RESUMO
Examination of the patterns of free-radical processes (FRP) and changes of the early screening markers to predict the course of hemorrhagic stroke (HS) and applied pathophysiologically based therapy can be of great practical importance. This study aimed to determine early changes in the parameters of oxidative stress and routine biochemistry blood tests in patients with HS and to assess their relationship with clinical outcome. The effects of early applied cytoflavin were also investigated. The prospective study included 151 patients with HS. Forty-eight percent of patients in the standard conservative therapy were given cytoflavin antioxidant energy therapy from the first day of hospitalization. The neurological status, neuroimaging, biochemical blood tests and FRP were assessed on days 1, 5, 10, and 20 of hospitalization. In patients with HS, an imbalance of all stages of FRP was detected proportionately to the severity of HS. The malondialdehyde concentration above 5.3 µmol/L, the number of leukocytes above 15 800, glucose above 11.9 mmol/L, lactate dehydrogenase above 574 IU/L, and lactate above 2.5 mmol/L, detected on the first day, predetermined a high risk of death. Additional cytoflavin treatment allowed stabilizing the clinical laboratory picture of HS, improved the treatment results, and reduced hospital mortality rate.
Assuntos
Antioxidantes/administração & dosagem , Mononucleotídeo de Flavina/administração & dosagem , Acidente Vascular Cerebral Hemorrágico/mortalidade , Inosina Difosfato/administração & dosagem , Niacinamida/administração & dosagem , Succinatos/administração & dosagem , Idoso , Animais , Biomarcadores/sangue , Glicemia , Encéfalo/diagnóstico por imagem , Combinação de Medicamentos , Feminino , Acidente Vascular Cerebral Hemorrágico/sangue , Acidente Vascular Cerebral Hemorrágico/diagnóstico , Acidente Vascular Cerebral Hemorrágico/tratamento farmacológico , Mortalidade Hospitalar , Humanos , L-Lactato Desidrogenase/sangue , Ácido Láctico/sangue , Imageamento por Ressonância Magnética , Masculino , Malondialdeído/sangue , Pessoa de Meia-Idade , Estresse Oxidativo/efeitos dos fármacos , Prognóstico , Estudos Prospectivos , Medição de Risco/métodos , Índice de Gravidade de Doença , Resultado do TratamentoRESUMO
The aim of the study was to assess the impact of cytoflavin and bioflavin therapy on the dynamics of clinical and psychophysiological status of patients with Osteochondrosis. 150 patients with osteochondrosis of a backbone were investigated. The patients were divided into two groups using method of randomization: the main group - 75 patients - and control group -75 patients. All patients received a standard treatment (non-steroidal anti-inflammatory drugs, myorelaxants, chondroprotectors, as well as physiotherapy). The main group in addition to standard treatment received biofeedback therapy and cytoflavin. The results showed that cytoflavin and biofeedback therapy significantly enhanced the positive effect of standard treatment and significantly increased the quality of life of patients. It is recommended to treat elderly patients with neurological complications of spinal osteochondrosis with Cytoflavin in combination with biofeedback therapy Before prescribing biofeedback therapy and Cytoflavin it is necessary to take into account a number of positive and negative predictors of their effectiveness in reducing severity of pain syndrome.
