RESUMO
The status of salivary glands and oral mucous membrane was investigated in 50 patients with chronic active hepatitis against the background of chronic alcoholism. The check up disclosed sialadenosis in 38% of patients and in 54% of patients - such diseases of oral mucous membrane as stomatitis, candidosis and geographic tonque. Besides there were disclosed such disturbances as big and small salivary glands secretion reduction, mixed saliva viscosity increase, increase of protein, P, K, Na and catalase content in it, glycogen hyperaccumulation in gingival tissues. The received data indicated the necessity of dispensary supervision of such patients and their treatment in stomatologist.
Assuntos
Candidíase Bucal/metabolismo , Glossite Migratória Benigna/metabolismo , Hepatite Alcoólica/complicações , Mucosa Bucal/metabolismo , Glândulas Salivares/metabolismo , Sialadenite/metabolismo , Estomatite/metabolismo , Adolescente , Adulto , Idoso , Candidíase Bucal/etiologia , Candidíase Bucal/patologia , Catalase/metabolismo , Feminino , Seguimentos , Gengiva/metabolismo , Glossite Migratória Benigna/etiologia , Glossite Migratória Benigna/patologia , Glicogênio/metabolismo , Hepatite Alcoólica/metabolismo , Humanos , Masculino , Pessoa de Meia-Idade , Mucosa Bucal/patologia , Fósforo/metabolismo , Potássio/metabolismo , Saliva/química , Glândulas Salivares/patologia , Índice de Gravidade de Doença , Sialadenite/etiologia , Sialadenite/patologia , Sódio/metabolismo , Estomatite/etiologia , Estomatite/patologia , ViscosidadeRESUMO
OBJECTIVE: To explore the immunological mechanism of exfoliative tongue fur in children with asthma. METHODS: Thirty-nine children with asthma, twenty-eight children with repetitive respiratory tract infection (non-asthma) and eleven healthy children were divided into five groups, which were asthma with exfoliative fur or with non-exfoliative fur groups, non-asthma with exfoliative fur or with non-exfoliative fur groups and normal control group. The concentrations of keratin 13 and bcl-2 in cells exfoliated from tongue fur were detected by immunohistochemical method. The expression levels of blood cell chemokine receptor-3 (CCR-3) and CD4(+) were examined by flow cytometry, and the levels of serum cortisol and IgE were detected by radioimmunoassay. RESULTS: The levels of blood CD4(+) and CCR-3 of children with asthma and exfoliative fur were higher than those in the asthma with non-exfoliative fur group and the normal control group (P<0.05). The serum level of cortisol in the groups of asthma with exfoliative fur and non-asthma with exfoliative fur were lower than that in the other groups (P<0.05). The serum levels of IgE in asthma with exfoliative fur or with non-exfoliative fur groups were higher than that in the other groups (P<0.05). Concentrations of keratin 13 in the cells exfoliated from tongue fur in the groups of asthma or non-asthma with exfoliative fur were lower than that of the other groups (P<0.05). There was no significant difference of expression level of bcl-2 in the cells exfoliated from tongue fur among these five groups. CONCLUSION: There is a reasonably close relationship between the formation of exfoliative tongue fur and the immune system such as low level of serum cortisol and high levels of blood CD4(+) and CCR-3, which may all promote the formation of exfoliative fur. The disability of keratinization and apoptosis of epithelial cells of tongue may also be one cause for its formation.