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1.
Health Promot J Austr ; 35(1): 225-234, 2024 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-36961054

RESUMO

ISSUE ADDRESSED: Aboriginal and Torres Strait Islander child ear health is complex and multiple. We examined relationships between parent-reported sociodemographic, child health, health service access factors and ear symptoms among Aboriginal and Torres Strait Islander children aged 3 to 7 years. METHODS: The Longitudinal Study of Indigenous Children is a large child cohort study with annual parent-reported data collection. Generalised linear mixed model analyses examined Wave 1 (1309 children 0-5 years; 2008) predictors of being free of parent-reported ear symptoms in both Waves 2 and 3. RESULTS: A total of 1030 (78.7%) had no reported ear symptoms in either Wave 2 or 3. In the fully adjusted model, children who had been hospitalised in the past year (aOR = 2.16; 95% CI 1.19-3.93) and those with no ear symptoms (aOR = 2.94; 95% CI, 1.59-5.46) at Wave 1 had higher odds of no ear symptoms in both the subsequent waves. There were also relationships between parent main source of income-government pension or allowance as well as parents who reported no history of their own ear symptoms and higher odds of no ear symptoms in Waves 2 and 3 after partial adjustment for sociodemographic factors. CONCLUSION: These findings suggest relationships between different sociodemographic and health factors and parent-reported ear symptoms among Aboriginal and Torres Strait Islander children that warrant further investigation. So what? Children with parent-reported ear symptoms during the early years need holistic support to prevent future ear symptoms that impact health, social and educational life trajectories.


Assuntos
Povos Aborígenes Australianos e Ilhéus do Estreito de Torres , Otopatias , Serviços de Saúde do Indígena , Criança , Humanos , Estudos de Coortes , Coleta de Dados , Estudos Longitudinais , Pais , Otopatias/epidemiologia
2.
Otolaryngol Clin North Am ; 56(5): 869-879, 2023 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-37550106

RESUMO

There are a large variety of over-the-counter home remedies and devices for cerumen impaction available in the United States. It is a challenge for clinicians to maintain awareness of the safety and efficacy of these tools, as they are not considered "medical devices" and frequently have no requirement for demonstrating safety or efficacy. This article provides a broad overview of the products being advertised to patients and discusses considerations when recommending home cerumen maintenance.


Assuntos
Meato Acústico Externo , Otopatias , Humanos , Cerume
3.
Med Sci Monit ; 29: e938879, 2023 Mar 10.
Artigo em Inglês | MEDLINE | ID: mdl-36895146

RESUMO

BACKGROUND Balloon dilation eustachian tuboplasty (BET) is used to treat eustachian dysfunction but its therapeutic effect and cost-effectiveness when combined with tympanotomy tube insertion (TBI) on refractory otitis media with effusion under local anesthesia with sedation compared to traditional general anesthesia are not well understood. MATERIAL AND METHODS Forty patients with refractory secretory otitis media who received BET+TBI were enrolled in this study and randomized into the local anesthesia with sedation group (n=20) and general anesthesia group (n=20). Tympanometry (TMM), 7-item eustachian tube dysfunction questionnaire (ETDQ-7) results, intraoperative anesthesia accidents, and operation costs were compared between the groups. RESULTS Patients in the local anesthesia with sedation group exhibited intraoperative awareness and pain. Differences in TMM, ETDQ-7 results, and postoperative VAS scores between the groups were comparable (P>0.05). Notably, operative time and treatment costs in the local anesthesia group were lower compared with general anesthesia group. CONCLUSIONS The treatment effects and safety of local anesthesia and general anesthesia under BET combined with TBI for treatment of refractory otitis media with effusion are comparable. However, further studies should aim at reducing pain and discomfort.


Assuntos
Otopatias , Tuba Auditiva , Otite Média com Derrame , Humanos , Otite Média com Derrame/cirurgia , Anestesia Local , Resultado do Tratamento , Tuba Auditiva/cirurgia , Dilatação/métodos , Estudos Prospectivos , Anestesia Geral , Otopatias/cirurgia , Dor
4.
Niger J Clin Pract ; 25(11): 1823-1830, 2022 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-36412289

