RESUMO
BACKGROUND: Skin rejuvenation can be achieved with minimally invasive treatments using energy-based devices that feature reduced side effects and downtime. Post-treatment care is key to minimize any potential side effects and skin reactions such as erythema, dryness, or dyschromia. OBJECTIVE: The objective of this study was to evaluate the efficacy and patient satisfaction of a novel carboxytherapy gel mask compared with petroleum-based lanolin-containing ointment to accelerate wound healing facial post-nanofractional radiofrequency treatment. METHODS AND MATERIALS: Ten subjects were enrolled in this pilot, prospective, randomized, single-blind study and randomized into two arms. One arm received one nanofractional radiofrequency treatment with ointment right after and four consecutive days of ointment applications twice a day, while the second arm followed this regimen with a carboxytherapy gel mask application right after and four consecutive days after treatment. Investigator, safety, and patient assessments were conducted at 24 hours and one-week post treatment. Safety was monitored throughout. The primary endpoint was defined as the degree of investigator global assessment (IGA) in photodamage, pigmentation, and wrinkles using standardized photographs. Secondary endpoints included investigator-rated degree of erythema, edema, crusting, exudation, percentage healing, improvement of skin quality, and patient satisfaction. RESULTS: Nine patients completed the study. There was improvement of one degree in IGA for photodamage, pigmentation and wrinkles in all patients using the carboxytherapy gel mask at the one-week follow up. Blinded investigator ratings showed significant improvement of dryness, erythema, edema, crusting, and percentage healing at the 24-hour follow up, with all patients remaining the same a week post treatment. All patients in the carboxytherapy group were satisfied with the treatment and had no adverse effects. Three patients in the petroleum-based lanolin-containing group experienced mild edema and acne breakout that resolved two weeks after treatment. CONCLUSION: Carboxytherapy delivered via a gel mask after skin rejuvenation procedures is a safe and effective strategy to improve clinical outcomes and reduce post-treatment side effects. J Drugs Dermatol. 20(4):461-465. doi:10.36849/JDD.5856.
Assuntos
Dióxido de Carbono/administração & dosagem , Técnicas Cosméticas/efeitos adversos , Eritema/tratamento farmacológico , Terapia por Radiofrequência/efeitos adversos , Rejuvenescimento , Administração Cutânea , Adulto , Eritema/diagnóstico , Eritema/etiologia , Face , Feminino , Géis , Humanos , Lanolina/administração & dosagem , Pessoa de Meia-Idade , Pomadas/administração & dosagem , Pomadas/química , Satisfação do Paciente , Petróleo , Fotografação , Projetos Piloto , Estudos Prospectivos , Hipofracionamento da Dose de Radiação , Terapia por Radiofrequência/métodos , Índice de Gravidade de Doença , Método Simples-Cego , Pele/diagnóstico por imagem , Pele/efeitos dos fármacos , Pele/efeitos da radiação , Envelhecimento da Pele/efeitos da radiação , Resultado do TratamentoAssuntos
Dermatite Atópica/tratamento farmacológico , Emolientes/administração & dosagem , Vitamina A/administração & dosagem , Vitamina D/administração & dosagem , Óleo de Fígado de Bacalhau/administração & dosagem , Óleo de Fígado de Bacalhau/efeitos adversos , Emolientes/efeitos adversos , Humanos , Lanolina/administração & dosagem , Lanolina/efeitos adversos , Pomadas , Parabenos/administração & dosagem , Parabenos/efeitos adversos , Vitamina A/efeitos adversos , Vitamina D/efeitos adversosAssuntos
Doenças do Prematuro/enfermagem , Unidades de Terapia Intensiva Neonatal , Higiene da Pele/enfermagem , Dermatopatias/enfermagem , Combinação de Medicamentos , Toxidermias/diagnóstico , Toxidermias/enfermagem , Feminino , Seguimentos , Idade Gestacional , Humanos , Recém-Nascido , Lanolina/administração & dosagem , Lanolina/efeitos adversos , Masculino , Pomadas , Azeite de Oliva , Ácido Pantotênico/administração & dosagem , Ácido Pantotênico/efeitos adversos , Ácido Pantotênico/análogos & derivados , Óleos de Plantas/administração & dosagem , Óleos de Plantas/efeitos adversos , Dermatopatias/congênitoRESUMO
To date, appropriate skin therapy for premature infants has not been clearly defined. Emollient creams are often used without solid evidence for a benefit to the neonate. The aim of the current study was to investigate the cutaneous effects of two different topical ointment therapies. Between October 2004 and November 2006 we prospectively enrolled 173 infants between 25 and 36 weeks of gestation admitted to a neonatal intensive care unit. Infants were randomly assigned to daily topical treatment with water-in-oil emollient cream (Bepanthen), olive oil cream (70% lanolin, 30% olive oil), or to a control group. Each neonate was continuously treated for a maximum of 4 weeks. Skin condition (skin score reflecting degree of dermatitis) in these groups was compared at weeks 1, 2, 3, and 4. Neonates treated with olive oil cream showed statistically less dermatitis than did neonates treated with emollient cream, and both had a better outcome than those in the control group (p < 0.001 in weeks 2-4). Treatment effects persisted throughout the study period and applied to infants of all gestational ages. This study demonstrates that topical skin therapy lowers the risk of dermatitis. Olive oil cream was superior to water-in-oil emollient cream.
