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Medicinas Complementares
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1.
Anticancer Res ; 40(2): 873-880, 2020 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-32014931

RESUMO

BACKGROUND/AIM: The acidic tumor microenvironment is associated both with the progression and drug resistance of cancer. We aimed to investigate the effects of alkalization therapy performed concurrently with chemotherapy on the survival of advanced pancreatic cancer patients (study registration: UMIN 000035659). PATIENTS AND METHODS: Twenty-eight patients with metastatic or recurrent pancreatic cancer were assessed in this study. Alkalization therapy consisted of an alkaline diet with supplementary oral sodium bicarbonate (3.0-5.0 g/day). RESULTS: The mean urine pH was significantly higher after the alkalization therapy (6.85±0.74 vs. 6.39±0.92; p<0.05). The median overall survival from the start of alkalization therapy of the patients with high urine pH (>7.0) was significantly longer than those with low urine pH (≤ 7.0) (16.1 vs. 4.7 months; p<0.05). CONCLUSION: An alkalization therapy may be associated with better outcomes in advanced pancreatic cancer patients treated with chemotherapy.


Assuntos
Recidiva Local de Neoplasia/dietoterapia , Recidiva Local de Neoplasia/tratamento farmacológico , Neoplasias Pancreáticas/dietoterapia , Neoplasias Pancreáticas/tratamento farmacológico , Bicarbonato de Sódio/administração & dosagem , Idoso , Idoso de 80 Anos ou mais , Suplementos Nutricionais , Feminino , Humanos , Concentração de Íons de Hidrogênio , Masculino , Pessoa de Meia-Idade , Metástase Neoplásica , Recidiva Local de Neoplasia/patologia , Recidiva Local de Neoplasia/urina , Neoplasias Pancreáticas/patologia , Neoplasias Pancreáticas/urina , Estudos Retrospectivos
2.
Expert Rev Proteomics ; 5(1): 21-3, 2008 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-18282120

RESUMO

The challenges encountered by proteomic researchers seeking diagnostic, prognostic and mechanistic markers were the subject of the 1-day meeting, Proteomics: Advances in Biomarker Discovery hosted by EuroSciCon. The speakers had a broad range of clinical and basic science interests, and presented data using a number of proteomic platforms to search for discriminant biomarkers of disease in easily accessible bodily fluids including serum and urine. Several potential pitfalls for proteomic researchers were mentioned and the potential of collaborative networks between research institutions to increase the size and power of clinical studies was discussed. Overall, the meeting highlighted the exciting opportunities that proteomic techniques offer for discovering not only diagnostic but also prognostic and mechanistic markers of a number of clinically important diseases.


Assuntos
Biomarcadores/análise , Proteômica/métodos , Adenocarcinoma/sangue , Adenocarcinoma/genética , Adenocarcinoma/urina , Animais , Artrite/imunologia , Artrite/metabolismo , Autoanticorpos/sangue , Biomarcadores Tumorais/análise , Biomarcadores Tumorais/imunologia , Neoplasias da Mama/radioterapia , Cartilagem Articular/química , Neoplasias Colorretais/química , Neoplasias Colorretais/diagnóstico , Proteínas de Ligação a DNA/imunologia , Análise Discriminante , Eletroforese Capilar/métodos , Eletroforese em Gel Bidimensional/métodos , Feminino , Humanos , Resistência à Insulina , Masculino , Espectrometria de Massas/métodos , Camundongos , Proteínas de Neoplasias/análise , Neoplasias Pancreáticas/genética , Neoplasias Pancreáticas/urina , Fosfopiruvato Hidratase/imunologia , Neoplasias da Próstata/sangue , Tolerância a Radiação/genética , Proteínas Supressoras de Tumor/imunologia
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