RESUMO

Background: The use of complementary and alternative medicine (CAM) in the treatment of various ailments globally has called for more research. Aim: This study aimed to draw the attention of the stakeholders to the prevalence, pattern and awareness of CAM usage in otorhinolaryngological ailments and the need to safeguard the health of CAM users in Ekiti state, south - west Nigeria. Patients and Methods: This is a cross sectional descriptive study carried out over a 12-month period (January to December, 2019) among consented patients that attended ear, nose, and Throat (ENT) clinics in two tertiary health institutions in Ekiti state. All the participants are aged 18 years and above. A self-administered semi structured questionnaire was used to collect data from our respondents. Results: A total of 148 respondents were analyzed comprising of 56 (37.8%) males and 92 (62.2%) females given a male to female ratio of 1:1.6. Their age ranged from 20-79 years with a mean of 48.03 ± 15.11 SD. The highest response was in the age group 40-49 years representing 30.4% of the respondents. About half (51.4%) of our respondents were aware of the use of CAM for throat-related conditions. Few of the respondents (18.9%) are currently using CAM. About 33.1% of our respondents were satisfied with CAM. Only 4 (2.7%) of them experienced side effects to the use of CAM. For ear-related problems, Anointing/Olive (Olea europaea) oil was most commonly used in 34.5% of our respondents; Effinrin (Ocimum gratissimum), a local herb was commonly used in 29.7% for nose and local gin in 37.2% of our respondents for throat problems. Majority of them 44 (29.7%) got information about the various agents used through Vendors/traditional health practitioner. Conclusion: This study showed that the prevalent of CAM usage in ORL is quite low in our setting, which represent about one-fifth of the respondents. Although respondents claimed that the system was efficacious, awareness to its usage was very low and there was no evidence to prove that the diagnosis were known before using CAM. The use of Orthodox method in treating Otorhinolaryngological ailments is still the best. We therefore recommend empirical studies on CAM in future.


Assuntos
Terapias Complementares , Otopatias , Humanos , Masculino , Feminino , Adulto Jovem , Adulto , Pessoa de Meia-Idade , Idoso , Estudos Transversais , Inquéritos e Questionários , Prevalência
5.
Int J Mol Sci ; 22(16)2021 Aug 18.
Artigo em Inglês | MEDLINE | ID: mdl-34445584

RESUMO

There are a large number of remedies in traditional medicine focused on relieving pain and inflammation. Flavanones have been a potential source in the search for leading compounds and biologically active components, and they have been the focus of much research and development in recent years. Eysenhardtia platycarpa is used in traditional medicine for the treatment of kidney diseases, bladder infections, and diabetes mellitus. Many compounds have been isolated from this plant, such as flavones, flavanones, phenolic compounds, triterpenoid acids, chalcones, sugars, and fatty acids, among others. In this paper, natural flavanone 1 (extracted from Eysenhardtia platycarpa) as lead compound and flavanones 1a-1d as its structural analogues were screened for anti-inflammatory activity using Molinspiration® and PASS Online in a computational study. The hydro alcoholic solutions (FS) of flavanones 1, 1a-1d (FS1, FS1a-FS1d) were also assayed to investigate their in vivo anti-inflammatory cutaneous effect using two experimental models, a rat ear edema induced by arachidonic acid (AA) and a mouse ear edema induced by 12-O-tetradecanoylphorbol acetate (TPA). Histological studies and analysis of pro-inflammatory cytokines TNF-α, IL-1ß, and IL-6 were also assessed in AA-inflamed rat ear tissue. The results showed that the flavanone hydro alcoholic solutions (FS) caused edema inhibition in both evaluated models. This study suggests that the evaluated flavanones will be effective when used in the future in skin pathologies with inflammation, with the results showing 1b and 1d to be the best.


Assuntos
Anti-Inflamatórios/farmacologia , Otopatias/tratamento farmacológico , Edema/tratamento farmacológico , Fabaceae/química , Flavanonas/farmacologia , Inflamação/tratamento farmacológico , Extratos Vegetais/farmacologia , Animais , Otopatias/patologia , Edema/patologia , Ensaios de Triagem em Larga Escala , Inflamação/patologia , Camundongos , Ratos , Ratos Wistar
6.
Undersea Hyperb Med ; 48(3): 209-219, 2021.
Artigo em Inglês | MEDLINE | ID: mdl-34390625

