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1.
Altern Ther Health Med ; 30(1): 289-295, 2024 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-37820654

RESUMO

Objective: This research was conducted to investigate the therapeutic effects of tympanoplasty on patients with chronic otitis media with tinnitus and analyze the possible influencing factors for patient prognosis. Methods: This is a pre-post control group study, 86 patients with chronic otitis media were included as the subjects and enrolled into tinnitus group (n = 46) and the non-tinnitus group (n = 40). All patients underwent tympanoplasty under microscope or ear endoscopy. A tinnitus severity and efficacy assessment scale was employed for the evaluation of the severity of tinnitus among the subjects. In addition, tinnitus handicap inventory (THI) was utilized to evaluate disease alleviation. Results: Before treatment, the proportions of the patients with tinnitus at grades I, II, III, IV, and V amounted to 15.22%, 32.61%, 21.74%, 17.39%, and 13.04%, respectively, while they were 30.43%, 45.65%, 13.04%, 8.71%, and 2.17%, respectively 3 months after treatment (P < .05). THI scores for the patients in the tinnitus group before and 3 months after treatment amounted to 17.96 ± 3.66 and 16.21 ± 3.29, respectively (P < .05). After treatment, the air conduction (AC) and bone conduction (BC) thresholds and air-bone gap (ABG) of the two groups apparently declined (P < .05). No statistical significance was detected in the differences in disease classification, disease courses, and whether an electric drill was used among the patients between effective and invalid groups (P > .05). Conclusion: To some extent, tympanoplasty alleviated tinnitus among patients with chronic otitis media and promoted the restoration of hearing. Hence, it is worthy of application in clinical treatment.


Assuntos
Otite Média , Zumbido , Humanos , Zumbido/cirurgia , Timpanoplastia , Otite Média/complicações , Otite Média/cirurgia , Prognóstico , Doença Crônica , Resultado do Tratamento , Estudos Retrospectivos
2.
Altern Ther Health Med ; 29(3): 166-171, 2023 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-36795519

RESUMO

Context: The most common cause of hearing loss is chronic otitis media. Patients often exhibit ear tightness, ear plugging, conductive hearing loss, and even secondary perforation of the tympanic membrane. Patients require antibiotics to improve symptoms, and some patients need surgical repair of the membrane. Objective: The study intended to examine the effects of two methods of surgical transplantation using porcine mesentery under an otoscope on the surgical outcomes of patients with tympanic-membrane perforation secondary to chronic otitis media, with the intent to provide a basis for clinical practice. Design: The research team conducted a retrospective case-controlled study. Setting: The study took place at the Sir Run Run Shaw Hospital of the College of Medicine at Zhejiang University in Hangzhou, Zhejiang, China. Participants: Participants were 120 patients with tympanic membrane perforations that were secondary to chronic otitis media who had been admitted to the hospital between December 2017 and July 2019. Intervention: The research team divided the participants into two groups according to the surgical indications for repair of their perforations: (1) for patients with the central type of perforations with a rich residual tympanic membrane, the surgeon used the internal implantation method, and (2) for patients with a marginal or central perforation with a low residual tympanic membrane, the surgeon used the interlayer implantation method. Both groups received the implantations under conventional microscopic tympanoplasty, and the Department of Otolaryngology Head & Neck Surgery at the hospital provided the porcine mesenteric material. Outcome Measures: The research team compared the differences between the groups in operation time, blood loss, changes in the level of hearing loss between baseline and postintervention, air-bone conductivity, treatment effects, and surgical complications. Results: The operation time and blood loss of the internal implantation group were significantly greater than those of interlayer implantation group (P < .05). At 12 months postintervention, one participant in the internal implantation group had perforation recurrence, and two participants in the interlayer implantation group had infections and two had perforation recurrence. No significant difference existed between the groups in the complication rate (P > .05). Conclusions: Endoscopic repair of tympanic membrane perforations that were secondary to chronic otitis media, using porcine mesentery as the material for implantation, is a reliable treatment with few complications and good postoperative hearing recovery.


Assuntos
Perda Auditiva , Otite Média , Perfuração da Membrana Timpânica , Humanos , Suínos , Animais , Membrana Timpânica/cirurgia , Estudos Retrospectivos , Resultado do Tratamento , Perfuração da Membrana Timpânica/cirurgia , Perfuração da Membrana Timpânica/complicações , Otite Média/complicações , Otite Média/cirurgia , Perda Auditiva/complicações , Doença Crônica , Intestino Delgado
3.
Am J Otolaryngol ; 43(6): 103628, 2022.
Artigo em Inglês | MEDLINE | ID: mdl-36115081

