Assessing the health risks of heavy metals and seasonal minerals fluctuations in Camellia sinensis cultivars during their growth seasons.

The risk assessment of heavy metals in tea is extremely imperative for the health of tea consumers. However, the effects of varietal variations and seasonal fluctuations on heavy metals and minerals in tea plants remain unclear. Inductively coupled plasma optical emission spectrometry (ICP-OES) was used to evaluate the contents of aluminum (Al), manganese (Mn), magnesium (Mg), boron (B), calcium (Ca), copper (Cu), cobalt (Co), iron (Fe), sodium (Na), zinc (Zn), arsenic (As), cadmium (Cd), chromium (Cr), nickel (Ni), and antimony (Sb) in the two categories of young leaves (YL) and mature leaves (ML) of tea (Camellia sinensis) cultivars throughout the growing seasons. The results showed significant variations in the contents of the investigated nutrients both among the different cultivars and growing seasons as well. Furthermore, the average concentrations of Al, Mn, Mg, B, Ca, Cu, Co, Fe, Na, Zn, As, Cd, Cr, Ni, and Sb in YL ranged, from 671.58-2209.12, 1260.58-1902.21, 2290.56-2995.36, 91.18-164.68, 821.95-5708.20, 2.55-3.80, 3.96-25.22, 37.95-202.84, 81.79-205.05, 27.10-69.67, 0.028-0.053, 0.065-0.127, 2.40-3.73, 10.57-12.64, 0.11-0.14 mg kg-1, respectively. In ML, the concentrations were 2626.41-7834.60, 3980.82-6473.64, 3335.38-4537.48, 327.33-501.70, 9619.89-13153.68, 4.23-8.18, 17.23-34.20, 329.39-567.19, 145.36-248.69, 40.50-81.42, 0.089-0.169, 0.23-0.27, 5.24-7.89, 18.51-23.97, 0.15-0.19 mg kg-1, respectively. The contents of all analyzed nutrients were found to be higher in ML than in YL. Target hazard quotients (THQ) of As, Cd, Cr, Ni, and Sb, as well as the hazard index (HI), were all less than one, suggesting no risk to human health via tea consumption. This research might provide the groundwork for essential minerals recommendations, as well as a better understanding and management of heavy metal risks in tea.

Evaluation of urinary trace element levels in patients with opioid use disorder undergoing methadone treatment in western Iran.

The monitoring of essential and toxic elements in patients with Opioid Use Disorder (OUD) undergoing methadone treatment (MT) is important, and there is limited previous research on the urinary levels of these elements in MT patients. Therefore, the present study aimed to analyze certain elements in the context of methadone treatment compared to a healthy group. In this study, patients with opioid use disorder undergoing MT (n = 67) were compared with a healthy group of companions (n = 62) in terms of urinary concentrations of some essential elements (selenium (Se), zinc (Zn), copper (Cu), iron (Fe), manganese (Mn), calcium (Ca)) and toxic elements (lead (Pb), cadmium (Cd), arsenic (As), and chromium (Cr)). Urine samples were prepared using the acid digestion method with a mixture of nitric acid and perchloric acid and assessed using the ICP-MS method. Our results showed that the two groups had no significant differences in terms of gender, education level, occupation, and smoking status. Urinary concentrations of Se, Cu, and Fe levels were significantly lower in the MT group compared to the healthy subjects. However, the concentrations of Pb, Cd, As, Mn, Cr, and Ca in the MT group were higher than in the healthy group (p < 0.05). No significant difference was established between the levels of Zn in the two groups (p = 0.232). The results of regression analysis revealed that the differences between the concentration levels of all metals (except Zn) between two groups were still remained significant after adjusting for all variables (p < 0.05). The data obtained in the current study showed lower urinary concentrations of some essential elements and higher levels of some toxic elements in the MT group compared to the healthy subjects. These findings should be incorporated into harm-reduction interventions.

Pollution indices of selected metals in tea (Camellia sinensis L.) growing soils of the Upper Assam region divulge a non-trifling menace of National Highway.