RESUMO

Eustachian tube dysfunction (ETD) and middle ear barotrauma (MEB) are common reported complications during hyperbaric oxygen treatment. Our Phase I study data was the first to demonstrate a statistically significant decrease in the occurrence of symptomatic ETD and MEB. The Phase I Trial suggested the total time interval and rate (slope) of compression (ROC) may be a determining factor in ETD and MEB. This Phase II study investigates an optimal rate of compression to reduce ETD and MEB when considering each multiplace treatment (with multiple patients) as the unit of observation as a group, rather than for each individual patient. Data were collected prospectively on 1,244 group patient-treatment exposures, collectively including 5,072 individual patient-treatment/exposures. We randomly assigned patient-treatment group exposures to four different time interval and rate (slope) of compression. These compression rates and slopes were identical to those used in the Phase I trial. All patients experiencing symptoms of MEB requiring compression stops were evaluated post treatment for the presence of ETD and MEB using the O'Neill Grading System (OGS) for ETD. Data were analyzed using the IBM-SPSS statistical software program. A statistically significant decrease in the number of compression holds was observed in the 15-minute compression schedule, correlating to the results observed in the Phase I trial. The 15-minute linear compression profile continues to demonstrate the decreased need for patient symptomatic compression stops (as in the Phase I trial) using a USN TT9 during elective hyperbaric oxygen treatments in a Class A multiplace hyperbaric chamber. Trial Registration: ClinicalTrials.gov Identifier: NCT04776967.


Assuntos
Barotrauma/epidemiologia , Otopatias/epidemiologia , Orelha Média/lesões , Tuba Auditiva/lesões , Oxigenoterapia Hiperbárica/efeitos adversos , Barotrauma/etiologia , Barotrauma/prevenção & controle , Otopatias/etiologia , Otopatias/prevenção & controle , Orelha Média/fisiologia , Humanos , Oxigenoterapia Hiperbárica/métodos , Oxigenoterapia Hiperbárica/estatística & dados numéricos , Incidência , Pressão/efeitos adversos , Estudos Prospectivos , Análise de Regressão , Fatores de Tempo , Suspensão de Tratamento/estatística & dados numéricos
7.
Vestn Otorinolaringol ; 86(3): 90-96, 2021.
Artigo em Russo | MEDLINE | ID: mdl-34269031

RESUMO

The article deals with the problem of inflammatory diseases of the external ear. A review of pruritic dermatoses of the external auditory canal was carried out. It has been shown that in chronic dermatoses, the contamination of the skin with bacterial and fungal pathogens significantly increases, which leads to a high risk of developing secondary infectious pathological processes. Treatment of dermatological inflammatory ear diseases includes careful daily hygiene of the external auditory canal and pharmacotherapy, a key aspect of which is the use of topical etiotropic, anti-inflammatory, and symptomatic drugs. The advantage of the combined drug candiderm is described, which, thanks to the unique combination of beclomethasone, gentamicin and clotrimazole in the composition, effectively relieves the symptoms of external ear dermatoses.


Assuntos
Otopatias , Otite Externa , Anti-Inflamatórios , Clotrimazol , Meato Acústico Externo , Otopatias/diagnóstico , Otopatias/tratamento farmacológico , Otopatias/etiologia , Gentamicinas , Humanos , Otite Externa/diagnóstico , Otite Externa/tratamento farmacológico
8.
BMC Complement Med Ther ; 21(1): 115, 2021 Apr 09.
Artigo em Inglês | MEDLINE | ID: mdl-33836731

RESUMO

BACKGROUND: Morus alba L. bark has been widely used in traditional medicine for treating several inflammatory diseases, such as hypertension, diabetes mellitus and coughing; however, the molecular mechanisms underlying its anti-inflammatory effects are not well understood. METHODS: We examined the effects of an extract of Morus alba L. bark (MabE) on Toll-like receptor (TLR) ligand-induced activation of RAW264.7 macrophages using a luciferase reporter assay and immunoassays. For the in vivo experiment, we used an imiquimod-induced ear edema model to examine the anti-inflammatory effects of MabE. RESULTS: MabE inhibited the TLR ligand-induced activation of NF-κB in RAW264.7 cells without affecting their viability. Consistent with the inhibition of NF-κB activation, MabE also inhibited the production of IL-6 and IL-1ß from TLR ligand-treated RAW264.7 cells. In vivo MabE treatment inhibited the ear swelling of IMQ-treated mice, in addition to the mRNA expression of IL-17A, IL-1ß and COX-2. The increases in splenic γδT cells in IMQ-treated mice and the production of IL-17A from splenocytes were significantly inhibited by MabE treatment. CONCLUSION: Our study suggests that the anti-inflammatory effects of MabE on the activation of the macrophage cell line RAW246.7 by TLRs and IMQ-induced ear edema are through the inhibition of NF-κB activation and IL-17A-producing γδT cells, respectively.


