RESUMO
Multiday hyperbaric exposure has been shown to reduce the incidence of decompression sickness (DCS) of compressed-air workers. This effect, termed acclimatization, has been addressed in a number of studies, but no comprehensive review has been published. This systematic review reports the findings of a literature search. PubMed, Ovid Embase, The Cochrane Library and Rubicon Research Repository were searched for studies reporting DCS incidence, venous gas embolism (VGE) or subjective health reports after multiday hyperbaric exposure in man and experimental animals. Twenty-nine studies fulfilled inclusion criteria. Three epidemiological studies reported statistically significant acclimatization to DCS in compressed-air workers after multiday hyperbaric exposure. One experimental study observed less itching after standardized simulated dives. Two human experimental studies reported lower DCS incidence after multiday immersed diving. Acclimatization to DCS has been observed in six animal species. Multiday diving had less consistent effect on VGE after hyperbaric exposure in man. Four studies observed acclimatization while no statistically significant acclimatization was reported in the remaining eight studies. A questionnaire study did not report any change in self-perceived health after multiday diving. This systematic review has not identified any study suggesting a sensitizing effect of multiday diving, and there is a lack of data supporting benefit of a day off diving after a certain number of consecutive diving days. The results suggest that multiday hyperbaric exposure probably will have an acclimatizing effect and protects from DCS. The mechanisms causing acclimatization, extent of protection and optimal procedure for acclimatization has been insufficiently investigated.
Assuntos
Aclimatação/fisiologia , Doença da Descompressão/prevenção & controle , Mergulho/fisiologia , Embolia Aérea/prevenção & controle , Oxigenoterapia Hiperbárica , Doenças Profissionais/prevenção & controle , Animais , Pressão Atmosférica , Gatos , Doença da Descompressão/epidemiologia , Autoavaliação Diagnóstica , Mergulho/efeitos adversos , Mergulho/estatística & dados numéricos , Cães , Embolia Aérea/epidemiologia , Cabras , Humanos , Incidência , Doenças Profissionais/epidemiologia , Coelhos , Ratos , Ratos Sprague-Dawley , Valores de Referência , Ovinos , Fatores de TempoRESUMO
BACKGROUND: Air embolism is an extremely rare complication that can follow gastrointestinal endoscopy. The most accepted treatment of cerebral air embolism (CAE) is hyperbaric oxygen (HBO). Limited evidence suggests that lidocaine may have a neuroprotective effect. The exact mechanism does not appear to be well elucidated. METHODS: We conducted a literature search using multiple combinations of keywords from PubMed and Ovid Medline databases according to the PRISMA guidelines. We included articles with cases of air embolism caused by an esophagogastroduodenoscopy (EGD). We excluded cases related to other procedures e.g. colonoscopy, endoscopic retrograde cholangiopancreatography, cholangioscopy, Kasai procedure, bronchoscopy, laparoscopy or thoracoscopy. We were able to identify 30 cases of CAE associated with EGD. We included our experience in treating one patient with CAE after elective EGD. RESULTS: Given the results of our literature search and this patient's characteristics, we chose to treat our patient with HBO and lidocaine infusion. Our case series consists of 31 patients of post EGD CAE, the mean age was 63.7 ± 11.14 years, 38.7% of the patients were women (nâ¯=â¯12). 38.7% of the cases underwent esophageal dilatation (nâ¯=â¯12), while 19.35% had EGD biopsy (nâ¯=â¯6), 9.6% had variceal ligation (nâ¯=â¯3), and 3.22% had variceal banding (nâ¯=â¯1). In 20 out of 31 cases, echocardiography has been documented, 20% of those patients (nâ¯=â¯4) had patent foramen ovale. HBO was used in treatment of 48% of cases (nâ¯=â¯15), among the included patients, 61% survived (nâ¯=â¯19). Our patient showed significant neurological improvement. CONCLUSIONS: Despite the rare incidence of CAE during or after EGD, physicians should be aware of this potential complication. In patients who develop sudden acute neurological symptoms, early diagnosis and intervention may prevent devastating neurological injury and death. The most accepted emergent treatment for CAE includes HBO, consideration of lidocaine, and work-up of source of the air embolism.
