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1.
Dermatol Surg ; 46(12): 1564-1571, 2020 12.
Artigo em Inglês | MEDLINE | ID: mdl-32932267

RESUMO

BACKGROUND: There is an increasing number of over-the-counter topical products that are said to prevent pathologic scar formation and improve scar cosmesis. However, robust clinical data are lacking to substantiate these claims and to guide selection of topical products. OBJECTIVE: To determine the effectiveness of topical scar management products, including silicone gel, Allium cepa onion extract, vitamin E, trolamine, and microporous tape. METHODS AND MATERIALS: A PubMed search (2005-2019) was performed to identify studies of topical scar management products. Randomized controlled trials (RCTs), quasi-RCTs, meta-analyses, and controlled clinical trials were included for analysis. RESULTS: A total of 34 trials were included in this study. Of the 16 trials investigating silicone gel sheets, numerous high-quality RCTs found that silicone gel sheets and silicone gels significantly improved scar outcomes. Only a limited number of studies supported the effectiveness of onion extract, vitamin E, trolamine, and microporous tape products. CONCLUSION: Silicone gel products are an effective noninvasive treatment to prevent formation of pathologic scars and improve mature scars. Further high-quality studies are needed to elucidate the long-term effectiveness of these therapies.


Assuntos
Cicatriz/prevenção & controle , Medicamentos sem Prescrição/administração & dosagem , Géis de Silicone/administração & dosagem , Cicatrização/efeitos dos fármacos , Administração Tópica , Cicatriz/tratamento farmacológico , Etanolaminas/administração & dosagem , Humanos , Cebolas/química , Extratos Vegetais/administração & dosagem , Ensaios Clínicos Controlados Aleatórios como Assunto , Resultado do Tratamento , Vitamina E/administração & dosagem
3.
J Wound Care ; 29(Sup4): S36-S42, 2020 Apr 01.
Artigo em Inglês | MEDLINE | ID: mdl-32279615

RESUMO

OBJECTIVE: Silicone gel has been shown effective in improving healing post-sternotomy scars. It remains to be determined whether adding herbal extracts to the gel would augment the healing effect. METHOD: After median sternotomy, patients were randomised into two groups. Group 1: topical silicone gel plus herbal extract gel (Allium cepa, Centella Asiatica, Aloe vera and Paper Mulberry) and Group 2: silicone gel. Patients were treated for six months. The postoperative scars were assessed at three and six months by plastic surgeons using the Vancouver Scar Scale (VSS) and the patient assessment scar scale. RESULTS: Each group comprised 23 patients (n=46 in total). The VSS was significantly lower in Group 1 than in Group 2 (p=0.018 and p=0.051, respectively). In Group 1, the four differences from baseline were vascularity scores at three and six months (-0.391, p=0.025; -0.435, p=0.013, respectively), and pigmentation scores at three and six months (-0.391, p=0.019; -0.609, p=0.000, respectively). In Group 2, differences from baseline were the pigmentation and vascularity score at six months (-0.6609, p=0.000; -0.348, p=0.046, respectively). CONCLUSION: Our results suggest, post-sternotomy scars trend to have better vascularity and pigmentation when treated with silicone gel plus herbal extracts.


Assuntos
Cicatriz Hipertrófica/tratamento farmacológico , Géis de Silicone/administração & dosagem , Esternotomia , Método Duplo-Cego , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Estudos Prospectivos , Resultado do Tratamento , Cicatrização
4.
J Drugs Dermatol ; 17(4): 421-425, 2018 Apr 01.
Artigo em Inglês | MEDLINE | ID: mdl-29601619

RESUMO

Scar formation is the body's natural healing response to reestablish dermal integrity following an injury. Excessive scarring, however, can cause significant cosmetic, functional, and psychological problems. A wide variety of topical creams, lotions, and oils are available for scar treatment or wound healing. Sieving through the options and selecting the best option for their patients can be challenging for clinicians, especially given that clinical evidence for many of the active agents in commonly used topical treatments is lacking. The goal of this review is to provide an overview of topical treatments utilized for scar management, including their mechanism of action and evidence of efficacy. As knowledge of the wound healing process is critical to understanding the effects of topical treatments, the pathophysiology of wound healing is also reviewed.

J Drugs Dermatol. 2018;17(4):421-425.

.