Assuntos
Otopatias/tratamento farmacológico , Edema/tratamento farmacológico , Morus , Casca de Planta , Receptores Toll-Like/efeitos dos fármacos , Animais , Anti-Inflamatórios/farmacologia , Edema/induzido quimicamente , Feminino , Imiquimode/efeitos adversos , Camundongos , Fitoterapia
9.
Curr Med Sci ; 41(1): 180-186, 2021 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-33582924

RESUMO

This study was designed to investigate the anti-inflammatory effects of volatile oil of Platycladus orientalis (L.) Franco leaves (VOPF) and the underlying molecular mechanisms by using the non-infectious inflammation rat models and infectious inflammation mouse models. Ear swelling and intraperitoneal capillary permeability in mice, and carrageenan-induced toe swelling and cotton ball-induced granuloma in rats were used to reveal anti-inflammatory effects of VOPF. Moreover, the lipopolysaccharide (LPS)-induced mouse model of acute lung injury was used to explore the anti-inflammatory mechanism of VOPF. The results showed that VOPF could significantly inhibit auricular swelling, intraperitoneal capillary permeability in mice, and reduce granuloma swelling and paw swelling in rats. Furthermore, it significantly alleviated the pathological damage of the lung tissue. In addition, VOPF could reduce the contents of IL-1ß and TNF-α and increase the content of IL-10 in the serum. It had little effect on the expression of p65 but reduced the phosphorylation level of p65 and IκB in NF-κB pathway. In conclusion, VOPF has anti-inflammatory effects and the mechanisms involve the down-regulation of the phosphorylation levels of p65 and IκB and blockage of the NF-κB signaling pathway.


Assuntos
Anti-Inflamatórios/uso terapêutico , Proteínas I-kappa B/metabolismo , Óleos Voláteis/uso terapêutico , Óleos de Plantas/uso terapêutico , Fator de Transcrição RelA/metabolismo , Animais , Anti-Inflamatórios/farmacologia , Permeabilidade Capilar , Carragenina/toxicidade , Otopatias/tratamento farmacológico , Otopatias/etiologia , Edema/tratamento farmacológico , Edema/etiologia , Granuloma/tratamento farmacológico , Granuloma/etiologia , Proteínas I-kappa B/genética , Interleucinas/genética , Interleucinas/metabolismo , Lipopolissacarídeos/toxicidade , Pulmão/efeitos dos fármacos , Pulmão/metabolismo , Masculino , Óleos Voláteis/farmacologia , Pinales/química , Folhas de Planta/química , Óleos de Plantas/farmacologia , Pneumonia/tratamento farmacológico , Pneumonia/etiologia , Ratos , Ratos Sprague-Dawley , Transdução de Sinais , Fator de Transcrição RelA/genética , Fator de Necrose Tumoral alfa/genética , Fator de Necrose Tumoral alfa/metabolismo
10.
Dermatol Ther ; 33(6): e14471, 2020 11.
Artigo em Inglês | MEDLINE | ID: mdl-33112026

RESUMO

The external auditory canal (EAC) comprises a special area where erythematous-scaly diseases are located. Among the main dermatoses that can affect EAC seborrheic dermatitis, psoriasis, irritant or allergic contact dermatitis, chronic external otitis (atrial eczematoid dermatitis) and cutaneous lupus should be considered. In this study, 25 consecutive patients were recruited on our dermatological outpatient clinic, 9 men and 16 women, with a clinical diagnosis of localized erythematous-squamous dermatoses in EAC. The mean age was 48.8 years (16-83). The mean time of evolution of the dermatoses was 11.44 months (2-36). Regarding the diagnosis, 14 patients were diagnosed with seborrheic dermatitis (56%), 9 patients with psoriasis (36%), 1 patient with subacute cutaneous lupus (4%), and 1 patient with allergic contact dermatitis to corticosteroids (4%). The indicated treatment was tacrolimus 0.1% and clotrimazole 1% in otic oil, twice a day, for 1 month. The EAC had to be cleaned initially with saline solution impregnated on a swab from the ears. The IGA score and pruritus showed a high results, with important improvement of almost all patients. The satisfaction of the patients obtained with the TSQM-9 questionnaire was 95.2. Retreatment showed an equal efficacy observed during the first treatment period. The efficacy and the absence of side effects with the treatment make this magistral formula an adequate therapeutic option for these dermatoses.