Assuntos
Embolia Aérea , Endoscopia Gastrointestinal/efeitos adversos , Embolia Intracraniana , Idoso , Idoso de 80 Anos ou mais , Embolia Aérea/epidemiologia , Embolia Aérea/fisiopatologia , Embolia Aérea/prevenção & controle , Embolia Aérea/terapia , Feminino , Humanos , Oxigenoterapia Hiperbárica , Incidência , Infusões Parenterais , Embolia Intracraniana/epidemiologia , Embolia Intracraniana/fisiopatologia , Embolia Intracraniana/prevenção & controle , Embolia Intracraniana/terapia , Lidocaína/administração & dosagem , Masculino , Pessoa de Meia-Idade , Fármacos Neuroprotetores/administração & dosagem , Medição de Risco , Fatores de Risco , Resultado do TratamentoRESUMO
Inadvertent exposure to radiation, chemical agents and biological factors are well recognized hazards associated with the health care delivery system. Less well appreciated yet no less harmful is risk of decompression sickness in those who accompany patients as inside attendants (IAs) during provision of hyperbaric oxygen therapy. Unlike the above hazards where avoidance is practiced, IA exposure to decompression sickness risk is unavoidable. While overall incidence is low, when calculated as number of cases over number of exposures or potential for a case during any given exposure, employee cumulative risk, defined here as number of cases over number of IAs, or risk that an IA may suffer a case, is not. Commonly, this unique occupational environmental injury responds favorably to therapeutic recompression and a period of recuperation. There are, however, permanent and career-ending consequences, and at least two nurses have succumbed to their decompression insults. The intent of this paper is to heighten awareness of hyperbaric attendant decompression sickness. It will serve as a review of reported cases and reconcile incidence against largely ignored individual worker risk. Mitigation strategies are summarized and an approach to more precisely identify risk factors that might prompt development of consensus screening standards is proposed.
Assuntos
Doença da Descompressão/etiologia , Pessoal de Saúde , Oxigenoterapia Hiperbárica/efeitos adversos , Doenças Profissionais/etiologia , Intoxicação por Monóxido de Carbono/terapia , Doença da Descompressão/epidemiologia , Doença da Descompressão/prevenção & controle , Embolia Aérea/epidemiologia , Embolia Aérea/etiologia , Embolia Aérea/prevenção & controle , Feminino , Humanos , Oxigenoterapia Hiperbárica/métodos , Incidência , Masculino , Doenças Profissionais/epidemiologia , Doenças Profissionais/prevenção & controle , Fatores de RiscoRESUMO
BACKGROUND: Using ultrasound imaging, vascular gas emboli (VGE) are observed after asymptomatic scuba dives and are considered a key element in the potential development of decompression sickness (DCS). Diving is also accompanied with vascular dysfunction, as measured by flow-mediated dilation (FMD). Previous studies showed significant intersubject variability to VGE for the same diving exposure and demonstrated that VGE can be reduced with even a single pre-dive intervention. Several preconditioning methods have been reported recently, seemingly acting either on VGE quantity or on endothelial inflammatory markers. METHODS: Nine male divers who consistently showed VGE postdive performed a standardized deep pool dive (33 m/108 ft, 20 min in 33°C water temperature) to investigate the effect of three different preconditioning interventions: heat exposure (a 30-min session of dry infrared sauna), whole-body vibration (a 30-min session on a vibration mattress), and dark chocolate ingestion (30 g of chocolate containing 86% cocoa). Dives were made one day per week and interventions were administered in a randomized order. RESULTS: These interventions were shown to selectively reduce VGE, FMD, or both compared to control dives. Vibration had an effect on VGE (39.54%, SEM 16.3%) but not on FMD postdive. Sauna had effects on both parameters (VGE: 26.64%, SEM 10.4%; FMD: 102.7%, SEM 2.1%), whereas chocolate only improved FMD (102.5%, SEM 1.7%). DISCUSSION: This experiment, which had the same subjects perform all control and preconditioning dives in wet but completely standardized diving conditions, demonstrates that endothelial dysfunction appears to not be solely related to VGE.Germonpré P, Balestra C. Preconditioning to reduce decompression stress in scuba divers. Aerosp Med Hum Perform. 2017; 88(2):114-120.