RESUMO

BACKGROUND: Chronic otitis media is a middle ear cleft disease presenting with tympanic membrane perforation and discharge. Wet ear after tympanoplasty and discharging mastoid cavity are problematic in clinical practice. MATERIAL AND METHODS: 1050 patients of age 10 to 50 years presenting with active ear discharge and clinically diagnosed with unilateral chronic suppurative otitis media were included in the study. The patients were equally divided into two equal groups, Group ET, and AT. All patients were prescribed topical ciprofloxacin, oral levocetirizine 5 mg and n-acetyl cysteine 600 mg BD for one week. Swabs of ear discharge were collected in ET groups for antibiogram. Both groups were evaluated on next visit and treatment changed in AT groups and result observed in next visit. Surgical outcome was evaluated at end of 2 yrs. RESULT: A total of 1158 organisms were isolated in culture out of which, 69.94 % were aerobes, 13.47 % anaerobes and 16.58 % were fungi. On the second visit in group AT, treatment of 85.14 % patients was changed in accordance with culture sensitivity report. In patients with mucosal disease, only 46.87 % patients of group ET had a favorable outcome in comparison to 90.28 % patients of group AT while in patients with squamosal disease, 17.56 % patients of group ET and 28.99 % patients in group AT had a dry ear. Surgeries in AT group were found to have statistically significant higher success rate as compared to ET group.


Assuntos
Otite Média Supurativa , Otite Média , Humanos , Criança , Adolescente , Adulto Jovem , Adulto , Pessoa de Meia-Idade , Cisteína/uso terapêutico , Otite Média/tratamento farmacológico , Otite Média/cirurgia , Otite Média Supurativa/tratamento farmacológico , Otite Média Supurativa/cirurgia , Timpanoplastia , Ciprofloxacina/uso terapêutico , Testes de Sensibilidade Microbiana , Doença Crônica , Resultado do Tratamento , Processo Mastoide/cirurgia
4.
Acta Otorhinolaryngol Ital ; 42(3): 293-299, 2022 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-35880370

RESUMO

Objective: To evaluate the long-term quality of life (QoL) in patients operated for cholesteatoma by canal wall-up tympanoplasty (CWUT) or canal wall-down tympanoplasty (CWDT) with mastoid obliteration. Methods: QoL was evaluated by the Chronic Otitis Media Questionnaire - 12 (COMQ-12). For each patient, the total score and three partial subscores, concerning disease activity, functional impairment and general impact on the patient's life were calculated. These scores were correlated with the surgical technique, as well as anatomical and functional results. Results: 68 procedures were classified as CWUT and 78 as CWDT with obliteration. The mean follow-up was 65 months. Total and partial COMQ-12 scores did not show any significant difference between the two groups. Correlation analysis showed a significant direct association between the postoperative Air-Bone Gap (ABG) and both the COMQ-12 total score and functional subscore in the CWUT group. Conclusions: This is the first study comparing CWUT and CWDT with obliteration with the COMQ-12, thus confirming the overlapping results in terms of QoL. These findings, together with the evidence of the significantly lower rates of recidivism, show that CWDT with obliteration should be considered as a good alternative to CWUT.


Assuntos
Colesteatoma da Orelha Média , Otite Média , Colesteatoma da Orelha Média/cirurgia , Doença Crônica , Humanos , Processo Mastoide/cirurgia , Otite Média/cirurgia , Qualidade de Vida , Resultado do Tratamento , Timpanoplastia/métodos
5.
Otolaryngol Pol ; 71(5): 12-17, 2017 Oct 30.
Artigo em Inglês | MEDLINE | ID: mdl-29154248

RESUMO

INTRODUCTION: Surgical treatment of conductive hearing loss runs the risk of damage to the inner ear in the mechanism of acoustic trauma. AIM: The aim of this study was to evaluate the function of the organ of Corti, expressed as bone conduction threshold at the frequency of 4000 Hz for selected operations: mastoidectomy and canal-wall-down procedure. MATERIAL AND METHODS: The material was collected from patients with chronic otitis media in the Department of Otolaryngology and ENT Oncology, Collegium Medicum of Nicolaus Copernicus University in Bydgoszcz in 2004-2009. All patients were examined with pure tone audiometry threshold before surgery and at least three years after surgery. The analyzed group of patients was divided into subgroups depending on the type of operation according to To classification and procedures for resection: mastoidectomy and canal-wall-down procedure. The results were statistically analyzed. RESULTS: In the analyzed period of three years after surgery there was no statistically significant difference between groups, although there were higher values for tympanoplasty type 1 with mastoidectomy compared with tympanoplasty type 1 without mastoidectomy - respectively 25.67 dB and 18.53 dB. In the study, there was no statistically significant the difference in bone conduction threshold for frequency 4000 Hz within the type 2 tympanoplasty according to Tosa comparing canal wall-up and canal-wall-down procedure. CONCLUSIONS: Mastoidectomy or canal-wall-down procedure do not affect the bone conduction threshold for a frequency of 4000 Hz after tympanoplasty in long-term observation.