Assuntos
Otopatias , Eritema , Tacrolimo , Adolescente , Adulto , Idoso , Idoso de 80 Anos ou mais , Clotrimazol , Meato Acústico Externo , Otopatias/tratamento farmacológico , Eritema/tratamento farmacológico , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Tacrolimo/uso terapêutico , Adulto Jovem
11.
Int J Equity Health ; 19(1): 62, 2020 05 07.
Artigo em Inglês | MEDLINE | ID: mdl-32381090

RESUMO

BACKGROUND: Hearing loss is a prevalent but neglected disease, especially in low- or middle-income countries. The role of Community Health Workers (CHWs) to deliver primary ear and hearing care has been explored in several studies from a technical standpoint, but understanding perceptions, barriers, and enablers of such an approach from the perspective of CHWs themselves through a health equity lens has been less well documented. METHODS: This qualitative study used photovoice to explore the views and experiences of CHWs in the Seeta Nazigo Parish of Mukono District in the delivery of ear and hearing care in the community. CHWs were trained in ear and hearing care, and provided with digital cameras to capture photographs related to their work in the community over the following 3 months. Individual interviews regarding the photographs were held at the end of each month, in addition to one focus group discussion. A community workshop was convened at the end of the study to display the photos. Thematic analysis of photographs was conducted using Braune and Clarkes six-step framework. We also used the data to explore potential roles for key stakeholders in primary ear and hearing care, and how photovoice may facilitate their engagement. RESULTS: 13 CHWs participated in the study. Several themes were generated from analysis. CHWs perceived a high burden of ear and hearing disorders in their community and recognised the role they could play in tackling that burden. Potential barriers identified included a lack of equipment, training, and supervision of CHWs; logistical, financial, or psychological barriers to community participation; and the widespread use of traditional medicine. CHWs identified roles for the government and NGO bodies to enable and support delivery of ear and hearing care in the community. The community workshop was a useful method to engage key stakeholders in this topic. CONCLUSIONS: Photovoice is a powerful method to capture issues affecting CHWs. Here it was used to identify a number of perceptions, barriers and enablers to the delivery of ear and hearing care. Our results may inform future strategy in the field of ear and hearing care, and the potential use of photovoice to enact sociocultural change.


Assuntos
Serviços de Saúde Comunitária/organização & administração , Serviços de Saúde Comunitária/estatística & dados numéricos , Agentes Comunitários de Saúde/psicologia , Otopatias/terapia , Equidade em Saúde/estatística & dados numéricos , Conhecimentos, Atitudes e Prática em Saúde , Transtornos da Audição/terapia , Adulto , Agentes Comunitários de Saúde/estatística & dados numéricos , Otopatias/epidemiologia , Feminino , Grupos Focais , Transtornos da Audição/epidemiologia , Humanos , Masculino , Pessoa de Meia-Idade , Pesquisa Qualitativa , Uganda/epidemiologia
12.
Clin Sports Med ; 38(4): 619-638, 2019 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-31472770

RESUMO

Athletic trainers, physical therapists, and team physicians have differing roles when providing care, yet often need to collaborate. Athletic trainers and physical therapists use a variety of therapeutic modalities and manual therapy techniques in conjunction with rehabilitation exercises to improve outcomes. Clinicians must be knowledgeable of the scientific rationale for each modality to choose the most effective treatment for the specific condition and stage of recovery. The team physician should be familiar with the use of common procedures in an athletic training room. Here, we review the most current evidence and the basic methods encountered in athletic training room settings.


Assuntos
Traumatismos em Atletas/terapia , Otopatias/cirurgia , Hematoma/cirurgia , Lacerações/terapia , Unhas/cirurgia , Modalidades de Fisioterapia , Traumatismos em Atletas/reabilitação , Bandagens Compressivas , Crioterapia , Ventosaterapia , Terapia por Estimulação Elétrica , Terapia por Exercício , Humanos , Hipertermia Induzida , Massagem , Unhas/lesões , Técnicas de Sutura , Terapia por Ultrassom
13.
Mediators Inflamm ; 2019: 3041438, 2019.
Artigo em Inglês | MEDLINE | ID: mdl-31263381

RESUMO

Despite the usefulness of glucocorticoids, they may cause hazardous side effects that limit their use. Searching for compounds that are as equally efficient as glucocorticoids, but with less side effects, the current study compared plant steroids, namely, glycyrrhetinic acid, guggulsterone, boswellic acid, withaferin A, and diosgenin with the classical glucocorticoid, fluticasone. This was approached both in silico using molecular docking against glucocorticoid receptor (GR) and in vivo in two different animal models. All tested compounds interacted with GR, but only boswellic acid and withaferin A showed docking results comparable to fluticasone, as well as similar in vivo anti-inflammatory effects, by significantly decreasing serum levels of interleukin-6 and tumor necrosis factor-α in cotton pellet-induced granuloma in rats. In addition, both compounds significantly decreased the percent of change in ear weight in croton oil-induced ear edema in mice and the granuloma weight in cotton pellet-induced granuloma in rats, to levels comparable to that of fluticasone. Both boswellic acid and withaferin A had no effect on adrenal index, but only withaferin A significantly increased the thymus index. In conclusion, boswellic acid may have comparable anti-inflammatory effects to fluticasone with fewer side effects.


