RESUMO
The thalamus located in the deep site of cerebrum with the risk of internal capsule injury during operation. The purpose of this study was to compare the anatomy for exposure and injury using simulative surgical corridor of 3-dimensional model. The 3-dimensional anatomy model of thalamus in cerebrum was created based on magnetic resonance imaging performed for 15 patients with trigeminal neuralgia. The midpoint of line between anterior edge and top of thalamus was the target exposed. Axis connecting the target with the anterior edge and top of caudate head was used to outline the cylinder, respectively, simulating surgical corridors 1 and 2 of transfrontal approach. Cerebral tissues involved in the corridors were observed, measured, and compared. Incision of cortex was made on the anterior portion of inferior frontal gyrus through corridor 1 and middle frontal gyrus through corridor 2. Both of the 2 corridors passed the caudate nucleus, the anterior limb and genu of internal capsule, ultimately reached the upper anterior portion of thalamus. The volumes of white matter, caudate head, and thalamus in the corridor 1 were more than those in corridor 2. Conversely, the volumes of cortex, internal capsule in corridor 2 were more than those in corridor 1. In conclusion, surgical anatomy-specific volume is helpful to postulate the intraoperative injury of transfrontal approach exposing anterior portion of the thalamus. The detailed information in the quantification of microsurgical anatomy will be used to develop minimally invasive operation.
Assuntos
Núcleo Caudado/anatomia & histologia , Cápsula Interna/anatomia & histologia , Microcirurgia , Córtex Pré-Frontal/anatomia & histologia , Tálamo/anatomia & histologia , Tálamo/cirurgia , Núcleo Caudado/diagnóstico por imagem , Núcleo Caudado/cirurgia , Simulação por Computador , Humanos , Cápsula Interna/diagnóstico por imagem , Cápsula Interna/cirurgia , Imageamento por Ressonância Magnética , Modelos Anatômicos , Córtex Pré-Frontal/diagnóstico por imagem , Córtex Pré-Frontal/cirurgia , Tálamo/diagnóstico por imagemRESUMO
OBJECTIVE The purpose of this study was to describe in detail the cortical and subcortical anatomy of the central core of the brain, defining its limits, with particular attention to the topography and relationships of the thalamus, basal ganglia, and related white matter pathways and vessels. METHODS The authors studied 19 cerebral hemispheres. The vascular systems of all of the specimens were injected with colored silicone, and the specimens were then frozen for at least 1 month to facilitate identification of individual fiber tracts. The dissections were performed in a stepwise manner, locating each gray matter nucleus and white matter pathway at different depths inside the central core. The course of fiber pathways was also noted in relation to the insular limiting sulci. RESULTS The insular surface is the most superficial aspect of the central core and is divided by a central sulcus into an anterior portion, usually containing 3 short gyri, and a posterior portion, with 2 long gyri. It is bounded by the anterior limiting sulcus, the superior limiting sulcus, and the inferior limiting sulcus. The extreme capsule is directly underneath the insular surface and is composed of short association fibers that extend toward all the opercula. The claustrum lies deep to the extreme capsule, and the external capsule is found medial to it. Three fiber pathways contribute to form both the extreme and external capsules, and they lie in a sequential anteroposterior disposition: the uncinate fascicle, the inferior fronto-occipital fascicle, and claustrocortical fibers. The putamen and the globus pallidus are between the external capsule, laterally, and the internal capsule, medially. The internal capsule is present medial to almost all insular limiting sulci and most of the insular surface, but not to their most anteroinferior portions. This anteroinferior portion of the central core has a more complex anatomy and is distinguished in this paper as the "anterior perforated substance region." The caudate nucleus and thalamus lie medial to the internal capsule, as the most medial structures of the central core. While the anterior half of the central core is related to the head of the caudate nucleus, the posterior half is related to the thalamus, and hence to each associated portion of the internal capsule between these structures and the insular surface. The central core stands on top of the brainstem. The brainstem and central core are connected by several white matter pathways and are not separated from each other by any natural division. The authors propose a subdivision of the central core into quadrants and describe each in detail. The functional importance of each structure is highlighted, and surgical approaches are suggested for each quadrant of the central core. CONCLUSIONS As a general rule, the internal capsule and its vascularization should be seen as a parasagittal barrier with great functional importance. This is of particular importance in choosing surgical approaches within this region.
