RESUMO
The COVID-19 pandemic poses a challenge to the management of non-COVID pathologies such as lymphatic diseases and lipoedema. The use of telemedicine can prevent the spread of the disease. A system is needed to help determine the clinical priority and selection of face-to-face or telemedicine options for each patient and how to carry them out during the pandemic. The Spanish Lymphology Group has drafted a consensus document with recommendations based on the literature and clinical experience, as clinical practice guidelines for the management of lymphatic abnormalities and lipoedema during the COVID-19 pandemic. These recommendations must be adapted to the characteristics of each patient, the local conditions of the centres, and the decisions of health care professionals. The document contains minimum criteria, subject to modifications according to the evolution of the pandemic, scientific knowledge and instructions from health authorities.
Assuntos
Betacoronavirus , Infecções por Coronavirus , Lipedema/terapia , Doenças Linfáticas/terapia , Pandemias , Pneumonia Viral , Telemedicina , COVID-19 , Comorbidade , Bandagens Compressivas , Continuidade da Assistência ao Paciente , Infecções por Coronavirus/complicações , Infecções por Coronavirus/epidemiologia , Infecções por Coronavirus/prevenção & controle , Gerenciamento Clínico , Emergências , Desenho de Equipamento , Necessidades e Demandas de Serviços de Saúde , Humanos , Lipedema/complicações , Lipedema/reabilitação , Doenças Linfáticas/complicações , Doenças Linfáticas/reabilitação , Drenagem Linfática Manual , Visita a Consultório Médico , Pandemias/prevenção & controle , Educação de Pacientes como Assunto , Participação do Paciente , Modalidades de Fisioterapia , Pneumonia Viral/complicações , Pneumonia Viral/epidemiologia , Pneumonia Viral/prevenção & controle , Medicina de Precisão , SARS-CoV-2 , Telefone , Triagem , Comunicação por VideoconferênciaAssuntos
Obstrução das Vias Respiratórias/diagnóstico por imagem , Bradicardia/terapia , Bronquite/diagnóstico por imagem , Técnica de Fontan , Doenças Linfáticas/diagnóstico por imagem , Complicações Pós-Operatórias/diagnóstico por imagem , Implantação de Prótese , Adolescente , Obstrução das Vias Respiratórias/tratamento farmacológico , Obstrução das Vias Respiratórias/etiologia , Bronquite/tratamento farmacológico , Bronquite/etiologia , Broncoscopia , Óleo Etiodado/uso terapêutico , Humanos , Doenças Linfáticas/complicações , Doenças Linfáticas/tratamento farmacológico , Linfografia , Masculino , Marca-Passo Artificial , Complicações Pós-Operatórias/tratamento farmacológicoRESUMO
Some patients use complementary medicine. We present a patient with Hodgkin's lymphoma, scanned with 18F-FDG PET/CT for evaluation of response after chemotherapy, who was self-administering mistletoe as a homeopathic medicine product. The careful review of the images of the entire scan and patient collaboration in anamnesis were crucial to avoid a false positive result. A review of the published scientific data on the effects of mistletoe is also presented (AU)
Algunas personas usan terapias alternativas. Presentamos el caso de una paciente con enfermedad de Hodgkin a la que se realiza una 18F-FDG PET/TC para evaluar la respuesta tras quimioterapia, en paciente que se autoadministraba muérdago como tratamiento homeopático. La cuidadosa evaluación de todas las imágenes de la prueba y la colaboración de la paciente durante la anamnesis fueron cruciales para evitar un resultado falso positivo. Además, se revisan los datos publicados sobre los efectos del muérdago (AU)
Assuntos
Humanos , Masculino , Erva-de-Passarinho/efeitos adversos , Linfoma/tratamento farmacológico , Linfoma , Fluordesoxiglucose F18/administração & dosagem , Fluordesoxiglucose F18/análise , Tomografia por Emissão de Pósitrons/instrumentação , Tomografia por Emissão de Pósitrons/métodos , Homeopatia/métodos , Anamnese Homeopática , Medicina Nuclear/métodos , Relação Dose-Resposta a Droga , Doenças Linfáticas/complicações , Doenças Linfáticas , Antígenos CD4/análise , Relação CD4-CD8RESUMO
This study investigates the association between lymph node-only and lung silicosis in uranium miners with lung cancer and exposure to quartz dust. Tissue slides of 4,384 German uranium miners with lung cancer were retrieved from an autopsy archive and reviewed by 3 pathologists regarding silicosis in the lungs and lymph nodes. Cumulative exposure to quartz dust was assessed with a quantitative job-exposure matrix. The occurrence of silicosis by site was investigated with regression models for exposure to quartz dust. Miners with lung silicosis had highest cumulative quartz exposure, followed by lymph node-only silicosis and no silicosis. At a cumulative quartz exposure of 40 mg/m(3) × years, the probability of lung silicosis was above 90% and the likelihood of lymph node-only silicosis and no silicosis do not differ anymore. The results support that lymph node silicosis can precede lung silicosis, at least in a proportion of subjects developing silicosis, and that lung silicosis strongly depends on the cumulative quartz dose.