Assuntos
Cicatriz/tratamento farmacológico , Pomadas/administração & dosagem , Creme para a Pele/administração & dosagem , Cicatrização/efeitos dos fármacos , Administração Tópica , Animais , Cicatriz/metabolismo , Humanos , Ácido Hialurônico/administração & dosagem , Metaloproteinases da Matriz/metabolismo , Preparações de Plantas/administração & dosagem , Géis de Silicone/administração & dosagem , Vitamina E/administração & dosagem , Cicatrização/fisiologia
5.
J Cosmet Laser Ther ; 20(2): 96-101, 2018 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-29020479

RESUMO

BACKGROUND: The effect of topical silicone gel has been studied to prevent scars from burn, postoperative wound and to treat hypertrophic scars. No previous studies have been done to evaluate the efficacy of topical silicone gel on atrophic acne scars. MATERIAL AND METHODS: Nineteen patients were treated with three sessions of ablative Er:YAG laser with 1-month intervals. Following each laser treatment, the randomlyassigned silicone gel or placebo was applied in split-face manner. Objective assessments, which included roughness, smoothness, hydration, transepidermal water loss were measured at baseline and prior to each treatment. Subjective assessments by dermatologists and subjects were done at baseline and 1 month after last laser treatment. RESULTS: The laser treatments were well tolerated and resulted in clinical improvements. Topical silicone gel treatment resulted in significantly less roughness at weeks 4 and 12 compared with placebo (p < 0.05). CONCLUSION: Adding topical silicone gel to ablative Er:YAG laser treatment may provide additional benefits in improving acne scars.


Assuntos
Acne Vulgar/complicações , Cicatriz/etiologia , Cicatriz/radioterapia , Terapia com Luz de Baixa Intensidade/instrumentação , Géis de Silicone/administração & dosagem , Administração Tópica , Adulto , Feminino , Humanos , Lasers de Estado Sólido/uso terapêutico , Terapia com Luz de Baixa Intensidade/efeitos adversos , Masculino , Método Simples-Cego , Adulto Jovem
6.
Int J Dermatol ; 53(8): 922-36, 2014 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-24697346

RESUMO

Cosmetic, functional, and structural sequelae of scarring are innumerable, and measures exist to optimize and ultimately minimize these sequelae. To evaluate the innumerable methods available to decrease the cosmetic, functional, and structural repercussions of scarring, pubMed search of the English literature with key words scar, scar revision, scar prevention, scar treatment, scar remodeling, cicatrix, cicatrix treatment, and cicatrix remodeling was done. Original articles and reviews were examined and included. Seventy-nine manuscripts were reviewed. Techniques, comparisons, and results were reviewed and tabulated. Overall, though topical modalities are easier to use and are usually more attractive to the patient, the surgical approaches still prove to be superior and more reliable. However, advances in topical medications for scar modification are on the rise and a change towards medical treatment of scars may emerge as the next best approach. Comparison studies of the innumerable specific modalities for scar revision and prevention are impossible. Standardization of techniques is lacking. Scarring, the body's natural response to a wound, can create many adverse effects. At this point, the practice of sound, surgical fundamentals still trump the most advanced preventative methods and revision techniques. Advances in medical approaches are available, however, to assist the scarring process, which even the most advanced surgical fundamentals will ultimately lead to. Whether through newer topical therapies, light treatment, or classical surgical intervention, our treatment armamentarium of scars has expanded and will allow us to maximize scar prevention and to minimize scar morbidity.


Assuntos
Cicatriz/terapia , Procedimentos Cirúrgicos Dermatológicos , Terapia a Laser , Administração Cutânea , Alantoína/administração & dosagem , Antimitóticos/uso terapêutico , Toxinas Botulínicas Tipo A/uso terapêutico , Cicatriz/fisiopatologia , Cicatriz/prevenção & controle , Dermabrasão , Procedimentos Cirúrgicos Dermatológicos/métodos , Combinação de Medicamentos , Heparina/administração & dosagem , Humanos , Extratos Vegetais/administração & dosagem , Géis de Silicone/administração & dosagem , Sitosteroides/administração & dosagem , Fator de Crescimento Transformador beta3/uso terapêutico
7.
Curr Opin Otolaryngol Head Neck Surg ; 18(4): 261-5, 2010 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-20631534