Assuntos
Anti-Inflamatórios não Esteroides/uso terapêutico , Biorretroalimentação Psicológica , Mononucleotídeo de Flavina/uso terapêutico , Inosina Difosfato/uso terapêutico , Doenças do Sistema Nervoso/terapia , Niacinamida/uso terapêutico , Modalidades de Fisioterapia , Osteocondrose da Coluna Vertebral/terapia , Succinatos/uso terapêutico , Idoso , Anti-Inflamatórios não Esteroides/administração & dosagem , Terapia Combinada , Combinação de Medicamentos , Mononucleotídeo de Flavina/administração & dosagem , Humanos , Inosina Difosfato/administração & dosagem , Pessoa de Meia-Idade , Doenças do Sistema Nervoso/tratamento farmacológico , Doenças do Sistema Nervoso/psicologia , Niacinamida/administração & dosagem , Estudos Retrospectivos , Osteocondrose da Coluna Vertebral/tratamento farmacológico , Osteocondrose da Coluna Vertebral/psicologia , Succinatos/administração & dosagem , Inquéritos e Questionários , Resultado do TratamentoRESUMO
The aim of the study was to evaluate the impact of various variants of multimodal anesthesia on the cognitive functions of elderly patients after surgical interventions on pelvic organs, the development of preventive measures for POCD. MATERIAL AND METHODS: A study was conducted in 76 elderly patients aged 62 to 84 years with an increased risk of developing POCD. Of these, 46 women and 30 men. Patients were divided into two groups, depending on the type of anesthesia. The 1st group consisted of 37 patients who had low-flow anesthesia with sevoflurane combined with epidural analgesia. 2nd - 39 patients who had anticipated multimodal analgesia on the basis of systemic administration of lidocaine, sulphate magnesia, verapamil. In each group, patients are divided into subgroups - the main (O) and control (K). In the main subgroups anesthetics were supplemented with 20 ml. Cytoflavin, administered 20-25 minutes before the end of surgery and on the 1-3 days of the perioperative period. Cognitive functions were assessed by standardized scales: Mini Mental State Examination (MMSE), Montreal Cognitive Evaluation Scale (MoCA), Frontal Assessment Batteries (FAB). The level of anxiety and depression was determined by the hospital scale of anxiety and depression (HADS). RESULTS: At oncological patients of advanced age in 52.5% of cases there is a moderate degree of cognitive impairment. In the perioperative period, in the study groups, when using different variants of multimodal anesthesia, there is an equivalent transient decrease in cognitive functions by 12.5 and 12.8%. The use of cytoflavin can reduce the manifestation of POCD from 1-day perioperative period, improve the cognitive status of patients. CONCLUSION: In cancer patients of advanced age, cognitive impairment is observed, aggravated after surgical treatment, regardless of the variant of multimodal anesthesia. Protection by Cytoflavin allows to restore the cognitive functions of elderly cancer patients, reduce the manifestations of POCD.
Assuntos
Anestesia/efeitos adversos , Anestésicos/efeitos adversos , Disfunção Cognitiva/prevenção & controle , Mononucleotídeo de Flavina/administração & dosagem , Inosina Difosfato/administração & dosagem , Fármacos Neuroprotetores/administração & dosagem , Niacinamida/administração & dosagem , Neoplasias Pélvicas/cirurgia , Succinatos/administração & dosagem , Idoso , Idoso de 80 Anos ou mais , Anestesia/métodos , Anestesia Epidural/efeitos adversos , Anestesia Geral/efeitos adversos , Anestésicos/administração & dosagem , Cognição/efeitos dos fármacos , Disfunção Cognitiva/induzido quimicamente , Disfunção Cognitiva/diagnóstico , Disfunção Cognitiva/etiologia , Combinação de Medicamentos , Feminino , Mononucleotídeo de Flavina/farmacologia , Humanos , Inosina Difosfato/farmacologia , Masculino , Pessoa de Meia-Idade , Fármacos Neuroprotetores/farmacologia , Testes Neuropsicológicos , Niacinamida/farmacologia , Succinatos/farmacologia , Procedimentos Cirúrgicos Operatórios/efeitos adversosRESUMO
Sports nutrition for 35 athletes was supplemented by the metabolic preparation cytoflavin 1 month before a pre-competition training camp. Their physical status was estimated using a specialized Omega-C hardware-software complex. It was shown that cytoflavin promotes physical fitness of the athletes by improving energy supply, psychoemotional conditions, and competition form. It is recommended to use cytoflavin for the training of athletes in the pre-competition period.
Assuntos
Desempenho Atlético/fisiologia , Suplementos Nutricionais , Mononucleotídeo de Flavina/farmacologia , Inosina Difosfato/farmacologia , Niacinamida/farmacologia , Aptidão Física/fisiologia , Succinatos/farmacologia , Adulto , Combinação de Medicamentos , Mononucleotídeo de Flavina/administração & dosagem , Humanos , Inosina Difosfato/administração & dosagem , Niacinamida/administração & dosagem , Succinatos/administração & dosagemRESUMO
The functional activity of mitochondria of the muscular coat of small intestine (MCSI) has been studied in the normal state and under experimental widespread purulent peritonitis (WPP) conditions. The experiments have been carried out on a group of 55 male rabbits of chinchilla breed. It is established that, as a result of the WPP development, the functional activity of mitochondria in MCSI considerably decreases. The comparative analysis of the efficiency of metabolic drugs cytoflavin and neoton showed advantage of the citoflavin preparation, the administration of which allowed the indices of mitochondria in intact animals to be exceeded on the fifth day of postoperative period. The research results show expediency of a complex treatment of WPP using cytoflavin preparation for the normalization of biological oxidation processes and elimination of enteric insufficiency.
