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1.
Eur Rev Med Pharmacol Sci ; 26(3): 1033-1041, 2022 02.
Artigo em Inglês | MEDLINE | ID: mdl-35179770

RESUMO

OBJECTIVE: Coronavirus disease 2019 (COVID-19) is a debilitating disease with numerous medical and non-medical consequences. Our study aimed to evaluate the efficacy of Persian barley water in controlling the clinical outcomes of hospitalized COVID-19 patients. PATIENTS AND METHODS: This was a single-blind, add-on therapy, randomized controlled clinical trial conducted in Shiraz, Iran, from January to March 2021. One hundred hospitalized COVID-19 patients with moderate disease severity were randomly allocated to receive routine treatment (per local protocols) with or without 250 ml of Persian barley water (PBW) daily for two weeks. Clinical outcomes and blood tests were recorded before and after the study period. Multivariable modeling was applied using Stata software for data analysis. RESULTS: The PBW product passed our standardization and safety assessments. Length of hospital stay (LHS) was 4.5 days shorter in the intervention group than the control group regardless of history of cigarette smoking (95% confidence interval: -7.22, -1.79 days). Also, body temperature, erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), and creatinine significantly dropped in the intervention group compared to the control group. No adverse events related to PBW occurred. CONCLUSIONS: This clinical trial demonstrated the efficacy of PBW in minimizing the LHS, fever, and levels of ESR, CRP, and creatinine among hospitalized COVID-19 patients with moderate disease severity. More robust trials can help find safe and effective herbal formulations as treatments for COVID-19.


Assuntos
COVID-19/terapia , Hordeum , Medicina Persa/métodos , Adulto , Idoso , Sedimentação Sanguínea/efeitos dos fármacos , Proteína C-Reativa/efeitos dos fármacos , Creatinina , Febre/terapia , Hospitalização , Humanos , Tempo de Internação , Masculino , Pessoa de Meia-Idade , Índice de Gravidade de Doença , Método Simples-Cego , Resultado do Tratamento
2.
Medicine (Baltimore) ; 99(51): e23549, 2020 Dec 18.
Artigo em Inglês | MEDLINE | ID: mdl-33371080

RESUMO

BACKGROUND: Chronic pelvic inflammatory disease (CPID) is one of common diseases of department of gynaecology, point to female inside genital and circumferential organization to suffer from infection of all sorts of pathogenic bacteria and cause chronic inflammation sex disease, also cause one of main factors of infertile of female of childbearing age period. Due to its insidious onset, it is not easy to find out in the early stage. Therefore, it is difficult to obtain satisfactory curative effect by taking routine treatment with antibiotics. In recent years, TCM has made great strides in the treatment of chronic pelvic inflammation, a number of clinical studies have shown that Guizhi Fuling wan combined with antibiotics can significantly improve the clinical symptoms and enhance the therapeutic effect. Therefore, we intend to conduct a system review and meta-analysis to further clarify the effectiveness and safety of GZFLW for CPID. METHODS: We will search each database from the built-in until September2020.The English literature mainly searches Cochrane Library, PubMed, EMBASE, and Web of Science, while the Chinese literature comes from CNKI, CBM, VIP, and Wangfang database. Simultaneously we will retrieval clinical registration tests and grey literatures. This study only screens the clinical randomized controlled trials (RCTs) about GZFLW for CPID to assess its efficacy and safety. The 2 researchers worked independently on literature selection, data extraction, and quality assessment. The dichotomous data is represented by relative risk (RR), and the continuous is expressed by mean difference (MD) or standard mean difference (SMD), eventually the data is synthesized using a fixed effect model (FEM) or a random effect model (REM) depending on whether or not heterogeneity exists. The clinical efficacy, pelvic effusion and mass were evaluated as the main outcomes. The serum interleukin-6 (IL-6), C-reactive protein (CRP), tumor necrosis factor (TNF)-α, erythrocyte sedimentation rate (ESR), erythrocyte specific volume was secondary outcomes. Finally, meta-analysis was conducted by RevMan software version 5.3. RESULTS: This study will provide high-quality evidence for treatment of CPID with GZFLW in terms of effectiveness and safety. CONCLUSION: This systematic review aims to provide new options for GZFLW treatment of CPID in terms of its efficacy and safety. ETHICS AND DISSEMINATION: This study does not require ethical approval. We will disseminate our findings by publishing results in a peer-reviewed journal. OSF REGISTRATION NUMBER: DOI 10.17605 / OSF.IO / R9NVT.