Assuntos
Córtex Cerebral/anatomia & histologia , Córtex Cerebral/cirurgia , Cérebro/anatomia & histologia , Cérebro/cirurgia , Microcirurgia/métodos , Gânglios da Base/anatomia & histologia , Gânglios da Base/cirurgia , Mapeamento Encefálico , Tronco Encefálico/anatomia & histologia , Tronco Encefálico/cirurgia , Núcleo Caudado/anatomia & histologia , Núcleo Caudado/cirurgia , Artérias Cerebrais/anatomia & histologia , Artérias Cerebrais/cirurgia , Veias Cerebrais/anatomia & histologia , Veias Cerebrais/cirurgia , Dominância Cerebral/fisiologia , Substância Cinzenta/anatomia & histologia , Substância Cinzenta/cirurgia , Humanos , Vias Neurais/anatomia & histologia , Vias Neurais/cirurgia , Tubérculo Olfatório/anatomia & histologia , Tubérculo Olfatório/cirurgia , Tálamo/cirurgia , Substância Branca/anatomia & histologia , Substância Branca/cirurgiaRESUMO
OBJECT: Recent neuroimaging and surgical results support the crucial role of white matter in mediating motor and higher-level processing within the frontal lobe, while suggesting the limited compensatory capacity after damage to subcortical structures. Consequently, an accurate knowledge of the anatomofunctional organization of the pathways running within this region is mandatory for planning safe and effective surgical approaches to different diseases. The aim of this dissection study was to improve the neurosurgeon's awareness of the subcortical anatomofunctional architecture for a lateral approach to the frontal region, to optimize both resection and postoperative outcome. METHODS: Ten human hemispheres (5 left, 5 right) were dissected according to the Klingler technique. Proceeding lateromedially, the main association and projection tracts as well as the deeper basal structures were identified. The authors describe the anatomy and the relationships among the exposed structures in both a systematic and topographical surgical perspective. Structural results were also correlated to the functional responses obtained during resections of infiltrative frontal tumors guided by direct cortico-subcortical electrostimulation with patients in the awake condition. RESULTS: The eloquent boundaries crucial for a safe frontal lobectomy or an extensive lesionectomy are as follows: 1) the motor cortex; 2) the pyramidal tract and premotor fibers in the posterior and posteromedial part of the surgical field; 3) the inferior frontooccipital fascicle and the superior longitudinal fascicle posterolaterally; and 4) underneath the inferior frontal gyrus, the head of the caudate nucleus, and the tip of the frontal horn of the lateral ventricle in the depth. CONCLUSIONS: Optimization of results following brain surgery, especially within the frontal lobe, requires a perfect knowledge of functional anatomy, not only at the cortical level but also with regard to subcortical white matter connectivity.
Assuntos
Mapeamento Encefálico , Neoplasias Encefálicas/cirurgia , Encéfalo/anatomia & histologia , Encéfalo/fisiologia , Estimulação Encefálica Profunda , Glioma/cirurgia , Monitorização Intraoperatória/métodos , Fibras Nervosas Mielinizadas , Vias Neurais/cirurgia , Procedimentos Neurocirúrgicos/efeitos adversos , Procedimentos Neurocirúrgicos/métodos , Distúrbios da Fala/prevenção & controle , Adulto , Gânglios da Base/anatomia & histologia , Gânglios da Base/fisiologia , Gânglios da Base/cirurgia , Encéfalo/cirurgia , Mapeamento Encefálico/métodos , Neoplasias Encefálicas/patologia , Neoplasias Encefálicas/fisiopatologia , Cadáver , Núcleo Caudado/anatomia & histologia , Núcleo Caudado/fisiologia , Núcleo Caudado/cirurgia , Estimulação Encefálica Profunda/métodos , Dissecação , Feminino , Lobo Frontal/anatomia & histologia , Lobo Frontal/fisiologia , Lobo Frontal/cirurgia , Glioma/patologia , Glioma/fisiopatologia , Humanos , Ventrículos Laterais/anatomia & histologia , Ventrículos Laterais/fisiologia , Ventrículos Laterais/cirurgia , Masculino , Córtex Motor/anatomia & histologia , Córtex Motor/fisiologia , Córtex Motor/cirurgia , Vias Neurais/anatomia & histologia , Vias Neurais/fisiologia , Testes Neuropsicológicos , Tratos Piramidais/anatomia & histologia , Tratos Piramidais/fisiologia , Tratos Piramidais/cirurgia , Resultado do Tratamento , VigíliaRESUMO
