RESUMO
Two novel phenethylamine alkaloids were isolated from Streptomyces sp. YIM 10049. On the basis of spectral data, their structures were determined as (S)-N-(cu-phenylethyl)-2 -hydroxyl-acrylimine (1) and (S)-N-nitroso-1-amino-p-hydroxy phenylethanol (2). Three known compounds, indole-3-carboxylic acid (3), cyclo(L-Ala-L-Tyr)(4), and bis(2-ethylhexyl) phthalate (5), were also isolated and characterized. Compound 1 is a rare enol tautomer, and compound 2 an unusual phenethylamine alkaloid with a N-NO group.
Assuntos
Alcaloides/química , Etilaminas/química , Fenetilaminas/química , Streptomyces/química , Alcaloides/isolamento & purificação , Alcaloides/farmacologia , Antibióticos Antineoplásicos/química , Antibióticos Antineoplásicos/farmacologia , Antifúngicos/farmacologia , Linhagem Celular Tumoral , Cromatografia em Camada Fina , Etilaminas/isolamento & purificação , Etilaminas/farmacologia , Fermentação , Fusarium/efeitos dos fármacos , Humanos , Espectroscopia de Ressonância Magnética , Espectrometria de Massas , Testes de Sensibilidade Microbiana , Fenetilaminas/isolamento & purificação , Streptomyces/crescimento & desenvolvimentoRESUMO
A beta-carboline-, a tryptamine-, and two phenylethylamine-derived alkaloids and three known aromatic compounds were isolated from the aerial parts and roots of Cyathobasis fruticulosa (Bunge) Aellen, and their structures were elucidated by spectroscopic techniques. The one new alkaloid, N-methyl-N-formyl-4-hydroxy-beta-phenylethylamine (1), showed marginal antifungal activity.