Assuntos
Medicamentos de Ervas Chinesas/uso terapêutico , Doença Inflamatória Pélvica/tratamento farmacológico , Sedimentação Sanguínea/efeitos dos fármacos , Doença Crônica , Medicamentos de Ervas Chinesas/efeitos adversos , Feminino , Humanos , Mediadores da Inflamação/metabolismo , Ensaios Clínicos Controlados Aleatórios como Assunto , Projetos de Pesquisa , Metanálise como Assunto
3.
Medicine (Baltimore) ; 99(8): e18912, 2020 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-32080074

RESUMO

BACKGROUND: Knee osteoarthritis (KOA) is the most common form of degenerative arthritis. We used Phellinus linteus (PL), which has been well-known anti-inflammatory function. In this study, we will evaluate if PL extract improves symptoms with KOA. METHODS: This study will be an 8-week single-center randomized controlled double-blind clinical trial. Total of 24 subjects with KOA will be enrolled and they will be divided into 3 groups, PL 1,000 mg, PL 1,500 mg and placebo. Subjects will be followed up every 4 weeks with efficacy and safety at the 2nd and 3rd visits. All subjects should maintain a dosage schedule for this protocol. The primary outcome will be assessed with the Korean version of the Western Ontario and McMasters Universities. And the secondary outcomes will be measured using the visual analog scale, quality of life scale (EQ-5D-3L), ESR, C-reactive protein, and C-telopeptide of type-II collagen. Statistical analysis will be performed on the principle of full analysis set. DISCUSSION: This study has inclusion and exclusion criteria and a well-controlled intervention. This clinical trial is the first step to assess the efficacy and safety of PL in patients with KOA. This study will make an important contribution to the literature and aid follow-up research into the use of PL in KOA.


Assuntos
Cartilagem Articular/efeitos dos fármacos , Articulação do Joelho/efeitos dos fármacos , Osteoartrite do Joelho/tratamento farmacológico , Extratos Vegetais/administração & dosagem , Administração Oral , Adulto , Idoso , Sedimentação Sanguínea/efeitos dos fármacos , Proteína C-Reativa/efeitos dos fármacos , Colágeno Tipo I/efeitos dos fármacos , Humanos , Pessoa de Meia-Idade , Osteoartrite do Joelho/sangue , Osteoartrite do Joelho/patologia , Peptídeos/efeitos dos fármacos , Phellinus , Placebos/administração & dosagem , Extratos Vegetais/uso terapêutico , Estudos Prospectivos , Qualidade de Vida , República da Coreia/epidemiologia , Resultado do Tratamento
4.
Molecules ; 25(1)2020 Jan 01.
Artigo em Inglês | MEDLINE | ID: mdl-31906332

RESUMO

Astragalin, isolated from flowers of Rosa chinensis Jacq., is a kind of flavonoid, with anti-inflammatory, antioxidant, antiviral, analgesic, antibacterial, antiallergic, and antihepatotoxic effects. However, no studieson the procoagulant effect of astragalin have been reported. This study aimed to investigate the procoagulant activity of astragalin and its mechanism. Its procoagulant effect was investigated by activated partial thromboplastin time (APTT), thrombin time (TT), prothrombin time (PT), and fibrinogen (FIB) in vitro, and a rat model established by heparin sodium was used to evaluate the mechanism for the procoagulant effect in vivo. The results showed that astragalin had good procoagulant effects compared with the control group in vitro. Compared with the model group in vivo, astragalin could shorten the coagulation time and significantly increase the number of platelets. Meanwhile, astragalin could significantly reduce the effectual time of PT and APTT and increase the content of FIB. The contents of 6-keto-PGF1α and eNOS significantly decreased. Astragalin could increase whole blood viscosity (WBV), plasma viscosity (PV), erythrocyte sedimentation rate (ESR) and packedcell volume (PCV). All of the above revealed that astragalin had good procoagulant effects by promoting the intrinsic and extrinsic coagulation system.


