RESUMO
Humans perceive and spontaneously move to one or several levels of periodic pulses (a meter, for short) when listening to musical rhythm, even when the sensory input does not provide prominent periodic cues to their temporal location. Here, we review a multi-levelled framework to understanding how external rhythmic inputs are mapped onto internally represented metric pulses. This mapping is studied using an approach to quantify and directly compare representations of metric pulses in signals corresponding to sensory inputs, neural activity and behaviour (typically body movement). Based on this approach, recent empirical evidence can be drawn together into a conceptual framework that unpacks the phenomenon of meter into four levels. Each level highlights specific functional processes that critically enable and shape the mapping from sensory input to internal meter. We discuss the nature, constraints and neural substrates of these processes, starting with fundamental mechanisms investigated in macaque monkeys that enable basic forms of mapping between simple rhythmic stimuli and internally represented metric pulse. We propose that human evolution has gradually built a robust and flexible system upon these fundamental processes, allowing more complex levels of mapping to emerge in musical behaviours. This approach opens promising avenues to understand the many facets of rhythmic behaviours across individuals and species. This article is part of the theme issue 'Synchrony and rhythm interaction: from the brain to behavioural ecology'.
Assuntos
Percepção Auditiva/fisiologia , Encéfalo/fisiologia , Periodicidade , Primatas/fisiologia , Estimulação Acústica , Animais , Sinais (Psicologia) , Humanos , Macaca/fisiologiaRESUMO
A new theory is proposed of mechanisms of navigation in primates including humans in which spatial view cells found in the primate hippocampus and parahippocampal gyrus are used to guide the individual from landmark to landmark. The navigation involves approach to each landmark in turn (taxis), using spatial view cells to identify the next landmark in the sequence, and does not require a topological map. Two other cell types found in primates, whole body motion cells, and head direction cells, can be utilized in the spatial view cell navigational mechanism, but are not essential. If the landmarks become obscured, then the spatial view representations can be updated by self-motion (idiothetic) path integration using spatial coordinate transform mechanisms in the primate dorsal visual system to transform from egocentric to allocentric spatial view coordinates. A continuous attractor network or time cells or working memory is used in this approach to navigation to encode and recall the spatial view sequences involved. I also propose how navigation can be performed using a further type of neuron found in primates, allocentric-bearing-to-a-landmark neurons, in which changes of direction are made when a landmark reaches a particular allocentric bearing. This is useful if a landmark cannot be approached. The theories are made explicit in models of navigation, which are then illustrated by computer simulations. These types of navigation are contrasted with triangulation, which requires a topological map. It is proposed that the first strategy utilizing spatial view cells is used frequently in humans, and is relatively simple because primates have spatial view neurons that respond allocentrically to locations in spatial scenes. An advantage of this approach to navigation is that hippocampal spatial view neurons are also useful for episodic memory, and for imagery.
Assuntos
Memória Episódica , Navegação Espacial , Animais , Hipocampo/fisiologia , Humanos , Neurônios/fisiologia , Primatas/fisiologia , Percepção Espacial/fisiologia , Navegação Espacial/fisiologiaRESUMO
The study of adaptation requires the integration of an array of different types of data. A single individual can find such integration daunting, if not impossible. In an effort to clarify the role of diet in the evolution of the primate craniofacial and dental apparatus, we assembled a team of researchers that have various types and degrees of expertise. This interaction has provided a range of insights for all contributors, and this has helped to refine questions, clarify the possibilities and limitations that laboratory and field settings offer, and further explore the ways in which laboratory and field data can be suitably integrated. A complete and accurate picture of dietary adaptation cannot be gained in isolation. Collaboration provides the bridge to a more holistic view of primate biology and evolution.
