Angiosarcoma of common iliac vein.

Angiosarcoma is a rare malignant tumour of endothelial cells. Primary angiosarcoma of venous origin is extremely rare, and has a very poor prognosis. A 63-year-old woman with retroperitoneal mass underwent en bloc resection on a part of iliac vein followed by adjuvant radiotherapy. No recurrence was detected during 3 years of follow-up.

Primary hepatic angiosarcoma: multi-institutional comprehensive cancer centre review of multiphasic CT and MR imaging in 35 patients.

OBJECTIVE: To assess the imaging features of primary hepatic angiosarcoma on multiphasic CT and MR. METHODS: Multi-institutional review identified 35 adults (mean age, 57.1 years; 22M/13F) with pathologically proven hepatic angiosarcoma and pretreatment multiphasic CT (n = 33) and/or MR (n = 7). RESULTS: Multifocal hepatic involvement was seen in all 35 cases, with at least 10 lesions in 74.3% (26/35). Mean size of the dominant mass was 8.9 ± 4.7 cm (range, 2.6-20 cm). Individual nodules were typically circumscribed. Arterial-phase foci of hypervascular enhancement without washout were seen in 89.7% (26/29). Heterogeneously expanding foci of enhancement generally followed blood pool in 88.6% (31/35). Progressive centripetal (n = 16) or diffuse "flash-fill" (n = 4) enhancement pattern resembling cavernous haemangiomas predominated in 20 cases, whereas a "reverse haemangioma" centrifugal pattern predominated in 11 cases. Rapid interval growth was seen in 24 (96.0%) of 25 cases with serial imaging. Vascular invasion was not seen in any case. Underlying cirrhotic morphology was seen in 42.3% (15/35). CONCLUSION: Primary hepatic angiosarcomas typically manifest as aggressive multifocal tumors containing small heterogeneous hypervascular foci that progressively expand and follow blood pool. The appearance can mimic cavernous haemangiomas, but distinction is generally possible. In the setting of cirrhosis, lack of tumour washout and vascular invasion argue against multifocal hepatocellular carcinoma. KEY POINTS: • Hepatic angiosarcoma manifests on CT and MR as rapidly progressive multifocal tumours • Multiphasic imaging demonstrates hypervascular foci that progressively expand and follow blood pool • Enhancement pattern can resemble cavernous haemangiomas or show a "reverse" centrifugal pattern • Lack of tumour washout of hypervascular lesions argues against multifocal hepatocellular carcinoma • Careful assessment of the cross-sectional imaging findings may suggest the diagnosis.

Angiosarcoma de mama: a propósito de un caso / Angiosarcoma of the breast: apropos of one case

El angiosarcoma de mama constituye una neoplasia vascular maligna muy poco frecuente en la mama, con una incidencia inferior al 0,05 por ciento de entre todos los tumores primarios que asientan en la mama. Teniendo en cuenta que su edad de aparición es a partir de la tercera-cuarta década de la vida, resulta preocupante la aparición de casos a edades cada vez más tempranas. Se presenta el caso clínico de una paciente de 25 años de edad con antecedente de fibroma mamario benigno desde los 17 años que degenera en un angiosarcoma mamario...

Breast Angiosarcoma is a malignant vascular neoplasm rare in the breast with an incidence of less than 0.05 percent of all primary tumors in the breast that seat. Given its age of onset is from the third to fourth decade of life, it is disturbing to the occurrence of increasingly early ages. We describe the case of a patient 25 years old with a history of benign breast fibroid from the 17 years that degenerates into a breast angiosarcoma...

Angiosarcoma de cuero cabelludo: revisión de la literatura a propósito de un caso / Angiosarcoma of the scalp: clinical case and literature review

El angiosarcoma es una neoplasia maligna originada en el endotelio vascular. Puede afectar cualquier parte del cuerpo. Es un tumor infrecuente que representa aproximadamente el 2 por ciento de los sarcomas de partes blandas. El angiosarcoma de cuero cabelludo es una forma diferenciada dentro de los angiosarcomas; suele tener una evolución insidiosa, por lo que sus manifestaciones clínicas pueden ser muy variadas. A continuación se presenta el caso de un paciente de sexo femenino que presentó un angiosarcoma de cuero cabelludo. Se realiza una revisión de la literatura, con particular énfasis en las claves diagnósticas clínicas y de tratamiento.

Angiosarcoma is a malignant tumor originated in the vascular endothelium. It can affect any part of the body. It is a rare tumor that represents about 2 percent of soft tissue sarcomas. Scalp angiosarcoma is a distinct form within the angiosarcomas; usually has an insidious evolution and clinical manifestations vary. We present the clinical case of a female patient who presented a scalp angiosarcoma. A review of the literature is presented with particular emphasis on key clinical diagnosis and treatment.