Assuntos
Mononucleotídeo de Flavina/uso terapêutico , Inosina Difosfato/uso terapêutico , Intestino Delgado/efeitos dos fármacos , Mitocôndrias/efeitos dos fármacos , Niacinamida/uso terapêutico , Fosforilação Oxidativa/efeitos dos fármacos , Peritonite/tratamento farmacológico , Fosfocreatina/uso terapêutico , Succinatos/uso terapêutico , Animais , Bacillus , Combinação de Medicamentos , Escherichia coli , Mononucleotídeo de Flavina/administração & dosagem , Injeções Intraperitoneais , Injeções Intravenosas , Inosina Difosfato/administração & dosagem , Intestino Delgado/metabolismo , Intestino Delgado/patologia , Masculino , Mitocôndrias/metabolismo , Músculo Liso/efeitos dos fármacos , Músculo Liso/metabolismo , Músculo Liso/patologia , Niacinamida/administração & dosagem , Peritonite/metabolismo , Peritonite/patologia , Fosfocreatina/administração & dosagem , Coelhos , Succinatos/administração & dosagem , SupuraçãoRESUMO
This article reports the results of applying basic pharmacotherapy (enalapril, cytoflavin) and its combination with physical factors (transcranial electrostimulation, combined application oftranscranial electrostimulation and low-frequency magnetic therapy) in the complex treatment of patients with stage I-II dyscirculatory encephalopathy. The study has demonstrated that the combined treatment with cytoflavin, enalapril, transcranial electrostimulation and low-frequency magnetic therapy produced the most pronounced therapeutic effect (82.5%), as confirmed by positive dynamics of clinical and functional parameters.
Assuntos
Circulação Cerebrovascular/fisiologia , Transtornos Cerebrovasculares/terapia , Terapia por Estimulação Elétrica/métodos , Estimulação Magnética Transcraniana/métodos , Adulto , Idoso , Anti-Hipertensivos/administração & dosagem , Anti-Hipertensivos/uso terapêutico , Transtornos Cerebrovasculares/diagnóstico , Transtornos Cerebrovasculares/tratamento farmacológico , Transtornos Cerebrovasculares/fisiopatologia , Terapia Combinada , Combinação de Medicamentos , Enalapril/administração & dosagem , Enalapril/uso terapêutico , Feminino , Mononucleotídeo de Flavina/administração & dosagem , Mononucleotídeo de Flavina/uso terapêutico , Humanos , Inosina Difosfato/administração & dosagem , Inosina Difosfato/uso terapêutico , Masculino , Pessoa de Meia-Idade , Fármacos Neuroprotetores/administração & dosagem , Fármacos Neuroprotetores/uso terapêutico , Niacinamida/administração & dosagem , Niacinamida/uso terapêutico , Índice de Gravidade de Doença , Succinatos/administração & dosagem , Succinatos/uso terapêutico , Resultado do TratamentoRESUMO
The problem of chronic prostatitis (CP) and erectile dysfunction (ED) involves not only their high prevalence, but also the insufficient effectiveness of their treatments. In this regard, there is need for administration the pathogenetic drugs with antihypoxic, antioxidant and neuroprotective effects and improving blood flow to the genitals. The study included 60 men with CP associated with ED, aged 22 to 60 years. Patients were randomized into 2 groups of 30 people. Patients of comparison group received baseline therapy (alpha1-adrenoblockers, non-specific anti-inflammatory drugs, digital prostate massage and vacuum phallostimulation). Antibiotics were applied on the basis of their potential effectiveness in chronic abacterial prostatitis. In addition to the above treatment, patients of main group received step-down therapy with cytoflavin (in infusion, then oral administration). Positive dynamics was noted in both groups of patients; however, according to the indicators of the severity of pain and dysuria, as well as quality of life, positive dynamics in the main group of patients was more significant. Similarly, the dynamics of objective criteria for inflammation in the prostate gland was more pronounced when using cytoflavin. After treatment, the rigid phase of erection during vacuum fallotest occurred within 2-3 min from the beginning of the procedure in 16 (53.3%) patients of main group and only in 9 (30%) patients of comparison group. During follow-up examination at 6 months after treatment, stable remission was found in 75% of patients of main group. Thus, the inclusion of cytoflavin in the scheme of complex treatment of patients with abacterial CP associated with ED is pathogenetically justified, makes it more efficient and provides good DFS.