Assuntos
Otopatias/tratamento farmacológico , Otopatias/metabolismo , Inflamação/tratamento farmacológico , Inflamação/metabolismo , Fitosteróis/uso terapêutico , Receptores de Glucocorticoides/metabolismo , Animais , Anti-Inflamatórios/uso terapêutico , Óleo de Cróton/toxicidade , Diosgenina/uso terapêutico , Otopatias/sangue , Otopatias/induzido quimicamente , Edema/sangue , Edema/induzido quimicamente , Edema/tratamento farmacológico , Edema/metabolismo , Ensaio de Imunoadsorção Enzimática , Ácido Glicirretínico/uso terapêutico , Inflamação/induzido quimicamente , Inflamação/imunologia , Interleucina-6/sangue , Camundongos , Simulação de Acoplamento Molecular , Pregnenodionas/uso terapêutico , Ratos , Software , Timo/efeitos dos fármacos , Timo/metabolismo , Triterpenos/uso terapêutico , Fator de Necrose Tumoral alfa/sangue , Vitanolídeos/uso terapêutico
14.
Otol Neurotol ; 40(8): e812-e815, 2019 09.
Artigo em Inglês | MEDLINE | ID: mdl-31356482

RESUMO

OBJECTIVE: To present the first case of osteonecrosis of the external auditory canal associated with sorafenib treatment. PATIENT: 58-year-old patient with right-sided otorrhea and otalgia was treated for otitis externa for 1 month without improvement. Otoscopic examination revealed a large defect in the inferior wall of the tympanic bone filled with skin debris and bony fragments. Previous medical history included treatment with sorafenib for metastatic renal cell cancer; he had never been exposed to radiotherapy. Computed tomography of the temporal bone showed a large right external auditory canal bony erosion with involvement of the tympanic bone and bony sequestra extending to the mastoid cells and temporomandibular joint. Histologic examination revealed necrotic bone and inflammatory changes with no signs of malignancy. A diagnosis of osteonecrosis of external auditory canal was made. INTERVENTION: Right subtotal petrosectomy with obliteration of surgical cavity with abdominal fat was performed. RESULTS: Final histological report revealed avascular necrosis of the bone with perivascular lymphocitic infiltration of the soft tissues. Diagnosis of medication-related external auditory canal osteonecrosis was confirmed. CONCLUSION: Medication-related osteonecrosis of the temporal bone is not a well-known entity among otolaryngologists and could therefore be misclassified as another diagnosis. In patients with othorrea and earache following sorafenib treatment, temporal bone osteonecrosis should be suspected.


Assuntos
Antineoplásicos/efeitos adversos , Meato Acústico Externo/patologia , Osteonecrose/induzido quimicamente , Sorafenibe/efeitos adversos , Osso Temporal/patologia , Carcinoma de Células Renais/tratamento farmacológico , Otopatias/induzido quimicamente , Otopatias/patologia , Humanos , Neoplasias Renais/tratamento farmacológico , Masculino , Pessoa de Meia-Idade
15.
Undersea Hyperb Med ; 46(1): 55-61, 2019.
Artigo em Inglês | MEDLINE | ID: mdl-31154685

RESUMO

Introduction: Eustachian tube dysfunction (ETD) and middle ear barotrauma (MEB) are the most common adverse effects of hyperbaric oxygen (HBO2) treatments. Patients practice equalization maneuvers to prevent ETD and MEB prior to hyperbaric exposure. Some patients are still unable to equalize middle ear pressure. This ETD results in undesirable consequences, including barotrauma, treatment with medications or surgical myringotomy with tube placement and interruption of HBO2. When additional medications and myringotomy are employed, they are associated with additional complications. Methods: A device known as the Ear Popper® has been reported to reduce complications from serous otitis media and reduce the need for surgical interventions (myringotomy). Patients unable to equalize middle ear pressure during initial compression in the hyperbaric chamber were allowed to use the device for rescue. All hyperbaric treatments were compressed using a United States Navy TT9, or a 45-fsw hyperbaric treatment schedule. Patients with persistent ETD and the inability to equalize middle ear pressure were given the Ear Popper upon consideration of terminating their treatment. Results: The Ear Popper allowed all patients to successfully equalize middle ear pressure and complete their treatments. Conclusion: This study substantiates the use of this device to assist in allowing pressurization of the middle ear space in patients otherwise unable to achieve equalization of middle ear pressure during HBO2 treatment in a multiplace chamber.


