fibers connecting different parts of the brain, in contrast to previous studies suggesting that it was a simple massa.


Assuntos
Tálamo , Substância Branca , Humanos , Feminino , Criança , Tálamo/cirurgia , Imageamento por Ressonância Magnética/métodos , Substância Branca/anatomia & histologia , Encéfalo , Dissecação/métodos
2.
Rehabilitacion (Madr) ; 54(4): 292-295, 2020.
Artigo em Espanhol | MEDLINE | ID: mdl-32680689

RESUMO

Chronic or recalcitrant plantar fasciitis is a cause of persistent plantar pain. These cases are usually resistant to conventional treatments consisting of exercises, orthoses, shock waves and infiltrations and require a surgical approach. Proximal medial gastrocnemius release is a surgical option that provides satisfactory results, but is not free of complications, which include injuries and nerve entrapment. We report the first published case of symptomatic medial gastrocnemius branch entrapment in the post-surgical scar of a tenotomy for the treatment of recalcitrant plantar fasciitis. We propose ultrasound-guided hydrodissection with local anesthetic as a treatment with promising results.


Assuntos
Dissecação/métodos , Fasciíte Plantar/cirurgia , Síndromes de Compressão Nervosa/terapia , Complicações Pós-Operatórias/terapia , Nervo Tibial/lesões , Ultrassonografia de Intervenção , Anestesia Local , Cicatriz/complicações , Dissecação/instrumentação , Feminino , Seguimentos , Humanos , Pessoa de Meia-Idade , Síndromes de Compressão Nervosa/etiologia , Complicações Pós-Operatórias/etiologia , Pressão , Recidiva , Soluções/administração & dosagem , Soluções/uso terapêutico , Tenotomia/efeitos adversos , Escala Visual Analógica
3.
Neurosurgery ; 86(6): 860-872, 2020 06 01.
Artigo em Inglês | MEDLINE | ID: mdl-31504849

RESUMO

BACKGROUND: The subthalamic nucleus (STN), globus pallidus internus (GPi), and pedunculopontine nucleus (PPN) are effective targets for deep brain stimulation (DBS) in many pathological conditions. Previous literature has focused on appropriate stimulation targets and their relationships with functional neuroanatomic pathways; however, comprehensive anatomic dissections illustrating these nuclei and their connections are lacking. This information will provide insight into the anatomic basis of stimulation-induced DBS benefits and side effects. OBJECTIVE: To combine advanced cadaveric dissection techniques and ultrahigh field magnetic resonance imaging (MRI) to explore the anatomy of the STN, GPi, and PPN with their associated fiber pathways. METHODS: A total of 10 cadaveric human brains and 2 hemispheres of a cadaveric head were examined using fiber dissection techniques. The anatomic dissections were compared with 11.1 Tesla (T) structural MRI and 4.7 T MRI fiber tractography. RESULTS: The extensive connections of the STN (caudate nucleus, putamen, medial frontal cortex, substantia innominata, substantia nigra, PPN, globus pallidus externus (GPe), GPi, olfactory tubercle, hypothalamus, and mammillary body) were demonstrated. The connections of GPi to the thalamus, substantia nigra, STN, amygdala, putamen, PPN, and GPe were also illustrated. The PPN was shown to connect to the STN and GPi anteriorly, to the cerebellum inferiorly, and to the substantia nigra anteriorly and superiorly. CONCLUSION: This study demonstrates connections using combined anatomic microdissections, ultrahigh field MRI, and MRI tractography. The anatomic findings are analyzed in relation to various stimulation-induced clinical effects. Precise knowledge of neuroanatomy, anatomic relationships, and fiber connections of the STN, GPi, PPN will likely enable more effective targeting and improved DBS outcomes.


