Uterine fibroids treatment: do we have new valid alternative? Experiencing the combination of vitamin D plus epigallocatechin gallate in childbearing age affected women.

OBJECTIVE: Uterine myomas are the most common benign tumors in females, and at least 25% of affected patients experience symptoms severe enough to need treatment, like heavy hemorrhage, pelvic pain, and infertility. Currently, a non-invasive approach is preferred in women of childbearing age who desire pregnancy. The aim of our study was to determine the effect of oral supplementation with a combination of vitamin D plus epigallocatechin gallate (EGCG) and vitamin B6 in women with myomas. PATIENTS AND METHODS: Between April and December 2020, we enrolled 95 women of childbearing age, afferent to our hospital, displaying at least one myoma with a diameter <4 cm. Patients were divided in two groups: 41 women were treated daily with two tablets of 25 µg vitamin D + 150 mg EGCG + 5 mg vitamin B6 for 4 months; 54 women, representing the control group, received no treatment. Total volume and vascularization of myomas were analyzed ultrasonographically. Bleeding and pelvic pain was also evaluated, as well as patients' quality of life and health through questionnaire Short Form Health Survey (SF-36) and Patient Global Impression of improvement (PGI-I). RESULTS: After treatment myomas' total volume and peripherical vascularization significantly decreased respectively by 37.9% (p<0.001) and 7.7%. On the other hand, we observed an increase in myomas' volume by 5.5 % and of peripherical vascularization by 5% in the control group. The treated group reported an improvement in SF-36 (p<0.001) and PGI-I (85.4%) questionnaire scores. CONCLUSIONS: We demonstrated, in young women who want to preserve fertility, that the combined supplementation of vitamin D, EGCG, and vitamin B6 reduced myomas' volume and improved patients' quality of life, without side effects.

Efectividad de la combinación magnetoterapia/laserterapia/homeopatía en el tratamiento del mioma uterino / Effectiveness of magnetic therapy/laser therapy/homeopathy combination in the treatment of uterine myoma

Fundamento: el fibroma uterino constituye un problema de salud que afecta a las mujeres en edad reproductiva, los tratamientos electivos, basados en la cirugía y la embolización de la arteria uterina, aunque reportan éxito, son invasivos y riesgosos.Objetivo: evaluar los efectos del tratamiento combinado de la magnetoterapia con laserterapia y homeopatía en mujeres con mioma uterino, remitidas a la consulta de medicina natural y tradicional del policlínico universitario Rafael Izquierdo”, entre julio de 2015 y marzo de 2016.Métodos: se realizó una intervención en 25 mujeres entre 20 y 49 años, con diagnóstico de mioma uterino, en el periodo de tiempo y área antes mencionados. Las pacientes se distribuyeron al azar en dos grupos, al primero le fue aplicada la terapia combinada y al segundo el tratamiento hormonal (medroxiprogesterona). El seguimiento se hizo de forma clínica y por ultrasonograma, a los tres y seis meses después de culminar el tratamiento.Resultados: a los seis meses el grupo estudio redujo el tamaño del tumor en 21,34 mm3, más que el control; en este último, a los tres meses el 7,7 por ciento redujo intensamente el tumor, mientras en el 92,3 por ciento fue moderada; a los seis meses los pacientes con reducción intensa se incrementaron al 30,8 por ciento; en el grupo de estudio solo el 16,7 por ciento alcanzaron la reducción intensa del tumor. En la reducción del tamaño del útero no existieron diferencias significativas entre ambos grupos. La evolución clínica fue superior en el grupo control.Conclusiones: la terapia hormonal mostró mejores resultados clínicos y ultrasonográficos; en ambos tratamientos se demostró inocuidad (AU)

Background: uterine fibroma is a health problem that affects women in reproductive age. Elective treatments based on surgery and uterine arterial embolization, although successful, are invasive and risky.Objective: to assess the effects of a combined treatment with magnetic therapy, laser therapy and homeopathy in women with uterine myoma referred to the department of natural and traditional medicine at “Rafael Izquierdo” Teaching Polyclinic from July 2015 to March 2016.Methods: an intervention study was carried out with 25 women of the 20 to 49 age group with a diagnosis of uterine myoma, in the place and during the period herein mentioned. Patients were distributed at random into two groups. The first group received a combined therapy, while the second group received hormonal treatment (medroxiprogesterone). Follow-up was conducted clinically and by ultrasound, at 3 and 6 months after the end of the treatment. Results: at 6 months of treatment, the study group reduced the tumor size in 21, 34 mm3, more than in the control group; the latter, at 3 months, reduced the tumor intensively in 7,7 percent, while 92,3 percent was moderate. At 6 months, the patients with intense reduction increased to 30,8 percent. In the study group only 16,7 percent reached the intense reduction of the tumor. Concerning the reduction of the uterus size there were no remarkable differences between the two groups. Clinical progress was higher in the control group.Conclusions: Hormonal therapy showed better clinical and ultrasonographic results; both treatments were Harmless (AU)

[The gynecological TURP syndrome. Severe hyponatremia and pulmonary edema during hysteroscopy]. / Das gynäkologische "TUR-Syndrom". Schwere Hyponatriämie und Lungenödem während operativer Hysteroskopie.

Fluid overload and dilutional hyponatremia are rare but typical complications of endoscopic transurethral resection of the prostate gland (TURP syndrome). Less commonly, this complication caused by excessive absorption of hypotonic, electrolyte-free non-conductive distention solution, may also occur during endoscopic surgery of the uterus, e.g. operative hysteroscopy. A case report is presented of a 44-year-old woman scheduled for operative hysteroscopy for intracavital myoma under general anaesthesia, suffering from severe absorption syndrome leading to hyponatremia of 106 mEq/l and pulmonary edema necessitating subsequent admission to ICU. Anatomical and physiological as well as technical aspects of this syndrome are discussed. Recommendations for anesthesiology management are offered and a possible treatment of acute hyponatremia is discussed.

Laparoscopy.

PIP: Laproscopic sterilization techniques and the diagnostic use of laparoscopy are discussed. In a series of 1000 laparoscopic sterilizations by the 2-incision technique, there was a total failure rate, surgical and operative, of .4%. In a similar series with the 1-incision technique and electrocagulation only, the total failure rate was 1.6%, though the complication rate was considerably reduced. The high failure rate was attributed to incomplete transection resulting in recanalization. The failure rate with a single-incision, 3-burn technique was .25% in a series of 2000 patients, and complications were few. Tubal occlusion with hemoclips has produced poor results (failure rate: 8-27%). The results with silastic bands, however, have been comparable to those for electrocoagulation, but with fewer complications. Means by which the cost of laparoscopic equipment may be reduced are discussed. Laparoscopy can be helpful in the diagnosis of infertility-endocrinology, ectopic pregnancy, pelvic pain, pelvic inflammatory disease, adnexal masses, and the retrieval of foreign bodies in the pelvic region. Contraindications to laparoscopy are reviewed. It is concluded that laparoscopy is a safe and effective means of sterilization on an outpatient basis, and is of value in the diagnosis of gynecologic disorders.^ieng