Assuntos
Comportamento Alimentar , Primatas/anatomia & histologia , Primatas/fisiologia , Adaptação Biológica , Animais , Dentição , Dieta/veterinária , Crânio/anatomia & histologiaRESUMO
Cortical networks are characterized by the origin, destination, and reciprocity of their connections, as well as by the diameter, conduction velocity, and synaptic efficacy of their axons. The network formed by parietal and frontal areas lies at the core of cognitive-motor control because the outflow of parietofrontal signaling is conveyed to the subcortical centers and spinal cord through different parallel pathways, whose orchestration determines, not only when and how movements will be generated, but also the nature of forthcoming actions. Despite intensive studies over the last 50 years, the role of corticocortical connections in motor control and the principles whereby selected cortical networks are recruited by different task demands remain elusive. Furthermore, the synaptic integration of different cortical signals, their modulation by transthalamic loops, and the effects of conduction delays remain challenging questions that must be tackled to understand the dynamical aspects of parietofrontal operations. In this article, we evaluate results from nonhuman primate and selected rodent experiments to offer a viewpoint on how corticocortical systems contribute to learning and producing skilled actions. Addressing this subject is not only of scientific interest but also essential for interpreting the devastating consequences for motor control of lesions at different nodes of this integrated circuit. In humans, the study of corticocortical motor networks is currently based on MRI-related methods, such as resting-state connectivity and diffusion tract-tracing, which both need to be contrasted with histological studies in nonhuman primates.
Assuntos
Atividade Motora/fisiologia , Rede Nervosa/fisiologia , Desempenho Psicomotor/fisiologia , Animais , Atenção/fisiologia , Mapeamento Encefálico , Conectoma , Imagem de Tensor de Difusão , Lobo Frontal/fisiologia , Intenção , Aprendizagem/fisiologia , Córtex Motor/fisiologia , Destreza Motora/fisiologia , Movimento/fisiologia , Condução Nervosa , Lobo Parietal/fisiologia , Primatas/fisiologia , Roedores/fisiologia , Tálamo/fisiologiaRESUMO
OBJECTIVES: Geophagy, the intentional consumption of earth, is widely practiced among humans and other mammals, but its causes are not well understood. Given the growing number of reports of geophagy among nonhuman primates (NHP), we sought to (1) advance and codify our understanding of the patterns and functional and evolutionary significance of geophagy among NHP and (2) provide a research agenda for a more unified approach to its study. METHODS: We systematically reviewed all available literature on NHP geophagy, extracted available data on taxa, geography, climate, diet, sex, age-class, reproductive status, and the characteristics of the earth. We used these data to evaluate three major hypotheses about geophagy, that it is protective, provides mineral supplementation, and is nonadaptive. RESULTS: We identified 287 accounts of geophagy among 136 species, adding 79 new primate species to the list of those considered in prior reviews. Nineteen percent of species were in the suborder Strepsirrhini, while 81% were in the suborder Haplorrhini. There were reports of geophagy from 9 of the 17 families and 39 of the 76 genera currently recognized by the International Union for Conservation of Nature. DISCUSSION: The limited evidence suggests that geophagy is adaptive, and provides protection and mineral supplementation. We specify the behavioral, dietary, and soil data required to more rigorously investigate these hypotheses across representative species of all taxonomic groups, geographical regions, and dietary classification. Given the plausibility of geophagy for maintaining the health of both wild and captive populations, we urge further study and conservation of geophagy sites.
Assuntos
Pica , Primatas/fisiologia , Animais , Antropologia Física , Feminino , MasculinoRESUMO
Parasitic and symbiotic relationships govern vast nutrient and energy flows, yet controversy surrounds their longevity. Enduring relationships may engender parallel phylogenies among hosts and parasites, but so may ephemeral relationships when parasites colonize related hosts. An understanding of whether symbiont and host populations have grown and contracted in concert would be useful when considering the temporal durability of these relationships. Here, we devised methods to compare demographic histories derived from genomic data. We compared the historical growth of the agent of severe human malaria, Plasmodium falciparum, and its mosquito vector, Anopheles gambiae, to human and primate histories, thereby discerning long-term parallels and anthropogenic population explosions. The growth history of Trichinella spiralis, a zoonotic parasite disseminated by swine, proved regionally specific, paralleling distinctive growth histories for wild boar in Asia and Europe. Parallel histories were inferred for an anemone and its algal symbiont (Exaiptasia pallida and Symbiodinium minutum). Concerted growth in potatoes and the agent of potato blight (Solanum tuberosum and Phytophthora infestans) did not commence until the age of potato domestication. Through these examples, we illustrate the utility of comparative historical demography as a new exploratory tool by which to interrogate the origins and durability of myriad ecological relationships. To facilitate future use of this approach, we introduce a tool called C-PSMC to align and evaluate the similarity of demographic history curves.