The study investigated the influence of a National Highway (NH) traversing tea estates (TEs) on heavy metal (HM) contamination in the top soils of Upper Assam, India. The dispersion and accumulation of six HMs, viz. cadmium (Cd), copper (Cu), iron (Fe), manganese (Mn), nickel (Ni), and zinc (Zn), within tea-growing soils were assessed using diverse indices: contamination factor (CF), degree of contamination (DC), enrichment factor (EF), geo-accumulation index (Igeo), modified degree of contamination (MDC), Nemerow pollution index (PINemerow), pollution load index (PLI), potential ecological risk factor (Eri), and potential ecological risk index (RI). The order of HM prevalence was Fe > Mn > Zn > Ni > Cu > Cd. Elevated Cd levels near the NH prompted immediate attention, while Cd and Zn showed moderate pollution in CF, EF, and RI. The remaining metals posed minimal individual risk (Eri< 40), resulting in an overall contamination range of "nil to shallow," signifying slight contamination from the studied metals. From MDC values for investigated metals, it was found to be "zero to very low degree of contamination" at all locations except the vicinity of NH. Soil pollution, as determined by PLI, indicated unpolluted soils in both districts, yet PINemerow values indicated slight pollution. The statistical analysis revealed that there is a significant decrease in most of the indices of HM as the distance from NH increases. The application of multivariate statistical techniques namely Principal Component Analysis and Cluster Analysis showed the presence of three distinct homogenous groups of distances based on different indices. This investigation underscores NH-associated anthropogenic effects on TE soil quality due to HM deposition, warranting proactive mitigation measures.

The combined effects of lanthanum-modified bentonite and Vallisneria spiralis on phosphorus, dissolved organic matter, and heavy metal(loid)s.

The use of lanthanum-modified bentonite (LMB) combined with Vallisneria spiralis (V∙s) (LMB + V∙s) is a common method for controlling internal phosphorus (P) release from sediments. However, the behaviors of iron (Fe) and manganese (Mn) under LMB + V∙s treatments, as well as the associated coupling effect on P, dissolved organic matter (DOM), and heavy metal(loid)s (HMs), require further investigations. Therefore, we used in this study a microelectrode system and high-resolution dialysis technology (HR-Peeper) to study the combined effects of LMB and V∙s on P, DOM, and HMs through a 66-day incubation experiment. The LMB + V∙s treatment increased the sediment DO concentration, promoting in-situ formations of Fe (III)/Mn (IV) oxyhydroxides, which, in turn, adsorbed P, soluble tungsten (W), DOM, and HMs. The increase in the concentrations of HCl-P, amorphous and poorly crystalline (oxyhydr) oxides-bound W, and oxidizable HMs forms demonstrated the capacity of the LMB + V∙s treatment to transform mobile P, W, and other HMs forms into more stable forms. The significant positive correlations between SRP, soluble W, UV254, and soluble Fe (II)/Mn, and the increased concentrations of the oxidizable HMs forms suggested the crucial role of the Fe/Mn redox in controlling the release of SRP, DOM, and HMs from sediments. The LMB + V∙s treatment resulted in SRP, W, and DOM removal rates of 74.49, 78.58, and 54.78 %, which were higher than those observed in the control group (without LMB and V∙s applications). On the other hand, the single and combined uses of LMB and V·s influenced the relative abundances of the sediment microbial communities without exhibiting effects on microbial diversity. This study demonstrated the key role of combined LMB and V∙s applications in controlling the release of P, W, DOM, and HMs in eutrophic lakes.

Probabilistic risk assessment for determining nonessential metals in commercial infant formula products in Taiwan.