Assuntos
Coagulação Sanguínea/efeitos dos fármacos , Fibrinogênio/metabolismo , Quempferóis/farmacologia , Agregação Plaquetária/efeitos dos fármacos , 6-Cetoprostaglandina F1 alfa/metabolismo , Animais , Testes de Coagulação Sanguínea , Sedimentação Sanguínea/efeitos dos fármacos , Viscosidade Sanguínea/efeitos dos fármacos , Medicamentos de Ervas Chinesas/metabolismo , Medicamentos de Ervas Chinesas/farmacologia , Endotelina-1/metabolismo , Feminino , Flavonoides/metabolismo , Flavonoides/farmacologia , Quempferóis/química , Quempferóis/isolamento & purificação , Quempferóis/metabolismo , Masculino , Óxido Nítrico Sintase Tipo III/metabolismo , Tempo de Tromboplastina Parcial , Tempo de Protrombina , Coelhos , Ratos , Ratos Sprague-Dawley , Rosaceae/química , Tempo de Trombina , Tromboxano B2/metabolismo
5.
Phytomedicine ; 54: 149-158, 2019 Feb 15.
Artigo em Inglês | MEDLINE | ID: mdl-30668364

RESUMO

BACKGROUND: Danshen (Salvia miltiorrhiza, DS) and Honghua (Carthamus tinctorius, HH) are commonly used traditional Chinese medicines for activating blood and removing stasis, and DS-HH (DH) herbal pair had potential synergistic effects on promoting blood circulation. Therefore, it is essential to make clear the active components of this herbal pair for better understanding their potential synergistic effects. PURPOSE: To comprehensively evaluate the activity of DH herbal pair on physiological coagulation system of rats, and seek their potential active components by spectrum-effect relationship analysis. METHODS: The water extracts of DH herbal pair with different proportions (DS: HH = 1:1, 2:1, 3:1, 5:1, 1:5 and 1:3) were prepared. Male Sprague-Dawley rats were randomly divided into eight groups: blank group, model group, model + 1:1 (DH) group, model + 2:1 group, model + 3:1 group, model + 5:1 group, model + 1:5 group and model + 1:3 group. The intragastric administration was performed for eight times with 12 h intervals. SC40 semi-automatic coagulation analyzer was employed to determine coagulation indices. Meanwhile, HPLC and LC-MS were applied for chemical analyses of DH extracts. Finally, the active ingredients were screened by spectrum-effect relationship analysis and the activities of major predicted compounds were validated in vitro. RESULTS: Different proportions of DH extracts could significantly prolong thrombin time (TT) and activated partial thromboplastin time (APTT), increase prothrombin time (PT) and decrease fibrinogen (FIB) content, reduced whole blood viscosity (WBV) and plasma viscosity (PV), decreased erythrocyte sedimentation rate blood (ESR) compared with model group. Furthermore, fifteen highly related components were screened out by the spectrum-effect relationship and LC-MS analysis, of which caffeic acid, salvianolic acid B, hydroxysafflor yellow A and lithospermate acid had significant blood-activing effect by prolong APTT and decrease FIB content at high (0.6 mM), medium (0.3 mM) and low (0.15 mM) (except lithospermate acid) concentrations in vitro. CONCLUSIONS: DH herbal pair showed strong blood-activating effect on blood stasis rat through regulating the parameters involved in haemorheology and plasma coagulation system. Four active compounds, caffeic acid, salvianolic acid B, hydroxysafflor yellow A and lithospermate acid predicted by spectrum-effect relationship analysis had good blood-activating effect. Therefore, spectrum-effect relationship analysis is an effective approach for seeking active components in herbal pairs.