[Rupture of the spleen in angiosarcoma: a case report and review of the literature]. / Rottura di milza in angiosarcoma: considerazioni su di un caso clinico e revisione della letteratura.

Splenic angiosarcoma is a rare neoplasm originating from endothelial cells of the blood vessels. Its incidence is about 0.14-0.25 per million. We report the case of a patient admitted in a state of hypovolaemic shock with haemoperitoneum due to rupture of the spleen. Splenectomy was performed with evacuation of the haemorrhagic effusion. The blood was aspirated and in part instilled during the operation through intraoperative blood salvage due to the large haemoperitoneum. Histological examination revealed a splenic angiosarcoma. Splenic angiosarcoma should be suspected in cases of splenomegaly with unknown anaemia and no lymphoma, leukaemia or myelofibrosis, because of its neoplastic aggressiveness and its invariably fatal outcome. It is important to perform a splenectomy before splenic rupture owing to its negative impact on long-term survival.

[Cutaneous neoplasms]. / Neoplasien der Haut.

The skin is the organ most commonly affected by malignancies. Various cancers of the skin show a dramatic increase in incidence over the last decades. Epithelial skin tumors are most frequently, e.g., basal cell carcinoma and the squamous cell carcinoma with its precursors, the actinic keratoses. Melanoma, which is extremely difficult to treat in advanced tumor stages, is dreaded. Besides that, there are other epithelial malignant diseases, e.g. Morbus Bowen and adnexal tumors originating from the skin appendices. Mesenchymal malignant neoplasias such as Morbus Kaposi, angiosarcomas and other dermal sarcomas, are rare. Since the majority of malignant neoplasms is removable and curable by a simple surgical intervention, the knowledge of the different skin tumors is essential for non-dermatologist.

[Angiosarcoma of the nasal septum]. / Angiosarkom des Nasenseptums.

This is a report on a female patient, 37 years old, with a polypous, sessile tumor on the nasal septum covered by smooth mucous membrane. She was treated with local excision. The histological diagnosis was an angiosarcoma, confirmed by immunohistological stain with factor VIII-like antigen, thrombomodulin, and UEA. She currently remains free of the disease 12 months after diagnosis. Angiosarcoma in the head and neck area and especially the localization in the nasal septum are extremely rare. Prognosis, differential diagnosis, metastasis formation, and therapy of this tumor are presented.

Angiosarcomas radioinducidos / Radioinducted angiosarcomas

Se contribuye a la casuística con la presentación de 2 casos de angiosarcoma radioinducido, diagnosticados ambos, en pacientes de sexo femenino que previamente habían recibido dosis total de radioterapia, uno por presentar un linfoma tipo Hodgkin, y otro por carcinoma ductal de mama. En una de las pacientes el tiempo de latencia fue de 10 años, mientras que en la otra fue de 25 años. La evolución fue dispar, ya que mientras una tiene un año de evolución sin evidencias de enfermedad, la otra falleció debido a metástasis pulmonares y complicaciones cardíacas al año de ser operada

Unusual cutaneous malignancies.

The most commonly occurring cutaneous malignancies are basal cell and squamous cell carcinoma. There are, however, other rare malignancies that are encountered and should be included in the differential, in which both the clinical and the histological diagnosis may be difficult. Here, the clinical and histological features, management, and prognostic factors of merkel cell carcinoma, microcystic adnexal carcinoma, leiomyosarcoma, dermatofibrosarcoma protuberans, and angiosarcoma are reviewed.

Angiosarcoma de cuero cabelludo: casos clínicos y revisión de la literatura / Angiosarcoma of the scalp: clinical cases and review of the literature

Se presentan dos casos de angiosarcoma de cuero cabelludo con dos variantes histológicas. El primer caso, un paciente de 58 años con una variedad epiteloide localizada en región temporal. El segundo caso una paciente de 80 años con una variedad predominantemente angiomatoide en la región parietal. Se evalúan los diagnósticos diferenciales clínicos e histológicos y su forma de presentación. Se destaca la importancia del diagnóstico precoz para evitar la ulceración y aparición de metástasis e incrementar la sobrevida de los pacientes (AU)

Angiosarcoma de cuero cabelludo: casos clínicos y revisión de la literatura / Angiosarcoma of the scalp: clinical cases and review of the literature

Se presentan dos casos de angiosarcoma de cuero cabelludo con dos variantes histológicas. El primer caso, un paciente de 58 años con una variedad epiteloide localizada en región temporal. El segundo caso una paciente de 80 años con una variedad predominantemente angiomatoide en la región parietal. Se evalúan los diagnósticos diferenciales clínicos e histológicos y su forma de presentación. Se destaca la importancia del diagnóstico precoz para evitar la ulceración y aparición de metástasis e incrementar la sobrevida de los pacientes