RESUMO
Background: Little is known about the physical and psychosocial work environment of chiropractors and their work-related health complaints, and this has never been described for Danish chiropractors. The aim of this study was, therefore, to describe work-related acute physical injuries, overuse complaints, and psychosocial stress in Danish chiropractic work settings. Methods: We developed a questionnaire specifically for this study and distributed it electronically in August 2016 using SurveyXact to all 575 members of the Danish Chiropractors' Association working in primary care clinics. Chiropractors were asked about their work-related acute physical injuries and overuse complaints as well as any psychosocial stress they experienced at work during the previous year. We described our sample and variables using means, medians, ranges, and confidence intervals where appropriate. Statistically significant differences between genders, types of complaints and injuries, and between clinic owners and associates were examined using Chi-square and Fischer's exact tests, where appropriate, or by examining confidence intervals for non-overlap. Results: 355 (65.2%) chiropractors answered the survey. Of these, 216 (61%, 95% CI 56-66) had experienced a work-related acute physical injury and/or overuse complaint during the previous year. Work-related overuse complaints were most commonly reported in the low back, wrist, thumb, and shoulder, and were more common among women (63%, 95% CI 56-70) than men (51%, 95% CI 43-59). Chiropractors with more than five years in practice (59%, 95% CI 52-64) reported significantly fewer work-related acute injuries and overuse complaints during the previous year compared with chiropractors with less than five years in practice (83%, 95% CI 73-91). In general, these practicing Danish chiropractors reported having a good psychosocial work environment, and 90% of chiropractors "always" or "often" felt that they were motivated and committed to their work. Conclusion: This sample of Danish practicing chiropractors commonly reported work-related acute physical injuries or overuse complaints. Overuse complaints were most commonly reported in the low back, wrist, thumb, and shoulder and were more common among women than men. Newly educated chiropractors reported more overuse complaints than experienced chiropractors. Collectively, this sample of Danish chiropractors reported that they had a good psychosocial work environment.
Assuntos
Quiroprática/estatística & dados numéricos , Doença Crônica/epidemiologia , Doenças Neuromusculares/epidemiologia , Doenças Profissionais/epidemiologia , Local de Trabalho/psicologia , Ferimentos e Lesões/epidemiologia , Adulto , Atitude do Pessoal de Saúde , Estudos Transversais , Dinamarca/epidemiologia , Feminino , Inquéritos Epidemiológicos , Humanos , Satisfação no Emprego , Masculino , Doenças Neuromusculares/etiologia , Doenças Neuromusculares/fisiopatologia , Doenças Profissionais/fisiopatologia , Doenças Profissionais/psicologia , Meio Social , Estresse Psicológico/epidemiologia , Ferimentos e Lesões/fisiopatologia , Ferimentos e Lesões/psicologiaRESUMO
Children with medical complexity (CMC) have chronic conditions, intense healthcare needs, and high healthcare utilization. Proposed changes in the healthcare environment initiated by the Affordable Care Act have led to efforts toward preventing hospital readmissions. The purpose of this integrative review is to explore the current empirical literature and examine how hospital readmissions and repeat emergency department visits have been studied among CMC. A computer database search and ancestry search were conducted, resulting in a sample of 26 studies. The results of the integrative review are presented along with gaps in the literature and implications for nursing practice and research.