Assuntos
Coagulação Sanguínea/efeitos dos fármacos , Carthamus tinctorius/química , Medicamentos de Ervas Chinesas/farmacologia , Salvia miltiorrhiza/química , Animais , Benzofuranos/análise , Benzofuranos/farmacologia , Sedimentação Sanguínea/efeitos dos fármacos , Ácidos Cafeicos/análise , Ácidos Cafeicos/farmacologia , Chalcona/análogos & derivados , Chalcona/análise , Chalcona/farmacologia , Cromatografia Líquida de Alta Pressão , Avaliação Pré-Clínica de Medicamentos/métodos , Medicamentos de Ervas Chinesas/química , Fibrinogênio/metabolismo , Hemorreologia/efeitos dos fármacos , Masculino , Tempo de Protrombina , Quinonas/análise , Quinonas/farmacologia , Ratos Sprague-Dawley
6.
Eur J Clin Nutr ; 71(1): 92-96, 2017 01.
Artigo em Inglês | MEDLINE | ID: mdl-27577177

RESUMO

BACKGROUND/OBJECTIVES: Since the main characteristics of Rheumatoid Arthritis (RA) are joint dysfunction caused by inflammation and serious pain, anti-inflammatory agents may alleviate the clinical symptoms in RA. Pomegranate juice is rich in polyphenolic compounds that possess antioxidant and anti-inflammatory activities. This study aimed to determine the beneficial effects of pomegranate extract (POMx) in RA patients. SUBJECTS/METHODS: A total of 55 RA patients were enrolled and randomly allocated to an intervention group (n=30) or a control group (n=25). The intervention group received 2 capsules of 250 mg POMx and the control group 2 capsules of 250 mg cellulose per day for 8 weeks. At the beginning of the study and after 8 weeks, Health Assessment Questionnaire (HAQ) and Disease Activity Score (DAS) 28 were completed and serum concentrations of C-reactive protein (CRP), matrix metalloproteinases 3 (MMP3), malondialdehyde (MDA), glutathione peroxidase (GPx) and erythrocyte sedimentation rate (ESR) were analyzed using standard methods and compared between the two groups. RESULTS: Compared with the placebo group, POMx supplement significantly reduced the score of DAS28 (P<0.001) which could be related to the decrease in swollen (P<0.001) and tender joints (P=0.001) count, pain intensity (P=0.003) and ESR levels (P= 0.03). POMx consumption also decreased HAQ score (P=0.007) and morning stiffness (P=0.04) and increased GPx concentrations (P<0.001). There were no differences in the change in mean MMP3, CRP and MDA levels between two groups. CONCLUSIONS: POMx alleviates disease activity and improves some blood biomarkers of inflammation and oxidative stress in RA patients.


Assuntos
Antioxidantes/administração & dosagem , Artrite Reumatoide/tratamento farmacológico , Lythraceae/química , Fitoterapia/métodos , Extratos Vegetais/administração & dosagem , Adulto , Artrite Reumatoide/sangue , Biomarcadores/sangue , Sedimentação Sanguínea/efeitos dos fármacos , Proteína C-Reativa/análise , Método Duplo-Cego , Feminino , Glutationa Peroxidase/sangue , Humanos , Inflamação , Masculino , Malondialdeído/sangue , Metaloproteinase 3 da Matriz/sangue , Pessoa de Meia-Idade , Estresse Oxidativo , Índice de Gravidade de Doença , Resultado do Tratamento
7.
J Tradit Chin Med ; 36(5): 625-33, 2016 10.
Artigo em Inglês | MEDLINE | ID: mdl-29933531