RESUMO

PURPOSE OF REVIEW: To examine the place of surgery and other modes of treating scar tissue given the plethora of measures that are advocated on the internet. RECENT FINDINGS: There is good evidence to support the use of silicone sheets, pulsed dye laser (PDL), intralesional triamcinolone and dermabrasion in reducing hypertrophic scars, but each needs qualifying in terms of their timing and the type of scar tissue that they are used for. SUMMARY: The surgical revision of scars should be delayed for at least 12 months unless there is webbing when redistributing skin tension forces with a Z-plasty or multiple Z-plasties or other local flaps negates the need to wait for the scar to mature. In a posttraumatic 'horse shoe' shaped, or a very oblique, cut an irregular contour is likely to occur. Under these circumstances a triamcinolone injection into any raised area can help and this needs to be re-evaluated after 6 weeks. With a less irregular contour dermabrasion can help if used 8 weeks after surgery. With hypertrophic scarring both silicone gel sheeting and PDL may help reduce the prominence of the scar. Most of all time helps scars to settle and fade and typical scar maturation takes 18-24 months. The role of stem cells, particularly from adipose tissue, warrants further study.


Assuntos
Cicatriz Hipertrófica/terapia , Adjuvantes Imunológicos/uso terapêutico , Aminoquinolinas/uso terapêutico , Dermabrasão , Estética , Glucocorticoides/administração & dosagem , Humanos , Imiquimode , Peptídeos e Proteínas de Sinalização Intercelular/uso terapêutico , Queloide/terapia , Terapia a Laser , Radioterapia , Procedimentos de Cirurgia Plástica , Géis de Silicone/administração & dosagem , Transplante de Células-Tronco , Expansão de Tecido , Triancinolona/administração & dosagem , Vitamina E/uso terapêutico , Vitaminas/uso terapêutico
8.
J Craniofac Surg ; 21(3): 719-23, 2010 May.
Artigo em Inglês | MEDLINE | ID: mdl-20485035

RESUMO

In this prospective study, we used the Patient and Observer Scar Assessment Scale (POSAS) to evaluate the outcome of the healing process of posttraumatic and surgical facial scars that were treated with self-drying silicone gel, by both the patient and the observer. In our division, the application of base cream and massage represents the standard management of facial scars after suture removal. In the current study, 15 patients (7 men and 8 women) with facial scars were treated with self-drying silicone gel that was applied without massage, and 15 patients (8 men and 7 women) were treated with base cream and massage. Both groups underwent a clinical evaluation of facial scars by POSAS at the time of suture removal (T0) and after 2 months of treatment (T1). The patient rated scar pain, itch, color, stiffness, thickness, and surface (Patient Scale), and the observer rated scar vascularity, pigmentation, thickness, relief, pliability, and surface area (Observer Scale [OS]). The Patient Scale reported the greatest improvement in the items color, stiffness, and thickness. Itch was the only item that worsened in the group self-drying silicone gel. The OS primarily reported an improvement in the items vascularization, pigmentation, and pliability. The only item in the OS that underwent no change from T0 to T1 was surface area. The POSAS revealed satisfactory healing of posttraumatic and surgical facial scars that were treated with self-drying silicone gel.


Assuntos
Cicatriz/patologia , Cicatriz/terapia , Face , Massagem , Índice de Gravidade de Doença , Géis de Silicone/uso terapêutico , Adolescente , Adulto , Idoso , Cicatriz/fisiopatologia , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Estudos Prospectivos , Géis de Silicone/administração & dosagem , Pigmentação da Pele , Resultado do Tratamento , Cicatrização/fisiologia
9.
Dermatol Surg ; 35 Suppl 2: 1612-9, 2009 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-19807755

RESUMO

BACKGROUND: A constantly increasing number of gel fillers for aesthetic and reconstructive purposes have been introduced during the last 20 years. Most of the new ones are modified versions of the original collagen and hyaluronic acid gels. They have been reconstructed, often by adding cross-bindings to the polymer in order to obtain a more dense molecular structure, which will prolong degradation and filling effect of the gel. Other gel fillers contain particles of organic (poly-lactic acid) or inorganic (calcium hydroxylapatite) material, which have been used in human tissue for other purposes (degradable suture material and bone cement, respectively). The permanent fillers (silicone oil and polyacrylamide gel) have been used for many years, silicone mainly in the US and polyacrylamide gel in most countries outside the US and Canada. OBJECTIVE: Complications occur, and they appear to be more frequent with particulated fillers, polyacrylamide gel and silicone oil. However, these complications differ in nature and depend on the filler type used. METHODS AND MATERIALS: This overview presents the different gel filler types, how they interact with host tissue, and what can go wrong. The results and conclusion are based on experimental and clinical observations coupled with a search of the literature. RESULTS AND CONCLUSION: Complications following homogenous hydrogels are caused by infection with bacteria, which have been inserted into the gel during injection. If not treated with relevant antibiotics (but instead steroids or large doses of NSAIDs) the bacteria form a biofilm, which gives rise to a low-grade chronic infection that is resistant to antibiotics. Complications following particulated gels and silicone oil are not known, but bacteria in a biofilm and/or endotoxins released by these is a possibility which deserves further investigations, primarily by using the fluorescence in situ hybridization (FISH) technique.