Clinical and neuropsychological study of 28 patients with arteriovenous malformations (AVM) of the caudate nucleus and 36 patients with AVM of the thalamus has been conducted. After surgical removal of the caudate nucleus, speech disturbances developed in 4 out of 8 patients with left-side AVM and in 1 patient, a converted left-hander, with right-side AVM. All 5 patients had mild speech disturbances, which differed by character in dependence of the AVM location. In case of AVM location in the head of the caudate nucleus, the speech disturbances were represented by perseverations and were similar to those caused by the lesion in the Broca area. In case of the caudate nucleus lesion, naming was mildly affected that resembled temporal aphasia. After surgical removal of AVM in the left thalamus in 9 patients, complex and rather stable speech disturbances developed in 7 cases. They were featured by the signs of frontal and temporal aphasias, i.e. there were perseverations and disturbances of naming, auditory and speech memory. The peculiarities of speech disturbances in lesions of the caudate nucleus and the thalamus were well explained by their anatomic and functional correlations with different regions of brain speech cortex. Speech disturbances in various subcortical lesions are reviewed. In the authors' opinion, subcortical aphasias do not have any particular character but include the same factors in different combinations as cortical ones that is determined by the presence of common functional systems for speech support which comprise cortical and subcortical patterns.
Assuntos
Afasia/etiologia , Núcleo Caudado/irrigação sanguínea , Malformações Arteriovenosas Intracranianas/complicações , Tálamo/irrigação sanguínea , Adolescente , Adulto , Afasia/diagnóstico , Núcleo Caudado/cirurgia , Angiografia Cerebral , Criança , Feminino , Humanos , Malformações Arteriovenosas Intracranianas/diagnóstico , Malformações Arteriovenosas Intracranianas/cirurgia , Imageamento por Ressonância Magnética , Masculino , Pessoa de Meia-Idade , Testes Neuropsicológicos , Índice de Gravidade de Doença , Tálamo/cirurgiaRESUMO
AIMS: To obtain an up to date review of the different possible surgical approaches in the management of certain psychiatric disorders that are refractory to conservative treatment (pharmacotherapy, psychotherapy, electroconvulsive therapy). METHOD: In order to conduct this research we reviewed the work published by centres with the most experience in this type of surgery, mainly in North America and Europe, since its beginnings in the 1930s, with the controversy concerning prefrontal leucotomy, until the appearance of modern stereotactic techniques. We analyse the anatomophysiological bases, their main clinical indications, the surgical techniques used and their results, as well as perspectives for the future of this neurosurgical treatment. CONCLUSIONS: The most noteworthy progress in psychosurgery in recent years has been the combination of a more rigorous selection of patients and the higher degree of specificity with which treatment is performed on the brain structures involved in psychiatric disease. The most widely employed psychosurgical procedures at present are cingulotomy, anterior capsulotomy, subcaudate tractotomy, limbic leucotomy and postero medial hypothalamotomy, with favourable responses in about 35 70% of cases. The psychiatric diagnoses where the best results are to be found are obsessive compulsive disorder, chronic anxiety states and major depression. Current progress in neuroimaging techniques, increased neurophysiological knowledge and the revolutionary neuromodulation techniques, especially deep brain stimulation, offer an even more promising future for psychiatric neurosurgery.
Assuntos
Encéfalo/cirurgia , Transtornos Mentais/cirurgia , Psicocirurgia/tendências , Núcleo Caudado/cirurgia , Terapia por Estimulação Elétrica/instrumentação , Giro do Cíngulo/cirurgia , Humanos , Hipotálamo/cirurgia , Cápsula Interna/cirurgia , Sistema Límbico/cirurgia , Transtornos Mentais/terapia , Transtorno Obsessivo-Compulsivo/cirurgia , Técnicas EstereotáxicasRESUMO
Forebrain heat shock protein 70 (HSP70) immunohistochemical reactivity was investigated in rats subjected to gamma knife irradiation focusing on the right caudate putamen nucleus. The forebrain sections of all experimental animals were processed with anti-HSP70 antiserum and then by avidin-biotin peroxidase complex immunohistochemistry after gamma ray irradiation with a dose of 100Gy and they each survived for different times (from 30 min to 30 days). Some neurons, glial cells, and endothelial cells were HSP70-like immunoreactivity (HSP70-LI) positive. HSP70-LI was mainly distributed in the target area of irradiation, as well as in non-target regions, e.g. the cortex, hippocampus, and hypothalamus, etc. The expression and change of HSP70-LI from 3 h to 30 days after irradiation followed the following rules: (1) Within 3 to 24 h, the dilated vessels with HSP70-LI endothelial cells were found at first, and a few lightly stained HSP70-LI neurons and glias were observed in the target and non-target regions; (2) In 3-7 days, darkly stained HSP70-LI neurons and glias were apparently increased and formed an expression peak. From 14 to 30 days, HSP70-LI cells were distinctly decreased and became weakly stained or negative. These results suggested that although the irradiation target of the gamma knife was localized, the response to irradiation occurred extensively.