During the early months of life, infant formula plays a crucial role as a primary source of both food and essential nutrients for infants, serving as a replacement for or supplement to breast milk. However, nonessential metals in infant formulas are a concern because infants are highly vulnerable to chemical exposure. The aim of this study was to investigate infant exposure to nonessential metals in infant formula products in Taiwan and assess the associated health risks. In this study, concentrations of arsenic (As), barium (Ba), cadmium (Cd), manganese (Mn), lead (Pb), and vanadium (V) in 45 formula products for 0-1-year-old infants were determined by inductively coupled plasma mass spectrometry. The mean As, Ba, Cd, Mn, Pb, and V concentrations were 6.42, 280, 3.72, 1425, 20.4, and 21.9 µg/kg, respectively. According to our probabilistic simulation of the estimated daily intake of metals, the proportion of hazard quotients exceeding one was 7.69% for As and 3.29% for Mn, and that of hazard index (HI) values exceeding 1 was >17% for metals. Arsenic had the largest HI contribution (46.9%), followed by Mn (22.3%) and Pb (12.7%). The nonessential metals content in infant formula raises potential noncarcinogenic health concerns for infants in Taiwan. Therefore, regulations for nonessential metals must be imposed on related food products in Taiwan, with a particular focus on As and Mn.

Exploring the association between two groups of metals with potentially opposing renal effects and renal function in middle-aged and older adults: Evidence from an explainable machine learning method.

BACKGROUND: Machine learning models have promising applications in capturing the complex relationship between mixtures of exposures and outcomes. OBJECTIVE: Our study aimed at introducing an explainable machine learning (EML) model to assess the association between metal mixtures with potentially opposing renal effects and renal function in middle-aged and older adults. METHODS: This study extracted data from two cycle years of the National Health and Nutrition Examination Survey (NHANES). Participants aged 45 years or older with complete data on six metals (lead, cadmium, manganese, mercury, and selenium) and related covariates were enrolled. The EML model was developed by the optimized machine learning model together with Shapley Additive exPlanations (SHAP) to assess the chronic kidney disease (CKD) risk with metal mixtures. The results from EML were further compared in detail with multiple logistic regression (MLR) and Bayesian kernel machine regression (BKMR). RESULTS: After adjusting for included covariates, MLR pointed out the lead and arsenic were generally positively associated with CKD, but manganese had a negative association. In the BKMR analysis, each metal was found to have a non-linear association with the risk of CKD, and interactions can exist between metals, especially for arsenic and lead. The EML ranked the feature importance: lead, manganese, arsenic and selenium were close behind in importance after gender, age or BMI for participants with CKD. Strong interactions between mercury and lead, manganese and cadmium and arsenic and manganese were identified by partial dependence plot (PDP) of SHAP and bivariate exposure-response effect plots of BKMR. The EML model determined the "trigger point" at which the risk of CKD abruptly changed. CONCLUSION: Co-exposure to metals with different nephrotoxicity could have different joint association with renal function, and EML can be a powerful method for studying complex exposure mixtures.

Magnesium and manganese induced changes on chemical, nutritional, antioxidant and antimicrobial properties of the pansy and Viola edible flowers.

Pansy and viola edible flowers were grown hydroponically with different levels of Mg and Mn. The nutritional composition was determined using standard methods. Free sugars, fatty acids, organic acids, tocopherols, and phenolic compounds were analyzed using various HPLC and GC devises. The extract's antimicrobial, antioxidant, cytotoxicity, and anti-inflammatory activity were assessed. The results indicated that Mg enrichment negatively affected plant growth and mineral accumulation but improved photosynthetic performance. The edible flowers contained significant amounts of protein, low levels of fat, and varying sugar contents, such as glucose and fructose. Various fatty acids and phenolic compounds were identified, with different concentrations depending on the treatment. The flowers exhibited antioxidant potential, antimicrobial activity, cytotoxic effects, and anti-inflammatory properties. The correlations between the investigated parameters not only expand knowledge on Mg and Mn interaction but also catalyze significant advancements in sustainable agriculture and food health, fostering a healthier and more conscious future.

Factors controlling accumulation and bioavailability of selenium in paddy soils: A case study in Luxi County, China.

