RESUMO
Morphea, dermatomyositis (DM), and discoid lupus erythematosus (DLE) are autoimmune collagen vascular diseases that can present at any age. In all three of these diseases, the tenants of diagnosis and treatment are largely the same in both children and adults, with a few notable differences. Children with morphea are more likely to present with the linear subtype and have a higher incidence of extracutaneous manifestations. Children often need early aggressive systemic treatment to try to prevent long-term sequelae of morphea. In DM, adult disease has a clear association with malignancy that is not seen in children. Adults have a higher rate of pulmonary involvement and increased mortality, whereas calcinosis is more common in juvenile DM. DLE in adults is generally considered to have a low rate of progression from discoid lesions alone to systemic lupus erythematosus (SLE). DLE is less common in children, but several studies have suggested a higher rate of progression from DLE to SLE in children compared with adults.
Assuntos
Anti-Inflamatórios/uso terapêutico , Dermatomiosite/diagnóstico , Imunossupressores/administração & dosagem , Lúpus Eritematoso Discoide/diagnóstico , Esclerodermia Localizada/diagnóstico , Esclerodermia Localizada/terapia , Administração Cutânea , Administração Oral , Adolescente , Adulto , Fatores Etários , Criança , Pré-Escolar , Dermatomiosite/tratamento farmacológico , Humanos , Lactente , Recém-Nascido , Lúpus Eritematoso Discoide/tratamento farmacológico , Terapia PUVA , PrognósticoRESUMO
From a clinician's point of view, diseases of the immune system are broadly grouped into the following categories: I. Immunodeficiency disorders II.Autoimmune diseases III. Hypersensitivity reactions (AU)
Assuntos
Humanos , Estomatite Aftosa/etiologia , Estomatite Aftosa/diagnóstico , Síndrome de Behçet/diagnóstico , Lúpus Eritematoso Sistêmico/complicações , Lúpus Eritematoso Sistêmico/diagnóstico , Lúpus Eritematoso Discoide/diagnóstico , Lúpus Eritematoso Discoide/etiologia , Líquen Plano Bucal/diagnóstico , Líquen Plano Bucal/tratamento farmacológico , Síndrome de Sjogren/diagnóstico , Epidermólise Bolhosa/diagnóstico , Dermatite Herpetiforme , Eritema Multiforme/diagnóstico , Eritema Multiforme/tratamento farmacológicoRESUMO
Osteopoikilosis is an uncommon, benign sclerosing bone dysplasia characterised by typical roentgenographic findings and usually seen in patients with dermatological problems. We report a case of osteopoikilosis and discoid lupus erythematosus presenting with skin and mucosal involvement, an association that has never previously been reported. We also discuss the differential diagnosis and the clinical pathologies accompanying osteopoikilosis in the literature.