RESUMO

OBJECTIVE: To investigate the effect of Sanhuangyilong decoction plus methotrexate (MTX) on Interferon gamma (IFN-γ) and tumor necrosis factor alpha (TNF-α) in the serum and synovial fluid of rheumatoid arthritis (RA) patients with damp-heat-obstruction symptom pattern, Sanhuangyilong decoction and the role of TNF-α and IFN-γ in the development of RA. METHODS: RA inpatients with damp-heat-obstruction symptom pattern (partly with knee joint effusion) were selected as the research subjects. Before the treatment, healthy subjects and osteoarthritis (OA) patients with knee joint effusion were assigned to the serum control group and the synovial fluid control group, respectively; during the treatment, RA patients with damp-heat-obstruction symptom pattern were divided into two groups: one is combined group that was administered Sanhuangyilong decoction plus MTX; the other group was MTX group that received MTX only. The expression levels of TNF-α and IFN-γ in the serum and synovial fluid were measured with enzyme-linked immunosorbent assay (ELISA) before and after the treatment, and the peripheral blood levels of erythrocyte sedimentation rate (ESR), C-reactive protein (CRP) and disease activity score in 28 joints (DAS28) were determined. RESULTS: Before treatment, the serum levels of TNF-α and IFN-γ in the RA patients with dampheat- obstruction symptom pattern were higher than those in healthy control group (P < 0.05).The expression levels of TNF-α and IFN-γ in the synovial fluid of the RA patients were higher than those in the serum of the RA patients (P < 0.05). The expression levels of TNF-α and IFN-γ in the synovial fluid of the RA patients were higher than those of the synovial fluid of the osteoarthritis patients (P < 0.05). The expression of TNF-α and IFN-γ in the serum and synovial fluid of the RA patients had no correlation with the inflammatory activity index ESR, CRP, or DAS28 (P > 0.05). After 2 weeks of treatment, the expression level of TNF-α and IFN-γ in the combined group had increased, although the difference was not statistically significant (P > 0.05); in contrast, ESR, CRP, and DAS28 decreased, and the difference was statistically significant (P < 0.01). After 4 weeks of therapy, TNF-alpha and IFN-γ, ESR, CRP, and DAS28 in the combined group decreased compared with the before-treatment levels (P < 0.01). After 2 w of treatment, the differences in the TNF-α and IFN-γ expression levels in the combined group were not statistically significant (P > 0.05) compared with that in the MTX group, although there were statistically significant differences in the ESR, CRP, and DAS28 (P < 0.05). After 4 weeks of treatment, differences in TNF-α, IFN-γ, ESR, CRP, and DAS28 in the combined group compared with MTX group were statistically significant (P < 0.01). CONCLUSION: TNF-α and IFN-γ might be involved in the development of RA. The RA patients with damp-heat-obstruction symptom pattern show better benefits from the treatment of Sanhuangyilong decoction plus MTX, and the treatment is superior to that of using MTX only.


Assuntos
Artrite Reumatoide/tratamento farmacológico , Medicamentos de Ervas Chinesas/administração & dosagem , Interferon gama/sangue , Metotrexato/administração & dosagem , Líquido Sinovial/metabolismo , Fator de Necrose Tumoral alfa/sangue , Idoso , Artrite Reumatoide/sangue , Artrite Reumatoide/diagnóstico , Sedimentação Sanguínea/efeitos dos fármacos , Proteína C-Reativa/metabolismo , Quimioterapia Combinada , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Líquido Sinovial/efeitos dos fármacos
8.
Oxid Med Cell Longev ; 2015: 421624, 2015.
Artigo em Inglês | MEDLINE | ID: mdl-26236424