Assuntos
Demografia/métodos , Interações Hospedeiro-Parasita , Simbiose , Animais , Anopheles/parasitologia , Anopheles/fisiologia , Dinoflagellida/fisiologia , Humanos , Mosquitos Vetores/parasitologia , Mosquitos Vetores/fisiologia , Phytophthora infestans/fisiologia , Plasmodium falciparum/fisiologia , Crescimento Demográfico , Primatas/fisiologia , Anêmonas-do-Mar/parasitologia , Solanum tuberosum/microbiologia , Solanum tuberosum/fisiologia , Suínos/parasitologia , Suínos/fisiologia , Trichinella spiralis/fisiologiaRESUMO
The use of optogenetics or photobiomodulation in non-human primate (NHP) requires the ability to noninvasively stimulate large and deep cortical brain tissues volumes. In this context, the optical and geometrical parameters of optodes are critical. Methods and general guidelines to optimize these parameters have to be defined. OBJECTIVE: We propose the design of an optode for safe and efficient optical stimulation of a large volume of NHP cortex, down to 3-5 mm depths without inserting fibers into the cortex. APPROACH: Monte Carlo simulations of optical and thermal transport have been carried out using the Geant4 application for tomographic emission (GATE) platform. Parameters such as the fiber diameter, numerical aperture, number of fibers and their geometrical arrangement have been studied. Optimal hardware parameters are proposed to obtain homogeneous fluence above the fluence threshold for opsin activation without detrimental thermal effects. MAIN RESULTS: The simulations show that a large fiber diameter and a large numerical aperture are preferable since they allow limiting power concentration and hence the resulting thermal increases at the brain surface. To obtain a volume of 200-500 mm3 of brain tissues receiving a fluence above the opsin activation threshold for optogenetics or below a phototocixity threshold for photobiomodulation, a 4 fibers configuration is proposed. The optimal distance between the fibers was found to be 4 mm. A practical implementation of the optode has been performed and the corresponding fluence and thermal maps have been simulated. SIGNIFICANCE: The present study defines a method to optimize the design of optode and the choice of stimulation parameters for optogenetics and more generally light delivery to deep and large volumes of tissues in NHP brain with a controlled irradiance dosimetry. The general guidelines are the use of silica fibers with a large numerical aperture and a large diameter. The combination of several fibers is required if large volumes need to be stimulated while avoiding thermal effects.
Assuntos
Córtex Cerebral/fisiologia , Optogenética/instrumentação , Estimulação Luminosa/instrumentação , Primatas/fisiologia , Animais , Simulação por Computador , Temperatura Alta , Fibras Minerais , Método de Monte Carlo , Córtex Motor/fisiologia , Opsinas/metabolismo , Optogenética/métodos , Estimulação Luminosa/métodos , Estimulação FísicaRESUMO
A central goal of neuroscience is to understand how populations of neurons coordinate and cooperate in order to give rise to perception, cognition, and action. Nonhuman primates (NHPs) are an attractive model with which to understand these mechanisms in humans, primarily due to the strong homology of their brains and the cognitively sophisticated behaviors they can be trained to perform. Using electrode recordings, the activity of one to a few hundred individual neurons may be measured electrically, which has enabled many scientific findings and the development of brain-machine interfaces. Despite these successes, electrophysiology samples sparsely from neural populations and provides little information about the genetic identity and spatial micro-organization of recorded neurons. These limitations have spurred the development of all-optical methods for neural circuit interrogation. Fluorescent calcium signals serve as a reporter of neuronal responses, and when combined with post-mortem optical clearing techniques such as CLARITY, provide dense recordings of neuronal populations, spatially organized and annotated with genetic and anatomical information. Here, we advocate that this methodology, which has been of tremendous utility in smaller animal models, can and should be developed for use with NHPs. We review here several of the key opportunities and challenges for calcium-based optical imaging in NHPs. We focus on motor neuroscience and brain-machine interface design as representative domains of opportunity within the larger field of NHP neuroscience.