Assuntos
Estimulação Encefálica Profunda/métodos , Dissecação/métodos , Globo Pálido/cirurgia , Núcleo Tegmental Pedunculopontino/cirurgia , Núcleo Subtalâmico/cirurgia , Tálamo/cirurgia , Autopsia , Globo Pálido/diagnóstico por imagem , Globo Pálido/patologia , Humanos , Imageamento por Ressonância Magnética/métodos , Núcleo Tegmental Pedunculopontino/diagnóstico por imagem , Núcleo Tegmental Pedunculopontino/patologia , Núcleo Subtalâmico/diagnóstico por imagem , Núcleo Subtalâmico/patologia , Tálamo/diagnóstico por imagem , Tálamo/patologia
4.
Low Urin Tract Symptoms ; 12(2): 137-142, 2020 May.
Artigo em Inglês | MEDLINE | ID: mdl-31762198

RESUMO

OBJECTIVES: To investigate the efficacy of transurethral resection (TUR) on relieving urinary symptoms in patients with keratinizing squamous metaplasia (KSM) of the urinary bladder. METHODS: Data were analyzed from a retrospective study of patients receiving transurethral bipolar plasma resection (bi-TUR) treatment for symptomatic KSM. Urinary symptoms were assessed by the International Prostate Symptom Score (IPSS) and a numeric rating scale pain score. Efficacy was assessed using the IPSS to determine changes from baseline in lower urinary tract symptoms (LUTS). Self-reported quality of life (QoL) was assessed by the last question of the IPSS questionnaire. RESULTS: A total of 92 female patients were included in the analysis. The median age was 42 years. LUTS, pain, and hematuria were the most common symptoms that affected patients. The median follow-up duration was 51 months. There were significant improvements in LUTS from baseline IPSS after TUR (P < .001). The percentage of the patients with moderate to severe LUTS went down from 52.2% to 18.5%. The median Numeric Rating Scale (NRS)-11 pain score reduced from 3 at baseline to 0 at the last visit. Twenty-one out of 40 patients reported that the pain symptoms disappeared completely. No patients reported hematuria symptoms at the final follow-up. Improvement of self-reported QoL was significant (P < .001). A total of 57.6% of patients reported an improvement, 26.1% of patients reported no improvement, and 16.3% reported deterioration. CONCLUSIONS: Bi-TUR therapy significantly relieved urinary symptoms in women with KSM. Improvement of QoL was acceptable with a success rate of 57.6%. Considering the very low complication rate, our study supported bi-TUR as an alternative treatment for patients who are resistant to medical therapy.


Assuntos
Cistoscopia , Leucoplasia , Sintomas do Trato Urinário Inferior , Metaplasia/patologia , Qualidade de Vida , Bexiga Urinária , Adulto , Cistoscopia/efeitos adversos , Cistoscopia/métodos , Dissecação/métodos , Feminino , Humanos , Leucoplasia/patologia , Leucoplasia/fisiopatologia , Leucoplasia/cirurgia , Sintomas do Trato Urinário Inferior/diagnóstico , Sintomas do Trato Urinário Inferior/etiologia , Sintomas do Trato Urinário Inferior/psicologia , Sintomas do Trato Urinário Inferior/terapia , Estudos Retrospectivos , Resultado do Tratamento , Bexiga Urinária/patologia , Bexiga Urinária/fisiopatologia , Bexiga Urinária/cirurgia , Neoplasias da Bexiga Urinária/prevenção & controle
5.
Eur Arch Otorhinolaryngol ; 276(6): 1707-1711, 2019 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-30895435

RESUMO

PURPOSE: Endoscopic approach represents a valid alternative to conventional septoplasty. The aim of this study is to analyze the objective and subjective data on 276 patients, who underwent traditional (147) or endoscopic (129) septoplasty. METHODS: This is a prospective observational study on 276 consecutive patients affected by deviated nasal septum (DNS), who underwent isolated septoplasty between 2011 and 2018. 147 of them were treated using an "open" approach, while 129 were treated with an endoscopic approach. The two groups were compared 3 months after surgery: the objective results (complications such as bleeding, hematoma, pain, synechiae, septal tears and incomplete correction), objective (rhinomanometric data) and subjective measurements (NOSE questionnaires). RESULTS: Both techniques are effective in decreasing nasal obstruction and discharge. Complications such as pain, synechiae, early postoperative bleeding, septal tears and incomplete correction are less frequent in the endoscopic group (p < 0.05). The rhinomanometric analysis reveal improvement in both groups without statistical differences. Subjective questionnaires show a good symptoms relief with an improved quality of life in all 276 patients without statistical difference between the two gropus. CONCLUSIONS: Both techniques are effective in reducing nasal obstruction and related symptoms with fewer overall complications in the endoscopic approach. The endoscope provides improved field of view, less mucosal damages and a more anatomic dissection. Finally, such approach can be a valuable teaching tool for assistants, residents and students.