Assuntos
Chocolate , Doença da Descompressão/prevenção & controle , Mergulho , Embolia Aérea/prevenção & controle , Banho a Vapor , Vibração/uso terapêutico , Adulto , Doenças Assintomáticas , Embolia Aérea/diagnóstico por imagem , Humanos , Masculino , Pessoa de Meia-Idade , Ultrassonografia , Vasodilatação , Adulto JovemRESUMO
OBJECTIVE/AIMS: To assess current practices in the management of children undergoing craniofacial surgery and identify areas of significant practice variability with the intent to direct future research. BACKGROUND: The perioperative management of infants and children undergoing craniofacial reconstruction surgery can be challenging because of the routine occurrence of significant blood loss with associated morbidity. A variety of techniques have been described to improve the care for these children. It is presently unknown to what extent these practices are currently employed. METHODS: A web-based survey was sent to representatives from 102 institutions. One individual per institution was surveyed to prevent larger institutions from being over-represented in the results. RESULTS: Requests to complete the survey were sent to 102 institutions; 48 surveys were completed. The survey was composed of two parts: management of infants undergoing strip craniectomies, and management of children undergoing major craniofacial reconstruction. CONCLUSIONS: Significant variability exists in the management of children undergoing these procedures; further study is required to determine the optimal management strategies. Clinical trials assessing the utility of central venous pressure and other hemodynamic monitoring modalities would enable evidence-based decision-making for monitoring in these children. The development of institutional transfusion thresholds should be encouraged, as there exists a body of evidence supporting their efficacy and safety.
Assuntos
Anormalidades Craniofaciais/cirurgia , Assistência Perioperatória/métodos , Procedimentos de Cirurgia Plástica , Antifibrinolíticos/uso terapêutico , Transfusão de Componentes Sanguíneos , Perda Sanguínea Cirúrgica , Transfusão de Sangue Autóloga , Pressão Venosa Central , Criança , Craniotomia , Embolia Aérea/prevenção & controle , Endoscopia , Eritropoetina/uso terapêutico , Pesquisas sobre Atenção à Saúde , Humanos , Monitorização Intraoperatória , Recuperação de Sangue OperatórioAssuntos
Cateterismo Venoso Central/efeitos adversos , Embolia Aérea/etiologia , Oxigenoterapia Hiperbárica , Embolia Intracraniana/etiologia , Edema Encefálico , Remoção de Dispositivo , Embolia Aérea/prevenção & controle , Embolia Aérea/terapia , Humanos , Embolia Intracraniana/prevenção & controle , Embolia Intracraniana/terapia , Oxigenoterapia , Acidente Vascular CerebralAssuntos
Cateterismo Venoso Central/efeitos adversos , Remoção de Dispositivo/efeitos adversos , Embolia Aérea/etiologia , Oxigenoterapia Hiperbárica , Embolia Intracraniana/etiologia , Animais , Edema Encefálico , Embolia Aérea/prevenção & controle , Embolia Aérea/terapia , Humanos , Embolia Intracraniana/prevenção & controle , Embolia Intracraniana/terapia , Oxigenoterapia , Acidente Vascular CerebralRESUMO
Scuba divers are at risk of decompression sickness due to the excessive formation of gas bubbles in blood and tissues following ascent, with potentially subsequent neurological injuries. Since nonprovocative dive profiles are no guarantor of protection against this disease, novel means are required for its prevention including predive procedures that could induce more resistance to decompression stress. In this article, we review the recent studies describing the promising preconditioning methods that might operate on the attenuation of bubble formation believed to reduce the occurrence of decompression sickness. The main practical applications are simple and feasible predive measures such as endurance exercise in a warm environment, oral hydration, and normobaric oxygen breathing. Rheological changes affecting tissue perfusion, endothelial adaptation with nitric oxide pathway, up-regulation of cytoprotective proteins, and reduction of preexisting gas nuclei from which bubbles grow could be involved in this protective effect.