Assuntos
Interfaces Cérebro-Computador , Sinalização do Cálcio , Cálcio/análise , Conectoma/métodos , Processamento de Imagem Assistida por Computador/métodos , Microscopia Intravital/métodos , Córtex Motor/fisiologia , Rede Nervosa/fisiologia , Neurônios/fisiologia , Primatas/anatomia & histologia , Análise de Célula Única , Algoritmos , Animais , Proteínas de Bactérias/análise , Proteínas de Bactérias/genética , Comportamento Animal , Conectoma/instrumentação , Técnicas Citológicas/instrumentação , Estimulação Elétrica , Corantes Fluorescentes , Proteínas de Fluorescência Verde/análise , Proteínas de Fluorescência Verde/genética , Imageamento Tridimensional , Microscopia Intravital/instrumentação , Proteínas Luminescentes/análise , Proteínas Luminescentes/genética , Microscopia de Fluorescência/instrumentação , Microscopia de Fluorescência/métodos , Modelos Neurológicos , Atividade Motora , Córtex Motor/citologia , Rede Nervosa/ultraestrutura , Neurônios/química , Neurônios/ultraestrutura , Primatas/fisiologia , Transdução Genética , VigíliaRESUMO
Insects and other invertebrates form a portion of many living and extinct primate diets. We review the nutritional profiles of insects in comparison with other dietary items, and discuss insect nutrients in relation to the nutritional needs of living primates. We find that insects are incorporated into some primate diets as staple foods whereby they are the majority of food intake. They can also be incorporated as complements to other foods in the diet, providing protein in a diet otherwise dominated by gums and/or fruits, or be incorporated as supplements to likely provide an essential nutrient that is not available in the typical diet. During times when they are very abundant, such as in insect outbreaks, insects can serve as replacements to the usual foods eaten by primates. Nutritionally, insects are high in protein and fat compared with typical dietary items like fruit and vegetation. However, insects are small in size and for larger primates (>1 kg) it is usually nutritionally profitable only to consume insects when they are available in large quantities. In small quantities, they may serve to provide important vitamins and fatty acids typically unavailable in primate diets. In a brief analysis, we found that soft-bodied insects are higher in fat though similar in chitin and protein than hard-bodied insects. In the fossil record, primates can be defined as soft- or hard-bodied insect feeders based on dental morphology. The differences in the nutritional composition of insects may have implications for understanding early primate evolution and ecology.
Assuntos
Fenômenos Fisiológicos da Nutrição Animal , Evolução Biológica , Dieta , Insetos/fisiologia , Primatas/fisiologia , Animais , Cadeia AlimentarRESUMO
The optogenetic approach to primate brain circuitry has unparalleled potential for uncovering genetically and temporally resolved neuronal mechanisms of higher brain functions. In order to optogenetically investigate the large and complex primate brain, an optical-/electrical probe, or "optrode", must be inserted deeply, which requires the optrode to be not only long and stiff, but also sharp and smooth to reduce possible tissue damage. This study presents a tungsten microelectrode-based optrode that encloses optical fibers within its insulation glass. Optical fibers and a tungsten wire were tightly bound to each other and integrally coated with a smooth, thin layer of glass. This design satisfied the structural requirements for use in deep brain structures. The performance of the optrode was then examined in the thalamus of the rat and macaque monkeys which were injected with lentiviral vectors carrying the channelrhodopsin-2-enhanced yellow fluorescent protein (ChR2-EYFP) transgene. With fluorescence measurements via the optical fiber, ChR2-EYFP expression was detected clearly in vivo, which was confirmed by histological analysis in the rat. With photostimulation and extracellular recording, photo-responsive single-unit activities were isolated in the monkeys. The depth distribution of these units and the peak of the EYFP fluorescence profile overlapped consistently with each other. Thus, by developing a new probe, optogenetic methodology was successfully applied to a primate subcortical structure. This smooth glass-coated optrode is a promising tool for chronic in vivo experiments with various research targets including deep brain structures in behaving monkeys.