Assuntos
Dissecação/métodos , Endoscopia , Deformidades Adquiridas Nasais , Complicações Pós-Operatórias , Qualidade de Vida , Rinoplastia , Adulto , Dissecação/efeitos adversos , Endoscopia/efeitos adversos , Endoscopia/métodos , Feminino , Humanos , Itália/epidemiologia , Masculino , Pessoa de Meia-Idade , Septo Nasal/cirurgia , Deformidades Adquiridas Nasais/epidemiologia , Deformidades Adquiridas Nasais/cirurgia , Avaliação de Processos e Resultados em Cuidados de Saúde , Complicações Pós-Operatórias/diagnóstico , Complicações Pós-Operatórias/epidemiologia , Complicações Pós-Operatórias/etiologia , Complicações Pós-Operatórias/psicologia , Estudos Prospectivos , Rinomanometria/métodos , Rinoplastia/efeitos adversos , Rinoplastia/métodos , Rinoplastia/estatística & dados numéricos , Inquéritos e Questionários
6.
Mo Med ; 115(1): 61-65, 2018.
Artigo em Inglês | MEDLINE | ID: mdl-30228685

RESUMO

The current study surveyed first-year osteopathic medical students about dissection, multimedia dissector, split laboratories, VH (virtual human) dissector, ultrasonography, and prior experience of anatomical concepts. Students perceived cadaveric dissection, multimedia dissector, and ultrasonography laboratories as important contributors for learning anatomy. Students felt cadaveric dissection was an important factor in their medical school selection. Study results suggested students perceived integrated anatomy courses that utilized dissection and multimodal approaches to deliver anatomical information as highly effective.


Assuntos
Anatomia/educação , Dissecação/educação , Educação de Graduação em Medicina/métodos , Medicina Osteopática/educação , Estudantes de Medicina/psicologia , Adulto , Cadáver , Dissecação/métodos , Feminino , Humanos , Masculino , Multimídia , Inquéritos e Questionários , Ultrassonografia , Realidade Virtual
7.
Minerva Chir ; 73(6): 528-533, 2018 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-29806756

RESUMO

"Modern" rectal cancer treatment began in the 18th century. However, initial results of the pioneer surgeons were very poor. During the next several decades, significant progress was made towards the cure of rectal cancer. Improvements have included lowering mortality, reducing recurrence, and optimizing functional outcomes. This article reviews the individuals and their advancements in rectal cancer treatment. It describes the changes in the surgical approach for tumor resection, the study of the lymphatic spread of rectal cancer and the advances in sphincter preservation procedures from the era of blunt dissection until the paradigm changing revolution of total mesorectal excision.


Assuntos
Procedimentos Cirúrgicos do Sistema Digestório/tendências , Dissecação/tendências , Neoplasias Retais/cirurgia , Canal Anal , Anastomose Cirúrgica/métodos , Anestesia/história , Anestesia/métodos , Procedimentos Cirúrgicos do Sistema Digestório/história , Procedimentos Cirúrgicos do Sistema Digestório/métodos , Dissecação/história , Dissecação/métodos , Egito , Europa (Continente) , História do Século XVIII , História do Século XIX , História do Século XX , História Antiga , Humanos , Tratamentos com Preservação do Órgão/história , Tratamentos com Preservação do Órgão/métodos , Neoplasias Retais/história , Grampeamento Cirúrgico/história , Grampeamento Cirúrgico/métodos
8.
Medicine (Baltimore) ; 97(16): e0329, 2018 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-29668581

RESUMO

INTRODUCTION: Here we present the case of a 56-year-old human immunodeficiency virus (HIV)-infected man with multiple anal condylomas and positivity for human papilloma virus (HPV) 18 on anal brushing. Biopsies of the anal mucosa led to the diagnosis of Bowen's disease and a subsequent pelvic magnetic resonance imaging (MRI) scan evidenced multiple reactive lymphoadenopathies and large intra-anal condylomas. The patient was treated with a complete excision of Bowen's lesion and with a 4 months course of supplementation with a high concentration multistrain probiotic formulation administered orally and by rectal instillation with the purpose to reduce local inflammation and to enhance local mucosal immunity. CONCLUSION: An MRI performed at the end of the supplementation period evidenced the clearance of the anal condylomas previously described and no evidence of residual lymphadenopathies. Trials are therefore required to confirm this therapeutic possibility and for a better understanding of the mechanisms by which this specific probiotic formulation interacts with local epithelium when administered by the anal route.