RESUMO

An involvement of the immune system has been suggested in Rett syndrome (RTT), a devastating neurodevelopmental disorder related to oxidative stress, and caused by a mutation in the methyl-CpG binding protein 2 gene (MECP2) or, more rarely, cyclin-dependent kinase-like 5 (CDKL5). To date, it is unclear whether both mutations may have an impact on the circulating cytokine patterns. In the present study, cytokines involved in the Th1-, Th2-, and T regulatory (T-reg) response, as well as chemokines, were investigated in MECP2- (MECP2-RTT) (n = 16) and CDKL5-Rett syndrome (CDKL5-RTT) (n = 8), before and after ω-3 polyunsaturated fatty acids (PUFAs) supplementation. A major cytokine dysregulation was evidenced in untreated RTT patients. In MECP2-RTT, a Th2-shifted balance was evidenced, whereas in CDKL5-RTT both Th1- and Th2-related cytokines (except for IL-4) were upregulated. In MECP2-RTT, decreased levels of IL-22 were observed, whereas increased IL-22 and T-reg cytokine levels were evidenced in CDKL5-RTT. Chemokines were unchanged. The cytokine dysregulation was proportional to clinical severity, inflammatory status, and redox imbalance. Omega-3 PUFAs partially counterbalanced cytokine changes, as well as aberrant redox homeostasis and the inflammatory status. RTT is associated with a subclinical immune dysregulation as the likely consequence of a defective inflammation regulatory signaling system.


Assuntos
Citocinas/análise , Ácidos Graxos Ômega-3/farmacologia , Inflamação , Proteína 2 de Ligação a Metil-CpG/metabolismo , Proteínas Serina-Treonina Quinases/metabolismo , Síndrome de Rett/patologia , Adolescente , Adulto , Sedimentação Sanguínea/efeitos dos fármacos , Criança , Pré-Escolar , Citocinas/sangue , Suplementos Nutricionais , Ensaio de Imunoadsorção Enzimática , Eritrócitos/citologia , Ácidos Graxos Ômega-3/uso terapêutico , Feminino , Humanos , Proteína 2 de Ligação a Metil-CpG/genética , Polimorfismo de Nucleotídeo Único , Proteínas Serina-Treonina Quinases/genética , Síndrome de Rett/tratamento farmacológico , Síndrome de Rett/metabolismo , Índice de Gravidade de Doença , Linfócitos T Reguladores/citologia , Linfócitos T Reguladores/efeitos dos fármacos , Linfócitos T Reguladores/metabolismo , Células Th1/citologia , Células Th1/efeitos dos fármacos , Células Th1/metabolismo , Células Th2/citologia , Células Th2/efeitos dos fármacos , Células Th2/metabolismo , Adulto Jovem
9.
Afr Health Sci ; 15(2): 606-12, 2015 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-26124810

RESUMO

BACKGROUND: The extract of the leaves of Viscum album (mistletoe) has been used for centuries in traditional medicine in many parts of the world. However, like many medicinal plants, the belief that things of natural origin are safe may not be entirely true. The blood is a good indicator of health and pathological mirror of the entire body. OBJECTIVE: Therefore, in this study, the acute effects of extracts of mistletoe, harvested from three hosts, on haematology indices of wistar albino rats was investigated. METHODS: Graded doses (400, 800, 1600 and 3200mg/kg body weight) of aqueous extracts of mistletoe from three different host plants, coffee (Coffee arabica), kola (Kola nitida), cocoa (Theobromae cacao), were administered orally to wistar albino rats for 14 days. Full haematological parameters were evaluated on whole blood collected from rats twenty four hours after the administration of the last dose. RESULTS: Mistletoe from kola caused a concentration dependent and statistically significant (p<0.05) reduction in platelets count in rats. Administration of mistletoe extract from cocoa and coffee led to reduction in hemoglobin concentration. Reductions in packed cell volume (PCV) and red blood cell (RBC) and increase in white blood cells (WBC) were also observed in rats administered all the extracts. CONCLUSION: Increase in the WBC count observed in rats administered mistletoe suggests that mistletoe extract contains agents that could stimulate the production of leucocytes and could serve as immune booster. However, there is need to be cautious in administration at high doses to prevent the risk of anaemia.