Assuntos
Encéfalo/fisiologia , Tecnologia de Fibra Óptica , Microeletrodos , Optogenética/métodos , Primatas/fisiologia , Tungstênio , Animais , Channelrhodopsins , Vetores Genéticos , Imuno-Histoquímica , Lentivirus/genética , Iluminação , Macaca , Macaca mulatta , Imageamento por Ressonância Magnética , Microscopia de Fluorescência , Rede Nervosa/fisiologia , Ratos , Ratos Wistar , Tálamo/citologia , Tálamo/fisiologiaRESUMO
Auditory signals are decomposed into discrete frequency elements early in the transduction process, yet somehow these signals are recombined into the rich acoustic percepts that we readily identify and are familiar with. The cerebral cortex is necessary for the perception of these signals, and studies from several laboratories over the past decade have made significant advances in our understanding of the neuronal mechanisms underlying auditory perception. This review will concentrate on recent studies in the macaque monkey that indicate that the activity of populations of neurons better accounts for the perceptual abilities compared to the activity of single neurons. The best examples address whether the acoustic space is represented along the "where" pathway in the caudal regions of auditory cortex. Our current understanding of how such population activity could also underlie the perception of the nonspatial features of acoustic stimuli is reviewed, as is how multisensory interactions can influence our auditory perception.
Assuntos
Estimulação Acústica/psicologia , Percepção Auditiva/fisiologia , Detecção de Sinal Psicológico/fisiologia , Animais , Córtex Auditivo/anatomia & histologia , Córtex Auditivo/fisiologia , Humanos , Modelos Biológicos , Primatas/fisiologia , Comportamento Espacial/fisiologia , Fatores de TempoRESUMO
Connections of the primate prefrontal cortex are associated with action. Within the lateral prefrontal cortex, there are preferential targets of projections from visual, auditory, and somatosensory cortices associated with directing attention to relevant stimuli and monitoring responses for specific tasks. Return pathways from lateral prefrontal areas to sensory association cortices suggest a role in selecting relevant stimuli and suppressing distracters to accomplish specific tasks. Projections from sensory association cortices to orbitofrontal cortex are more global than to lateral prefrontal areas, especially for posterior orbitofrontal cortex (pOFC), which is connected with sensory association cortices representing each sensory modality and with structures associated with the internal, or emotional, environment. A specialized projection from pOFC to the intercalated masses of the amygdala is poised to flexibly affect autonomic responses in emotional arousal or return to homeostasis. The amygdala projects to the magnocellular mediodorsal thalamic nucleus, which projects most robustly to pOFC among prefrontal cortices, suggesting sequential processing for emotions. The specialized connections of pOFC distinguish it as a separate orbitofrontal region that may function as the primary sensor of information for emotions. Lateral prefrontal areas 46 and 9 and the pOFC send widespread projections to the inhibitory thalamic reticular nucleus, suggesting a role in gating sensory and motivationally salient signals and suppressing distracters at an early stage of processing. Intrinsic connections link prefrontal areas, enabling synthesis of sensory information and emotional context for selective attention and action, in processes that are disrupted in psychiatric disorders, including attention-deficit/hyperactivity disorder.
Assuntos
Vias Aferentes/fisiologia , Tonsila do Cerebelo/fisiologia , Emoções/fisiologia , Córtex Pré-Frontal/fisiologia , Primatas/fisiologia , Tálamo/fisiologia , Animais , Mapeamento Encefálico/métodos , Memória/fisiologia , Modelos Neurológicos , Vias Neurais/fisiologiaRESUMO
This study describes the psychometric similarities and differences in motor timing performance between 20 human subjects and three rhesus monkeys during two timing production tasks. These tasks involved tapping on a push-button to produce the same set of intervals (range of 450 to 1,000 ms), but they differed in the number of intervals produced (single vs. multiple) and the modality of the stimuli (auditory vs. visual) used to define the time intervals. The data showed that for both primate species, variability increased as a function of the length of the produced target interval across tasks, a result in accordance with the scalar property. Interestingly, the temporal performance of rhesus monkeys was equivalent to that of human subjects during both the production of single intervals and the tapping synchronization to a metronome. Overall, however, human subjects were more accurate than monkeys and showed less timing variability. This was especially true during the self-pacing phase of the multiple interval production task, a behavior that may be related to complex temporal cognition, such as speech and music execution. In addition, the well-known human bias toward auditory as opposed to visual cues for the accurate execution of time intervals was not evident in rhesus monkeys. These findings validate the rhesus monkey as an appropriate model for the study of the neural basis of time production, but also suggest that the exquisite temporal abilities of humans, which peak in speech and music performance, are not all shared with macaques.