Assuntos
Doença de Bowen , Condiloma Acuminado , Dissecação/métodos , Infecções por HIV/complicações , Mucosa Intestinal/efeitos dos fármacos , Papillomaviridae/isolamento & purificação , Probióticos/administração & dosagem , Administração Oral , Administração Retal , Canal Anal/patologia , Canal Anal/cirurgia , Doença de Bowen/diagnóstico , Doença de Bowen/cirurgia , Doença de Bowen/terapia , Doença de Bowen/virologia , Condiloma Acuminado/diagnóstico , Condiloma Acuminado/cirurgia , Condiloma Acuminado/terapia , Condiloma Acuminado/virologia , Suplementos Nutricionais , Soropositividade para HIV/diagnóstico , Humanos , Masculino , Pessoa de Meia-Idade , Resultado do Tratamento
9.
J Int Adv Otol ; 14(2): 290-294, 2018 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-29460825

RESUMO

OBJECTIVE: There is still ongoing research on the relationship of arcuate eminence (AE) and superior semicircular canal (SSC). We aimed to evaluate the precision of predictability of SSC through the morphology of AE via radiological means. MATERIALS AND METHODS: This investigation is performed on 12 dry skulls belonging to Mersin University Medical Faculty department of anatomy. Computed tomography (CT) assessment is performed with 0.5-mm-thin sections temporal bone algorithm on dry skulls which were marked with fixated copper wire by scotch tapes on the most prominent part of the middle fossa floor assuming the location of AE. The data are reformatted on the workstation with vitrea 2.0. The distances of the determined three points including lateral (A), apical (B), and medial (C) of the SSC and the copper wire are measured radiologically. Also, the height between the most apical part of the SSC to the floor of the skullbase (H) is measured. The angles between the placed copper wires and the SSC (E) are calculated. The angle between SSC and the midpoint of the IAC (F) and SSC to the sulcus of the greater GSPN (G) were measured. The nearest distance was measured between the most posterior part of the SSC and the point marked by the perpendicular line drawn from the medial border of the petrous bone to the most posterior part of the internal auditory canal (IAC) (D). RESULTS: The right and left A, B, and C distances are 2.54+/- 2.75, 3.67+/-3.16, 5.85+/-3.77; 2.92+/-2.24, 3.68+/-2.93, 6.09+/-3.40, respectively. We could not find any statistical significance when the right A, B, and C distances were compared with the left values. Examination of the values revealed that C distance is greater than the A distance of the same side both for right (p=0.040) and left (p=0.022) measurements. The calculated left and right E angles are 30.313+/-12.838, and 35.558+/-18.437 degrees, respectively. Statistical significance was not found between the right and left angles. The right and left F, G angles were 53.17, 47.25; 93.58, 100.92 degrees; and D distances are 8.01, 8.13 millimeters, respectively. Statistical significance was not found when right and left E, F, G angles and D distances were compared. Among 12 left and 12 right sides, the copper wire was found to be nearly overlapping to SSC in two in the right and only one in the left. CONCLUSION: This study reveals that there is a great variability predicting the exact location of SSC through the prominence of AE. Complementary studies are needed with greater number of dry skulls and cadavers. Comparison of different hypothesis including the effect of temporal lobe sulcus is to be discussed to better enlighten the exact relationship of the aforementioned anatomical structures.


Assuntos
Fossa Craniana Média/diagnóstico por imagem , Dissecação/métodos , Canais Semicirculares/anatomia & histologia , Algoritmos , Cadáver , Fossa Craniana Média/anatomia & histologia , Fossa Craniana Média/cirurgia , Humanos , Osso Petroso/anatomia & histologia , Osso Petroso/diagnóstico por imagem , Osso Petroso/cirurgia , Canais Semicirculares/diagnóstico por imagem , Canais Semicirculares/cirurgia , Osso Temporal/anatomia & histologia , Osso Temporal/diagnóstico por imagem , Osso Temporal/cirurgia , Tomografia Computadorizada por Raios X/métodos
10.
Oper Neurosurg (Hagerstown) ; 14(4): 432-440, 2018 04 01.
Artigo em Inglês | MEDLINE | ID: mdl-28531285