Assuntos
Doença Crônica/terapia , Crianças com Deficiência , Serviço Hospitalar de Emergência/estatística & dados numéricos , Avaliação de Resultados em Cuidados de Saúde , Readmissão do Paciente/estatística & dados numéricos , Doenças Cardiovasculares/diagnóstico , Doenças Cardiovasculares/epidemiologia , Doenças Cardiovasculares/terapia , Estudos de Casos e Controles , Criança , Pré-Escolar , Doença Crônica/economia , Doença Crônica/epidemiologia , Anormalidades Congênitas/diagnóstico , Anormalidades Congênitas/epidemiologia , Anormalidades Congênitas/terapia , Bases de Dados Factuais , Feminino , Custos de Cuidados de Saúde , Humanos , Incidência , Lactente , Assistência de Longa Duração/economia , Assistência de Longa Duração/estatística & dados numéricos , Pneumopatias/diagnóstico , Pneumopatias/epidemiologia , Pneumopatias/terapia , Masculino , Doenças Neuromusculares/diagnóstico , Doenças Neuromusculares/epidemiologia , Doenças Neuromusculares/terapia , Patient Protection and Affordable Care Act , Medição de Risco , Estados Unidos , Populações VulneráveisRESUMO
OBJECTIVE: The purpose of this study was to describe Danish chiropractic patients younger than 18 years. METHODS: Questionnaires were mailed to all chiropractic clinics in Denmark during a randomly assigned month between September 2007 and September 2008. All patients younger than 18 years or their parents were asked to complete a questionnaire collecting information on age, presenting complaint, duration and consequences of this complaint, referral mode, and use of pain medication. RESULTS: Babies were the most common pediatric patients with about one third being between 0 and 4 months of age. Infantile colic was the most common presenting complaint in this age group. For the older children, musculoskeletal problems were the most dominant complaint, ranging from 33% among the preschool children to 75% among the teenagers. These complaints were often chronic and about a third of the children older than 2 years had experienced symptoms for more than 1 year before seeing the chiropractor. These health complaints were reported to restrict activity as well as alter mood, and 39% of the 2- to 17-year olds used analgesics. There was limited referral of patients from other health care professionals. CONCLUSIONS: Babies made up most of the Danish chiropractic patients younger than 18 years. Among the older children and the adolescents, musculoskeletal complaints were most common and mostly of a chronic nature. The large number of pediatric patients in chiropractic practices and the paucity of evidence of treatment effectiveness indicate the need for further research in these age groups.
Assuntos
Nível de Saúde , Manipulação Quiroprática/estatística & dados numéricos , Doenças Neuromusculares/epidemiologia , Doenças Neuromusculares/terapia , Adolescente , Criança , Proteção da Criança/estatística & dados numéricos , Pré-Escolar , Doença Crônica , Dinamarca/epidemiologia , Feminino , Pesquisas sobre Atenção à Saúde , Humanos , Lactente , Pediatria/estatística & dados numéricos , Índice de Gravidade de DoençaRESUMO
Neuromuscular disease is an extremely common complication of end-stage kidney disease (ESKD), manifesting in almost all dialysis patients, and leading to weakness, reduced exercise capacity, and disability. Recent studies have suggested that hyperkalemia may underlie the development of neuropathy. As such, maintenance of serum K(+) within normal limits between periods of dialysis in ESKD patients manifesting early neuropathic symptoms may reduce neuropathy development and progression. For patients with more severe neuropathic syndromes, increased dialysis frequency or a switch to high-flux dialysis may prevent further deterioration, while ultimately, renal transplantation is required to improve and restore nerve function. Exercise training programs are beneficial for ESKD patients with muscle weakness due to neuropathy or myopathy, and are capable of improving exercise tolerance and quality of life. Specific treatments have recently been evaluated for symptoms of autonomic neuropathy, including sildenafil for impotence and midodrine for intra-dialytic hypotension, and have been shown to be effective and well tolerated. Other important management strategies for neuropathy include attention to foot care to prevent callus and ulceration, vitamin supplementation, and erythropoietin. Treatment with membrane-stabilizing agents, such as amitryptiline and gabapentin, are highly effective in patients with painful neuropathy.