Assuntos
Neoplasias Pulmonares/complicações , Doenças Linfáticas/complicações , Mineração/estatística & dados numéricos , Silicose/complicações , Urânio , Idoso , Poeira , Alemanha/epidemiologia , Humanos , Neoplasias Pulmonares/patologia , Doenças Linfáticas/patologia , Masculino , Pessoa de Meia-Idade , Exposição Ocupacional/efeitos adversos , Exposição Ocupacional/estatística & dados numéricos , Quartzo/toxicidade , Silicose/patologia , Fatores de TempoRESUMO
We present here an 18-yr-old male who presented with intermittent fever of moderate grade and of 15 days duration, followed by maculopapular erythematous rashes over upper and lower extremities, face, and trunk developing over 10-12 days. He was suffering from recurrent seizures since last 3 months for which he was started on carbamazepine 200mg twice daily for the past 6 weeks. He was febrile on admission. Generalized lymphadenopathy with discreet, non-matted, firm and tender inguinal lymph nodes. Patch test with 1% and 5% solution of carbamazepine was strongly positive.
Assuntos
Anticonvulsivantes/efeitos adversos , Carbamazepina/efeitos adversos , Dermatite Esfoliativa/induzido quimicamente , Eosinofilia/induzido quimicamente , Epilepsia/tratamento farmacológico , Exantema/induzido quimicamente , Doenças Linfáticas/induzido quimicamente , Adolescente , Biópsia , Dermatite Esfoliativa/complicações , Toxidermias , Hipersensibilidade a Drogas , Eosinofilia/complicações , Exantema/complicações , Humanos , Hipertermia Induzida , Doenças Linfáticas/complicações , Masculino , Testes do Emplastro , Testes Cutâneos , Síndrome , Resultado do TratamentoRESUMO
SUMMARY: A 34-year-old male with a 20-year history of epilepsy was treated with valproic acid and phenobarbital. As he had frequent convulsive fits, carbamazepine (CBZ) was added. Thirty-four days later, the patient developed hyperthermia, (39.5 degrees C), cervical lymphadenopathy and generalized cutaneous exfoliated maculae and papulae. Biochemical investigation was characterized by a white cell count of 16.1 x 103/microl (17% eosinophils) and increased levels of aspartate aminotransferase and alanine aminotransferase (50 and 116 IU/L, respectively). HHV6 serological tests performed on day 21, detected anti HHV6 IgM, suggesting a HHV6 primary infection. Hence, CBZ was discontinued. One month later, the skin eruption, fever, lymph node swelling, liver dysfunction, and eosinophilia were progressively relieved. Six weeks after complete recovery, prick and patch skin tests were performed. They were strongly positive at 48-h reading. This report suggests the usefulness of skin tests in diagnosing CBZ-induced-DRESS, as well as s possible association between DRESS and HHV6 primary infection.
Assuntos
Anticonvulsivantes/efeitos adversos , Carbamazepina/efeitos adversos , Eosinofilia/induzido quimicamente , Eosinofilia/complicações , Epilepsia/tratamento farmacológico , Exantema Súbito/complicações , Exantema/induzido quimicamente , Exantema/complicações , Doenças Hematológicas/induzido quimicamente , Doenças Hematológicas/complicações , Hipertermia Induzida , Doenças Linfáticas/induzido quimicamente , Doenças Linfáticas/complicações , Infecções por Roseolovirus/complicações , Testes Cutâneos , Adulto , Anticonvulsivantes/uso terapêutico , Carbamazepina/uso terapêutico , Herpesvirus Humano 6 , Humanos , Masculino , Índice de Gravidade de Doença , SíndromeRESUMO
Diseases of the lymphatic system in children include a group of exceptional conditions difficult to manage. The anatomy of lymphatic system is complex in the lung. Variable from one subject to another, its complex physiology plays an important role in air-blood exchanges occurring in the lung. In the pulmonary interstitium and in the pleura, the lymphatic system acts like an overflow valve capable of regulating variations in interstitial fluid. The presence or development of dysplasic lymphatics causes leakage, dilatation, and reflux of the lymph through incontinent valves leading to chylothorax and/or fluid overload in the pulmonary interstitium. Symptomatic care is usually proposed, based on a fat-free diet supplemented with light-chain triglycerides and liposoluble vitamins. Other therapeutic options can be proposed. Medical options include cytotoxic agents, somatostatin, and interferon-alpha. Surgery may also be useful, but an assessment of therapeutic efficacy is very difficult due to partial effects and the small number of cases studied.
