A Brief History of Psoriasis Management in Canada.

Psoriasis is a chronic, inflammatory disease with a varying degree of clinical presentations. Managing psoriasis has always been arduous due to its chronicity and its propensity to relapse. Prior to the development of targeted biologic therapies, there were few effective treatments for psoriasis. Ancient psoriasis therapies included pinetar, plant extracts, psychotherapy, arsenic, and ammoniated mercury. In the 19th century, chrysarobin was developed. Then, in the early half of the 20th century, anthralin and coal tar were in widespread use. In the latter half of the 20th century, treatments were limited to topical first-line therapies, systemic drugs, and phototherapy. However, as the treatment of psoriasis has undergone a revolutionary change with the development of novel biologic therapies, patients with moderate to severe psoriasis have been able to avail therapies with high efficacy and durability along with an acceptable safety profile. This article is a brief historical review of the management of psoriasis prior to the inception of biologics and with the development of novel biologic therapies.

Psoriasis and Treatment: Past, Present and Future Aspects.

The management of psoriasis has evolved considerably over the past 100 years. This has occurred in parallel with our understanding of the pathogenesis of this common, complex and enigmatic disease. It should be celebrated as an outstanding example of successful translational research. With precise targeting of immune pathways for the treatment of psoriasis with new biologics and small molecules has come the realisation that the most effective approach to patient management is a holistic one which encompasses the biopsychosocial nature of the disease. This involves a stratified medicine approach to identifying the best drug for an individual allied to patient education, screening for comorbidity, and regular review as both the clinical presentation and the patient's needs will change over time. Al-though there is not yet a cure for psoriasis - the whole person, systems approach to patient management, that is in part dependent on early intervention, should help to ensure an optimal outcome.

Use of mineral waters in the treatment of psoriasis: Perspectives of Persian and conventional medicine.

Psoriasis is a chronic inflammatory disease, which is accompanied by social and emotional complications leading to considerable disability. There is no definitive cure and treatment options carry complications. Balneotherapy has been used for years in psoriasis. Antibiotic, keratolytic, and anti-inflammatory effects of these waters have been proved. Persian medicine (PM) is a source of natural remedies for skin disease. The aim of study is to explain scientific evidences of Persian mineral waters as a treatment option for psoriasis. This is a narrative review, which investigates medical manuscripts of medieval Persia from 10th to 19th centuries AD noted as credible textbooks about mineral waters. Furthermore, balneotherapy evidences searched in databases including Pubmed, Scopus, and Cochrane until December 2017 to obtain clinical evidences related to psoriasis. In PM, mineral waters have keratolytic activity and can regulate superficial skin layers hyperproliferation, which is recommended for psoriasis treatment. In various studies, antiproliferative, keratolytic, antibiotic, anti-inflammatory, and antioxidant effects of these waters have been proved completely. There are scientific evidences, which demonstrate that mineral waters in Persia, can reduce clinical symptoms of psoriasis and improve quality of life in patients. Therefore, this method might be considered as treatment options for psoriasis.

Terapia Biológica en Psoriasis / Biologic therapy in psoriasis

La psoriasis es una enfermedad inflamatoria crónica, medida inmunológicamente, de etiología desconocida que afecta del 1 al 3 por ciento de la poblalción mundial. Se caracteriza por la Hiperproliferación de queratinositos causada por la estimulación persistente de celulas T por inmunogenos de origen epidermico. Se asocia información dermica y secundariamente hiperplasia epidermica, suceptible de control mediante tratamiento médico prolongado, no curable, con grados diferentes de afectación. Existen múltiples tratamientos como son la terapia tópica, fototerapia y sistémica, con resultados variables. El desarrollo de la biología molecular, la ingeniería genética y biotecnología ha permitido la creación de moléculas dirigidas a etapas específicas de la patogenia de varias enfermedades mediadas por el sistema inmunitario. Estos elementos así obtenidos se denominan productos biológicos, y al uso de estos, terapia biológica. La terapia biológica en pacientes con psoriasis ha mostrado beneficios significativos con perfiles de tolerabilidad y seguridad satisfactorios. La limitación que la terapia biológica presenta dentro de las estrategias de tratamiento es definitivamente, su costo.

Psoriasis is a chronic inflammatory disease, immunologicaly mediated, of unknown etiology, affecting 1 to 3 per cent of the worldÆs population; is characterized by hiperproliferación of keratinocytes, caused by persistent stimulation of T cells by immunogens of epidermal origin, which associates skin inflammation and secondarily epidermal hyperplasia, which could control through prolonged medical treatment, not curable, with varying degrees of involvement. There are multiple treatments such as topical and systemic therapy, with varying results. The development of molecular biology, genetic engineering and biotechnology has enabled the creation of molecules aimed at specific stages of the pathogenesis of several diseases mediated by the immune system. These elements thus obtained are called biological products, and its use biological therapy. Biological therapy in patients with psoriasis has shown significant benefits with profiles of successful safety and tolerability. The restriction that the biological therapy introduced in the treatment strategies is definitely its cost.

Historical development of local therapy of psoriasis vulgaris.

Throughout the history people have used various remedies for the treatment of psoriasis. Some of them were bizarre, some ineffective and harmful, and some have survived until today and are still in use. Salicylic acid, anthralin, coal tar, corticosteroids, vitamin D3 analogues, retinoids must be mentioned as remarkably effective ones. Phototherapy and laser therapy are both promising techniques, as well as immunomodulators. Underlying mechanisms of psoriasis and mode of action of therapeutics that have been elucidated over the time allowed for the development of more potent and promising therapy of psoriasis.

History of the treatment of psoriasis.

This article reviews the history of selected therapeutic agents for psoriasis: arsenic (including Fowler's solution), ammoniated mercury, chrysarobin and anthralin, tars, aminopterin and methotrexate, and corticosteroids. The developers of these drugs paved the way for the new and improved treatments available today for the treatment of psoriasis.

History of psoriasis and parapsoriasis.

Parapsoriasis is not a disease entity. It is an auxiliary term introduced in 1902 to group several dermatoses with a faint similarity to psoriasis. The historical development leading to the creation of the term parapsoriasis is outlined and the history of psoriasis is briefly reviewed.

Lepra, psora, psoriasis.

This article traces the curious history of how psoriasis came to be called by its present appellation. In retelling the story, psoriasis is seen as a disease (known since antiquity) that has been confused with leprosy, with some tragic results.