Selenium (Se) accumulation in rice (Oryza sativa L.) has become a major global concern. Se offers multiple health benefits in humans; however, its inadequate or excessive intake can be harmful. Therefore, determining the factors driving Se abundance and bioavailability in paddy soils is essential to ensure the safety of human Se intake. This study investigated the accumulation, bioavailability, and distribution of Se in 820 paddy soil and rice grain samples from Luxi County, China to assess how soil properties (soil organic matter [SOM], cation exchange capacity [CEC], and pH), geographical factors (parent materials, elevation, and mean annual precipitation [MAP] and temperature [MAT]), and essential micronutrients (copper [Cu], zinc [Zn], and manganese [Mn]) govern Se accumulation and bioavailability in paddy soils. Results showed that the average soil Se content was 0.36 mg kg-1, which was higher than that in China (0.29 mg kg-1). Alternatively, the average rice grain Se content was 0.032 mg kg-1, which was lower than the minimum allowable content in Se-rich rice grains (0.04 mg kg-1). Five studied parent materials all had a significant effect on soil Se content but had little effect on Se bioavailability (p < 0.05). CEC, elevation, and SOM, as well as the soil contents of Cu, Zn, and Mn were positively correlated with soil Se content, but pH, MAP, and MAT were negatively correlated. Correspondingly, Se bioavailability was negatively correlated with SOM and soil Zn content, but positively correlated with MAP and grain contents of Cu, Zn, and Mn. Furthermore, partial least squares path analysis revealed the interactive impacts of the influencing factors on Se accumulation and bioavailability in soils. On this basis, prediction models were established to predict Se accumulation and bioavailability in paddy soils, thereby providing theoretical support for developing efficient control measures to meet Se challenges in agriculture.

Influence on the release of arsenic and tungsten from sediment, and effect on other heavy metals and microorganisms by ceria nanoparticle capping.

In this study, ceria nanoparticle (CNP) was used as a capping agent to investigate the efficiency and mechanism of simultaneously controlling the release of sediment internal Arsenic (As) and tungsten (W). The results of incubation experiment demonstrated that CNP capping reduced soluble As and W by 81.80% and 97.97% in overlying water, respectively; soluble As and W by 65.64% and 60.13% in pore water, respectively; and labile As and W in sediment by 45.20% and 53.20%, respectively. The main mechanism of CNP controlling sediment internal As and W was through adsorption via ligand exchange and inner-sphere complexation, as determined through adsorption experiments, XPS and FIRT spectra analysis. Besides, CNP also acted as an oxidant, facilitating the oxidation of AsⅢ to AsV and thereby enhancing the adsorption of soluble As. Additionally, sediment As and W fractions experiments demonstrated that the immobilization of As and W with CNP treatment via transforming mobile to stable fractions was another mechanism inhibiting sediment As and W release. The obtained significant positive correlation between soluble As/W and Fe/Mn, labile As/W and Fe/Mn indicated that iron (Fe) and manganese (Mn) oxidation, influenced by CNP, serve as additional mechanisms. Moreover, Fe redox plays a crucial role in controlling internal As and W, while Mn redox plays a more significant role in controlling As compared to W. Meanwhile, CNP capping effectively prevented the release of As and W by reducing the activity of microorganisms that degrade Fe-bound As and W and reduced the release risk of V, Cr, Co, Ni, and Zn from sediments. Overall, this study proved that CNP was a suitable capping agent for simultaneously controlling the release of As and W from sediment.

Novel surface-treatment for bottom ash from municipal solid waste incineration to reduce the heavy metals leachability for a sustainable environment.

Unconventional treatments can provide a modification to convert ash waste into valuable materials that can be used in various applications. This study focuses on bottom ash (BA) collected from a local incineration plant and characterizes its chemical composition before and after pretreatment by coating with polymers. The toxicity-characteristic leaching procedure (TCLP) was used to identify selected heavy metal leaching after treatment with vinyl-terminated polydimethylsiloxane (PDMS) of different molecular weights. BA coatings were incorporated in two ratios, 0.5% and 1%, by milling to avoid heavy metal leaching. The results showed that all the coating batches had reduced concentrations of copper (Cu), manganese (Mn), and zinc (Zn), whereas the concentrations of chromium (Cr) and cadmium (Cd) showed higher amounts of BAV34 (0.5%) and BAV25 (1%). The treated BA with GP demonstrated percentages of reduction of 70%, 65%, 80%, 75%, 90%, and 80% for Cu, Mn, Ni, Zn, Pb, and Cd, respectively. The milling procedure reduced the particle size of the coated ash. Hydrophobicity was observed in all coating batches compared to untreated BA. The thermogravimetric analysis (TGA) results showed variations between BA and treated BA, which confirmed that PDMS caused surface modification. These features have potential significance for extending the use of coated ash as a sustainable material for construction applications.