Assuntos
Primatas/fisiologia , Desempenho Psicomotor/fisiologia , Detecção de Sinal Psicológico , Percepção do Tempo/fisiologia , Estimulação Acústica/métodos , Adulto , Análise de Variância , Animais , Percepção Auditiva/fisiologia , Feminino , Humanos , Macaca mulatta , Masculino , Estimulação Luminosa/métodos , Psicometria/métodos , Psicofísica , Tempo de Reação/fisiologia , Análise de Regressão , Fatores de Tempo , Percepção Visual/fisiologia , Adulto JovemRESUMO
Reproduction in mammals is directly controlled by GnRH neurons. These neurons are regulated by many external and internal factors, among which sexual steroids, in particular oestradiol, play an important part. However the mechanisms through which these steroids regulate GnRH secretion are largely unappreciated, and the neurochemical identity of central neurons liable to transmit the steroidal information to GnRH neurons is not completely clarified. Many functional neuroanatomy studies have been carried out on the ovine model, which is particularly favorable to understand the neuroendocrine mechanisms controlling reproduction. These studies have brought about the identification of some of the potential actors in this regulation. The present review reports the major results concerning two recently discovered neuropeptides, galanin and kisspeptin, which appear to be major actors in integration of signals regulating reproduction, among which steroids. These results have revealed the major interaction sites between neurons expressing these neuropeptides and GnRH neurons.
Assuntos
Galanina/fisiologia , Hormônio Liberador de Gonadotropina/fisiologia , Hipotálamo/fisiologia , Neurônios/fisiologia , Neuropeptídeos/fisiologia , Ovinos/anatomia & histologia , Animais , Estradiol/fisiologia , Feminino , Hipotálamo/anatomia & histologia , Kisspeptinas , Camundongos , Camundongos Knockout , Primatas/fisiologia , Proteínas/genética , Proteínas/fisiologia , Reprodução/fisiologia , Roedores/fisiologia , Especificidade da EspécieRESUMO
Previously, we have reported that 17beta-estradiol (E(2)) induces an increase in firing activity of primate LH-releasing hormone (LHRH) neurons. The present study investigates whether E(2) alters LHRH release as well as the pattern of intracellular calcium ([Ca(2+)](i)) oscillations and whether G protein-coupled receptor 30 (GPR30) plays a role in mediating the rapid E(2) action in primate LHRH neurons. Results are summarized: 1) E(2), the nuclear membrane-impermeable estrogen, estrogen-dendrimer conjugate, and the plasma membrane-impermeable estrogen, E(2)-BSA conjugate, all stimulated LHRH release within 10 min of exposure; 2) whereas the estrogen receptor antagonist, ICI 182,780, did not block the E(2)-induced LHRH release, E(2) application to cells treated with pertussis toxin failed to induce LHRH release; 3) GPR30 mRNA was expressed in olfactory placode cultures, and GPR30 protein was expressed in a subset of LHRH neurons; 4) pertussis toxin treatment blocked the E(2)-induced increase in [Ca(2+)](i) oscillations; 5) knockdown of GPR30 in primate LHRH neurons by transfection with small interfering RNA (siRNA) for GPR30 completely abrogated the E(2)-induced changes in [Ca(2+)](i) oscillations, whereas transfection with control siRNA did not; 6) the estrogen-dendrimer conjugate-induced increase in [Ca(2+)](i) oscillations also did not occur in LHRH neurons transfected with GPR30 siRNA; and 7) G1, a GPR30 agonist, resulted in changes in [Ca(2+)](i) oscillations, similar to those observed with E(2). Collectively, E(2) induces a rapid excitatory effect on primate LHRH neurons, and this rapid action of E(2) appears to be mediated, in part, through GPR30.