Assuntos
Terapia por Exercício/métodos , Falência Renal Crônica/terapia , Doenças Neuromusculares , Diálise Renal/efeitos adversos , Saúde Global , Humanos , Morbidade/tendências , Doenças Neuromusculares/epidemiologia , Doenças Neuromusculares/etiologia , Doenças Neuromusculares/prevenção & controle , Prognóstico , Qualidade de Vida , Fatores de RiscoRESUMO
The prevalence of pain and its impact on outpatients with neuromuscular disease, and their attitude towards the use of analgesics were studied. Seventy-eight outpatients at the university hospital, Tokyo, diagnosed with Parkinson's disease, spinocerebellar degeneration, amyotrophic lateral sclerosis, or multiple sclerosis were asked whether they had experienced pain in the preceding week. The Brief Pain Inventory, Japanese version was used to interview participants reporting pain, about its intensity and interference with activities, the way they dealt with it, attitudes to pain and use of analgesics, and desire for treatment. Forty-six participants experienced pain in the preceding week (59%). The mean pain intensity was 4.1 out of 10, and 20% of participants reported that the degree of interference with mobility was at least 6 out of 10. Most participants dealt with their pain without medication, by changing posture frequently or massage. Approximately 80% of participants regarded pain as something they should endure. Half of the participants wanted more information on methods for pain relief. Approximately 80% of participants were anxious about adverse reactions of analgesics. These findings suggest that medical staffs should provide appropriate information and educate their patients.
Assuntos
Analgésicos/uso terapêutico , Atitude Frente a Saúde , Doenças Neurodegenerativas/epidemiologia , Doenças Neuromusculares/epidemiologia , Dor/epidemiologia , Dor/psicologia , Atividades Cotidianas/psicologia , Adaptação Psicológica , Adulto , Analgésicos/efeitos adversos , Ansiedade/epidemiologia , Comorbidade , Feminino , Humanos , Japão/epidemiologia , Masculino , Massagem/estatística & dados numéricos , Pacientes Ambulatoriais/psicologia , Pacientes Ambulatoriais/estatística & dados numéricos , Dor/tratamento farmacológico , Medição da Dor/métodos , Aceitação pelo Paciente de Cuidados de Saúde , Educação de Pacientes como Assunto/estatística & dados numéricos , Relações Médico-Paciente , Postura/fisiologia , Prevalência , Inquéritos e QuestionáriosRESUMO
Critical illness neuromyopathy (CINM) is the most common peripheral neuromuscular disorder encountered in the ICU. Bilateral diffuse weakness predominant in the proximal part of the limbs after improvement of the acute phase of the critical illness is highly suggestive of CINM. Although muscle and peripheral nerve often are involved in combination, muscle involvement alone increasingly is identified on electrophysiological investigation, including direct muscle stimulation. Respiratory muscles also are involved, and CINM may cause delayed weaning and prolonged MV. Besides muscle immobilization and prolonged sepsis-induced multiple organ failure, which are both strong contributors to CINM, hyperglycemia and use of corticosteroids also might have a deleterious effect on the neuromuscular system in critically ill patients.
Assuntos
Estado Terminal/epidemiologia , Doenças Neuromusculares/epidemiologia , Animais , Repouso em Cama/efeitos adversos , Comorbidade , Terapia por Estimulação Elétrica , Eletromiografia , Glucocorticoides/efeitos adversos , Humanos , Unidades de Terapia Intensiva , Doenças Neuromusculares/fisiopatologia , Doenças Neuromusculares/prevenção & controle , Respiração Artificial , Músculos Respiratórios/fisiopatologia , Sepse/fisiopatologia , SíndromeRESUMO
OBJECTIVE: The objective of this study was to evaluate pain frequency, severity, location, treatment, and relief in a population of adult patients with neuromuscular disorders (NMD). DESIGN: The authors used a self-completion mail questionnaire from the Physical Medicine Clinic at the Lille University Medical Center (northern France). Two hundred eighty-one adults with a confirmed diagnosis of hereditary neuromuscular disease were mailed a questionnaire, which was returned by 125 subjects (response rate = 45%). The main outcome measures were mean motor deficiency scores (on the Brooke and Vignos scales), anxiety and depression scores, pain intensity (on a 0-10 numeric scale) and location, frequency of pain-aggravating situations, and pain treatment and relief. RESULTS: Seventy-three percent of respondents reported pain and 62% reported chronic pain (defined as pain for at least 3 mos). The mean pain intensity was 6.1/10 with 40% reporting severe pain (a score of > or = 7). Forty-six percent and 16% of subjects had a high risk for anxiety and depression, respectively. The most common pain-aggravating situations were "walking," "standing," and "muscle stretching." Walking was more frequently cited as a pain-aggravating situation by the chronic pain population than by the acute pain population. Seventy percent of patients with pain had received at least one analgesic drug. Massage was the most frequently prescribed physical treatment. CONCLUSIONS: Pain is a frequent symptom in adult patients with NMD and needs to be better characterized in this population. The use of painkillers and physical pain treatments did not seem to provide adequate relief for the patients studied here.