Study on the removal of iron (II) and manganese (II) in acidic mine drainage by red mud: Performance and mechanism.

Red mud is an environmental burden during the alumina production process. To mitigate the hazards associated with red mud storage, this study investigated the utilization of alkaline red mud as a treatment agent for acidic mine drainage (AMD) with high concentrations of Fe(II) and Mn(II). This study explored the influence of reaction times, addition amounts of red mud, and pH values on the removal efficiency of Fe (II) and Mn(II) from high-concentration AMD. Various parameters such as suspended solids levels, effluent pH, and zeta potentials were measured to meet discharge standards. The adsorption mechanism of red mud was examined using SEM, XRD, EDX, XPS, and 3D-EEM analysis. Optimal conditions were determined as a reaction time of 2 h, pH value of 5.01 and the addition of 100 g/L red mud, achieving effective removal of Fe(II) (reduced from 1000 to 0.224 mg/L) and Mn (II) (reduced from 20 to 1.03 mg/L). The treated AMD meets discharge standards with reduced suspended matter content of 37.4 mg/L. These findings provided valuable insights for the utilization of red mud waste in engineering applications.

Maternal hair segments reveal metal(loid) levels over the course of pregnancy: a preliminary study in Southern China.

Characterization of metal(loid) variation during pregnancy and identification of the affecting factors are important for assessing pregnancy exposures in epidemiological studies. In this study, maternal hair was collected in three segments (each 3 cm) from pregnant women in Guangzhou, China. Ten metal(loid)s, including six essential trace metal(loid)s and four toxic trace metal(loid)s, were analyzed to investigate the levels of various metal(loid)s during pregnancy and the factors that influence them. Strong pairwise correlations were observed between manganese (Mn), cobalt (Co), and vanadium (V), between selenium (Se), arsenic (As), and antimony (Sb), and between cadmium (Cd) and lead (Pb). All metal(loid)s except for Se, Mn, and Co showed strong correlations among the three hair segments, and most of the metal(loid)s had good reproducibility, with intraclass correlation coefficients (ICCs) ranging from 0.510 to 0.931, except for As (ICC = 0.334), Mn (ICC = 0.231), and Co (ICC = 0.235). Zn levels decreased, while Sb increased, in maternal hair during pregnancy. Maternal sociodemographic characteristics and dietary intake affected metal(loid) levels in maternal hair. These results provide foundational data for using maternal hair segmental analysis to evaluate exposure variation to metal(loid)s during pregnancy and the potential factors associated with them.

Effects of Diabetes on Elemental Levels and Nanostructure of Root Canal Dentin.

INTRODUCTION: This study evaluated the effects of diabetes mellitus (DM) on the nanostructure of root canal dentin using high-resolution transmission electron microscopy (HRTEM) and inductively coupled plasma mass spectrometry (ICP-MS). METHODS: Twenty extracted human premolars from diabetic and nondiabetic patients (n = 10 in each group) were decoronated and sectioned horizontally into 40 2-mm-thick dentin discs, with each disc designated for a specific test. ICP-MS was used to determine the different elemental levels of copper, lithium, zinc, selenium, strontium, manganese, and magnesium in diabetic and nondiabetic specimens. HRTEM was used to analyze the shape and quantity of the apatite crystals in diabetic and nondiabetic dentin at the nanostructural level. Statistical analysis was performed using Kolmogorov-Smirnov and Student t test (P < .05). RESULTS: ICP-MS revealed significant differences in trace element concentrations between the diabetic and nondiabetic specimens (P < .05), with lower levels of magnesium, zinc, strontium, lithium, manganese, and selenium (P < .05), and higher levels of copper in diabetic specimens (P < .05). HRTEM revealed that diabetic dentin exhibited a less compact structure with smaller crystallites and significantly more crystals in the 2500 nm2 area (P < .05). CONCLUSION: Diabetic dentin exhibited smaller crystallites and altered elemental levels more than nondiabetic dentin, which could explain the higher root canal treatment failure rate in diabetic patients.