Assuntos
Pneumopatias/complicações , Doenças Linfáticas/complicações , Criança , Humanos , Pneumopatias/classificação , Pneumopatias/terapia , Doenças Linfáticas/classificação , Doenças Linfáticas/terapia , Sistema Linfático/anatomia & histologia , Sistema Linfático/fisiologiaRESUMO
The role of hyperbaric oxygenation in the treatment of radiation-induced sequelae and chronic ulcer is well established. On the contrary, a possible cancer-causing or growth-enhancing effect by hyperbaric oxygenation was highly controversial. Herein, we present a 55-year-old Chinese woman with recurrent squamous cell carcinoma of the cervix on her left inguinal area. She received concurrent chemoradiation therapy followed by radical inguinal lymphadenectomy due to persistent tumor mass. The patient was complicated with severe radiation fibrosis and unhealed wounds, so she was treated with hyperbaric oxygenation (HBO). However, the patient died of complications of the disease after completing HBO therapy I month later and autopsy of the patient showed carcinomatosis of the abdominal cavity and lower abdominal wall. Because previous studies have been inconclusive regarding the effect of HBO on tumor cells, we reviewed the possible relation between the HBO and tumor cells.
Assuntos
Carcinoma de Células Escamosas/patologia , Oxigenoterapia Hiperbárica/efeitos adversos , Recidiva Local de Neoplasia/patologia , Neoplasias do Colo do Útero/patologia , Protocolos de Quimioterapia Combinada Antineoplásica/uso terapêutico , Biópsia , Bleomicina/administração & dosagem , Carcinoma de Células Escamosas/tratamento farmacológico , Carcinoma de Células Escamosas/radioterapia , Cisplatino/administração & dosagem , Etoposídeo/administração & dosagem , Evolução Fatal , Feminino , Humanos , Excisão de Linfonodo , Doenças Linfáticas/complicações , Doenças Linfáticas/tratamento farmacológico , Doenças Linfáticas/radioterapia , Imageamento por Ressonância Magnética , Pessoa de Meia-Idade , Recidiva Local de Neoplasia/tratamento farmacológico , Recidiva Local de Neoplasia/radioterapia , Tomografia Computadorizada por Raios X , Neoplasias do Colo do Útero/tratamento farmacológico , Neoplasias do Colo do Útero/radioterapiaRESUMO
The authors report on 12 personal observations of lymphoportal fistulas, which represented 0.24% of their series of lymphographies. This rare complication of lymphography has no clinical or biological liver manifestations. Review of 71 cases in the literature confirmed that hepatic oil embolization only occurs when there are lymphatic masses, with or without associated thrombosis of the inferior vena cava.
Assuntos
Embolia/induzido quimicamente , Óleo Iodado/efeitos adversos , Fígado/diagnóstico por imagem , Adulto , Idoso , Embolia/complicações , Embolia/diagnóstico por imagem , Feminino , Fístula/complicações , Fístula/diagnóstico por imagem , Humanos , Doenças Linfáticas/complicações , Doenças Linfáticas/diagnóstico por imagem , Linfografia/efeitos adversos , Masculino , Pessoa de Meia-Idade , Neoplasias/complicações , Neoplasias/diagnóstico , Veia PortaRESUMO
Intestinal lymphangiectasia, a disease characterized by excessive intestinal protein loss, asymmetrical peripheral edema, ascites, immunologic deficiencies, lymphocytopenia, hypoalbuminemia, imparied lymphocyte transformation, gastrointestinal symptoms and retarded growth, is the result of abnormal, distorted and obstructed lymph channels, causing rupture of intestinal lacteals from back-flow of lymph, with leakage of nutrient-laden lymph into the lumen of the bowel. A case of congenital intestinal lymphagiectasia is described, with the additional problems of allergic asthma, rhinitis, eczema and lactase deficiency. This patient, an 11-year-old child, was greatly benefited by proper allergy management (elimination diet, hyposensitization) plus restriction of fats and supplementing the diet with medium-chain triglycerides (MCT).