Assuntos
Estradiol/farmacologia , Hormônio Liberador de Gonadotropina/metabolismo , Neurônios/efeitos dos fármacos , Primatas , Receptores Acoplados a Proteínas G/fisiologia , Animais , Sinalização do Cálcio/efeitos dos fármacos , Células Cultivadas , Dendrímeros/farmacologia , Embrião de Mamíferos , Estradiol/análogos & derivados , Estrogênios Conjugados (USP)/farmacologia , Feminino , Fulvestranto , Hipotálamo/efeitos dos fármacos , Hipotálamo/metabolismo , Macaca mulatta , Neurônios/metabolismo , Condutos Olfatórios/efeitos dos fármacos , Condutos Olfatórios/metabolismo , Toxina Pertussis/farmacologia , Gravidez , Primatas/metabolismo , Primatas/fisiologia , RNA Interferente Pequeno/farmacologia , Receptores Acoplados a Proteínas G/antagonistas & inibidores , Receptores Acoplados a Proteínas G/genética , Receptores Acoplados a Proteínas G/metabolismo , Soroalbumina Bovina/farmacologia , Transmissão Sináptica/efeitos dos fármacosRESUMO
The Palaeocene-Eocene transition is characterized by a significant turnover of mammalian taxa in the fossil record of the northern continents, and primates are among the groups that make their first appearance at this time. One of the many questions that remain to be answered with regard to the earliest evolution of primates is the reason for their sudden and virtually simultaneous appearance in the fossil records of Asia, Europe and North America. The most obvious environmental correlate of the Palaeocene-Eocene transition is a sharp but relatively short-lived warming event leading up to the Palaeocene-Eocene thermal maximum (PETM) and evidenced in the stratigraphic record by a negative delta(13)C excursion. It remains unclear, however, whether or how this warming event may have influenced Palaeocene-Eocene faunal turnovers. This paper explores the hypothesis that environmental changes associated with the PETM facilitated an invasion of Western Europe by primates by comparing the ecological structure of local mammalian fauna immediately before and following the Palaeocene-Eocene transition. The results suggest that changes to the ecological profile of local mammalian fauna were relatively small and did not favour an invasion by primates, although a major uncertainty remains with respect to the availability of arboreal niches. At present it seems more likely that the invasion of western Europe by primates was due to the breakdown of one or more dispersal barriers close to the end of the Palaeocene.
Assuntos
Clima , Fósseis , Paleontologia/métodos , Primatas/fisiologia , Animais , Ásia , Evolução Biológica , Isótopos de Carbono/análise , Emigração e Imigração , Europa (Continente) , Feminino , Geografia , História Antiga , Masculino , América do Norte , Fatores de TempoRESUMO
Revised age estimates for the primate-bearing localities of the Jebel Qatrani Formation (Fayum area, northern Egypt) have provided a new perspective on primate response to early Oligocene climate change in North Africa. Environmental changes associated with early Oligocene cooling might have driven the local extinction of at least 4 strepsirrhine primate clades (adapids, djebelemurines, plesiopithecids and galagids). Contrary to previous suggestions, oligopithecid (and possibly proteopithecid) anthropoids persisted beyond the Eocene-Oligocene boundary (EOB) in the Fayum area, and the former group evidently continued to diversify through the early Oligocene at lower latitudes. Propliopithecids and parapithecine parapithecids first appear in the Jebel Qatrani Formation millions of years after the EOB, so their derived dental and gnathic features can no longer be interpreted as sudden adaptive morphological responses to earliest Oligocene climatic events. Evidence for latitudinal contraction of Afro-Arabian primate distribution through the early Oligocene suggests that the profound late Oligocene restructuring of Afro-Arabian primate communities is most likely to have occurred in equatorial and low-latitude tropical Africa.
Assuntos
Evolução Biológica , Clima , Extinção Biológica , Fósseis , Primatas/fisiologia , Adaptação Fisiológica , África do Norte , Animais , Antigo Egito , Feminino , História Antiga , Masculino , Omã , Paleontologia/métodosRESUMO
Selective progesterone receptor modulators (SPRMs) represent a new class of progesterone receptor ligands that exert clinically relevant tissue-selective progesterone agonist, antagonist, partial, or mixed agonist/antagonist effects on various progesterone target tissues in an in vivo situation depending on the biological action studied. The SPRM asoprisnil is being studied in women with symptomatic uterine leiomyomata and endometriosis. Asoprisnil shows a high degree of uterine selectivity as compared to effects on ovulation or ovarian hormone secretion in humans. It induces amenorrhea and decreases leiomyoma volume in a dose-dependent manner in the presence of follicular phase estrogen concentrations. It also has endometrial antiproliferative effects. In pregnant animals, the myometrial, i.e. labor-inducing, effects of asoprisnil are blunted or absent. Studies in non-human primates played a key role during the preclinical development of selective progesterone receptor modulators. These studies provided the first evidence of uterus-selective effects of asoprisnil and structurally related compounds, and the rationale for clinical development of asoprisnil.
