RESUMO
The article covers results of studies concerning time of fluorosis development in patients with signs of connective tissue dysplasia syndrome (CTDS). if compared with patients without CTDS, and of studies concerning hyperostosis coefficient in accordance with presence or absence of CTDS. Efficiency of physical therapy and balneotherapy for these patients are also reported by the authors.
Assuntos
Doenças do Tecido Conjuntivo , Fluoretos Tópicos/intoxicação , Hiperostose , Doenças Profissionais , Exposição Ocupacional/efeitos adversos , Adulto , Balneologia/métodos , Estudos de Coortes , Doenças do Tecido Conjuntivo/epidemiologia , Doenças do Tecido Conjuntivo/etiologia , Doenças do Tecido Conjuntivo/fisiopatologia , Doenças do Tecido Conjuntivo/terapia , Progressão da Doença , Terapia por Exercício/métodos , Humanos , Hiperostose/epidemiologia , Hiperostose/etiologia , Hiperostose/fisiopatologia , Hiperostose/terapia , Masculino , Metalurgia , Doenças Profissionais/epidemiologia , Doenças Profissionais/etiologia , Doenças Profissionais/terapia , Federação Russa/epidemiologia , Índice de Gravidade de Doença , Síndrome , Fatores de Tempo , Resultado do Tratamento , Recursos Humanos , Adulto JovemRESUMO
UNLABELLED: Vertebral hyperostosis typically predominates at the thoracic spine and causes only minor symptoms. Involvement of the cervical spine may cause dysphagia due to pressure on the esophagus. We report three cases of dysphagia revealing cervical hyperostosis. CASE REPORTS: The patients were 3 men aged 54-73 years. Dysphagia was moderate in 2 patients and severe in 1 patient who had lost 4 kg over 6 months. Stiffness of the neck with mild pain was present. One patient reported a neck injury in childhood and another had a brother and father with similar symptoms. Radiographs showed exuberant anterior cervical hyperostosis. Two patients also had hyperostotic changes at the thoracic spine and pelvis. The skin and neurological evaluation were normal. Findings were normal from standard blood tests (C-reactive protein, calcium, and vitamin D). Tests were negative for the HLA-B27 antigen in all 3 patients. Serum vitamin A levels were high, ranging from 894 to 1123 microg/L (normal, 489-720). None of the patients reported taking retinoids or having unusual eating habits. DISCUSSION: Dysphagia can result from anterior cervical hyperostosis. A role for hypervitaminosis A in the genesis of hyperostosis has long been suspected. In our patients, the absence of vitamin A supplementation suggests an abnormality in vitamin A metabolism.
Assuntos
Vértebras Cervicais , Transtornos de Deglutição/etiologia , Hiperostose/complicações , Hiperostose/etiologia , Hipervitaminose A/complicações , Idoso , Vértebras Cervicais/diagnóstico por imagem , Transtornos de Deglutição/sangue , Transtornos de Deglutição/fisiopatologia , Humanos , Hiperostose/fisiopatologia , Hipervitaminose A/diagnóstico , Hipervitaminose A/fisiopatologia , Masculino , Pessoa de Meia-Idade , Radiografia , Vitamina A/sangueRESUMO
A 5-year-old castrated male Shetland Sheepdog was examined because of progressive bilateral hind limb thickening. Cyanosis of the preputial mucous membranes was evident, whereas the oral mucous membranes had a normal color. A well-structured, palisade-like periosteal reaction with no underlying bone destruction was evident on radiographs of the hind limbs. The radiographic changes were consistent with hypertrophic osteopathy (HO). Severe right-sided cardiomegaly was seen on thoracic radiographs, and a diagnosis of patent ductus arteriosus with right-to-left shunting was made by means of echocardiography and contrast echoaortography. The cyanotic heart disease was believed to be the cause of the HO. Hypertrophic osteopathy has been associated with a number of diseases in animals and humans. In humans, congenital heart defects that cause cyanosis are among the most common causes of HO.