Assuntos
Núcleo Caudado/cirurgia , Proteínas de Choque Térmico HSP70/metabolismo , Prosencéfalo/metabolismo , Prosencéfalo/cirurgia , Putamen/cirurgia , Radiocirurgia , Animais , Hipocampo/metabolismo , Hipotálamo/metabolismo , Masculino , Ratos , Ratos Sprague-Dawley , Análise de Sobrevida , Distribuição TecidualRESUMO
Clinical and neuropsychologic examination of 141 patients with arteriovenous malformations (AVM) was examined according to A.R.Lurye method. AVM of caudate nucleus were found in 27 patients, of thalamus in 34 ones, of hippocampal formation in 39 individuals, of gyrus cinguli in 41 cases. 102 patients were operated. Both total impairment of the memory and its peculiarities in damages of different structures were found in patients with AVM. A common peculiarity was the development of the amnestic symptom complex similar to Korsakov's syndrome. Such disorders occur only in combined damages of the deep structures (before the operation in patients with ventricular hemorrhages), excluding patients with AVM of caudate nucleus. The memory impairments were modal-nonspecific; in all the patients an audio-speech delayed memory was altered and reproduction in visual memory. Peculiarities of memory impairments in damage of separate structures were functional asymmetry of the defects of memory in AVM of caudate nucleus and thalamus (if present) as well as permanent inclusions and contaminations in AVM of gyrus cinguli. During process of evolution separate sides of memory function might be doubled in different structures, and each of them might have its own contribution to memory function.
Assuntos
Núcleo Caudado/irrigação sanguínea , Núcleo Caudado/fisiopatologia , Giro do Cíngulo/irrigação sanguínea , Giro do Cíngulo/fisiopatologia , Hipocampo/irrigação sanguínea , Hipocampo/fisiopatologia , Malformações Arteriovenosas Intracranianas/complicações , Malformações Arteriovenosas Intracranianas/fisiopatologia , Transtornos da Memória/etiologia , Transtornos da Memória/fisiopatologia , Tálamo/irrigação sanguínea , Tálamo/fisiopatologia , Adolescente , Adulto , Núcleo Caudado/cirurgia , Criança , Feminino , Giro do Cíngulo/cirurgia , Hipocampo/cirurgia , Humanos , Masculino , Transtornos da Memória/diagnóstico , Pessoa de Meia-Idade , Testes Neuropsicológicos , Tálamo/cirurgiaRESUMO
OBJECTIVE: We have developed a frameless stereotactic neuronavigation system that allows navigation during neurosurgical procedures through an image formed from integrating ultrasonography and preoperative magnetic resonance (MR) imaging and/or x-ray computed tomography. METHODS: The system consists of a ultrasound imaging scanner, a workstation with an image capture board, and an ultrasonic tracking sensor with a 5-MHz ultrasonographic transducer. The ultrasonic tracking sensor measures the position and orientation of the ultrasonographic transducer. The oblique plane of the MR/computed tomographic image corresponding to the ultrasound image is then displayed on the workstation monitor. A three-dimensional computer graphic representation of the integrated image is also reported as a preliminary test. For the patient-image registration, the coordinates of digitized and imaged markers on a specifically developed reference frame are used. The reference frame is noninvasive because it is not bolted but only fastened to the patient's head with silicon. RESULTS: Based on the findings from the clinical application of the system in three cases, the system was advantageous because of the surgical procedures could be controlled by intraoperative ultrasonography as well as by preoperative MR/computed tomographic images. Missing parts in the ultrasonogram were supplemented with preoperative MR/computed tomographic images. At other times, spatial positioning and visualization by ultrasonography were useful for identifying anatomical objects in the image. CONCLUSION: This preliminary study of the frameless integration of ultrasonography into stereotactic space demonstrated its clinical usefulness. We believe that the concept of pre- and intraoperative image-guided surgery presented here will find increasing use in the future.