Assuntos
Condução Óssea , Otite Média/cirurgia , Discriminação da Altura Tonal , Timpanoplastia/efeitos adversos , Estimulação Acústica , Audiometria , Limiar Auditivo , Doença Crônica , Feminino , Humanos , Masculino , Resultado do Tratamento
6.
PLoS One ; 10(11): e0142341, 2015.
Artigo em Inglês | MEDLINE | ID: mdl-26580411

RESUMO

Synapses between cochlear nerve terminals and hair cells are the most vulnerable elements in the inner ear in both noise-induced and age-related hearing loss, and this neuropathy is exacerbated in the absence of efferent feedback from the olivocochlear bundle. If age-related loss is dominated by a lifetime of exposure to environmental sounds, reduction of acoustic drive to the inner ear might improve cochlear preservation throughout life. To test this, we removed the tympanic membrane unilaterally in one group of young adult mice, removed the olivocochlear bundle in another group and compared their cochlear function and innervation to age-matched controls one year later. Results showed that tympanic membrane removal, and the associated threshold elevation, was counterproductive: cochlear efferent innervation was dramatically reduced, especially the lateral olivocochlear terminals to the inner hair cell area, and there was a corresponding reduction in the number of cochlear nerve synapses. This loss led to a decrease in the amplitude of the suprathreshold cochlear neural responses. Similar results were seen in two cases with conductive hearing loss due to chronic otitis media. Outer hair cell death was increased only in ears lacking medial olivocochlear innervation following olivocochlear bundle cuts. Results suggest the novel ideas that 1) the olivocochlear efferent pathway has a dramatic use-dependent plasticity even in the adult ear and 2) a component of the lingering auditory processing disorder seen in humans after persistent middle-ear infections is cochlear in origin.


Assuntos
Cóclea/fisiopatologia , Nervo Coclear/fisiopatologia , Perda Auditiva Condutiva/fisiopatologia , Membrana Timpânica/fisiopatologia , Estimulação Acústica , Animais , Limiar Auditivo , Cóclea/inervação , Cóclea/cirurgia , Nervo Coclear/cirurgia , Modelos Animais de Doenças , Potenciais Evocados Auditivos do Tronco Encefálico/fisiologia , Células Ciliadas Auditivas Externas/patologia , Perda Auditiva Condutiva/cirurgia , Humanos , Masculino , Camundongos , Otite Média/fisiopatologia , Otite Média/cirurgia , Sinapses/patologia , Membrana Timpânica/inervação , Membrana Timpânica/cirurgia
7.
Clinics (Sao Paulo) ; 68(7): 954-9, 2013 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-23917659

RESUMO

OBJECTIVE: To analyze auditory processing test results in children suffering from otitis media in their first five years of age, considering their age. Furthermore, to classify central auditory processing test findings regarding the hearing skills evaluated. METHODS: A total of 109 students between 8 and 12 years old were divided into three groups. The control group consisted of 40 students from public school without a history of otitis media. Experimental group I consisted of 39 students from public schools and experimental group II consisted of 30 students from private schools; students in both groups suffered from secretory otitis media in their first five years of age and underwent surgery for placement of bilateral ventilation tubes. The individuals underwent complete audiological evaluation and assessment by Auditory Processing tests. RESULTS: The left ear showed significantly worse performance when compared to the right ear in the dichotic digits test and pitch pattern sequence test. The students from the experimental groups showed worse performance when compared to the control group in the dichotic digits test and gaps-in-noise. Children from experimental group I had significantly lower results on the dichotic digits and gaps-in-noise tests compared with experimental group II. The hearing skills that were altered were temporal resolution and figure-ground perception. CONCLUSION: Children who suffered from secretory otitis media in their first five years and who underwent surgery for placement of bilateral ventilation tubes showed worse performance in auditory abilities, and children from public schools had worse results on auditory processing tests compared with students from private schools.


Assuntos
Percepção Auditiva/fisiologia , Otite Média/fisiopatologia , Estimulação Acústica , Estudos de Casos e Controles , Criança , Feminino , Audição/fisiologia , Testes Auditivos , Humanos , Masculino , Ventilação da Orelha Média , Otite Média/cirurgia , Valores de Referência , Estatísticas não Paramétricas
8.
Clinics ; 68(7): 954-959, jul. 2013. tab, graf
Artigo em Inglês | LILACS | ID: lil-680718

RESUMO

OBJECTIVE: To analyze auditory processing test results in children suffering from otitis media in their first five years of age, considering their age. Furthermore, to classify central auditory processing test findings regarding the hearing skills evaluated. METHODS: A total of 109 students between 8 and 12 years old were divided into three groups. The control group consisted of 40 students from public school without a history of otitis media. Experimental group I consisted of 39 students from public schools and experimental group II consisted of 30 students from private schools; students in both groups suffered from secretory otitis media in their first five years of age and underwent surgery for placement of bilateral ventilation tubes. The individuals underwent complete audiological evaluation and assessment by Auditory Processing tests. RESULTS: The left ear showed significantly worse performance when compared to the right ear in the dichotic digits test and pitch pattern sequence test. The students from the experimental groups showed worse performance when compared to the control group in the dichotic digits test and gaps-in-noise. Children from experimental group I had significantly lower results on the dichotic digits and gaps-in-noise tests compared with experimental group II. The hearing skills that were altered were temporal resolution and figure-ground perception. CONCLUSION: Children who suffered from secretory otitis media in their first five years and who underwent surgery for placement of bilateral ventilation tubes showed worse performance in auditory abilities, and children from public schools had worse results on auditory processing tests compared with students from private schools. .