Assuntos
Doenças Neuromusculares/fisiopatologia , Dor/fisiopatologia , Adolescente , Adulto , Idoso , Analgésicos/uso terapêutico , Ansiedade/epidemiologia , Doença Crônica , Depressão/epidemiologia , Feminino , França/epidemiologia , Humanos , Extremidade Inferior/fisiopatologia , Masculino , Massagem/estatística & dados numéricos , Pessoa de Meia-Idade , Limitação da Mobilidade , Doenças Neuromusculares/epidemiologia , Dor/epidemiologia , Manejo da Dor , Medição da Dor , Inquéritos e QuestionáriosRESUMO
BACKGROUND: The use of complementary and alternative medicine (CAM), including Traditional Chinese Medicine (TCM) and acupuncture, has substantially increased in western countries in the past decade. However, informative data concerning large-scale investigations of acupuncture used in the Chinese society remain rare so far. DESIGN AND OUTCOME MEASURE: The complete datasets of acupuncture outpatient reimbursement claims from 1996 to 2002 were supplied by the National Health Insurance Research Database, Taiwan, and the usage frequencies and characteristics of the acupuncture users, as well as the disease categories that were treated by acupuncture in Taiwan were analyzed. RESULTS: At the end of 2002, among the 21,869,478 total valid beneficiaries of National Health Insurance (NHI), 1,362,351 subjects (6.2%) used acupuncture during this year, but 4,948,464 subjects (22.6%) had used it for the whole 7-year period since 1996. A mean increment of 1,191,164 (53.6%) new users had been involved yearly. Among all those acupuncture users, a female predominance was observed (female:male = 1.12:1), and the age distribution displayed a peak at around the 40s, followed by the 30s and 50s. Private TCM clinics provided more acupuncture usage (82.0%) than did private TCM hospitals (13.7%). The disease categories treated mostly by acupuncture were diseases of the musculoskeletal system (46.2%); injury (41.8%); diseases of the nervous system (3.5%); and symptoms, signs, and ill-defined conditions (2.7%). CONCLUSIONS: Twenty-three percent (23%) of people in Taiwan had used acupuncture during this 7-year period. Musculoskeletoal and neurologic disorders were two major categories commonly treated with acupuncture.
Assuntos
Terapia por Acupuntura/economia , Terapia por Acupuntura/estatística & dados numéricos , Benefícios do Seguro/estatística & dados numéricos , Doenças Neuromusculares/epidemiologia , Doenças Neuromusculares/terapia , Terapia por Acupuntura/classificação , Adolescente , Adulto , Distribuição por Idade , Idoso , Idoso de 80 Anos ou mais , Criança , Feminino , Humanos , Masculino , Prontuários Médicos/estatística & dados numéricos , Pessoa de Meia-Idade , Programas Nacionais de Saúde , Doenças Neuromusculares/economia , Distribuição por Sexo , Fatores Socioeconômicos , Taiwan/epidemiologiaRESUMO
OBJECTIVE: Does the use of nifedipine and magnesium sulfate together increase serious magnesium-related effects? STUDY DESIGN: This was a retrospective chart review of women who were admitted to BC Women's Hospital and Health Centre (1997-2001) and were given intravenous magnesium sulfate for preeclampsia. Serious magnesium-related effects were compared among 162 cases who received magnesium sulfate and contemporaneous nifedipine and 215 control subjects who received magnesium sulfate and either another antihypertensive (n=32 women) or no antihypertensive (n=183 women) medication. Chi-squared test, Fisher's exact test, or the Student t test was used for data comparison between cases and each control group. A probability value of <.05 was considered statistically significant. RESULTS: The cases had more severe preeclampsia and a longer magnesium sulfate infusion. However, cases had no excess of neuromuscular weakness (53.1%) versus control subjects who received antihypertensive medication (53.1%; P=.99) or control subjects who received no antihypertensive medication (44.8%; P=.13) or other serious magnesium-related effects. Cases versus control subjects who received antihypertensive medication had less neuromuscular blockade (odds ratio, 0.04; 95% CI, 0.002-0.80). Cases versus control subjects who received no antihypertensive medication had less maternal hypotension (41.4% vs 53.0%; P=.04). CONCLUSION: The use of nifedipine and magnesium sulfate together does not increase the risk of serious magnesium-related effects.