Assuntos
Doença da Descompressão/prevenção & controle , Mergulho/efeitos adversos , Resistência Física/fisiologia , Doença da Descompressão/fisiopatologia , Mergulho/fisiologia , Embolia Aérea/prevenção & controle , Exercício Físico/fisiologia , Temperatura Alta , Humanos , Oxigenoterapia Hiperbárica , Masculino , Oxigênio/uso terapêutico , Risco , Vibração , Equilíbrio HidroeletrolíticoRESUMO
Effect of in-water oxygen prebreathing at different depths on decompression-induced bubble formation and platelet activation in scuba divers was evaluated. Six volunteers participated in four diving protocols, with 2 wk of recovery between dives. On dive 1, before diving, all divers breathed normally for 20 min at the surface of the sea (Air). On dive 2, before diving, all divers breathed 100% oxygen for 20 min at the surface of the sea [normobaric oxygenation (NBO)]. On dive 3, before diving, all divers breathed 100% O2 for 20 min at 6 m of seawater [msw; hyperbaric oxygenation (HBO) 1.6 atmospheres absolute (ATA)]. On dive 4, before diving, all divers breathed 100% O2 for 20 min at 12 msw (HBO 2.2 ATA). Then they dove to 30 msw (4 ATA) for 20 min breathing air from scuba. After each dive, blood samples were collected as soon as the divers surfaced. Bubbles were measured at 20 and 50 min after decompression and converted to bubble count estimate (BCE) and numeric bubble grade (NBG). BCE and NBG were significantly lower in NBO than in Air [0.142+/-0.034 vs. 0.191+/-0.066 (P<0.05) and 1.61+/-0.25 vs. 1.89+/-0.31 (P<0.05), respectively] at 20 min, but not at 50 min. HBO at 1.6 ATA and 2.2 ATA has a similar significant effect of reducing BCE and NBG. BCE was 0.067+/-0.026 and 0.040+/-0.018 at 20 min and 0.030+/-0.022 and 0.020+/-0.020 at 50 min. NBG was 1.11+/-0.17 and 0.92+/-0.16 at 20 min and 0.83+/-0.18 and 0.75+/-0.16 at 50 min. Prebreathing NBO and HBO significantly alleviated decompression-induced platelet activation. Activation of CD62p was 3.0+/-0.4, 13.5+/-1.3, 10.7+/-0.9, 4.5+/-0.7, and 7.6+/-0.8% for baseline, Air, NBO, HBO at 1.6 ATA, and HBO at 2.2 ATA, respectively. The data show that prebreathing oxygen, more effective with HBO than NBO, decreases air bubbles and platelet activation and, therefore, may be beneficial in reducing the development of decompression sickness.
Assuntos
Doença da Descompressão/prevenção & controle , Mergulho , Embolia Aérea/prevenção & controle , Oxigenoterapia Hiperbárica , Inalação , Oxigênio/administração & dosagem , Ativação Plaquetária , Administração por Inalação , Adulto , Descompressão/efeitos adversos , Doença da Descompressão/sangue , Doença da Descompressão/diagnóstico por imagem , Doença da Descompressão/fisiopatologia , Embolia Aérea/sangue , Embolia Aérea/diagnóstico por imagem , Embolia Aérea/fisiopatologia , Humanos , Imersão , Integrina beta3/sangue , Masculino , Pessoa de Meia-Idade , Selectina-P/sangue , Glicoproteína IIb da Membrana de Plaquetas/sangue , Fatores de Tempo , Ultrassonografia Doppler , Adulto JovemAssuntos
Embolia Aérea/etiologia , Histerectomia , Complicações Intraoperatórias/etiologia , Laparoscopia , Embolia Aérea/epidemiologia , Embolia Aérea/prevenção & controle , Feminino , Forame Oval Patente/patologia , Humanos , Oxigenoterapia Hiperbárica , Complicações Intraoperatórias/epidemiologia , Complicações Intraoperatórias/prevenção & controle , Doenças do Sistema Nervoso/epidemiologia , Doenças do Sistema Nervoso/etiologia , PosturaRESUMO
It is generally accepted that the incidence of decompression sickness (DCS) from hyperbaric exposures is low when few or no bubbles are present in the circulation. To date, no data are available on the influence of in-water oxygen breathing on bubble formation following a provocative dive in man. The purpose of this study was to compare the effect of post-dive hyperbaric versus normobaric oxygen breathing (NOB) on venous circulating bubbles. Nineteen divers carried out open-sea field air dives at 30 msw depth for 30 min followed by a 9 min stop at 3 msw. Each diver performed three dives: one control dive, and two dives followed by 30 min of hyperbaric oxygen breathing (HOB) or NOB; both HOB and NOB started 10 min after surfacing. For HOB, divers were recompressed in-water to 6 msw at rest, whereas NOB was performed in a dry room in supine position. Decompression bubbles were examined by a precordial pulsed Doppler. Bubble count was significantly lower for post-dive NOB than for control dives. HOB dramatically suppressed circulating bubble formation with a bubble count significantly lower than for NOB or controls. In-water recompression with oxygen to 6 msw is more effective in removing gas bubbles than NOB. This treatment could be used in situations of "interrupted" or "omitted" decompression, where a diver returns to the water in order to complete decompression prior to the onset of symptoms. Further investigations are needed before to recommend this protocol as an emergency treatment for DCS.