Assuntos
Criança , Feminino , Humanos , Masculino , Percepção Auditiva/fisiologia , Otite Média/fisiopatologia , Estimulação Acústica , Estudos de Casos e Controles , Testes Auditivos , Audição/fisiologia , Ventilação da Orelha Média , Otite Média/cirurgia , Valores de Referência , Estatísticas não Paramétricas
9.
Otol Neurotol ; 33(1): 48-53, 2012 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-22143300

RESUMO

OBJECTIVES: Investigate the recurrence of chronic otitis media after primary and revision myringoplasty, compare long-term anatomic and audiologic results of underlay and overlay myringoplasty, and examine the prognostic factors. STUDY DESIGN: Retrospective study. PATIENTS: Approximately 1,040 adult patients with chronic simple otitis media undergoing a myringoplasty (overlay and underlay) by different surgeons at a single institution (ENT Department of Bergamo Ospedali Riuniti) between May 1999 and March 2009. METHODS: The cumulative recurrence rate of chronic otitis media during 10-year follow-up period was calculated using a Kaplan-Meier survival analysis. A multivariate analysis was used to evaluate different prognostic factors based on long-term outcome in myringoplasty. RESULTS: The overall 10-year graft success rate was 78% in 1,040 patients. The 10-year recurrence rate of chronic otitis media was 15% in overlay myringoplasty and 26% using the underlay technique (p < 0.05). In revision myringoplasty, the overlay technique showed a better success rate than underlay (p < 0.05). Significant recovery was observed in the air conduction thresholds and air-bone gaps in both groups with no statistical difference between techniques (p = 0.1). Multivariate analysis demonstrated that the underlay myringoplasty technique, a pathologic contralateral ear and an anterior or subtotal perforation, using a perichondrial graft or age of surgery younger than 40 years were statistically significant (p < 0.01) factors that negatively influenced the myringoplasty outcomes. CONCLUSION: More successful outcomes in primary and revision surgery for chronic otitis media occurred using overlay myringoplasty, although there were more minor postoperative complications. Both clinical and technical variables affected the success rate of myringoplasty.


Assuntos
Miringoplastia/métodos , Otite Média/cirurgia , Adulto , Idoso , Idoso de 80 Anos ou mais , Anestesia Local , Ossículos da Orelha/patologia , Orelha Média/patologia , Epitélio/patologia , Feminino , Perda Auditiva Condutiva/etiologia , Humanos , Estimativa de Kaplan-Meier , Masculino , Pessoa de Meia-Idade , Análise Multivariada , Otite Média/patologia , Prognóstico , Reoperação , Análise de Sobrevida , Resultado do Tratamento , Membrana Timpânica/patologia , Perfuração da Membrana Timpânica/complicações , Perfuração da Membrana Timpânica/cirurgia , Adulto Jovem
10.
Acta Otolaryngol ; 129(11): 1206-11, 2009 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-19863312

RESUMO

CONCLUSION: The pathology of chronic otitis media (COM) could delay and reduce the energy transfer of sound to the inner ear. The significant improvement of postoperative vestibular evoked myogenic potential (VEMP) response rate and p13 latencies in the group of patients with no or negative postoperative ABG gain provided evidence that the sound energy inducing a VEMP might be different from the energy producing the auditory perception. OBJECTIVE: To evaluate the VEMP in patients with COM before and after surgery. SUBJECTS AND METHODS: Twenty-four subjects with unilateral COM were enrolled. A pure tone audiogram and VEMP using 500 Hz unilateral short tone-burst stimulations were recorded before and 3 months after surgery. The postoperative VEMP responses were compared with the responses before surgery and the healthy controls. RESULTS: After surgery, the 500 Hz air-bone gap (ABG) decreased significantly and the VEMP response rate increased significantly from 41.7% to 66.7% (p<0.05, bi-test). However, both the preoperative and postoperative p13 latencies were significantly longer than those of the healthy controls (p<0.05, Wilcoxon rank-sum test). In the 18 patients whose 500 Hz ABG did not improve with surgery, the p13 latencies were significantly shorter postoperatively (p<0.05, sign test), and the response rate also improved significantly from 44.4% (8/18) to 77.8% (14/18) (p<0.05, bi-test).