RESUMO

BACKGROUND: Although the term paraclival carotid pervades recent skull base literature, no clear consensus exists regarding boundaries or anatomical segments. OBJECTIVE: To reconcile various internal carotid artery (ICA) nomenclatures for transcranial and endoscopic-endonasal perspectives, we reexamined the transition between lacerum (C3) and cavernous (C4) segments using a C1-C7 segments schema. In this cadaveric study, we obtained a 360°-circumferential view integrating histological, microsurgical, endoscopic, and neuroradiological analyses of this C3-C4 region and identified a distinct transitional segment. METHODS: In 13 adult, silicone-injected, formalin-fixed cadaveric heads (26 sides), transcranial-extradural-subtemporal and endoscopic-endonasal CT-guided dissections were performed. A quadrilateral area was noted medial to Meckel's cave between cranial nerve VI, anterolateral and posterolateral borders of the lateral-paratrigeminal aspect of the precavernous ICA, and posterior longitudinal ligament. Endoscopically, a medial-paraclival aspect was defined. Anatomical correlations were made with histological and neuroradiological slides. RESULTS: We identified a distinct precavernous C3-C4 transitional segment. In 18 (69%) specimens, venous channels were absent at the quadrilateral area, on the paratrigeminal border of the precavernous ICA. A trigeminal membrane, seen consistently on the superior border of V2, defined the lateral aspect of the cavernous sinus floor. The medial aspect of the precavernous ICA corresponded with the paraclival ICA. CONCLUSION: Our study revealing the juncture of 2 complementary borders of the ICA, endoscopic endonasal (paraclival) and transcranial (paratrigeminal), reconciles various nomenclature. A precavernous segment may clarify controversies about the paraclival ICA and support the concept of a "safe door" for lesions involving Meckel's cave, cavernous sinus, and petrous apex.


Assuntos
Artéria Carótida Interna/anatomia & histologia , Adulto , Cadáver , Seio Cavernoso/anatomia & histologia , Dissecação/métodos , Humanos , Neuroendoscopia/métodos , Tomografia Computadorizada por Raios X
11.
J Anat ; 231(2): 169-191, 2017 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-28547827

RESUMO

The African clawed frog, Xenopus laevis, is one of the most widely used model organisms in biological research. However, the most recent anatomical description of X. laevis was produced nearly a century ago. Compared with other anurans, pipid frogs - including X. laevis - exhibit numerous unusual morphological features; thus, anatomical descriptions of more 'typical' frogs do not detail many aspects of X. laevis skeletal and soft-tissue morphology. The relatively new method of using iodine-based agents to stain soft tissues prior to high-resolution X-ray imaging has several advantages over gross dissection, such as enabling dissection of very small and fragile specimens, and preserving the three-dimensional topology of anatomical structures. Here, we use contrast-enhanced computed tomography to produce a high-resolution three-dimensional digital dissection of a post-metamorphic X. laevis to successfully visualize: skeletal and muscular anatomy; the nervous, respiratory, digestive, excretory and reproductive systems; and the major sense organs. Our digital dissection updates and supplements previous anatomical descriptions of this key model organism, and we present the three-dimensional data as interactive portable document format (PDF) files that are easily accessible and freely available for research and educational purposes. The data presented here hold enormous potential for applications beyond descriptive purposes, particularly for biological researchers using this taxon as a model organism, comparative anatomy and biomechanical modelling.


Assuntos
Anatomia Comparada/métodos , Dissecação/métodos , Imageamento Tridimensional/métodos , Tomografia Computadorizada por Raios X/métodos , Xenopus laevis/anatomia & histologia , Animais , Meios de Contraste , Processamento de Imagem Assistida por Computador/métodos
13.
Clin Neurol Neurosurg ; 156: 35-40, 2017 May.
Artigo em Inglês | MEDLINE | ID: mdl-28292695