Optimized photodegradation of palm oil agroindustry waste effluent using multivalent manganese-modified black titanium dioxide.

This article presents a methodological approach to use manganese (Mn3+Mn7+)-modified black titanium dioxide (Mn/BTiO2) as a photocatalyst to optimize and improve visible-light-driven photodegradation of treated agro-industrial effluent (TPOME). A modified wet chemical process was used to prepare BTiO2. The BTiO2 was then wet impregnated with Mn and calcined at 300 °C for 1 h to produce Mn/BTiO2. The activity of Mn/BTiO2 was investigated in terms of photo-assisted elimination of chemical oxygen demand (COD), phenolic compounds (PCs), color, and total organic carbon (TOC). Using the design of experiments (DOE), the conditions of the photocatalytic process, including photocatalyst loading, Mn concentration, hydrogen peroxide (H2O2) dose, and irradiation time, were optimized. Under the optimum conditions (0.85 g/L photocatalyst loading, 0.048 mol/L H2O2 dose, 0.301 wt.% Mn concentration, and 204 min irradiation time) COD, PCs, color, and TOC removal efficiencies of 88.87%, 86.04%, 62.8%, and 84.66%, respectively, were obtained. Statistical analysis showed that the response variable's removal from TPOME estimation had high R2 and low RMSE, MSE, MAD, MAE, and MAPE values, indicating high reliability. This study demonstrated the significant potential of the developed photocatalytic system for the treatment of waste effluent generated by the palm oil industry and other agro-industries, with the ability to simultaneously reduce a number of organic pollution indicators (OPIs).

Assessment of the Concentration of 51 Elements in the Liver and in Various Parts of the Human Brain-Profiling of the Mineral Status.

The anthropogenic environment and diet introduce many metals into the human body, both essential and toxic. Absorption leads to systemic exposure and accumulation in body fluids and tissues. Both excess and deficiency of trace elements are health hazards. The primary aim of the present study was to evaluate the concentration of 51 elements in liver samples and 11 selected brain regions obtained at post-mortem examination from a population of adults living in south-eastern Poland (n = 15). A total of 180 analyses were performed by inductively coupled plasma mass spectrometry in two independent replicates. The collected data show very high individual variability in the content of the investigated elements. Macroelements such as sodium, magnesium, phosphorus, potassium, calcium, iron, and zinc occurred in the highest concentrations and with the greatest statistically significant variations. Although the elemental content of the brain and liver differed significantly, the strongest positive correlation between liver and polus frontalis was observed for the essential element selenium (0.9338) and the strongest negative one for manganese (-0.4316) and lanthanum (-0.5110). The brain areas studied have different requirements for phosphorus, manganese, iron, and molybdenum. In addition, males had a significantly (p < 0.05) higher brain content of lanthanides and actinides than females. The results of this study show that the inhabitants of south-eastern Poland are exposed to a fairly uniform accumulation of aluminum and vanadium in the brain, which have the highest affinity to the thalamus dorsalis. This result proves that there is environmental exposure to these elements.

Reduction and adsorption of uranium(VI) from aqueous solutions using nanoscale zero-valent manganese.

Nano zero-valent manganese (nZVMn) is theoretically expected to exhibit high reducibility and adsorption capacity, yet its feasibility, performance, and mechanism for reducing and adsorbing hexavalent uranium (U(VI)) from wastewater remain unclear. In this study, nZVMn was prepared via borohydride reduction, and its behaviors about reduction and adsorption of U(VI), as well as the underlying mechanism, were investigated. Results indicated that nZVMn exhibited a maximum U(VI) adsorption capacity of 625.3 mg/g at a pH of 6 and an adsorbent dosage of 1 g/L, and the co-existing ions (K+, Na+, Mg2+, Cd2+, Pb2+, Tl+, Cl-) at studied range had little interference on U(VI) adsorption. Furthermore, nZVMn effectively removed U(VI) from rare-earth ore leachate at a dosage of 1.5 g/L, resulting in a U(VI) concentration of lower than 0.017 mg/L in the effluent. Comparative tests demonstrated the superiority of nZVMn over other manganese oxides (Mn2O3 and Mn3O4). Characterization analyses, including X-ray diffraction and depth profiling X-ray photoelectron spectroscopy, combined with density functional theory calculation revealed that the reaction mechanism of U(VI) using nZVMn involved reduction, surface complexation, hydrolysis precipitation, and electrostatic attraction. This study provides a new alternative for efficient removal of U(VI) from wastewater and improves the understanding of the interaction between nZVMn and U(VI).