Assuntos
Potencial Evocado Motor/fisiologia , Otite Média/fisiopatologia , Otite Média/cirurgia , Complicações Pós-Operatórias/fisiopatologia , Testes de Função Vestibular , Estimulação Acústica , Adulto , Idoso , Audiometria de Tons Puros , Limiar Auditivo/fisiologia , Condução Óssea/fisiologia , Colesteatoma da Orelha Média/fisiopatologia , Colesteatoma da Orelha Média/cirurgia , Doença Crônica , Feminino , Seguimentos , Humanos , Masculino , Mastoidite/fisiopatologia , Mastoidite/cirurgia , Pessoa de Meia-Idade , Músculos do Pescoço/inervação , Tempo de Reação/fisiologia , Reflexo/fisiologia , Processamento de Sinais Assistido por Computador , Timpanoplastia , Nervo Vestibular/fisiopatologia
11.
Otol Neurotol ; 30(3): 332-8, 2009 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-19174710

RESUMO

OBJECTIVE: To compare the reconstruction results of a long incus process defect using 3 different partial ossicular replacement prostheses (PORP). STUDY DESIGN: Temporal bone experiments and retrospective case review. SETTING: Tertiary referral center. EXPERIMENTAL MATERIAL AND PATIENTS: The experimental study was performed on 18 temporal bones; 66 patients with retraction pockets, chronic otitis media with or without cholesteatoma. INTERVENTIONS: Ossiculoplasty using 3 different PORP: titanium angle prosthesis, autologous incus interposition, and titanium clip prosthesis. MAIN OUTCOME MEASURES: Laser Doppler vibrometry in temporal bones measured transmission properties of the PORP. Patients were retrospectively assessed up to 5 years after surgery. Audiologic data were analyzed for preoperative and postoperative air conduction and air-bone gap at 0.5, 1, 2, 3, and 4 kHz. Statistical analyses compared the outcome in the experimental and clinical setting. RESULTS: Experimentally, the titanium PORP showed similar transmission properties because the overall difference to the intact specimen was -4.14 +/- 0.59 dB for the titanium angle prosthesis and -4.61 +/- 0.57 dB for the titanium clip prosthesis. The transmission after an autologous incus interposition was significantly worse (-9.32 +/- 0.39 dB, p < or = 0.001) compared with the other prostheses. Patients' mean postoperative air-bone gap was 25.5 +/- 1.2 dB and less than 20 dB in at least 66% of cases without any significant differences between the groups. CONCLUSION: In the clinical setting, the confounding factors that influence the acoustic outcome after partial ossiculoplasty obscure the prosthesis-related transmission factors that can otherwise be derived in the experimental setting. The results do not generally favor the use of 1 specific prosthesis, rather they suggest that the correct choice of a prosthesis be based on the anatomic and pathophysiologic conditions found in the individual patient.


Assuntos
Ossículos da Orelha/cirurgia , Prótese Ossicular , Substituição Ossicular/métodos , Procedimentos Cirúrgicos Otológicos , Estimulação Acústica , Adulto , Audiometria , Audiometria de Tons Puros , Condução Óssea/fisiologia , Colesteatoma/complicações , Colesteatoma/cirurgia , Interpretação Estatística de Dados , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Otite Média/complicações , Otite Média/cirurgia , Estribo/patologia , Osso Temporal/patologia , Resultado do Tratamento , Perfuração da Membrana Timpânica/complicações , Perfuração da Membrana Timpânica/cirurgia , Timpanoplastia
12.
Acta Otolaryngol ; 129(7): 726-8, 2009 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-18787981

RESUMO

CONCLUSION: Retroauricular tympanoplasty and tympanomastoidectomy under local anesthesia with sedation can be well tolerated by the patient, with minimum discomfort. OBJECTIVES: To evaluate patient discomfort from pain, body/neck position, noise, and anxiety during tympanoplasties and mastoidectomies performed under local anesthesia with sedation. PATIENTS AND METHODS: This was a prospective study of 83 surgeries in 62 patients (28 type I tympanoplasties, 12 tympanoplasties with ossicular reconstruction, 40 canal wall up mastoidectomies, and 3 revision tympanoplasties). Local infiltration used lidocaine 2% with 1:100 000 epinephrine infiltrated in the retroauricular area and from below the pinna in a 'V' pattern. Sedation was achieved with 50 mg of intramuscular promethazine 1 h before surgery and intravenous midazolam (0.03 mg/kg) at the beginning of surgery. Subsequent doses of midazolam were given to maintain adequate sedation, up to 10 mg. The discomfort during surgery was assessed by the patient with a score from 0 to 4 (0 = no discomfort and 4 = extreme discomfort). RESULTS: Discomfort due to pain had a mean score of 0.83. Noise discomfort (from drilling and manipulation of instruments) had the lowest mean score (0.70), and discomfort from body and neck position had the highest mean score (1.51).


