1.
Urology
; 23(6 Suppl): 4-5, 1984 Jun.
Artigo
em Inglês
| MEDLINE
| ID: mdl-6730141
2.
Semin Oncol
; 10(3 Suppl 3): 46-7, 1983 Sep.
Artigo
em Inglês
| MEDLINE
| ID: mdl-6364367
Assuntos
Estramustina/farmacologia , Compostos de Mostarda Nitrogenada/farmacologia , Animais , Ensaios Clínicos como Assunto , Avaliação Pré-Clínica de Medicamentos , Estramustina/metabolismo , Estramustina/uso terapêutico , Humanos , Masculino , Neoplasias da Próstata/tratamento farmacológico , Ratos
3.
Acta Pharmacol Toxicol (Copenh)
; 44(1): 1-6, 1979 Jan.
Artigo
em Inglês
| MEDLINE
| ID: mdl-104546
RESUMO
Rat mammary tumours induced by 7,12-dimethylbenz(a)anthracene had a higher concentration of 3H and 14C than muscle after injection of estramustine phosphate labelled with 3H in the oestrogen moiety and 14C in the alkylating moiety. Thin-layer chromatography showed that dephosphorylated estramustine phosphate was present in the tumours but no free oestradiol-17beta. The uptake of the drug in the tumours was parallelled by a dose dependant retardation of tumour growth and a prevention of tumour number increase. Estramustine phosphate also retarded growth of mammary tumours resistant to treatment with oestradiol-17 beta. It is concluded that estramustine phosphate has a greater effect on tumour growth than oestrogen.