Assuntos
Avaliação Pré-Clínica de Medicamentos , Modelos Animais , Primatas/fisiologia , Congêneres da Progesterona/síntese química , Congêneres da Progesterona/uso terapêutico , Receptores de Progesterona/agonistas , Receptores de Progesterona/antagonistas & inibidores , Animais , Endométrio/efeitos dos fármacos , Estrenos/química , Estrenos/farmacologia , Feminino , Humanos , Leiomioma/tratamento farmacológico , Glândulas Mamárias Animais/efeitos dos fármacos , Modelos Biológicos , Modelos Moleculares , Especificidade de Órgãos , Oximas/química , Oximas/farmacologia , Congêneres da Progesterona/farmacologia , Receptores de Progesterona/metabolismo , Hemorragia Uterina/tratamento farmacológico , Neoplasias Uterinas/tratamento farmacológico , Útero/efeitos dos fármacosRESUMO
The process of reproductive senescence in many female mammals, including humans, is characterized by a gradual transition from regular reproductive cycles to irregular cycles to eventual acyclicity, and ultimately a loss of fertility. In the present review, the role of the hypothalamic gonadotropin-releasing hormone (GnRH) neurons is considered in this context. GnRH neurons provide the primary driving force upon the other levels of the reproductive axis. With respect to aging, GnRH cells undergo changes in biosynthesis, processing and release of the GnRH decapeptide. GnRH neurons also exhibit morphologic and ultrastructural alterations that appear to underlie these biosynthetic properties. Thus, functional and morphologic changes in the GnRH neurosecretory system may play causal roles in the transition to acyclicity. In addition, GnRH neurons are regulated by numerous inputs from neurotransmitters, neuromodulators and glia. The relationship among GnRH cells and their inputs at the cell body (thereby affecting GnRH biosynthesis) and the neuroterminal (thereby affecting GnRH neurosecretion) is crucial to the function of the GnRH system, with age-related changes in these relationships contributing to the reproductive senescent process. Therefore, the aging hypothalamus is characterized by changes intrinsic to the GnRH cell, as well as its regulatory inputs, which summate to contribute to a loss of reproductive competence in aging females.
Assuntos
Hormônio Liberador de Gonadotropina/fisiologia , Menopausa/fisiologia , Sistemas Neurossecretores/fisiologia , Adulto , Animais , Feminino , Humanos , Hipotálamo/fisiologia , Pessoa de Meia-Idade , Modelos Animais , Neuroglia/fisiologia , Neurônios/citologia , Neurônios/fisiologia , Sistemas Neurossecretores/citologia , Primatas/fisiologiaRESUMO
Sensory information from the tongue and teeth is used to evaluate and distinguish food and nonfood items in the mouth, reject some and masticate and swallow others. While it is known that primates have a complex array of 10 or more somatosensory areas that contribute to the analysis of sensory information from the hand, less is known about what cortical areas are involved in processing information from receptors of the tongue and teeth. The tongue contains taste receptors, as well as mechanoreceptors. Afferents from taste receptors and mechanoreceptors of the tongue access different ascending systems in the brainstem. However, it is uncertain how these two sources of information are processed in cortex. Here the parts of somatosensory areas 3b, 3a, and presumptive 1 that represent the mechanoreceptors of the teeth and tongue are identified, and evidence is presented that the representations of the tongue also get information from the taste nucleus of the thalamus, VPMpc. As areas 3b, 3a, and 1 project to other areas of somatosensory cortex, and those areas to additional areas, some or all of the currently defined somatosensory areas of cortex may be involved in processing gustatory, as well as tactile, information from the tongue and thus have a role in the biologically important function of evaluating food in the mouth.