Assuntos
Anestesia Local , Sedação Consciente , Processo Mastoide/cirurgia , Otite Média/cirurgia , Medição da Dor , Satisfação do Paciente , Timpanoplastia/métodos , Adolescente , Adulto , Anestesia Local/psicologia , Ansiedade/prevenção & controle , Ansiedade/psicologia , Doença Crônica , Sedação Consciente/psicologia , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Medição da Dor/psicologia , Estudos Prospectivos , Timpanoplastia/psicologia , Adulto Jovem
13.
Otol Neurotol ; 27(2): 265-9, 2006 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-16436999

RESUMO

HYPOTHESIS: Irrigation of the mastoid with a quinolone antibiotic-steroid solution may mitigate hearing loss caused by iatrogenic semicircular canal injury in the presence of Pseudomonas aeruginosa (PA) otitis media (OM). BACKGROUND: Studies have shown the cochlea to be more vulnerable to semicircular canal transection (SCT)-related hearing loss in the presence of PA OM. Prophylactic systemic antibiotics and steroids may decrease this hearing loss, but SCT is usually not planned. The aim of this study was to determine if irrigation with ciprofloxacin-dexamethasone (cipro-dex) could improve hearing outcomes following SCT in PA OM. METHODS: PA OM was induced in 28 animals. After three to five days, unilateral SCT was performed in each animal, with sham SCT on the contralateral ear. At surgery, half of the animals (n = 14) underwent irrigation of the both mastoid bullae with cipro-dex; the second group of animals (n = 14) underwent irrigation of the bullae with sterile saline. Auditory thresholds were obtained immediately prior to SCT and 7-10 days after SCT. RESULTS: SCT ears treated with cipro-dex showed a mean click threshold improvement of 4.6 dB from pre-transection to 7-10 days post-transection, whereas thresholds in the SCT ears treated with saline worsened by 7.5 dB (p = 0.15). CONCLUSION: Irrigation of the guinea pig bulla with cipro-dex following SCT in the setting of PA OM appears safe and may yield beneficial effects on hearing.


Assuntos
Anti-Infecciosos/uso terapêutico , Glucocorticoides/uso terapêutico , Perda Auditiva Neurossensorial/tratamento farmacológico , Otite Média/cirurgia , Infecções por Pseudomonas/cirurgia , Canais Semicirculares/cirurgia , Animais , Anti-Infecciosos/administração & dosagem , Limiar Auditivo/efeitos dos fármacos , Ciprofloxacina/administração & dosagem , Ciprofloxacina/uso terapêutico , Dexametasona/administração & dosagem , Dexametasona/uso terapêutico , Glucocorticoides/administração & dosagem , Cobaias , Perda Auditiva Neurossensorial/etiologia , Processo Mastoide , Otite Média/microbiologia , Cuidados Pós-Operatórios , Complicações Pós-Operatórias/tratamento farmacológico , Complicações Pós-Operatórias/etiologia , Pseudomonas aeruginosa/patogenicidade , Canais Semicirculares/lesões , Irrigação Terapêutica , Resultado do Tratamento
14.
J Am Vet Med Assoc ; 227(5): 748-55, 2005 Sep 01.
Artigo em Inglês | MEDLINE | ID: mdl-16178396

RESUMO

OBJECTIVE: To evaluate differences in bacterial numbers, identity, and susceptibility in samples obtained from the tympanic cavity on entry (preflush) and after evacuation and lavage (postflush) and assess perioperative and empiric antimicrobial selection in dogs that underwent total ear canal ablation (TECA) with lateral bulla osteotomy (LBO) or reoperation LBO. DESIGN: Prospective clinical study. ANIMALS: 34 dogs. PROCEDURE: TECA with LBO or reoperation LBO was performed on 47 ears. Pre- and postflush aerobic and anaerobic samples were obtained from the tympanic cavity. Isolates and antimicrobial susceptibility patterns were compared. RESULTS: Different isolates (31/44 [70%] ears) and susceptibility patterns of isolate pairs (6/44 [14%] ears) were detected in pre- and postflush samples from 84% of ears. Evacuation and lavage of the tympanic cavity decreased the number of bacterial isolates by 33%. In 26% of ears, bacteria were isolated from post-flush samples but not preflush samples. Only 26% of isolates tested were susceptible to cefazolin. At least 1 isolate from 53% of dogs that received empirically chosen antimicrobials postoperatively was resistant to the selected drugs. Anaerobic bacteria were recovered from 6 ears. CONCLUSIONS AND CLINICAL RELEVANCE: Accurate microbiologic assessment of the tympanic cavity should be the basis for selection of antimicrobials in dogs undergoing TECA with LBO. Bacteria remain in the tympanic cavity after evacuation and lavage. Cefazolin was a poor choice for dogs that underwent TECA with LBO, as judged on the basis of culture and susceptibility testing results.