Assuntos
Mergulho/fisiologia , Embolia Aérea/prevenção & controle , Imersão , Consumo de Oxigênio/fisiologia , Oxigênio/farmacologia , Respiração , Adulto , Descompressão/efeitos adversos , Doença da Descompressão/fisiopatologia , Doença da Descompressão/prevenção & controle , Humanos , Oxigenoterapia Hiperbárica/métodos , Masculino , Pessoa de Meia-Idade , Concentração Osmolar , Oxigênio/uso terapêutico , Água , Adulto JovemAssuntos
Cateterismo Venoso Central/efeitos adversos , Remoção de Dispositivo/efeitos adversos , Embolia Aérea/etiologia , Embolia Aérea/terapia , Oxigenoterapia Hiperbárica , Embolia Intracraniana/etiologia , Embolia Intracraniana/terapia , Medicina Militar/normas , Animais , Edema Encefálico , Embolia Aérea/prevenção & controle , Feminino , Humanos , Embolia Intracraniana/prevenção & controle , Pessoa de Meia-Idade , Oxigenoterapia , Acidente Vascular Cerebral , Estados UnidosAssuntos
Cateterismo Venoso Central/efeitos adversos , Remoção de Dispositivo/efeitos adversos , Embolia Aérea/etiologia , Embolia Aérea/terapia , Oxigenoterapia Hiperbárica , Embolia Intracraniana/etiologia , Embolia Intracraniana/terapia , Medicina Militar/normas , Edema Encefálico , Embolia Aérea/prevenção & controle , Feminino , Humanos , Embolia Intracraniana/prevenção & controle , Pessoa de Meia-Idade , Oxigenoterapia , Acidente Vascular CerebralRESUMO
Although differences exist, hypobaric and hyperbaric exposures share common physiological, biochemical, and clinical features, and their comparison may provide further insight into the mechanisms of decompression stress. Although altitude decompression illness (DCI) has been experienced by high-altitude Air Force pilots and is common in ground-based experiments simulating decompression profiles of extravehicular activities (EVAs) or astronauts' space walks, no case has been reported during actual EVAs in the non-weight-bearing microgravity environment of orbital space missions. We are uncertain whether gravity influences decompression outcomes via nitrogen tissue washout or via alterations related to skeletal muscle activity. However, robust experimental evidence demonstrated the role of skeletal muscle exercise, activities, and/or movement in bubble formation and DCI occurrence. Dualism of effects of exercise, positive or negative, on bubble formation and DCI is a striking feature in hypobaric exposure. Therefore, the discussion and the structure of this review are centered on those highlighted unresolved topics about the relationship between muscle activity, decompression, and microgravity. This article also provides, in the context of altitude decompression, an overview of the role of denitrogenation, metabolic gases, gas micronuclei, stabilization of bubbles, biochemical pathways activated by bubbles, nitric oxide, oxygen, anthropometric or physiological variables, Doppler-detectable bubbles, and potential arterialization of bubbles. These findings and uncertainties will produce further physiological challenges to solve in order to line up for the programmed human return to the Moon, the preparation for human exploration of Mars, and the EVAs implementation in a non-zero gravity environment.