Assuntos
Ecoencefalografia/instrumentação , Processamento de Imagem Assistida por Computador/instrumentação , Imageamento por Ressonância Magnética/instrumentação , Técnicas Estereotáxicas/instrumentação , Tomografia Computadorizada por Raios X/instrumentação , Adolescente , Mapeamento Encefálico/instrumentação , Neoplasias Encefálicas/diagnóstico , Neoplasias Encefálicas/cirurgia , Núcleo Caudado/patologia , Núcleo Caudado/cirurgia , Gráficos por Computador/instrumentação , Sistemas Computacionais , Desenho de Equipamento , Humanos , Masculino , Imagens de Fantasmas , TransdutoresAssuntos
Comportamento Animal/fisiologia , Corpo Estriado/fisiologia , Substância Negra/fisiologia , Núcleos Talâmicos/fisiologia , Estimulação Acústica , Potenciais de Ação/efeitos dos fármacos , Potenciais de Ação/fisiologia , Animais , Comportamento Animal/efeitos dos fármacos , Gatos , Núcleo Caudado/fisiologia , Núcleo Caudado/cirurgia , Condicionamento Psicológico/efeitos dos fármacos , Condicionamento Psicológico/fisiologia , Corpo Estriado/efeitos dos fármacos , Cães , Dopamina/fisiologia , Antagonistas de Dopamina/farmacologia , Estimulação Elétrica , Histocitoquímica , Masculino , Vias Neurais/fisiologia , Oxidopamina/farmacologia , Substância Negra/efeitos dos fármacos , Núcleos Talâmicos/efeitos dos fármacosRESUMO
Experiments in dogs with striatal deficiency revealed an important role of dopaminergic mechanisms in establishment of the situation conditioning. A rearrangement of the background unit activity of the caudate and thalamic nuclei preceding presentation of a conditioned stimulus and correlating with correct accomplishment of a motor task, was revealed in cats. Afferents from intralaminar and ventral nuclei of the thalamus were shown. Participation of striatal, nigral and thalamic levels in systemic organisation of motor conditioning is discussed.
Assuntos
Comportamento Animal/fisiologia , Corpo Estriado/fisiologia , Substância Negra/fisiologia , Núcleos Talâmicos/fisiologia , Estimulação Acústica , Potenciais de Ação/efeitos dos fármacos , Potenciais de Ação/fisiologia , Animais , Comportamento Animal/efeitos dos fármacos , Gatos , Núcleo Caudado/fisiologia , Núcleo Caudado/cirurgia , Condicionamento Clássico/efeitos dos fármacos , Condicionamento Clássico/fisiologia , Corpo Estriado/efeitos dos fármacos , Cães , Antagonistas de Dopamina/farmacologia , Estimulação Elétrica , Comportamento Alimentar/efeitos dos fármacos , Comportamento Alimentar/fisiologia , Masculino , Oxidopamina/farmacologia , Comportamento Estereotipado/efeitos dos fármacos , Comportamento Estereotipado/fisiologia , Substância Negra/efeitos dos fármacos , Núcleos Talâmicos/efeitos dos fármacosRESUMO
Ten patients were studied before and after autologous adrenal medullary transplantation to the central nervous system for Parkinson's disease to determine if the presence of new catecholamine-producing tissue near the hypothalamus would alter hypothalamic or pituitary function, mineralocorticoid levels, or catecholamine production. No clinically apparent ill effects occurred. Changes in endocrine function were largely short-term and transient: at 7-10 days after surgery, urinary catecholamine levels were significantly increased, PRL levels were significantly elevated despite markedly increased serum dopamine levels, and gonadal steroid levels (estradiol and testosterone) were significantly lower despite unchanged basal and stimulated levels of gonadotropins. Dehydroepiandrosterone sulfate was significantly reduced at 7-10 days after surgery and remained low at 3-6 months. Other changes at 3-6 months after surgery included increased stimulated corticotropin levels and reduced serum aldosterone response to upright posture. The changes at 7-10 days were probably due to stress or unilateral adrenalectomy or both; the changes at 3-6 months were likely due to unilateral adrenalectomy. We conclude that unilateral adrenalectomy and autologous adrenal medullary transplantation to the central nervous system does not produce clinically important changes in endocrine function; however, possible adverse consequences of long-term reduction of dehydroepiandrosterone sulfate levels cannot be excluded.