Assuntos
Antibacterianos/uso terapêutico , Doenças do Cão/cirurgia , Meato Acústico Externo/cirurgia , Orelha Média , Otite Externa/veterinária , Otite Média/veterinária , Animais , Antibacterianos/farmacologia , Contagem de Colônia Microbiana/veterinária , Doenças do Cão/tratamento farmacológico , Doenças do Cão/microbiologia , Cães , Farmacorresistência Bacteriana , Orelha Média/microbiologia , Orelha Média/cirurgia , Feminino , Bactérias Gram-Negativas/efeitos dos fármacos , Bactérias Gram-Negativas/crescimento & desenvolvimento , Bactérias Gram-Positivas/efeitos dos fármacos , Bactérias Gram-Positivas/crescimento & desenvolvimento , Masculino , Testes de Sensibilidade Microbiana/veterinária , Osteotomia/veterinária , Otite Externa/tratamento farmacológico , Otite Externa/microbiologia , Otite Externa/cirurgia , Otite Média/tratamento farmacológico , Otite Média/microbiologia , Otite Média/cirurgia , Estudos Prospectivos
15.
Laryngoscope ; 115(2): 363-5, 2005 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-15689767

RESUMO

OBJECTIVE: To compare the effectiveness of ciprofloxacin and oxymetazoline solutions instilled after tympanostomy tube placement in the prevention of postoperative otorrhea and tube occlusion. STUDY DESIGN: Prospective cross-sectional series. METHODS: We reviewed all bilateral myringotomy and tube placement operations performed by two full-time attending pediatric otolaryngologists during a 9 month period. Data from 488 patients who underwent surgery for otitis media were collected. Demographic and clinical variables including age, sex, number of tube insertions in the past, previous adenoidectomy, type of effusion present at surgery, and type of drop prescribed postoperatively were recorded. All patients were evaluated in the office 2 to 4 weeks postoperatively. Multivariate logistic regression analysis was used to estimate the relationship of these variables with the occurrence of otorrhea and tube patency. Odds ratios were calculated. RESULTS: No significant differences in postoperative otorrhea or tube patency were found between ciprofloxacin (Ciloxan) and oxymetazoline solutions (Afrin, Visine LR). CONCLUSION: Oxymetazoline and ciprofloxacin solutions are equivalent in the prevention of postoperative otorrhea and tube occlusion after tympanostomy tube placement. The implications for medication cost and potential adverse reactions are discussed.


Assuntos
Agonistas alfa-Adrenérgicos/uso terapêutico , Anti-Infecciosos/uso terapêutico , Antibioticoprofilaxia , Ciprofloxacina/uso terapêutico , Ventilação da Orelha Média , Otite Média com Derrame/prevenção & controle , Otite Média/cirurgia , Oximetazolina/uso terapêutico , Complicações Pós-Operatórias/prevenção & controle , Administração Tópica , Adolescente , Anti-Infecciosos/administração & dosagem , Criança , Pré-Escolar , Doença Crônica , Ciprofloxacina/administração & dosagem , Humanos , Lactente , Modelos Logísticos , Recidiva
16.
Ann Otol Rhinol Laryngol ; 111(7 Pt 1): 642-52, 2002 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-12126022

RESUMO

We measured blood levels of fatty acids, vitamin A, and trace metals in children undergoing ambulatory surgery for placement of tympanostomy tubes and a comparison group having other ambulatory surgical procedures. We then performed a small, outpatient, secondary prevention study using nutritional supplements chosen on the basis of those blood levels. The study subjects had lower levels of red blood cell eicosapentaenoic acid (EPA) than did adult controls. Consistent with previous reports, the levels of vitamin A were < or = 40 microg/dL for 69% of our subjects, and the plasma selenium levels for children were lower than published values for adults. We then studied one otitis media (OM) season; 8 children (0.8 to 4.4 years of age) received 1 teaspoon of lemon-flavored cod liver oil (containing both EPA and vitamin A) and 1 half-tablet of a selenium-containing children's chewable multivitamin-mineral tablet per day. During this OM season, study subjects received antibiotics for OM for 12.3% +/- 13.4% (SD; p < .05) fewer days during supplementation than before supplementation. Larger, controlled trials are warranted to assess the utility of cod liver oil (of acceptable purity and taste) and a children's multivitamin-mineral preparation containing selenium, both for the prevention of OM and for the acceptance of delayed prescription of antibiotics for this disorder.


Assuntos
Óleo de Fígado de Bacalhau/uso terapêutico , Suplementos Nutricionais , Minerais/uso terapêutico , Otite Média/prevenção & controle , Vitaminas/uso terapêutico , Doença Aguda , Pré-Escolar , Citrus , Ácido Eicosapentaenoico/sangue , Eritrócitos/química , Feminino , Aromatizantes , Humanos , Lactente , Masculino , Ventilação da Orelha Média , Minerais/análise , Otite Média/cirurgia , Projetos Piloto , Vitaminas/análise
17.
Laryngoscope ; 111(1): 87-9, 2001 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-11192905

RESUMO

OBJECTIVE: To describe the role of OtoScan laser-assisted myringotomy (OtoLAM) for indications other than chronic otitis media or recurrent acute otitis media. STUDY DESIGN: Cross-sectional review. METHODS: Twenty-seven office-based OtoLAM procedures were performed in 21 patients for "atypical" reasons. The indications included middle ear dysfunction with necessary air travel (n = 10) or hyperbaric oxygen treatment (n = 6), mastoiditis with postauricular cellulitis (n = 2), canal exostosis prohibiting tympanostomy (n = 1), acute otitis media accompanied by seizures (n = 1), and chronic middle ear effusion in a patient with hemophilia (n = 1). RESULTS: In each of the 20 cases available for follow-up, middle ear disease resolved with closure of the laser-assisted myringotomy. At a later date, two patients (10%) underwent another OtoLAM in the opposite ear and four patients (20%) required repeat OtoLAM in the same or both ears. Three patients (15%) ultimately underwent myringotomy tube placement because of recurrent middle ear dysfunction. CONCLUSIONS: Although this report contains preliminary data, the data suggest that OtoLAM may provide an additional option in the care of certain patients who have previously been treated with myringotomy tubes.


