Change of temperature in mouse tumour tissue immersed in a water bath at 44 degrees C.

We investigated the change in temperature in tumour and normal tissues of mice when immersed in a water bath at 44.0 degrees C as part of a series of studies of hyperthermia. The right hind legs of the mice bearing the experimental tumour sarcoma 180 were immersed in the water bath, and measurements were performed using the multi-thermocouple thermosensor from a radiofrequency (RF) generator every 24 sec with a precision of 0.1 degrees C. The temperature in all tumour tissues exceeded 43.0 degrees C only at 1 min 24 sec after immersion of the limbs. The rise in temperature then reached a plateau phase, and was maintained around 44.0 degrees C. However, we found that the temperature of the normal tissue was about 0.6 degrees C lower than that of the tumour tissue or the tissue around the tumour at the plateau phase.

[Morphological and functional characteristics of hemopoiesis during the combined use of cyclophosphane with millimeter-band radio waves of nonthermal intensity]. / Morfologicheskie i funktsional'nye osobennosti krovetvoreniia pri kombinirovannom ispol'zovanii tsiklofosfana s radiovolnami millimetrovogo diapazona neteplovoi intensivnosti.

Material is presented on combined effects of mm-band radio waves and cyclophosphane on the hemopoietic system and inoculated tumor sarcoma-180. The role of the bone marrow truncal cells in the acceleration of regenerative processes and a two-fold increase of clonogenic activity of the bone marrow were determined in the combined group in comparison with the bone marrow of animals receiving just the preparation. The sensitizing effect of mm-waves in combination with cyclophosphane was distinctly manifested after two courses of administration of the preparation, leading to 85-100% resorption of the tumours without further relapses during the year of observation over the animals.

Antitumor activity in mice of orally administered polysaccharide from Kefir grain.

The antitumor activity of a water-soluble polysaccharide (KGF-C), isolated from the Kefir grain, was studied in the mice subcutaneously inoculated with Ehrlich carcinoma (EC) or Sarcoma 180 (S-180). The growth of EC and S-180 solid tumor was inhibited by 40-59% and 21-81%, respectively, by oral administration of KGF-C as compared with the unadministered mice. The tumor growth was similarly inhibited by intraperitoneal administration. The mechanism of the antitumor activity of KGF-C was considered to be host-mediated because of the lack of direct in vitro effect on tumor cells.