Clinical-microbiological research of action ozone therapy and light-emetting diode radiation of red range (630 nanometers) on microflora of the hole extracted toothatalveolitis and limited osteomyelitis of jaws. / Kliniko-mikrobiologicheskoe issledovanie deistviya ozonoterapii i svetodiodnogo izlucheniya krasnogo diapazona (630 nm) na mikrofloru lunki udalennogo zuba pri al'veolite i ogranichennom osteomielite chelyustei.

As a result of cliniko-microbiological research the data testifying to substantial improvement of efficiency of antimicrobictherape at inclusion in a complex of medical actions at alveolitis and the limited osteomyelitis of a jow ozone therapy in a combination with a light-emettinf diode irradiation of the hole extracted teeth red ( 630 nanometers) are obtained by light.

[The effectiveness of the application of mineral water from the Klyuchi health resort in the programs of combined spa-based rehabilitation of the patients presenting with acquired jaw defects].

The results of the present study give evidence of the well-apparent sanation effect of balneotherapy with the use of therapeutic mineral water (MW) extracted at the Klyuchi health resort. Irrigation of the oral cavity with this mineral water was shown to reduce the number of the strains of opportunistic microorganisms and their virulence potential. It is concluded that the proposed method may be recommended for the treatment and prevention of dysbiosis in the oral cavity of the patients presenting with acquired jaw defects.

[The improvement of complex treatment of odontogenous periostitis in elderly patients].

The paper presents the results of clinical examination of 114 patients aged 60-88 years with acute odontogenous periostitis receiving treatment in in-patient maxillofacial surgery unit. The dynamic of clinical symptoms is used to carry out the comparative effectiveness study of several peroral antibiotics in elderly patients.

Resolution of oral bisphosphonate and steroid-related osteonecrosis of the jaw--a serial case analysis.

PURPOSE: To offer recommendations of risk factors, prevention, and treatment of oral bisphosphonate and steroid-related osteonecrosis of the jaw (BSRONJ) in Taiwan. MATERIALS AND METHODS: Twelve patients were clinicopathologically proved to have bisphosphonate-related osteonecrosis of the jaw (BRONJ). All of the patients were taking oral bisphosphonates and were concurrently administered long-term steroids. Of the 12 patients, 3 patients were assigned to the first stage of BRONJ; 5 patients were assigned to the second stage, and 4 patients were assigned to the third stage. The patients' symptoms, localization of necrosis, presence of a fistula, and association with possible triggering factors for onset of the lesion were recorded. RESULTS: The radiologic investigations revealed osteolytic areas and scintigraphy demonstrated increased bone metabolism. Microbiologic analysis showed pathogenic actinomycosis organisms in a majority of patients (91.6%). Antibiotic therapy, minor debridement surgery, and combined hyperbaric oxygen therapy were useful in obtaining short-term symptomatic relief. CONCLUSIONS: Comorbidities of steroid use along with bisphosphonates may cause osteonecrosis of the jaw to occur sooner, be more severe, and respond more slowly to a drug discontinuation. The clinical disease of BSRONJ is more severe and more unpredictable to treat than BRONJ. From the data gained from other published studies of BRONJ and our clinical experience with the series of cases of BSRONJ, we offer recommendations of risk factors, prevention, and treatment of BSRONJ in southern Taiwan.

Contemporary concepts in the treatment of chronic osteomyelitis.

Although there are relatively standard treatment approaches for chronic osteomyelitis, many avenues of investigation are being pursued to reflect contemporary concerns. The mainstays of care continue to include timely and thorough surgical débridement and culture-directed antibiotics. Sensitive diagnostic screening is essential, and advances in radiology can lead to early confirmation of disease and accurate surveillance. There is potential to greatly reduce overall morbidity, chance of recurrent infection, and treatment courses by using the local delivery systems currently researched by orthopedic surgeons. The challenges posed by multidrug-resistant bacterium may be countered by sound culturing techniques and new antibiotics. The general purpose of this article is to survey the new directions in oral surgery, orthopedics, infectious disease, immunology, and radiology that may have application to the treatment of maxillofacial osteomyelitis.

Osteomyelitis of the jaws: a 50-year perspective.

The incidence of osteomyelitis of the jaws has decreased dramatically, except for a few subsets of individuals. This has been due, in no small part, to the availability of bacteriocidal antimicrobial therapy. The pathogenesis of osteomyelitis of the jaws is predominately due to odontogenic microorganisms rather than the classic skin contaminant, Staphylococcus. This causative relationship relegates the classification of osteomyelitis of the bimaxillary skeleton to predominately that of contiguous foci. These may be regionally progressive, secondary to microvascular compromise brought about by inherent flaws in regional anatomic calcified tissue vascular perfusion as well as by inflammatory metaplastic processes. Diagnosis is based on the presence of painful sequestra and suppurative areas of tooth-bearing jaw bone unresponsive to debridement and conservative therapy. This is usually accompanied by regional or systemic compromise of the immune response, microvascular decompensation, or both. Treatment of both acute and chronic forms of the disease, as outlined in Table 5, is successful if surgically supported. Sustained bacteriocidal antibiotic therapy is pertinent, especially in the face of potentially refractory virulent microorganisms and compromised regional vascular penetrance. The use of adjunctive hyperbaric oxygen therapy also may be included in the more refractory forms of osteomyelitis of the jaws to enhance the local and regional immune response of the jaws as well as to produce microvascular neoangiogenesis for reperfusion support. With resolution of infection, hard and soft tissue reconstruction may be necessary to augment the reparative process.