Assuntos
Emolientes/administração & dosagem , Lanolina/administração & dosagem , Óleos de Plantas/administração & dosagem , Pele/efeitos dos fármacos , Administração Cutânea , Dermatite/tratamento farmacológico , Dermatite/etiologia , Idade Gestacional , Humanos , Recém-Nascido , Doenças do Prematuro/tratamento farmacológico , Azeite de Oliva , Síndrome do Desconforto Respiratório do Recém-Nascido/complicações , Perda Insensível de Água/efeitos dos fármacosRESUMO
OBJECTIVES: To determine whether the application of a eutectic mixture of anesthetic cream (EMLA cream) can decrease the pain of lidocaine injection during vasectomy. METHODS: A double-blind, prospective study was performed in which each patient acted as his own control. One hour before a double-incision vasectomy, EMLA cream was applied to one side of the scrotum and a white lanolin hand cream to the other side. A double-incision vasectomy was performed, and each patient was asked to rate the pain associated with each side of the procedure. RESULTS: Eighty-nine patients agreed to the study; 61 patients thought the EMLA cream decreased the pain of the vasectomy, 16 preferred the lanolin hand cream, and 3 said there was no difference. These results were significant at the 0.0001 level using the Student t test. CONCLUSIONS: EMLA cream significantly decreases the pain associated with lidocaine injections given as local anesthesia for vasectomy.
Assuntos
Anestésicos Locais/administração & dosagem , Lidocaína/administração & dosagem , Dor/prevenção & controle , Prilocaína/administração & dosagem , Vasectomia/métodos , Anestesia Local/métodos , Método Duplo-Cego , Humanos , Injeções/efeitos adversos , Lanolina/administração & dosagem , Lanolina/uso terapêutico , Combinação Lidocaína e Prilocaína , Masculino , Pomadas , Medição da Dor , Estudos Prospectivos , Escroto/efeitos dos fármacos , Vasectomia/efeitos adversosRESUMO
Nickel contact sensitivity was successfully induced in guinea pigs using an open epicutaneous application method. Immediately after pretreatment with 1% aqueous sodium lauryl sulfate, upper back skin was treated daily for 4 weeks with 0.3%-3% nickel sulfate in either a 1% lanolin cream (Vaseline, pH 5 SAD crème) or hydroxypropyl cellulose. Weekly intradermal injections with aluminium potassium sulfate were used as adjuvant. The animals were challenged twice with a one week interval, with nickel sulfate 2% in water and 1% in petrolatum, respectively. The response rates in the test groups treated with nickel sulfate 1% or 3% in the lanolin cream or 1% in hydroxypropyl cellulose were significantly different from the response rate in the control group. Considering both readings at both challenges, the frequency of sensitization was 57-93% (8 of 14 to 13 of 14 animals) in the group treated with 1% in the lanolin cream, 60-100% (9/15 to 15/15 animals) in the group treated with 3% in the lanolin cream, and 67-75% (8/12 to 9/12 animals) in the group treated with 1% in hydroxypropyl cellulose. Rechallenge of initially sensitized animals 10 weeks later confirmed that a lasting contact allergy had been obtained.
Assuntos
Dermatite de Contato/etiologia , Irritantes/administração & dosagem , Níquel/administração & dosagem , Animais , Celulose/administração & dosagem , Celulose/análogos & derivados , Feminino , Cobaias , Lanolina/administração & dosagem , Veículos FarmacêuticosRESUMO
This study was designed to investigate the effects of a new product of counterirritant, Eucalyptamint, on the cutaneous circulation and on skin and muscle temperatures. Ten normal subjects (six males and four females, with an average age of 34 +/- 6 yr) were involved in this study. Eucalyptamint was applied to the anterior forearm skin of one side, and placebo was applied to the contralateral forearm. The subjective feelings, cutaneous blood flow, and skin temperature were measured before and periodically (5-min intervals) after the application of the compound. Muscle temperature was measured before and 30 min after the application of the Eucalyptamint. There was no significant effect on the subjective sensation. However, there were statistically significant (P less than 0.05) increases in cutaneous blood flow (up to 4 times base-line) and skin temperatures (up to 0.8 degrees C higher than base-line) after the application of Eucalyptamint with the effects lasting up to 45 min after the application. The muscle temperature was also increased (0.4 degrees C) significantly (P less than 0.05) 30 min after application of the Eucalyptamint. There were no significant changes in the placebo application. The results of this study suggested that the new product of counterirritant, Eucalyptamint, produced significant physiologic responses that may be beneficial for pain relief and/or useful to athletes as a passive form of warm-up.