RESUMO
OBJECTIVES: Burning mouth syndrome (BMS) is characterized by burning of the oral mucosa in the absence of underlying dental or medical causes. The results of previous systematic reviews have generally been equivocal. However, findings for most interventions are based on searches of 5-10years ago. This study therefore updates previous searches of randomized controlled trials (RCTs) for pain as assessed by Visual Analogue Scales (VAS). Secondary outcomes included quality of life, mood, taste and salivary flow. METHODS: A search of MEDLINE and Embase up to 2016. RESULTS: 24 RCTs were identified. Meta-analyses were impossible because of wide variations in study method and quality. The commonest interventions were alpha-lipoic acid (ALA) (8 comparisons), capsaicin or an analogue (4 comparisons), clonazepam (3 comparisons) and psychotherapy (2 comparisons). ALA and capsaicin led to significantly greater improvements in VAS (4 studies each), as did clonazepam (all 3 studies), at up to two month follow-up. However, capsaicin led to prominent dyspepsia. Psychotherapy significantly improved outcomes in one study at two and 12month follow-up. Catauma and tongue-protectors also showed promise (one study each). There were no significant differences in any of the secondary outcomes except in the one study of tongue protectors. CONCLUSIONS: At least in some studies and for some outcomes, ALA, clonazepam, capsaicin and psychotherapy may show modest benefit in the first two months. However, these conclusions are limited by generally short follow-up periods, high study variability and low participant numbers. Further RCTs with follow-up of at least 12months are indicated.
Assuntos
Síndrome da Ardência Bucal/psicologia , Síndrome da Ardência Bucal/terapia , Psicoterapia/métodos , Ensaios Clínicos Controlados Aleatórios como Assunto/métodos , Síndrome da Ardência Bucal/epidemiologia , Capsaicina/farmacologia , Capsaicina/uso terapêutico , Humanos , Dor/epidemiologia , Dor/psicologia , Manejo da Dor/métodos , Manejo da Dor/psicologia , Medição da Dor/efeitos dos fármacos , Medição da Dor/métodos , Medição da Dor/psicologia , Qualidade de Vida/psicologia , Ácido Tióctico/farmacologia , Ácido Tióctico/uso terapêutico , Resultado do TratamentoRESUMO
El síndrome de boca ardiente se considera un 'dolor urente en la lengua o en otra localización de la mucosa oral sin signos patológicos específicos con evolución de al menos 4-6 meses', según la Asociación Internacional para el estudio del Dolor (IASP). La prevalencia oscila entre el 0,7% - 4,6%, siendo más frecuente en el sexo femenino (7:1) en la etapa peri-postmenopáusica. La etiología es multifactorial, por lo que debemos eliminar los factores locales, sistémicos y psicológicos que como factores precipitantes o consecuentes, están siempre presentes en esta entidad. En cuanto al tratamiento hemos de retirar los agentes causantes de la patología y disminuir en la medida de lo posible la sintomatología. A pesar de haber obtenido resultados con las terapias descritas en las revisiones sistemáticas y en los estudios clínicos son necesarios más ensayos clínicos aleatorizados, con muestras homogéneas, diseños apropiados y periodos de seguimiento prolongados que permitan evaluar la eficacia clínica y los posibles efectos adversos a largo plazo (AU)
Burning mouth syndrome is considered a burning pain in the tongue or in another location of the oral mucosa without specific pathological features with the development in at least 4-6 months, according to the International Association for the Study of Pain (IASP). The prevalence ranges from 0.7% - 4.6%, being more common in females (7:1) in the peri-menopausal stage. The etiology is multifactorial, so we must delete local, systemic and psychological factors as precipitating or consequential factors are always present in this entity. Despite of the results obtained with the therapies described in systematic reviews and clinical studies more randomized clinical trials with homogeneous samples, appropriate designs and longer follow-up periods to evaluate the clinical efficacy and potential adverse effects are needed long term (AU)
Assuntos
Humanos , Síndrome da Ardência Bucal/epidemiologia , Síndrome da Ardência Bucal/tratamento farmacológico , Ácido Tióctico/uso terapêutico , Capsaicina/uso terapêutico , Antidepressivos/uso terapêutico , Benzidamina/uso terapêutico , GABAérgicos/uso terapêutico , Clonazepam/uso terapêuticoAssuntos
Síndrome da Ardência Bucal/diagnóstico , Síndrome da Ardência Bucal/terapia , Algoritmos , Analgésicos/uso terapêutico , Antidepressivos/uso terapêutico , Síndrome da Ardência Bucal/classificação , Síndrome da Ardência Bucal/epidemiologia , Síndrome da Ardência Bucal/etiologia , Síndrome da Ardência Bucal/psicologia , Terapias Complementares , Prótese Dentária/efeitos adversos , Doenças do Sistema Endócrino/complicações , Feminino , Humanos , Irritantes/efeitos adversos , Masculino , Transtornos Mentais/complicações , Boca/microbiologia , Neuropeptídeos/metabolismo , Prevalência , Psicoterapia , Lesões por Radiação/complicações , Doenças Reumáticas/complicações , Xerostomia/complicaçõesRESUMO
Burning mouth syndrome is a complex pathology for which there is very little information about the etiology and pathogenesis. This lack of knowledge leaves patients with suboptimal treatments. This article discusses the existing scientific evidence about this disease. Since topical oral use of clonazepam have been shown to be effective and safe to treat some patients suffering with burning mouth syndrome, formulations including clonazepam are included with this article. Compounding topical preparations of clonazepam offers opportunities for compounding pharmacists to be more involved in improving the quality of life of burning mouth syndrome patients.
Assuntos
Síndrome da Ardência Bucal/terapia , Terapia por Acupuntura , Síndrome da Ardência Bucal/diagnóstico , Síndrome da Ardência Bucal/epidemiologia , Síndrome da Ardência Bucal/etiologia , Clonazepam/uso terapêutico , Humanos , Paroxetina/uso terapêutico , Prevalência , Ácido Tióctico/uso terapêuticoRESUMO
El síndrome de boca ardiente (SBA) es una entidad patológica caracterizada por la presencia de síntomas crónicos de ardor o dolor en la mucosa bucal clínicamente normal. El SBA afecta principalmente a mujeres peri y posmenopáusicas. Su causa es desconocida, pero su relación con una compleja asociación de factores biológicos y psicológicos hace suponer una etiología multifactorial. Aunque se han encontrado tratamientos eficaces en casos particulares, se sigue buscando un tratamiento que resulte eficaz en la mayoría de los casos. Esta revisión hace especial referencia a los factores etiológicos y al tratamiento del síndrome (AU)
The burning mouth syndrome (BMS) is characterized by the presence of chronic symptoms of burning or paining clinically normal oral mucosa. This syndrome primarily affects peri and postmenopausal women. The cause is unknown, but the relationship between the BMS and a complex association of biological and psychological factors suggest a multifactorial etiology. Although some treatments have been found effective in particular cases, the clinical searchers are still looking for a treatment that can be effective in most cases. This review makes particular reference to the etiological factors and the treatment of the síndrome (AU)