RESUMO
Elephantiasis nostras verrucosa (ENV) is a rare dermatological disease associated with chronic lymphedema caused by obesity, soft tissue infection, or chronic venous insufficiency. Although surgical debridement may be sufficient to treat the skin manifestations of ENV, treatment of ENV should focus on reducing lymph stasis to improve the skin changes and prevent recurrence. In this case report, we present the case of a 79-year-old woman who developed obesity-associated ENV in the lower leg. She was successfully treated by a combination of lymphaticovenous anastomoses and the oriental herbal medicine Bofutsushosan. To our knowledge, this is the first reported obesity-associated ENV case in which skin pathology was not only healed, but both edema relief and weight loss were successful. A treatment combining both surgery and the herbal medicine could be a potential therapeutic candidate for obesity-associated ENV.
Assuntos
Elefantíase , Idoso , Medicamentos de Ervas Chinesas , Elefantíase/diagnóstico , Elefantíase/etiologia , Feminino , Medicina Herbária , Humanos , Perna (Membro) , Obesidade/complicaçõesAssuntos
Cefalexina/administração & dosagem , Doxepina/administração & dosagem , Elefantíase , Metotrexato/administração & dosagem , Mupirocina/administração & dosagem , Ácido Micofenólico/administração & dosagem , Terapia PUVA/métodos , Escleroderma Sistêmico , Terfenadina/análogos & derivados , Antibacterianos/administração & dosagem , Bandagens , Biópsia/métodos , Fármacos Dermatológicos/administração & dosagem , Elefantíase/diagnóstico , Elefantíase/etiologia , Elefantíase/fisiopatologia , Elefantíase/terapia , Feminino , Humanos , Pessoa de Meia-Idade , Escleroderma Sistêmico/complicações , Escleroderma Sistêmico/diagnóstico , Escleroderma Sistêmico/tratamento farmacológico , Escleroderma Sistêmico/fisiopatologia , Pele/patologia , Creme para a Pele , Terfenadina/administração & dosagem , Resultado do TratamentoRESUMO
BACKGROUND: Podoconiosis is one of the forgotten types of leg swelling (elephantiasis) in the tropics. Unlike the other, better-known types of leg swelling, podoconiosis is not caused by any parasite, virus or bacterium, but by an abnormal reaction to minerals found in the clay soils of some tropical highland areas. Non-governmental Organizations (NGOs) have been responsible for the development of simple treatment methods without systematic evaluation of its effectiveness. It is essential that a large scale, fully controlled, pragmatic trial of the intervention is conducted. We aim to test the hypothesis that community-based treatment of podoconiosis lymphoedema reduces the frequency of acute dermatolymphangioadenitis episodes ('acute attacks') and improves other clinical, social and economic outcomes. METHODS/DESIGN: This is a pragmatic, individually randomised controlled trial. We plan to randomly allocate 680 podoconiosis patients from the East Gojjam Zone in northern Ethiopia to one of two groups: 'Standard Treatment' or 'Delayed Treatment'. Those randomised to standard treatment will receive the hygiene and foot-care intervention from May 2015 for one year, whereas those in the control arm will be followed through 2015 and be offered the intervention in 2016. The trial will be preceded by an economic context survey and a Rapid Ethical Assessment to identify optimal methods of conveying information about the trial and the approaches to obtaining informed consent preferred by the community. The primary outcome will be measured by recording patient recall and using a simple, patient-held diary that will be developed to record episodes of acute attacks. Adherence to treatment, clinical stage of disease, quality of life, disability and stigma will be considered secondary outcome measures. Other outcomes will include adverse events and economic productivity. Assessments will be made at baseline and at 3, 6, 9 and 12 months thereafter. DISCUSSION: The evidence is highly likely to inform implementation of the new master plan for integrated control of Neglected Tropical Diseases (NTDs), in which podoconiosis is identified as one of eight NTDs prioritised for control. Potentially, an estimated 3 million patients in Ethiopia will therefore benefit from the results of this trial. TRIAL REGISTRATION: International Standard Randomised Controlled Trial Number. REGISTRATION NUMBER: ISRCTN67805210. Date of registration: 24 January 2013.
Assuntos
Elefantíase/terapia , Doenças Negligenciadas/terapia , Autocuidado , Tempo para o Tratamento , Doença Aguda , Bandagens , Protocolos Clínicos , Efeitos Psicossociais da Doença , Avaliação da Deficiência , Elefantíase/diagnóstico , Elefantíase/fisiopatologia , Elefantíase/psicologia , Etiópia , Terapia por Exercício , Conhecimentos, Atitudes e Prática em Saúde , Humanos , Higiene , Consentimento Livre e Esclarecido , Doenças Negligenciadas/diagnóstico , Doenças Negligenciadas/fisiopatologia , Doenças Negligenciadas/psicologia , Cooperação do Paciente , Educação de Pacientes como Assunto , Preconceito/psicologia , Qualidade de Vida , Projetos de Pesquisa , Autorrelato , Índice de Gravidade de Doença , Sapatos , Estereotipagem , Fatores de Tempo , Resultado do TratamentoRESUMO
AIM: The aim of this paper was to report on a novel approach to the intensive outpatient treatment of elephantiasis of an underprivileged population. METHODS: Prospective, random study, the diagnosis of lymphedema was clinical and the inclusion of patients was by order of arrival in the treatment center where all were invited to participate in the study. Intensive outpatient therapy was performed for 6 to 8 hours daily over a period of four weeks. Eleven legs with grade III elephantiasis of 8 patients were evaluated in a random prospective study. Three patients were men and five were women with ages ranging between 28 and 66 years old. Treatment included mechanical lymph drainage using the RAGodoy® apparatus for a period of 6 to 8 hours daily and the Godoy & Godoy cervical stimulation technique for 20 minutes per day, both associated to the use of a home-made medical compression stocking using a low-stretch cotton-polyester material. Additionally, manual lymph drainage using the Godoy & Godoy technique was performed for one hour. Perimetry was used to compare measurements made before and after treatment, of the three points of the limb with the largest circumferences. The paired t-test was utilized for statistical analysis with an alpha error greater than 5% (P-value <0.05). RESULTS: Reductions in the perimeter of affected limbs were significant over this 4-week treatment program (P-value=0.001). CONCLUSION: Intensive outpatient treatment is an option for all types of lymphedema with large volumetric reductions being possible in a short period when treating elephantiasis.
Assuntos
Assistência Ambulatorial , Drenagem/métodos , Elefantíase/terapia , Extremidade Inferior/patologia , Meias de Compressão , Adulto , Idoso , Brasil , Elefantíase/diagnóstico , Elefantíase/patologia , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Estudos Prospectivos , Índice de Gravidade de Doença , Fatores de Tempo , Resultado do Tratamento , Populações VulneráveisRESUMO
Fifty-nine persons, who immigrated into a Brugia timori endemic area from non-filarial areas on the island of Flores, Indonesia were examined for filariasis after residing in the village for 2 to 10 years. Six persons had B. timori microfilaremia and 31 had filarial disease. The disease seems to affect immigrants from non-filarial areas severely within a relatively short period. Among those residing in the village, for 2 years, the microfilaria rate was 5% and the elephantiasis rate 21%. Selective treatment using 50 mg diethylcarbamazine per Kg body weight was given to all microfilaria (Mf) positive persons. Approximately one year later the Mf-rate by finger stick and Nuclepore filtration was 9% and 18% respectively. There was indirect indications that the Mf-rate might increase with the passage of time. However, the total filarial disease rate remained constant during the one year period. The relationship between these findings and American servicemen exposed to filariasis during World World II is briefly discussed.