Assuntos
Materiais Biocompatíveis/administração & dosagem , Técnicas Cosméticas , Fármacos Dermatológicos/administração & dosagem , Géis/administração & dosagem , Granuloma de Corpo Estranho/induzido quimicamente , Rejuvenescimento , Envelhecimento da Pele/efeitos dos fármacos , Resinas Acrílicas/administração & dosagem , Materiais Biocompatíveis/efeitos adversos , Materiais Biocompatíveis/química , Materiais Biocompatíveis/classificação , Colágeno/administração & dosagem , Fármacos Dermatológicos/efeitos adversos , Fármacos Dermatológicos/química , Fármacos Dermatológicos/classificação , Medicina Baseada em Evidências , Face , Géis/efeitos adversos , Géis/química , Géis/classificação , Granuloma de Corpo Estranho/prevenção & controle , Humanos , Ácido Hialurônico/administração & dosagem , Hidrogéis/administração & dosagem , Injeções/efeitos adversos , Injeções/métodos , Polímeros/administração & dosagem , Sefarose/administração & dosagem , Géis de Silicone/administração & dosagem , Fatores de Tempo , Resultado do Tratamento
10.
Dermatol Online J ; 13(3): 9, 2007 Jul 13.
Artigo em Inglês | MEDLINE | ID: mdl-18328203

RESUMO

Keloid formation occurs as a result of abnormal wound healing. Despite the high prevalence of keloids in the general population, they remain one of the more challenging dermatologic conditions to manage. More than a cosmetic nuisance, they are often symptomatic and can have a significant psychosocial burden for the patient. Although multiple treatment modalities exist, no single treatment has proven widely effective. In fact, recurrence following treatment is generally the norm. Combination therapy is likely the optimal strategy. In this review, we highlight the clinical features, pathophysiology and management of keloids.


Assuntos
Adjuvantes Imunológicos/administração & dosagem , Crioterapia/métodos , Glucocorticoides/administração & dosagem , Queloide , Terapia com Luz de Baixa Intensidade/métodos , Géis de Silicone/administração & dosagem , Procedimentos Cirúrgicos Operatórios/métodos , Administração Tópica , Animais , Apoptose , Bandagens , Colágeno/biossíntese , Fibroblastos/metabolismo , Fibroblastos/patologia , Humanos , Injeções Intralesionais , Peptídeos e Proteínas de Sinalização Intercelular/biossíntese , Queloide/etiologia , Queloide/patologia , Queloide/terapia , Radioterapia Adjuvante/métodos , Fatores de Risco , Resultado do Tratamento , Ferimentos e Lesões/complicações
11.
J Am Acad Dermatol ; 55(6): 1024-31, 2006 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-17097399

RESUMO

Hypertrophic scars represent an abnormal, exaggerated healing response after skin injury. In addition to cosmetic concern, scars may cause pain, pruritus, contractures, and other functional impairments. Therapeutic modalities include topical medications, intralesional corticosteroids, laser therapy, and cryosurgery. Topical therapies, in particular, have become increasingly popular because of their ease of use, comfort, noninvasiveness, and relatively low cost. This review will discuss the properties and effectiveness of these agents, including pressure therapy, silicone gel sheeting and ointment, polyurethane dressing, onion extract, imiquimod 5% cream, and vitamins A and E in the prevention and treatment of hypertrophic scars.


Assuntos
Cicatriz Hipertrófica/terapia , Administração Cutânea , Aminoquinolinas/administração & dosagem , Aminoquinolinas/efeitos adversos , Aminoquinolinas/uso terapêutico , Bandagens , Curativos Biológicos , Cicatriz Hipertrófica/tratamento farmacológico , Cicatriz Hipertrófica/prevenção & controle , Ensaios Clínicos como Assunto , Método Duplo-Cego , Humanos , Imiquimode , Curativos Oclusivos , Cebolas , Fitoterapia , Extratos Vegetais/administração & dosagem , Extratos Vegetais/uso terapêutico , Poliuretanos , Pressão , Ensaios Clínicos Controlados Aleatórios como Assunto , Géis de Silicone/administração & dosagem , Géis de Silicone/uso terapêutico , Método Simples-Cego , Vitamina A/administração & dosagem , Vitamina A/efeitos adversos , Vitamina A/uso terapêutico , Vitamina E/administração & dosagem , Vitamina E/efeitos adversos , Vitamina E/uso terapêutico , Cicatrização/efeitos dos fármacos
12.
Plast Reconstr Surg ; 117(1): 286-300, 2006 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-16404281