Assuntos
Medula Suprarrenal/transplante , Núcleo Caudado/cirurgia , Hipotálamo/fisiologia , Doença de Parkinson/cirurgia , Adeno-Hipófise/fisiologia , Adulto , Idoso , Feminino , Seguimentos , Humanos , Masculino , Pessoa de Meia-Idade , Testes de Função Hipofisária , Transplante AutólogoRESUMO
The ethics of psychosurgery involve questions of moral philosophy and pragmatism in alleviating human suffering. The weighing of scientific data along with philosophical oughts and shoulds is required. The medical literature indicates definite efficacy for some kinds of limbic surgery, mainly cingulotomy and capsulotomy, in some kinds of conditions, namely major depression, pain and anxiety. The relative utility of these procedures given the severity of the illnesses and the safety of the procedures described is significant. Ethical and moral conflicts over altruism, autonomy and suffering require recognition before their due considerations (Kleinig 1985). The following recommendations emerge from these considerations: 1. No consideration of ethics in psychosurgery is complete without consideration of both the scientific data and moral conflicts. 2. The considerable efficacy and safety of cingulotomy and capsulotomy must be acknowledged. 3. Indications and contraindications do exist for selecting patients. Major psychiatric Axis I diagnoses of depression and anxiety are the indications. Personality disorders are not indications. 4. Peer review, unfettered consent and knowledge of the psychodynamics of severe illness are three ingredients necessary for wise decisions about performing limbic surgery. 5. The liberal advocation of autonomy without responsibility is an amoral, not liberating, point of view. 6. Politics should be denounced as the most serious ethical problem in medical decision making. Political intrusion into the scientific matters and the doctor-patient relationship has created ethical problems with psychosurgery and continues to do so today.
Assuntos
Ética Médica , Transtornos Mentais/cirurgia , Psicocirurgia , Núcleo Caudado/cirurgia , Lobo Frontal/cirurgia , Giro do Cíngulo/cirurgia , Humanos , Transtornos da Personalidade/psicologia , Complicações Pós-Operatórias/psicologia , Fatores de Risco , Tálamo/cirurgiaRESUMO
A review on indications, target points and results of stereotactic operations for treatment of psychiatric diseases is given, based on personal experiences and reports in the literature. As a conclusion the author suggests that the anatomical target should be chosen selectively. There is strong evidence that different approaches lead to different results. Cingulotomy is effective for chronic pain with addiction and depression, anterior capsulotomy for obsessive-compulsive and anxiety neurosis, innominotomy for chronic and recurrent depression, and postero-medial hypothalamotomy for restless, aggressive and destructive behaviour. Therefore, the target should be selected according to the individual symptoms of the patient. The results of operation are usually good and most patients can return to a normal life. The side-effects are infrequent and seldom serious. Modern psychosurgery does not modify the personality of the patient. On the contrary it often relieves it from disturbing symptoms of illness.
Assuntos
Transtornos Mentais/cirurgia , Psicocirurgia/tendências , Núcleo Caudado/cirurgia , Corpo Caloso/cirurgia , Seguimentos , Lobo Frontal/cirurgia , Giro do Cíngulo/cirurgia , Humanos , Hipotálamo/cirurgia , Vias Neurais/cirurgia , Putamen/cirurgiaRESUMO
A series of 250 surgically treated cerebral arteriovenous malformations (AVM's) is presented, in which 22 lesions were located primarily in the thalamus and caudate nucleus. A standardized interhemispheric approach through the posterior corpus callosum and into the atrium of the lateral ventricle was utilized for the surgical removal of these AVM's. Total removal was confirmed by angiography in 18 patients; removal was subtotal in four cases. There were no deaths in this group of patients. Disturbances of recent memory pre- and postoperatively were seen in half of the patients, but most of these deficits were temporary. Other complications included: postoperative homonymous hemianopsia (six cases), transient hemiparesis (three cases), hemisensory loss (two cases), Parinaud's syndrome (one case), and recurrent hemorrhage 2 years after surgery (one case). All 22 patients returned to their previous occupations and are leading independent lives. The results of this experience indicate that thalamocaudate AVM's can be effectively treated by resection.