RESUMO

OBJECTIVE: The Klingler fiber dissection technique is a relevant and reliable method for neurosurgery to identify with accuracy the fine structure of the brain anatomy highlighting white matter tracts. In order to demonstrate the significance of the application of this technique, we aimed to observe the course and relations of the mammillothalamic and habenulo-interpeduncular tracts as there are very few papers showing these important diencephalic tracts. MATERIAL AND METHODS: Twelve formalin-fixed brains were dissected using the Klingler technique in order to expose the medial diencephalic surface. Diencephalic white matter tracts, particularly the mammillothalamic and habenulo-interpeduncular tracts, were dissected using wooden spatulas and metallic dissectors with different sizes and tips. Several measurements were performed in both dissected hemispheres relative to the mammillothalamic and habenulo-interpeduncular tracts. RESULTS: The course and length of these two tracts were visualized and the relations with other fiber systems and with the neighboring gray matter structures quantified and registered. The mammillothalamic tract approximately marks the anteroposterior coordinate of the anterior pole of the subthalamic nucleus in the anterior commissure - posterior commissure plane. CONCLUSION: The present study helps to understand the three-dimensional architecture of the white matter systems of tracts when the Klingler technique is used. The numerical data obtained may be helpful to neurosurgeons while approaching brain paraventricular and ventricular lesions and deep brain stimulation. Finally, the anatomical knowledge can lower surgical complications and improve patient care particularly in the field of neurosurgery.


Assuntos
Diencéfalo/anatomia & histologia , Diencéfalo/cirurgia , Procedimentos Neurocirúrgicos/métodos , Tratos Piramidais/anatomia & histologia , Tratos Piramidais/cirurgia , Substância Branca/anatomia & histologia , Substância Branca/cirurgia , Cadáver , Pedúnculo Cerebral/anatomia & histologia , Pedúnculo Cerebral/cirurgia , Dissecação/métodos , Habenula/anatomia & histologia , Habenula/cirurgia , Humanos , Corpos Mamilares/anatomia & histologia , Corpos Mamilares/cirurgia , Tálamo/anatomia & histologia , Tálamo/cirurgia , Fixação de Tecidos
14.
Rev. bras. cardiol. invasiva ; 23(4): 279-281, out.-dez. 2015. ilus
Artigo em Português | LILACS | ID: biblio-846619

RESUMO

A dissecção coronária espontânea é uma entidade rara e, por conseguinte, de etiologia, fisiopatologia e tratamento ainda não estabelecidos. Acomete, em geral, mulheres jovens, sem os clássicos fatores de risco cardiovascular, comumente ao longo do ciclo gravídico-puerperal. Vários fatores influenciam na estratégia de tratamento, como quadro clínico, status hemodinâmico, topografia da dissecção, número de artérias afetadas e fluxo coronário distal. Como no caso relatado, em pacientes estáveis, com dissecções bem delimitadas e, sobremodo, quando o fluxo coronário é reestabelecido, pode-se optar por uma abordagem conservadora, em razão da alta incidência de resolução espontânea e da baixa incidência de eventos adversos a longo prazo


Spontaneous coronary dissection is a rare entity and, therefore, its etiology, pathophysiology, and treatment are not yet established. It affects mainly young women without the classic cardiovascular risk factors, commonly during the pregnancy-childbirth cycle. Several factors influence the treatment strategy, such as clinical presentation, hemodynamic status, topography, number of affected arteries, and distal coronary flow. As in the reported case, in stable patients with well-defined dissections and mainly when the coronary flow has been re-established, one can choose a conservative approach, due to the high incidence of spontaneous resolution and low incidence of long-term adverse events


Assuntos
Humanos , Feminino , Pessoa de Meia-Idade , Terapêutica , Doença das Coronárias/terapia , Dissecação/métodos , Prognóstico , Angiografia/métodos , Diagnóstico Clínico/diagnóstico , Vasos Coronários/cirurgia
16.
Dis Colon Rectum ; 58(3): 304-13, 2015 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-25664708