Assuntos
Disfunção Erétil/terapia , Mononucleotídeo de Flavina/administração & dosagem , Inosina Difosfato/administração & dosagem , Niacinamida/administração & dosagem , Prostatite/terapia , Succinatos/administração & dosagem , Antagonistas de Receptores Adrenérgicos alfa 1/administração & dosagem , Adulto , Anti-Inflamatórios/administração & dosagem , Doença Crônica , Combinação de Medicamentos , Disfunção Erétil/complicações , Disfunção Erétil/fisiopatologia , Humanos , Masculino , Pessoa de Meia-Idade , Modalidades de Fisioterapia , Prostatite/complicações , Prostatite/fisiopatologiaRESUMO
Experiment carried out on laboratory animals (rats) were aimed at comparative evaluation of the effect of several neuroprotective drugs under the conditions of model brain ischemia-reperfusion. The experimental methods included staining of brain tissue sections by hematoxiline-eosine, Nissl staining, and expression of NOS1, NOS3, TRAIL by imunnohistological means. The intensity of damage in various parts of brain and the nature of apoptosis without neuroprotection and with popular neuroprotectors (cytoflavin, actovegin, mexidol) and a test drug at the stage ofpreclinical trial (AKF-90-7) were evaluated. Characteristic cytotoxic (coagulative pycnomorphic and colliquative necrosis of neurons) and vascular (hemostasia, erythropedesis) changes were revealed. The neuroprotective effectof drugs decreases in the following order: AKF-90-7 > cytoflavin > actovegin > mexidol.
Assuntos
Encéfalo/efeitos dos fármacos , Glicina/análogos & derivados , Hemostasia/efeitos dos fármacos , Neurônios/efeitos dos fármacos , Fármacos Neuroprotetores/uso terapêutico , Picolinas/uso terapêutico , Traumatismo por Reperfusão/tratamento farmacológico , Animais , Encéfalo/metabolismo , Encéfalo/patologia , Combinação de Medicamentos , Avaliação Pré-Clínica de Medicamentos , Amarelo de Eosina-(YS)/análise , Mononucleotídeo de Flavina/administração & dosagem , Mononucleotídeo de Flavina/uso terapêutico , Glicina/administração & dosagem , Glicina/uso terapêutico , Hematoxilina/análise , Heme/administração & dosagem , Heme/análogos & derivados , Heme/uso terapêutico , Imuno-Histoquímica , Inosina Difosfato/administração & dosagem , Inosina Difosfato/uso terapêutico , Masculino , Necrose/prevenção & controle , Neurônios/metabolismo , Neurônios/patologia , Fármacos Neuroprotetores/administração & dosagem , Niacinamida/administração & dosagem , Niacinamida/uso terapêutico , Óxido Nítrico Sintase Tipo I/análise , Óxido Nítrico Sintase Tipo I/biossíntese , Óxido Nítrico Sintase Tipo III/análise , Óxido Nítrico Sintase Tipo III/biossíntese , Picolinas/administração & dosagem , Ratos , Ratos Endogâmicos , Traumatismo por Reperfusão/sangue , Succinatos/administração & dosagem , Succinatos/uso terapêutico , Ligante Indutor de Apoptose Relacionado a TNF/análise , Ligante Indutor de Apoptose Relacionado a TNF/biossínteseRESUMO
The stroma of red blood cells in rats injected with riboxin after extracorporal treatment with essentiale acquired immunomodulant properties, with a significant increase in Mg2+ -ATPase activity. Light erythrocytes producing immunosuppressing action appeared in the blood of animals poisoned with phenylhydrazine or sodium nitrite. Introduction of hemotropic poisons reduced the activity of Mg2+ -ATPase in the stroma. Riboxin injections in poisoned animals, followed by essentiale treatment of the stroma induced immunostimulating properties and normalized Mg2+ -ATPase activity of erythrocyte membranes.