Evaluation of trace metallic element levels in coffee by icp-ms: a comparative study among different origins, forms, and packaging types and consumer risk assessment.

Trace elements (TE) contamination of foods and beverages constitutes a public health issue. In this context, the main objective of this study was to determine metals and metalloids content in coffee and to assess the health risks associated with contaminated coffee consumption. To this end, 44 samples of coffee from different origins, forms, and packaging types were analyzed. TE analysis was performed by ICP-MS after digestion. The data analysis was based on principal components analysis (PCA) and analysis of variance (ANOVA). Health risk assessment was determined by the estimated daily intake (EDI), target hazard quotient (THQ), and hazard index (HI). The findings showed that TE levels in coffee varied widely. The highest levels were related to aluminum (Al) (59.88 ± 54.86 mg/kg), manganese (Mn) (16.26 ± 24.59 mg/kg), copper (Cu) (11.60 ± 11.55 mg/kg), and cadmium (Cd) (9.92 ± 10.32 mg/kg). In terms of coffee form and packaging type, a significant difference (P < 0.0001) was observed in nickel (Ni), chromium (Cr), zinc (Zn), cobalt (Co), Cu, Mn, and Al content. The highest EDI was found in Al (0.0109 mg/kg BW/day) in ground coffee packaged in capsules. In terms of chronic daily intake (CDI), Cd and Al were above the reference dose (RfD). THQ of these elements were greater than 1.0, and HI was above the value of 1.0 in different forms of coffee. More interdisciplinary research on the relationships between the metal concentrations in coffee samples and those in feed, water, and soil would be quite interesting.

Assessing gestational exposure to trace elements in an area of unconventional oil and gas activity: comparison with reference populations and evaluation of variability.

BACKGROUND: Located in Northeastern British Columbia, the Montney formation is an important area of unconventional oil and gas exploitation, which can release contaminants like trace elements. Gestational exposure to these contaminants may lead to deleterious developmental effects. OBJECTIVES: Our study aimed to (1) assess gestational exposure to trace elements in women living in this region through repeated urinary measurements; (2) compare urinary concentrations to those from North American reference populations; (3) compare urinary concentrations between Indigenous and non-Indigenous participants; and (4) evaluate inter- and intra-individual variability in urinary levels. METHODS: Eighty-five pregnant women participating in the Exposures in the Peace River Valley (EXPERIVA) study provided daily spot urine samples over 7 consecutive days. Samples were analyzed for 20 trace elements using inductively-coupled mass spectrometry (ICP-MS). Descriptive statistics were calculated, and inter- and intra-individual variability in urinary levels was evaluated through intraclass correlation coefficient (ICC) calculation for each trace element. RESULTS: When compared with those from North American reference populations, median urinary levels were higher in our population for barium (~2 times), cobalt (~3 times) and strontium (~2 times). The 95th percentile of reference populations was exceeded at least 1 time by a substantial percentage of participants during the sampling week for barium (58%), cobalt (73%), copper (29%), manganese (28%), selenium (38%), strontium (60%) and vanadium (100%). We observed higher urinary manganese concentrations in self-identified Indigenous participants (median: 0.19 µg/g creatinine) compared to non-Indigenous participants (median: 0.15 µg/g of creatinine). ICCs varied from 0.288 to 0.722, indicating poor to moderate reliability depending on the trace element. SIGNIFICANCE: Our results suggest that pregnant women living in this region may be more exposed to certain trace elements (barium, cobalt, copper, manganese, selenium, strontium, and vanadium), and that one urine spot sample could be insufficient to adequately characterize participants' exposure to certain trace elements. IMPACT STATEMENT: Unconventional oil and gas (UOG) is an important industry in the Peace River Valley region (Northeastern British Columbia, Canada). Information on the impacts of this industry is limited, but recent literature emphasizes the risk of environmental contamination. The results presented in this paper highlight that pregnant women living near UOG wells in Northeastern British Columbia may be more exposed to some trace elements known to be related to this industry compared to reference populations. Furthermore, our results based on repeated urinary measurements show that one urine sample may be insufficient to adequately reflect long-term exposure to certain trace elements.