RESUMO

BACKGROUND: Keloid management can be difficult and frustrating, and the mechanisms underlying keloid formation are only partially understood. METHODS: Using original and current literature in this field, this comprehensive review presents the major concepts of keloid pathogenesis and the treatment options stemming from them. RESULTS: Mechanisms for keloid formation include alterations in growth factors, collagen turnover, tension alignment, and genetic and immunologic contributions. Treatment strategies for keloids include established (e.g., surgery, steroid, radiation) and experimental (e.g., interferon, 5-fluorouracil, retinoid) regimens. CONCLUSION: The scientific basis and empiric evidence supporting the use of various agents is presented. Combination therapy, using surgical excision followed by intradermal steroid or other adjuvant therapy, currently appears to be the most efficacious and safe current regimen for keloid management.


Assuntos
Queloide/fisiopatologia , Queloide/terapia , Antimetabólitos/uso terapêutico , Colágeno/metabolismo , Terapia Combinada , Matriz Extracelular/fisiologia , Fibroblastos/fisiologia , Fluoruracila/uso terapêutico , Humanos , Injeções Intralesionais , Interferons/uso terapêutico , Queloide/imunologia , Queloide/metabolismo , Queloide/patologia , Terapia a Laser , Pressão , Retinoides/uso terapêutico , Sebo/imunologia , Géis de Silicone/administração & dosagem , Estresse Mecânico , Fator de Crescimento Transformador beta/fisiologia , Triancinolona Acetonida/administração & dosagem
13.
Zentralbl Chir ; 129(4): 296-306, 2004 Aug.
Artigo em Alemão | MEDLINE | ID: mdl-15354252

RESUMO

Many techniques for management of hypertrophic scars and keloids have been proven through extensive use, but few have been supported by prospective studies with adequate control groups. Several new therapies showed good results in small-scale trials, but these have not been repeated in larger trials with long-term follow-up. This article reports a qualitative overview of the available clinical literature by an international panel of experts using standard methods of appraisal. The article provides evidence- based recommendations on prevention and treatment of abnormal scarring and, where studies are insufficient, consensus on best practice. The recommendations focus on the management of hypertrophic scars and keloids, and are internationally applicable in a range of clinical situations. These recommendations support a move to a more evidence-based approach in scar management. This approach highlights a primary role for silicon gel sheeting and intralesional corticosteroids in the management of a wide variety of abnormal scars. The authors concluded that these are the only treatments for which sufficient evidence exists to make evidence-based recommendations. A number of other therapies that are in common use have achieved acceptance by the authors as standard practice. However, it is highly desirable that many standard practice and new emerging therapies undergo large-scale studies with long-term follow-up before being recommended conclusively as alternative therapies for scar management.


Assuntos
Cicatriz/terapia , Medicina Baseada em Evidências , Corticosteroides/administração & dosagem , Corticosteroides/uso terapêutico , Algoritmos , Anti-Inflamatórios/administração & dosagem , Anti-Inflamatórios/uso terapêutico , Bleomicina/administração & dosagem , Bleomicina/uso terapêutico , Cicatriz/classificação , Cicatriz/diagnóstico , Cicatriz/tratamento farmacológico , Cicatriz/prevenção & controle , Cicatriz/radioterapia , Cicatriz/cirurgia , Cicatriz Hipertrófica/diagnóstico , Cicatriz Hipertrófica/tratamento farmacológico , Cicatriz Hipertrófica/prevenção & controle , Cicatriz Hipertrófica/radioterapia , Cicatriz Hipertrófica/cirurgia , Cicatriz Hipertrófica/terapia , Crioterapia , Seguimentos , Humanos , Injeções Intralesionais , Queloide/diagnóstico , Queloide/tratamento farmacológico , Queloide/prevenção & controle , Queloide/radioterapia , Queloide/cirurgia , Queloide/terapia , Terapia a Laser , Projetos Piloto , Estudos Prospectivos , Dosagem Radioterapêutica , Ensaios Clínicos Controlados Aleatórios como Assunto , Géis de Silicone/administração & dosagem , Fatores de Tempo , Triancinolona/administração & dosagem , Triancinolona/uso terapêutico
14.
Artigo em Chinês | MEDLINE | ID: mdl-15065421