Assuntos
Altitude , Doença da Descompressão/sangue , Descompressão , Embolia Aérea/sangue , Nitrogênio/sangue , Oxigênio/sangue , Voo Espacial , Ausência de Peso/efeitos adversos , Animais , Fenômenos Biomecânicos , Descompressão/métodos , Doença da Descompressão/diagnóstico por imagem , Doença da Descompressão/etiologia , Doença da Descompressão/prevenção & controle , Embolia Aérea/diagnóstico por imagem , Embolia Aérea/etiologia , Embolia Aérea/prevenção & controle , Exercício Físico , Marcha , Humanos , Oxigenoterapia Hiperbárica , Modelos Biológicos , Contração Muscular , Músculo Esquelético/metabolismo , Músculo Esquelético/fisiopatologia , Óxido Nítrico/metabolismo , Oxigenoterapia , Postura , Ultrassonografia DopplerAssuntos
Transfusão de Sangue Autóloga/efeitos adversos , Transfusão de Sangue Autóloga/instrumentação , Embolia Aérea/etiologia , Embolia Aérea/prevenção & controle , Embolia Aérea/mortalidade , Segurança de Equipamentos , Equipamentos e Provisões Hospitalares , Humanos , Complicações Intraoperatórias/prevenção & controleRESUMO
BACKGROUND: While clinically symptomatic cerebral air embolism secondary to neuro-angiographic procedures is rare, the incidence in a large series of procedures is unknown. Understanding this complication's frequency and etiology is critical if systems are to be instituted to reduce its incidence. METHODS: We prospectively reviewed 4,568 consecutive neuro-angiographic procedures performed between June 2000 and July 2005. The occurrence and etiology of a symptomatic air embolus was noted, and an incidence was calculated for all procedures and for diagnostic arteriograms and interventional procedures individually. RESULTS: Four symptomatic cerebral arterial air emboli occurred in 4,568 neuro-angiographic procedures over the five-year period (0.08%). No events occurred in 3,150 diagnostic angiograms while four occurred during 1,418 interventional procedures (0.2%). Two cases occurred during aneurysm coiling embolization (2/548; 0.4%); one case occurred during a carotid stent placement (1/138; 0.7%); one occurred during an internal carotid artery balloon occlusion test (1/73; 1.3%). Three of these complications resulted in permanent neurologic deficits while one resulted in a transient neurologic change that cleared within 60 min of onset. Sources for the emboli included the pressurized arterial flush lines connected to internal carotid artery catheters (three cases) and sudden hypotension with air subsequently entering the internal carotid artery catheter (one case). Two patients were treated with hyperbaric oxygen therapy. CONCLUSION: Symptomatic cerebral air embolism is a rare event during neuro-angiographic procedures. Analysis of the etiologies of this infrequent event may permit us to further reduce its incidence.
Assuntos
Angiografia Cerebral/efeitos adversos , Embolia Aérea/epidemiologia , Embolia Aérea/prevenção & controle , Embolia Intracraniana/epidemiologia , Embolia Intracraniana/prevenção & controle , Procedimentos Neurocirúrgicos/efeitos adversos , Estudos de Coortes , Embolia Aérea/diagnóstico , Embolização Terapêutica/efeitos adversos , Feminino , Humanos , Oxigenoterapia Hiperbárica , Incidência , Embolia Intracraniana/diagnóstico , Pessoa de Meia-Idade , Estudos Retrospectivos , Fatores de RiscoRESUMO
INTRODUCTION: There is a relationship between gas bubble formation in the vascular system and serious decompression sickness. Hence, control of the formation of vascular bubbles should allow safer decompression procedures. METHODS: There were 12 pigs that were randomly divided into an experimental group (EXP) and a control group (CTR) of 6 animals each. The pigs were compressed to 500 kPa (5 ATA) in a dry hyperbaric chamber and held for 90 min bottom time breathing air. CTR animals were decompressed according to a modified USN dive profile requiring four stops. EXP followed the same profile except that a 5-min recompression of 50 kPa (0.5 ATA) was added at the end of each of the last three decompression stops before ascending to the next stop depth. RESULTS: All CTR animals developed bubbles, compared with only one animal in EXP. The number of bubbles detected during and after the dive was 0.02 +/- 0.02 bubbles x cm(-2) in CTR, while the number of bubbles detected in EXP were 0.0009 +/- 0.005 bubbles x cm(-2); the difference was highly significant. CONCLUSION: By brief recompression during late decompression stops, the amount of bubbles was reduced. Our findings give further support for a gas phase model of decompression.