Trace elements and Alzheimer dementia in population-based studies: A bibliometric and meta-analysis.

Alterations in the concentrations of trace elements may play a vital role in Alzheimer dementia progression. However, previous research results are inconsistent, and there is still a lack of review on the relationship between all the studied-trace elements and AD from various perspectives of population-based studies. In this study, we systematically reviewed previous population-based studies and identified the altered trace elements in AD patients. We searched the Web of Science Core Collection, PubMed, and Scopus database, and ultimately included 73 articles. A bibliometric analysis was conducted to explore the evolution of the field from an epidemiological perspective. Bibliometric data such as trace elements, biological materials, detection methods, cognitive tests, co-occurrence and co-citation statistics are all analyzed and presented in a quantitative manner. The 73 included studies analyzed 39 trace elements in total. In a further meta-analysis, standardized mean differences (SMDs) of 13 elements were calculated to evaluate their altered in AD patients, including copper, iron, zinc, selenium, manganese, lead, aluminum, cadmium, chromium, arsenic, mercury, cobalt, and manganese. We identified four trace elements-copper (serum), iron (plasma), zinc (hair), and selenium (plasma)-altered in AD patients, with SMDs of 0.37 (95% confidence interval [CI]: 0.10, 0.65), -0.68 (95% CI: -1.34, -0.02), -0.35 (95% CI: -0.62, -0.08), and -0.61 (95% CI: -0.97, -0.25), respectively. Finally, we formed a database of various trace element levels in AD patients and healthy controls. Our study can help future researchers gain a comprehensive understanding of the advancements in the field, and our results provide comprehensive population-based data for future research.

Characteristics and health risk assessment of heavy metal pollution in atmospheric particulate matter in different regions of the Yellow River Delta in China.

To understand the characteristics, temporal and spatial variation, and health risks of atmospheric heavy metal pollution in different areas of the YRD (Yellow River Delta), atmospheric particles samples were collected in the YRD in China during 2016-2017. A total of 10 monitoring points were chosen in different areas (industrial parks, main urban areas, and rural areas) in the YRD, heavy metals were monitored using atomic fluorescence spectrometry and graphite furnace atomic absorption spectrometry. The results showed that TSP (total suspended particulate), PM10 (particulate matter with an aerodynamic diameter less than 10 µm), and PM2.5 (particulate matter with an aerodynamic diameter less than 2.5 µm) contents were higher in the Kenli EDZ (economic development zone) and Kenli urban areas than those in other points. The concentration range of heavy metals in atmospheric samples at 10 points was different, with a difference of five orders of magnitude, of which the content of copper (Cu) was the highest, with the highest concentration of 4.375 µg/m3, and the content of particulate mercury (Hg) was the lowest, with the minimum concentration of 0.00001 µg/m3. Among the nine heavy metals, the contents of cadmium (Cd), lead (Pb), and Hg were higher in winter than in summer, and chromium (Cr), nickel (Ni), Cu, and manganese (Mn) were higher in summer than in winter. In addition to Hg, the contents of the other eight heavy metals in particulate matter showed a trend that urban areas and EDZs had higher concentrations than cities and towns and nature reserves, which can be attributed to industrial activities and coal-fired fuel emissions. Health risk assessment was carried out for adults and children, respectively, and the results showed that carcinogens have no obvious carcinogenic risk, but As and Cr have major potential carcinogenic risk. Among the noncarcinogenic substances, Mn has the greatest noncarcinogenic risk, and urban areas and economic development zones have the greatest risk. This study investigated the characteristics and health risk assessment of atmospheric heavy metal pollution in different areas in the YRD to supplement the research contents of atmospheric particulate heavy metals in the YRD in domestics and overseas. It is also critical to study the pollution and migration of heavy metals in China.