Assuntos
Anti-Hipertensivos/uso terapêutico , Bloqueadores dos Canais de Cálcio/uso terapêutico , Sulfato de Magnésio/efeitos adversos , Sulfato de Magnésio/uso terapêutico , Nifedipino/uso terapêutico , Pré-Eclâmpsia/tratamento farmacológico , Adulto , Estudos de Casos e Controles , Estudos de Coortes , Quimioterapia Combinada , Feminino , Humanos , Incidência , Injeções Intravenosas , Sulfato de Magnésio/administração & dosagem , Doenças Neuromusculares/induzido quimicamente , Doenças Neuromusculares/epidemiologia , Gravidez , Estudos Retrospectivos , RiscoRESUMO
An analysis of claims data from a managed care health plan was performed to evaluate whether patients use chiropractic care as a substitution for medical care or in addition to medical care. Rates of neuromusculoskeletal complaints in 9e diagnostic categories were compared between groups with and without chiropractic coverage. For the 4-year study period, there were 3,129,752 insured member years in the groups with chiropractic coverage and 5,197,686 insured member years in the groups without chiropractic coverage. Expressed in terms of unique patients with neuromusculoskeletal complaints, the cohort with chiropractic coverage experienced a rate of 162.0 complaints per 1000 member years compared with 171.3 complaints in the cohort without chiropractic coverage. These results indicate that patients use chiropractic care as a direct substitution for medical care.
Assuntos
Quiroprática/economia , Cobertura do Seguro , Seguro Saúde , Programas de Assistência Gerenciada/estatística & dados numéricos , Doenças Neuromusculares/epidemiologia , Adulto , Idoso , California , Criança , Feminino , Humanos , Cobertura do Seguro/estatística & dados numéricos , Masculino , Programas de Assistência Gerenciada/economia , Pessoa de Meia-Idade , Saúde OcupacionalRESUMO
BACKGROUND: The vast majority of information on chiropractic and chiropractic patients originates from English-speaking countries. Lately, however, reports describing chiropractic patients and practice in other European countries have emerged. OBJECTIVE: To describe basic characteristics of Danish chiropractic patients. DESIGN: Survey questionnaire. All chiropractic clinics in Denmark were asked to collect information on new patients during 1 randomly assigned week in 1999. SETTING: Private chiropractic practice and a nonprofit research institution. OUTCOME MEASURES: Age and sex, location and duration of chief complaint, pain intensity, limitation of activities of daily living from chief complaint, and mode of referral. RESULTS: Eighty-eight percent of all chiropractic clinics in Denmark participated in the study. Out of 2020 patients from the participating clinics, 1897 (94%) filled out a self-administered questionnaire. The mean age of participants was 42 years, and slightly more women than men returned the questionnaire. By far the most frequent area of complaint was pain related to the lower back (50%) followed by pain related to the neck (15%). The majority of patients had complaints in the subacute or chronic category (duration 1-6 months). Patients with sciatica had significantly higher pain scores and limitation in activities of daily living (ADL) than any other group, whereas patients with neck pain tended to score lower. Patients in the subacute category had the highest pain scores and limitation in ADL. For complaints lasting more than 6 months, limitation in ADL remained constant at a low level. Twenty-three percent of all patients were referred to the chiropractor, most frequently by a general medical practitioner. More than half of all patients had previously been treated for the same or similar problems, most frequently by a chiropractor. Fifty-one percent had also received chiropractic care for other types of problems. CONCLUSIONS: Most Danish chiropractic patients complain of pain related to the low back or neck of between 1 and 6 months' duration. This study confirms that chiropractic is fairly well integrated in the Danish primary health care system. There are differences between the chiropractic patient population in Denmark compared with that of Sweden and Holland.