RESUMO

BACKGROUND: Perineal soft tissue tumors are rare, so that little is known about their management and the outcome of treatment. OBJECTIVE: The aim of this study is to describe the presentation, management, and outcome of the surgical treatment of soft tissue tumors and to provide a final decision algorithm. DESIGN: This is a retrospective study. SETTINGS: The study was conducted in a single tertiary care hospital with a dedicated unit on sarcoma. PATIENTS: Fifty-one consecutive patients from 1998 to 2013 were included. MAIN OUTCOME MEASURES: The primary outcomes measured are patient demographics, treatment decisions, and outcome of surgical treatment. RESULTS: Forty-nine patients presented with a primary soft tissue tumor, and 2 underwent simple excisions for isolated metastases. The median tumor size was 75 mm (50-110). Symptoms were nonspecific, and MRI had insufficient specificity for malignancy so that a preoperative biopsy was systematically performed according to European Society for Medical Oncology and National Comprehensive Cancer Network soft tissue tumor guidelines. Six benign soft tissue tumors (3 lipomas, 3 leiomyomas), 16 intermediate soft tissue tumors (12 aggressive angiomyxoma, 4 desmoid tumors), and 27 sarcomas were identified. Treatments and surgery were tailored from the beginning according to histology. All but 1 benign soft tissue tumor were treated by 'shelling out.' Aggressive angiomyxoma were treated with en bloc resection sparing uninvolved organs. Nonsurgical treatments were our first choice for desmoid tumors. Wide en bloc surgery was planned for all sarcomas (n = 27) after the induction treatment for 16 patients (chemotherapy, n = 12; radiotherapy, n = 4). In the sarcoma group, the 5-year estimated metastasis-free, local recurrence-free, and overall survival rates were 68.1% (95% CI, 50.7-91.5), 84.7% (95% CI, 66.7-100), and 85.7% (95% CI, 71.8-100). In the benign and intermediate tumor groups, there were no deaths, local recurrences, or progression. LIMITATIONS: This study was limited by the small number of patients, given the rarity of this disease in the perineum. CONCLUSION: We provide useful indications for the best strategy necessary to treat these rare tumors located in a complex site.


Assuntos
Dissecação , Períneo/patologia , Sarcoma , Neoplasias de Tecidos Moles , Adulto , Algoritmos , Biópsia , Gerenciamento Clínico , Dissecação/métodos , Dissecação/mortalidade , Feminino , França/epidemiologia , Humanos , Imageamento por Ressonância Magnética , Masculino , Estadiamento de Neoplasias , Avaliação de Resultados em Cuidados de Saúde , Cuidados Pré-Operatórios/métodos , Prognóstico , Estudos Retrospectivos , Sarcoma/epidemiologia , Sarcoma/patologia , Sarcoma/cirurgia , Neoplasias de Tecidos Moles/classificação , Neoplasias de Tecidos Moles/epidemiologia , Neoplasias de Tecidos Moles/patologia , Neoplasias de Tecidos Moles/cirurgia , Taxa de Sobrevida
17.
J Endourol ; 29(1): 63-9, 2015 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-25000418

RESUMO

PURPOSE: To evaluate the safety and efficacy of a novel robotic tissue ablation system (PROCEPT Aquablation(™) System), in performing prostate ablation in a survival canine model. MATERIALS AND METHODS: This novel technology uses a high-velocity saline stream that aims to selectively ablate prostatic glandular tissue while sparing collagenous structures such as blood vessels and capsule. Once the ablation is complete, a laser beam is captured by a low-pressure water jet to produce surface hemostasis. The extent and depth of ablation is predetermined by endoscopic and transrectal ultrasonography guidance. The procedure was performed in eight noncastrated male beagles aged 6 years or older (Acute 2, Chronic 6) through a previously created perineal urethrostomy. RESULTS: Aquablation time ranged from 40 to 84 seconds (mean 60.5 sec). There was no active bleeding in any of the dogs during or after Aquablation. Water jet-guided laser coagulation was used for purposes of monitoring its safety and efficacy. Five of the six dogs reached the predetermined 6-week mark. Complications included two dogs with infection successfully treated with antibiotics, a false passage created during catheter placement, and two bladder neck perforations (from mechanical insertion), one leading to euthanasia. Histologic evaluation at 6 weeks revealed a normal cellular architecture and full reepithelialization of the treatment cavity. CONCLUSIONS: We report the initial survival data in the animal model of a novel robotic device developed for managing symptomatic benign prostatic hyperplasia (BPH). Aquablation produces ablation of adenomatous elements while preserving collagenous structures and is a promising technology for surgical management of symptomatic BPH.


