RESUMO
OBJECTIVE: To observe the effects of polydatin on dynamic changes of excitatory amino acids in cerebrospinal fluid and water content of brain tissue of cerebral hemorrhage rats. And to discuss the therapeutic action and mechanisms of polydatin on brain hemorrhagic injured rats. METHOD: A quantitative determination method of Asp and Glu was established by microdialysis-HPLC. The cerebral hemorrhage model in rats was induced by local injection of type VII collagenase. The dynamic changes of Asp and Glu in cerebrospinal fluid were observed on 0, 6, 12, 24, 36, 48, 60, 72, 84, 96, 108 h of cerebral hemorrhage rats, and then the water content of brain tissue was detected. RESULT: The content of Asp and Glu increased rapidly within 24 h after cerebral hemorrhage, and to the highest in 24 h, then decreased gradually. Compared with the cerebral hemorrhage model group, the content of Asp and Glu increased slowly in polydatin group, and there were significant differences in 12-72 h and 6-84 h (P < 0.01, P < 0.05), but there was no significant difference after 84 h and 96 h. Compared with sham group, water content of brain tissue significantly higher in model group, while significantly lower (P < 0.01) in polydatin group. CONCLUSION: Polydatin can inhibit increasing content of Asp and Glu in cerebrospinal fluid dynamics, and significantly inhibit cerebral edema of cerebral hemorrhage rats. It shows that the mechanisms of anti-cerebral hemorrhage injury of polydatin may be related to increasing of excitatory amino acids after cerebral hemorrhage.
Assuntos
Hemorragia Cerebral/tratamento farmacológico , Medicamentos de Ervas Chinesas/uso terapêutico , Aminoácidos Excitatórios/líquido cefalorraquidiano , Glucosídeos/uso terapêutico , Estilbenos/uso terapêutico , Animais , Ácido Aspártico/líquido cefalorraquidiano , Hemorragia Cerebral/líquido cefalorraquidiano , Modelos Animais de Doenças , Ácido Glutâmico/líquido cefalorraquidiano , Humanos , Masculino , Ratos , Ratos Sprague-DawleyAssuntos
Hemorragia Cerebral , Tálamo/irrigação sanguínea , Idoso , Afasia/etiologia , Hemorragia Cerebral/líquido cefalorraquidiano , Hemorragia Cerebral/complicações , Hemorragia Cerebral/diagnóstico , Hemorragia Cerebral/patologia , Eletrocardiografia , Eletroencefalografia , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Paralisia/etiologia , Sensação , Tálamo/patologiaRESUMO
Two cases of spontaneous intracerebral haemorrhage in adolescent girls suspected of having multiple sclerosis are reported. Surgical evacuation of haematomas in the left thalamus and left side of the pons, respectively, was performed with excellent recovery in both cases. Some clinical and pathological aspects of small arteriovenous malformations are discussed and the pertinent literature reviewed.