Assuntos
Barotrauma/prevenção & controle , Otopatias/prevenção & controle , Tuba Auditiva , Oxigenoterapia Hiperbárica/efeitos adversos , Estudo de Prova de Conceito , Terapia de Salvação/instrumentação , Adulto , Idoso , Idoso de 80 Anos ou mais , Pressão Atmosférica , Deglutição , Desenho de Equipamento , Tuba Auditiva/fisiologia , Feminino , História do Século XIX , Humanos , Masculino , Pessoa de Meia-Idade , Otolaringologia/história , Terapia de Salvação/métodos
16.
Am J Otolaryngol ; 40(5): 645-649, 2019.
Artigo em Inglês | MEDLINE | ID: mdl-31130270

RESUMO

PURPOSE: To assess the effectiveness of Buteyko breathing technique in patients with obstructive Eustachian tube dysfunction (ETD). MATERIALS AND METHODS: Fifty-one patients (77 ears) aged between 21 and 62 years were randomized to Buteyko breathing in conjunction with medical management (nasal steroid) group or medical management alone group. The Eustachian Tube Dysfunction Questionnaire (ETDQ-7) symptom scores, tympanogram, positive Valsalva maneuver were evaluated at baseline, 6-week and 12-week follow-up. RESULTS: Normalization of ETDQ-7 symptom scores at 6-week follow-up was observed in 30.0% (12/40) of the Buteyko breathing group versus 16.2% (6/37) of the controls (P > 0.05). At 12-week follow-up, the ratio rose to 50.0% (20/40) in the Buteyko breathing group and 24.3% (9/37) in the controls (P < 0.05). Tympanogram normalization at 12-week follow-up was observed in 53.6% (15/28) of the Buteyko breathing group versus 26.9% (7/26) of the controls (P < 0.05). The Buteyko breathing group showed slight improvement in positive Valsalva maneuver at 6- and 12-week follow-up (P > 0.05). CONCLUSIONS: Our study shows that Buteyko breathing technique might be an effective adjunctive intervention in treatment of obstructive ETD, especially for those patients who are refractory to medical treatment and cannot afford Eustachian tube balloon dilation surgery.


Assuntos
Exercícios Respiratórios/métodos , Constrição Patológica/fisiopatologia , Otopatias/terapia , Tuba Auditiva/fisiopatologia , Adulto , Fatores Etários , Distribuição de Qui-Quadrado , Otopatias/diagnóstico , Feminino , Seguimentos , Humanos , Masculino , Pessoa de Meia-Idade , Estudos Prospectivos , Valores de Referência , Medição de Risco , Fatores Sexuais , Resultado do Tratamento , Manobra de Valsalva , Adulto Jovem
17.
Laryngorhinootologie ; 98(S 01): S5-S31, 2019 Mar.
Artigo em Inglês, Alemão | MEDLINE | ID: mdl-31096294

RESUMO

The increasing plurality and complexity of technical assistance systems pose a challenge for clinically active physicians. Particularly in the operating theater, there is a growing need to integrate medical systems and software solutions into a holistic clinical infrastructure. The primary goal of building a "digital (ENT) operating room of the future" is not just the pure technical improvement of the individual computer-aided equipment and instruments, but rather their dynamic networking and system integration in an open modular system. Promising scientific projects address the question of how to improve the quality, safety and user-friendliness of technical systems in the health care system of the 21st century. The work on SCOT, MD PnP and OR.NET show the various components that make the vision of the ENT operating room of the future tangible and realistic in the overall context.