Assuntos
Quiroprática/estatística & dados numéricos , Quiroprática/normas , Dor Lombar/epidemiologia , Cervicalgia/epidemiologia , Adolescente , Idoso , Idoso de 80 Anos ou mais , Criança , Doença Crônica , Dinamarca/epidemiologia , Feminino , Humanos , Lactente , Dor Lombar/terapia , Masculino , Pessoa de Meia-Idade , Cervicalgia/terapia , Doenças Neuromusculares/epidemiologia , Inquéritos e QuestionáriosRESUMO
BACKGROUND: Despite the worldwide popularity of chiropractic, there is still relatively little known about the patients who visit chiropractors in the Netherlands and other European countries. OBJECTIVE: To describe in-depth the patient population of new patients to chiropractors in the Netherlands. DESIGN: Study population consisted of 10 consecutive new patients per participating chiropractor. A retrospective-type questionnaire was used. SETTING: Private practice. OUTCOME MEASURES: Mode of referral, area, and nature of the complaints; related to the chief complaint: previous treatments, examinations, type of referral, days lost at work, level of pain, and treatment expectations. RESULTS: Of the 130 chiropractors registered with the Netherlands Chiropractors'Association, 94 chiropractors(78%) participated. Eight hundred thirty-three patients (89%) returned questionnaires. By far, the greatest reason that patients visit chiropractors in the Netherlands is for neuromusculoskeletal (NMS) complaints. At the time of examination, 86% of the patients had spinal-related complaints, of which 12% involved multiple areas of the spine. Non-NMS complaints are minimal (<2%). Seventy-seven percent of patients with NMS complaints have chronic complaints (>12 weeks). Three-quarters of these patients have undergone previous conservative therapy for their complaint, which includes physical and manual therapy, postural correction, and exercise therapy. Despite the chronic nature of their complaints, patients have high expectations that their treatment will be effective. CONCLUSIONS: Most patients who see chiropractors in the Netherlands have chronic NMS-related complaints. Chiropractors are not a part of the normal referral system in this country, with the result that the patients have rather long histories, including previous evaluations by medical specialists and other previous forms of (conservative) care.
Assuntos
Quiroprática/estatística & dados numéricos , Adolescente , Idoso , Criança , Doença Crônica , Feminino , Humanos , Lactente , Dor Lombar/epidemiologia , Dor Lombar/terapia , Masculino , Pessoa de Meia-Idade , Países Baixos/epidemiologia , Doenças Neuromusculares/epidemiologia , Doenças Neuromusculares/terapia , Inquéritos e QuestionáriosRESUMO
BACKGROUND: Acute myopathy following mechanical ventilation for near-fatal asthma (NFA) has been described recently, and some researchers have suggested that this complication is related to the use of neuromuscular blocking agents (NMBAs) and corticosteroids (CSs). OBJECTIVES: To determine the incidence of acute myopathy in a group of patients and to examine the most important predictors of its development. DESIGN AND METHODS: A retrospective cohort study over a 10-year period (1985 to 1995) of all asthma patients who received mechanical ventilation at two centers in Vancouver (designated center 1 and center 2). RESULTS: In center 1, there were 58 patients who had 64 episodes of NFA, and in center 2, there were 28 patients who had 30 episodes. NMBAs were used in 30 of 86 admissions for acute severe asthma (35%). The mean (+/- SD) duration of muscle paralysis was 3.1+/-2.3 days. A total of 9 patients (10.4%) developed significant myopathy. The incidence of myopathy was 9 of 30 (30%) among patients who received NMBAs. In a multiple logistic regression model, the development of myopathy was only significantly associated with the duration of muscle relaxation. The odds ratio for the development of myopathy increased by 2.1 (95% confidence interval, 1.4 to 3.2) with each additional day of muscle relaxation. The dose and the type of the CS were not significantly associated with the myopathy in the multiple logistic regression analysis. CONCLUSION: Our study showed that there is a high incidence of acute myopathy when NMBAs are used for NFA. The incidence of myopathy increases with each additional day of muscle relaxation.
