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Neurochirurgie ; 67(4): 336-345, 2021 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-33232713

RESUMO

OBJECT: Optic pathway tumors (OPT) represent a challenge for pediatric neurosurgeons. Role of surgery is debated due to the high risk of iatrogenic damage, and in lasts decades it lost its importance in favor of chemotherapy. However, in some cases surgery is necessary to make biomolecular and histological diagnosis, to manage intracranial hypertension (IH) and to cooperate with medical therapies in controlling tumor relapse. With the aim to standardize selection of surgical OPT cases, we propose a simple, practical and reproducible classification. METHODS: We retrospectively analyzed data of 38 patients with OPT treated at our institution (1990-2018). After careful analysis of MRI images, we describe a new classification system. Group 1: lesion limited to one or both optic nerve(s). Group 2: chiasmatic lesions extending minimally to hypothalamus. Group 3: hypothalamo-chiasmatic exophitic lesions invading the third ventricle; they can be further divided on the base of concomitant hydrocephalus. Group 4: hypothalamo-chiasmatic lesions extending widely in lateral direction, toward the temporal or the frontal lobes. Patients' data and adopted treatment are reported and analyzed, also depending on this classification. RESULTS: Twenty children were operated on for treatment of OPT during the study period. Permanent clinical impairment was noted in 5 (25%) of operated patients, while visual improvement was noted in 1 patient. OS rate was 100% at 5 years, with a median follow up of 9 years (ranging from 2 to 23). Prevalence of intracranial hypertension and proportion of first-line surgical treatment decision were significantly higher in groups 3-4 compared to groups 1-2 (P<0.001 for both tests). CONCLUSION: Surgery can offer a valuable therapeutic complement for OPT without major risk of iatrogenic damage. Surgery is indispensable in cases presenting with IH, as in groups 3 and 4 lesions. Eligibility of patients to surgery can be based on this new classification system.


Assuntos
Procedimentos Neurocirúrgicos/classificação , Procedimentos Neurocirúrgicos/métodos , Neoplasias do Nervo Óptico/classificação , Neoplasias do Nervo Óptico/cirurgia , Criança , Pré-Escolar , Feminino , Seguimentos , Humanos , Hipotálamo/diagnóstico por imagem , Hipotálamo/cirurgia , Lactente , Imageamento por Ressonância Magnética/métodos , Masculino , Recidiva Local de Neoplasia/classificação , Recidiva Local de Neoplasia/diagnóstico por imagem , Recidiva Local de Neoplasia/cirurgia , Quiasma Óptico/diagnóstico por imagem , Quiasma Óptico/cirurgia , Nervo Óptico/diagnóstico por imagem , Nervo Óptico/cirurgia , Glioma do Nervo Óptico/classificação , Glioma do Nervo Óptico/diagnóstico por imagem , Glioma do Nervo Óptico/cirurgia , Neoplasias do Nervo Óptico/diagnóstico por imagem , Estudos Retrospectivos
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