Assuntos
Salas Cirúrgicas , Software , Otopatias , Doenças Nasais , Doenças Faríngeas
18.
Undersea Hyperb Med ; 46(2): 95-100, 2019.
Artigo em Inglês | MEDLINE | ID: mdl-31051053

RESUMO

Introduction: Symptomatic Eustachian tube dysfunction (ETD) and middle ear barotrauma (MEB) are the most common reported complications during hyperbaric oxygen (HBO2) treatment. There is no standardized rate of compression (ROC) reported to decrease the incidence rates of ETD and MEB during hyperbaric treatments. Few studies actually demonstrate that the ROC decreases the incidence of ETD or MEB. Methods: Our study was designed to determine an optimal hyperbaric chamber compression rate that might reduce the incidence of symptomatic ETD leading to MEB during the compression phase of treatment in a multiplace hyperbaric chamber. Data was collected prospectively over 2,807 elective patient treatments compressed using a U.S. Navy Treatment Table 9 (USN TT9) with a modified ROC. ROC was assigned using two variables, time (10 vs.15 minutes) and slope (linear vs. non-linear compression). Patients were exposed to all four compression schedules in a consecutive daily fashion. We recorded any patient requiring a stop during initial compression due to ear discomfort. Anyone requiring a stop was evaluated post treatment for MEB. Findings were compared to our standard 10-minute linear ROC. Evaluation of the tympanic membrane was accomplished using video otoscopy. Barotrauma when present was classified using both the Teed and O'Neill grading systems. Data was analyzed using basic statistical methods. Results: When comparing four different rates of compression during an elective USN TT9 in a multiplace (Class A) chamber there is a decreased incidence for symptomatic ETD when using a 15-minute linear compression schedule (p-value ⟨0.05). Conclusion: Using a 15-minute linear compression schedule is associated with less symptomatic ETD and less MEB when performing an elective 45 fsw (USN TT9) hyperbaric treatment in a Class A chamber. Asymptomatic ETD and MEB were not considered in this study.


Assuntos
Barotrauma/prevenção & controle , Otopatias/prevenção & controle , Tuba Auditiva/lesões , Oxigenoterapia Hiperbárica/métodos , Suspensão de Tratamento/estatística & dados numéricos , Barotrauma/etiologia , Protocolos Clínicos , Otopatias/etiologia , Orelha Média/lesões , Humanos , Oxigenoterapia Hiperbárica/efeitos adversos , Incidência , Otoscopia/métodos , Pressão , Estudos Prospectivos , Fatores de Tempo , Membrana Timpânica
19.
J Laryngol Otol ; 133(4): 285-288, 2019 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-30935435

RESUMO

OBJECTIVES: Animal studies have suggested that exposure of the middle ear to topical local anaesthesia may be ototoxic. This study aimed to report sensorineural hearing outcomes and patients' satisfaction in those who underwent myringotomy and ventilation tube insertion using topical local anaesthesia. METHODS: Twenty-nine patients (32 ears) were operated on. Pre- and post-operative audiology findings were compared. A Likert-type questionnaire on treatment satisfaction was completed at the end of the procedure. RESULTS: Median patient age was 55 years (range, 27-88 years). Pre- and post-operative bone conduction pure tone averages were 26.76 dB and 25.26 dB respectively (mean reduction of -1.22 dB, 95 per cent confidence interval of -5.91 to 8.13 dB; p = 0.7538). One ear (3 per cent) had a reduction in pure tone average of 10 dB. CONCLUSION: The results suggest that sensorineural hearing loss is not a complication of ear exposure to topical local anaesthesia during myringotomy and ventilation tube insertion. The procedure was well perceived.


Assuntos
Anestesia Local/efeitos adversos , Otopatias/cirurgia , Perda Auditiva Neurossensorial/diagnóstico , Ventilação da Orelha Média/métodos , Satisfação do Paciente/estatística & dados numéricos , Administração Tópica , Adulto , Idoso , Idoso de 80 Anos ou mais , Feminino , Perda Auditiva Neurossensorial/induzido quimicamente , Perda Auditiva Neurossensorial/epidemiologia , Testes Auditivos , Humanos , Masculino , Pessoa de Meia-Idade , Inquéritos e Questionários
20.
Otolaryngol Clin North Am ; 52(3): 509-520, 2019 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-30905561

RESUMO

Balloon dilation of the Eustachian tube (BDET) is an effective treatment of Eustachian tube dysfunction. This procedure can be performed under local anesthesia in the office. This article outlines the evolution of BDET under local anesthesia, describes the techniques of in-office BDET and provides an algorithm to identify suitable patients for this procedure.


Assuntos
Procedimentos Cirúrgicos Ambulatórios/métodos , Cateterismo/métodos , Otopatias/cirurgia , Tuba Auditiva/cirurgia , Algoritmos , Anestesia Local , Dilatação/métodos , Endoscopia , Humanos
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