Assuntos
Doença da Descompressão/prevenção & controle , Descompressão/efeitos adversos , Descompressão/métodos , Embolia Aérea/prevenção & controle , Oxigenoterapia Hiperbárica , Animais , Descompressão/normas , Doença da Descompressão/sangue , Doença da Descompressão/fisiopatologia , Modelos Animais de Doenças , Embolia Aérea/sangue , Feminino , Masculino , Artéria Pulmonar/fisiopatologia , Distribuição Aleatória , Sus scrofaRESUMO
OBJECTIVE: In an effort to minimize the effect of extracorporeal circulation (ECC), mini-bypass is gaining clinical acceptance in routine coronary artery bypass grafting (CABG). These small circuits target combine the clinical advantages of reduced prime, 100% bio-coating and suction blood separation. We demonstrate that the use of mini-bypass in routine CABG reduces homologous blood product use and postoperative bleeding. Our goal was to also demonstrate that these small systems are effective in gaseous microemboli (GME) management as compared to a conventional extracorporeal system. METHODS: Prospective, randomized study comparing 30 mini-bypass (Dideco ECC.O) to 30 conventional systems (n=30, Dideco 903 Avant). Study included CABG cases only, independent of preoperative coagulative status; clinic ethical committee approval and informed patient consent was obtained before initiating study. RESULTS: There were no statistical differences in terms of patient demographics. Statistically significant differences were seen in transfusion frequency (27% of the study group vs 43% in the control group, p=0.05), transfused volume (133.3+/-244.5 ml vs 325+/-483.1 ml, p<0.05), fresh frozen plasma (0 unit vs 3 units, p<0.001), postoperative bleeding (301.8+/-531.9 ml vs 785.5+/-1000.4 ml, p<0.05) and GME activity post-arterial filter (0.14 microl vs 5.32 microl, p<0.05). CONCLUSIONS: The adoption of mini-bypass significantly potentially reduces hemodilution, donor blood usage, postoperative bleeding and exposure to GME in routine CABG patients as compared to the use of conventional extracorporeal circulation circuits.
Assuntos
Perda Sanguínea Cirúrgica/prevenção & controle , Transfusão de Sangue Autóloga , Ponte de Artéria Coronária/instrumentação , Embolia/prevenção & controle , Idoso , Ponte Cardiopulmonar/instrumentação , Ponte Cardiopulmonar/métodos , Ponte de Artéria Coronária/métodos , Cuidados Críticos/métodos , Embolia Aérea/prevenção & controle , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Plasma , Estudos Prospectivos , Tromboembolia/prevenção & controleRESUMO
Intravascular gas embolism can occur with decompression in space flight, and it commonly occurs during cardiac and vascular surgery. Intravascular bubbles may be deposited into any end organ such as the heart or the brain. Surface interactions between the bubble and the endothelial cells lining the vasculature result in serious impairment of blood flow and can lead to heart attack, stroke, or even death. Surfactant-based intervention is a novel treatment for gas embolism. Intravascular surfactant can adsorb onto the gas-liquid interface and compete with blood-borne macromolecules for interfacial occupancy. Surfactants can retard the progress of pathophysiological molecular and cellular events stimulated by the bubble surface, including endothelial cell injury and initiation of blood clotting. Bulk and surface transport of a surfactant to provide competition for interfacial occupancy is a therapeutic strategy because surfactant adsorption can dominate protein (or other macromolecule) adsorption. The presence of surfactant along the gas-liquid interface also induces variation in the interfacial tension, which in turn affects the blood flow and the bubble motion. We describe the interplay between biological transport processes and physiological events occurring and the cellular and molecular level in vascular gas embolization. Special consideration is given to modeling the transport and hydrodynamic interactions associated with surfactant-based intervention.