Assuntos
Duodenite/reabilitação , Gastrite/reabilitação , Terapia com Luz de Baixa Intensidade , Adolescente , Adulto , Doença Crônica , Duodenite/etiologia , Duodenite/patologia , Duodenite/radioterapia , Famotidina/uso terapêutico , Feminino , Gastrite/etiologia , Gastrite/patologia , Gastrite/radioterapia , Antagonistas dos Receptores H2 da Histamina/uso terapêutico , Humanos , Masculino , Pessoa de Meia-Idade , Resultado do TratamentoRESUMO
BACKGROUND AND OBJECTIVES: Helicobacter pylori (HP) is an endemic pathogenic bacterium causing gastritis and gastroduodenal ulceration in humans and is linked to the development of gastric malignancies. These first human in vivo studies investigated the photoeradication of HP using laser and white light. STUDY DESIGN/MATERIALS AND METHODS: In 13 HP-positive volunteers, a zone of gastric antrum was irradiated with laser (410 nm, 50 J/cm(2)) or endoscopic white light (10 J/cm(2)) 45 minutes after oral 5-aminolevulinic acid (5-ALA) 20 mg/kg. HP-eradication was assessed by biopsy urease test and HP-culture from irradiated and control zones 5 minutes, 4 and 48 hours post-irradiation. RESULTS: A maximum eradication effect was achieved at 4 hours post-irradiation when 85% of biopsies in the monochromatic and 66% in the white light exposed zones, and 58 and 33% in the respective control zones were HP-negative. CONCLUSIONS: HP numbers were greatly reduced following exposure to 5-ALA and either laser or white light in vivo. Photoeradication appears feasible, but further light dosimetry and the development of convenient application methods is required.
Assuntos
Ácido Aminolevulínico/farmacologia , Infecções por Helicobacter/tratamento farmacológico , Infecções por Helicobacter/radioterapia , Helicobacter pylori/efeitos dos fármacos , Helicobacter pylori/efeitos da radiação , Terapia com Luz de Baixa Intensidade/métodos , Fármacos Fotossensibilizantes/farmacologia , Fototerapia/métodos , Adulto , Ácido Aminolevulínico/uso terapêutico , Biópsia , Feminino , Gastrite/complicações , Gastrite/tratamento farmacológico , Gastrite/microbiologia , Gastrite/radioterapia , Gastroscopia , Infecções por Helicobacter/complicações , Infecções por Helicobacter/microbiologia , Humanos , Luz , Masculino , Pessoa de Meia-Idade , Úlcera Péptica/complicações , Úlcera Péptica/tratamento farmacológico , Úlcera Péptica/microbiologia , Úlcera Péptica/radioterapia , Fármacos Fotossensibilizantes/uso terapêutico , Estômago/efeitos dos fármacos , Estômago/microbiologia , Fatores de TempoRESUMO
The authors studied effects of microwave electromagnetic irradiation on the course of peptic ulcers and dissemination with Helicobacter pylori in 60 patients with various severity of the disease. Microwave irradiation not only hastens clinico-endoscopical remission of the disease but also considerably reduces dissemination of mucosa with Helicobacter pylori.
Assuntos
Infecções por Helicobacter/radioterapia , Helicobacter pylori , Micro-Ondas/uso terapêutico , Úlcera Péptica/radioterapia , Pontos de Acupuntura , Adolescente , Adulto , Doença Crônica , Terapia Combinada , Feminino , Gastrite/radioterapia , Humanos , Masculino , Pessoa de Meia-Idade , Indução de RemissãoRESUMO
He-Ne laser irradiation of biologically active points and infrared laser irradiation of the liver were employed to improve gallbladder and sphincter functions, bile production and biochemistry, respectively, in a total of 57 patients with biliary dyskinesia presenting as hypokinetic dyskinesia of the gallbladder, hyperkinetic dyskinesia of the sphincter of Oddi or the combination of the two affections. Simultaneous use of the two kinds of laser irradiation appreciably shortens treatment duration, abolishes biliferous dysfunction, reestablishes physiological balance of bile components in case of its initial lithogenic potential.