Assuntos
Asma/terapia , Glucocorticoides/efeitos adversos , Bloqueadores Neuromusculares/efeitos adversos , Doenças Neuromusculares/induzido quimicamente , Respiração Artificial/métodos , APACHE , Doença Aguda , Adulto , Eletromiografia , Feminino , Seguimentos , Humanos , Hidrocortisona/efeitos adversos , Incidência , Masculino , Metilprednisolona/efeitos adversos , Pessoa de Meia-Idade , Doenças Neuromusculares/diagnóstico , Doenças Neuromusculares/epidemiologia , Razão de Chances , Pancurônio/efeitos adversos , Estudos RetrospectivosRESUMO
During six consecutive months, seven patients admitted to our ICU (15 beds, general ICU, approximately 300 intubated patients per year) for acute respiratory failure requiring intubation and mechanical ventilation presented with a peculiar neuromuscular disorder. After the occurrence of this cluster group of patients, we detected two more similar but isolated cases in the following 18 months, ie, altogether 9 patients in 2 years of observation, or 1.55 percent of all intubated patients in our ICU. Sedation was achieved using midazolam, curarization was effected with the neuromuscular non-depolarizing agent pancuronium bromide (PB), and corticosteroids were administered to eight patients. Shortly after discontinuation of sedation and curarization, we observed a persistent tetraparetic syndrome and/or peroneal palsy with a concomitant increase of serum creatine kinase (CK). None of the patients was septic or had the multisystem organ failure. A strong association between CK increase and PB administration was found, whereas no patient suffered severe liver or kidney failure. The duration of the neurologic deficit ranged from 4 to 52 weeks, with only partial recovery for some patients; the duration of dysfunction was apparently related to the total dose of corticosteroids received. Two patients had difficulty being weaned from the respirator and required tracheostomy. Electrophysiologic studies showed signs of axonal neuropathy and myopathic changes, ie, motor units of brief duration, small amplitude, overly abundant for the voluntary effort being exerted. Muscle biopsies showed significant myopathic alterations, with foci of muscle necrosis in most patients and minimal lymphocytic inflammation in one patient. The neurologic complication described differs from the polyneuropathy in critically ill patients. Furthermore, PB or corticosteroids or both appear to be the causal agents. The duration of the neuromuscular dysfunction may be related to concomitant steroid therapy. The CK enzyme seems to be a marker of the disorder. This disorder is associated with myopathic alterations and axonal degeneration in some patients. Pancuronium bromide should be used with caution, particularly when associated with steroids therapy, and it may cause difficulty in weaning patients from the respirator.
Assuntos
Doenças Neuromusculares/induzido quimicamente , Pancurônio/efeitos adversos , Respiração Artificial , Adulto , Idoso , Análise por Conglomerados , Creatina Quinase/sangue , Eletromiografia , Feminino , Humanos , Unidades de Terapia Intensiva , Masculino , Pessoa de Meia-Idade , Músculos/patologia , Condução Nervosa , Doenças Neuromusculares/epidemiologia , Doenças Neuromusculares/patologia , Doenças Neuromusculares/fisiopatologia , Paresia/induzido quimicamente , Paresia/epidemiologia , Paresia/patologia , Paresia/fisiopatologiaRESUMO
An epidemiologic study in India showed that 50% of the severely disabled (1.8% of the total population) had locomotor disorders. There is a considerable difference in the incidence of disability and disease in rural and urban populations. The deformities from poliomyelitis are encountered predominantly in the rural areas (53.5%). The incidence in urban areas is only 1%. After poliomyelitis, the pathomechanics of deformity are prominent in the lower limbs. In a developing country, the management of contractures differs considerably from treatment in economically advanced nations. The use of postural exercises with body weight is well illustrated by certain Yoga postures such as paschimottansana or ushtrasana and is a prescribed treatment.