RESUMO

OBJECTIVE: To study the curative effects of keloid by operation combined with postoperative beta radiation and silicone gel sheeting. METHODS: From 1996 to 2002, 598 patients with keloid (243 males, 355 females, aging 15-55 years with an average of 28.6 years) were treated by integrated therapy. Their disease courses were from 6 months to 6 years. The keloid area ranged from 1.0 cm x 1.5 cm-8.0 cm x 15 cm. First, keloid was removed by operation, and then the wounds were sutured directly (group suture) or covered with skin graft (group graft). In group suture, the operational sites were managed by beta ray radiotherapy 24-48 hours after operation. The total doses of radiation were 12-15 Gy, 5 times 1 week (group suture A) and 10 times 2 weeks (group suture B). Radiotherapy was not taken until stitches were taken out in group graft, and then the same methods were adopted as group suture B. After radiotherapy, silicone gel sheeting was used in 325 cases for 3-6 months. RESULTS: All patients were followed up for 12-18 months. (1) The overall efficacy was 91.3% in group suture A (n = 196), and 95.8% in group suture B (n = 383), respectively. There was significant difference between the two groups (P < 0.01). (2) Radiotherapy was of no effect in 6 cases of group graft (n = 19). (3) Silicone gel sheeting had effectiveness in 185 cases. Silicone gel sheeting had no obvious effect on the overall efficacy, but it could improve the quality of texture and color of skin. CONCLUSION: By use of integrated methods to treat keloid, if the wound can be sutured directly, skin grafting should not be adopted. The results in group suture B are better than those in group suture A; silicone gel sheeting should be used as possible.


Assuntos
Queloide/cirurgia , Géis de Silicone/administração & dosagem , Transplante de Pele , Adolescente , Adulto , Partículas beta , Terapia Combinada , Procedimentos Cirúrgicos Dermatológicos , Relação Dose-Resposta à Radiação , Feminino , Humanos , Queloide/tratamento farmacológico , Queloide/radioterapia , Masculino , Pessoa de Meia-Idade , Géis de Silicone/uso terapêutico , Resultado do Tratamento
15.
Gut ; 51(2): 225-8, 2002 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-12117884

RESUMO

BACKGROUND: A weak or disrupted internal anal sphincter can cause passive faecal incontinence. Conservative measures may help some patients but there is no simple surgical solution for those who fail conservative treatment. A successful technique using trans-sphincteric injection of a bulking agent to augment the internal anal sphincter was developed in a previous pilot study. AIM: To determine the clinical results and underlying physiological effects of biomaterial injection. PATIENTS: Six patients (four males, median age 53 years (range 36-65)) with faecal incontinence to solid or liquid stool related to poor internal anal sphincter function, of varied aetiology, were recruited. METHODS: Silicone based biomaterial injections were performed, under local anaesthesia, with antibiotic cover. Three injections were placed circumferentially, trans-sphincterically, entering away from the anal margin and injecting at or just above the dentate line. Anorectal physiological studies, endoanal ultrasound, a bowel symptom diary, a validated incontinence score, and quality of life questionnaires were completed before treatment and on completion of follow up. RESULTS: At a median follow up of 18 months (range 15-19), five of six patients had marked symptom improvement. Faecal incontinence scores improved from a median of 14/24 (range 11-20) before to 8/24 (6-15) after injection. Short form-36 quality of life physical and social function scores improved from a median of 26/100 (5-33) to 79/100 (25-100) and from 10/100 (5-37) to 100/100 (50-100), respectively. There was a corresponding physiological increase in maximum anal resting and squeeze pressures. Ultrasound showed the Bioplastique to be retained in the correct position in the improved patients without migration. There were no complications. CONCLUSION: Trans-sphincteric injection of silicone biomaterial can provide a marked improvement in faecal incontinence related to a weak or disrupted internal anal sphincter. This is associated with improved sphincter function and quality of life.


Assuntos
Canal Anal/fisiopatologia , Materiais Biocompatíveis/administração & dosagem , Incontinência Fecal/terapia , Géis de Silicone/administração & dosagem , Adulto , Idoso , Anestesia Local , Incontinência Fecal/fisiopatologia , Feminino , Seguimentos , Humanos , Injeções , Masculino , Pessoa de Meia-Idade , Resultado do Tratamento
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