Assuntos
Técnicas de Ablação/métodos , Hiperplasia Prostática/cirurgia , Procedimentos Cirúrgicos Robóticos/métodos , Cloreto de Sódio , Cirurgia Assistida por Computador/métodos , Ressecção Transuretral da Próstata/métodos , Animais , Dissecação/métodos , Cães , Endoscopia , Masculino , Modelos Animais , Duração da Cirurgia
18.
Neurol Med Chir (Tokyo) ; 54(11): 901-6, 2014.
Artigo em Inglês | MEDLINE | ID: mdl-25367582

RESUMO

Tarsal tunnel syndrome (TTS) is an entrapment neuropathy of the posterior tibial nerve and its branches in the tarsal tunnel. We present our less invasive surgical treatment of TTS in 69 patients (116 feet) and their clinical outcomes. The mean follow-up period was 64.6 months. With the patient under local anesthesia we use a microscope to perform sharp dissection of the flexor retinaculum and remove the connective tissues surrounding the posterior tibial nerve and vessels. To prevent postoperative adhesion and delayed neuropathy, decompression is performed to achieve symptom improvement without excessive dissection. Decompression is considered complete when the patient reports intraoperative symptom abatement and arterial pulsation is sufficient. The sensation of numbness and/or pain and of foreign substance adhesion was reduced in 92% and 95% of our patients, respectively. In self-assessments, 47 patients (68%) reported the treatment outcome as satisfactory, 15 (22%) as acceptable, and 7 (10%) were dissatisfied. Of 116 feet, 4 (3%) required re-operation, initial decompression was insufficient in 2 feet and further decompression was performed; in the other 2 feet improvement was achieved by decompression of the distal tarsal tunnel. Our surgical method involves neurovascular bundle decompression to obtain sufficient arterial pulsation. As we use local anesthesia, we can confirm symptom improvement intraoperatively, thereby avoiding unnecessary excessive dissection. Our method is simple, safe, and without detailed nerve dissection and it prevents postoperative adhesion.


Assuntos
Dissecação/métodos , Cirurgia de Descompressão Microvascular/métodos , Síndrome do Túnel do Tarso/cirurgia , Adulto , Idoso , Idoso de 80 Anos ou mais , Anestesia Local , Feminino , Seguimentos , Humanos , Masculino , Pessoa de Meia-Idade , Síndrome do Túnel do Tarso/diagnóstico
19.
Vestn Khir Im I I Grek ; 172(1): 81-4, 2013.
Artigo em Russo | MEDLINE | ID: mdl-23808234

RESUMO

The author considers results of inestigation for studying an efficiency of permanent intramesenteric (retroperitoneal) blockade and applying lymphotropic therapy for prevention of incompetence of sutures of intestinal anastomosis against the background of diffuse peritonitis and acute intestinal obstruction. An infusion was carried out 4-6 times a day with a special solution (novocain 0.5% (7 ml/kg/day); heparin (150 units/kg/days); proserin (0.03 mg/kg/day) and seftriakson (15 mg/kg/days)) in order to obtain the effect of permanent intramesenteric blockade and lymphotropic therapy. The solution is administered by droplet injection with the rate 100-120 drops a minute (80-120 ml per each infusion). Due to the application of the given method the frequency of cases of the incompetent sutures of intestinal anastomoses in patients of the main group decreased from 15.5% to 3.4% (X2 = 16.2; p < 0.001) as compared with the other patients.


Assuntos
Fístula Anastomótica , Procedimentos Cirúrgicos do Sistema Digestório , Motilidade Gastrointestinal/efeitos dos fármacos , Enteropatias/cirurgia , Complicações Pós-Operatórias , Circulação Esplâncnica/efeitos dos fármacos , Deiscência da Ferida Operatória , Adulto , Anastomose Cirúrgica/efeitos adversos , Anastomose Cirúrgica/métodos , Fístula Anastomótica/etiologia , Fístula Anastomótica/prevenção & controle , Anestesia Local/métodos , Antibacterianos/administração & dosagem , Anticoagulantes/administração & dosagem , Inibidores da Colinesterase/administração & dosagem , Procedimentos Cirúrgicos do Sistema Digestório/efeitos adversos , Procedimentos Cirúrgicos do Sistema Digestório/métodos , Dissecação/efeitos adversos , Dissecação/métodos , Vias de Administração de Medicamentos , Feminino , Humanos , Enteropatias/classificação , Enteropatias/complicações , Obstrução Intestinal/complicações , Intestinos/irrigação sanguínea , Intestinos/fisiopatologia , Masculino , Peritonite/complicações , Cuidados Pós-Operatórios/métodos , Complicações Pós-Operatórias/etiologia , Complicações Pós-Operatórias/prevenção & controle , Deiscência da Ferida Operatória/etiologia , Deiscência da Ferida Operatória/prevenção & controle , Resultado do Tratamento
20.
J Indian Med Assoc ; 110(3): 189-90, 2012 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-23029953
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