Assuntos
Terapia a Laser/métodos , Membrana Timpânica/cirurgia , Doença Aguda , Adolescente , Adulto , Idoso , Aeronaves , Celulite (Flegmão)/cirurgia , Criança , Pré-Escolar , Doença Crônica , Estudos Transversais , Meato Acústico Externo/cirurgia , Otopatias/cirurgia , Orelha Média/cirurgia , Exostose/cirurgia , Seguimentos , Hemofilia A/complicações , Humanos , Oxigenoterapia Hiperbárica , Lactente , Mastoidite/cirurgia , Pessoa de Meia-Idade , Ventilação da Orelha Média , Otite Média/cirurgia , Otite Média com Derrame/cirurgia , Recidiva , Reoperação , Estudos Retrospectivos , Convulsões/complicações , Viagem
18.
Nihon Jibiinkoka Gakkai Kaiho ; 99(12): 1746-50, 1996 Dec.
Artigo em Japonês | MEDLINE | ID: mdl-8997092

RESUMO

Between 1978 and 1981, Feldmann's osteopathic approach was often used to manage chronic middle ear disease. In this procedure, the superior and posterior segment of the ear canal wall was cut after complete mastoidectomy, removed temporarily and re-positioned in the previous position after handling the diseased focus in the tympanic isthmus area. Forty-one cases (24 cases of non-cholesteatomatous chronic otitis media and 17 cases of cholesteatoma) were followed and long-term results of this procedure were studied with regard to re-operative findings following this procedure. Among the 41 patients, 13 (31.7%) required revision surgery because of cholesteatoma formation, infection etc. Seven of these 13 patients (53.8%) required revision surgery because of cholesteatoma formation after this procedure. None of these 7 cases appeared to involve residual cholesteatoma. The most important problem is that 3 of the 7 patients showing cholesteatoma formation had non-cholesteatomatous chronic otitis media before this procedure. In other words, the Feldmann's osteoplastic approach may iatrogenically induce cholesteatoma formation in non-cholesteatomatous chronic otitis media. The re-operative findings indicated that the re-positioned canal wall in this procedure may have small bony defects or bony erosion, inducing pocket formation through these defects to create a new cholesteatoma. Although recent literature concerning tympanoplasty recommends posterior canal wall reconstruction using cartilage, bone, ceramic material or bone-pate rather than the canal wall down method, careful follow-up should be continued with regard to pocket formation and/or cholesteatoma formation.


Assuntos
Colesteatoma da Orelha Média/cirurgia , Meato Acústico Externo/cirurgia , Otite Média/cirurgia , Doença Crônica , Humanos , Microcirurgia/métodos , Reoperação
20.
Otolaryngol Pol ; 48(3): 282-7, 1994.
Artigo em Polonês | MEDLINE | ID: mdl-8090493

RESUMO

The bone conduction threshold changes of 295 ears which underwent chronic ear surgery (177 ears) or stapedectomy (118 ears) were determined by comparing last preoperative with 4 to 6 weeks postoperative audiogram. Three types of middle ear operations were evaluated: radical mastoidectomy, modified radical mastoidectomy and intact wall mastoidectomy with tympanoplasty (first stage). A total stapedectomy was performed with adipose seal and tarflen prosthesis. The preoperative mean bone conduction thresholds of radical mastoidectomy at 2000-4000 Hz frequency range was significantly worse when compared to radical modified mastoidectomy and to mastoidectomy with tympanoplasty (first stage). A significant deterioration of mean bone conduction thresholds at 500 Hz, 1000 Hz, 2000 Hz and 4000 Hz was observed after open techniques and at 2000 Hz and 4000 Hz after intact wall mastoidectomy with tympanoplasty (first stage). After stapedectomy a positive change (improvement of mean bone conduction) was noted at 1000 Hz and 2000 Hz. It seems that observed changes in the bone conduction thresholds may be due to damaging risk of surgical procedure (chronic ear surgery and stapedectomy) and influence of ossicular chain mobilisation on bone conduction transmission (stapedectomy).


Assuntos
Condução Óssea , Orelha Média/cirurgia , Otite Média/cirurgia , Cirurgia do Estribo , Estimulação Acústica , Adolescente , Adulto , Idoso , Audiometria , Limiar Auditivo , Doença Crônica , Orelha Média/fisiopatologia , Feminino , Humanos , Masculino , Processo Mastoide/cirurgia , Pessoa de Meia-Idade , Otite Média/fisiopatologia , Timpanoplastia
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