Assuntos
Sedimentação Sanguínea/efeitos dos fármacos , Eritrócitos/efeitos dos fármacos , Hemoglobinas/análise , Folhas de Planta/química , Viscum album/química , Animais , Cacau , Coffea , Cola , Hematócrito , Humanos , Contagem de Leucócitos , Masculino , Extratos Vegetais/administração & dosagem , Extratos Vegetais/farmacologia , Ratos , Ratos Wistar
10.
Eksp Klin Farmakol ; 78(1): 39-42, 2015.
Artigo em Russo | MEDLINE | ID: mdl-25826874

RESUMO

The influence of administration of the antioxidant complexes consisting of nonenzymatic antioxidants (alpha-tocopherol acetate preparation) and enzymatic antioxidants (ceruloplasmin) has been studied in rabbits with experimental arthritis. The introduction of alpha-tocopherol acetate (at a daily dose of 4 mg) improved metabolic processes in the organism (decreased in the rate of erythrocyte precipitation, total leukocytes and their stub and segmental forms; increased in erythrocyte count; reduced the glycosaminoglycan content as determined from uronic acid and hexose level; decreased ceruloplasmin activity and malonic dialdehyde level ion blood serum, all at p < 0.05), thus favoring reduction in the total activity of the inflammatory process as judged from hematological and biochemical data. Intra-articular introduction of ceruloplasmin (1.5 mg/kg, once per week) positively influenced the state of joint structures in damaged knee joints of the animals: decreased the activity of ceruloplasmin (from 5.28 ± 0.06 to 3.94 ± 0.01 AU), and malonic dialdehyde level (0.18 ± 0.02 to 0.08 ± 0.01 µM) in the articular fluid (all at p < 0.05). These effects are probably related to the elimination of inefficiency of the antioxidant system in the synovial medium, thus preventing inflammatory destruction of articular tissues, hindering the development of pannus, and assisting the activation of reparative regeneration of connective tissue structures.


Assuntos
Anti-Inflamatórios/farmacologia , Antioxidantes/farmacologia , Artrite Experimental/tratamento farmacológico , Ceruloplasmina/farmacologia , Regeneração/fisiologia , alfa-Tocoferol/farmacologia , Animais , Artrite Experimental/metabolismo , Artrite Experimental/patologia , Sedimentação Sanguínea/efeitos dos fármacos , Chinchila , Tecido Conjuntivo/efeitos dos fármacos , Tecido Conjuntivo/metabolismo , Tecido Conjuntivo/patologia , Quimioterapia Combinada , Glicosaminoglicanos/metabolismo , Hexoses/metabolismo , Injeções Intra-Articulares , Masculino , Malondialdeído/metabolismo , Joelho de Quadrúpedes/efeitos dos fármacos , Joelho de Quadrúpedes/metabolismo , Joelho de Quadrúpedes/patologia , Líquido Sinovial/química , Líquido Sinovial/efeitos dos fármacos , Ácidos Urônicos/metabolismo
11.
J Med Food ; 17(9): 1022-6, 2014 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-24896807

RESUMO

The purpose of this study was to ascertain whether an oral, non-prescription, nutritional supplement compound composed of a proprietary alkali-buffered creatine monohydrate and cetylated fatty acids mixture (Kre-Celazine(®)) was efficacious in reducing or eliminating refractory pain and inflammation, without untoward effects, in Juvenile Rheumatoid Arthritis (JRA), which is also called Juvenile Idiopathic Arthritis (JIA). JRA/JIA is a patho-physiologically complex, chronic childhood autoimmune inflammatory disease of unknown etiology. Numerous studies have unsuccessfully attempted to pinpoint a possible common initiation event. Officially considered an affliction of children below the age of 16 years, an initial diagnosis has been confirmed in infants less than 1 year old, to individuals older then 17 years. In this study, sixteen juveniles, ages 7 through 16 years, experiencing long-standing, unremitting pain and inflammation despite previous use of prescription anti-inflammatory drugs and NSAIDs, were enrolled in a 30-day, open-label clinical study and treated with Kre-Celazine. Efficacy of this nutritional supplement was determined by the juvenile's personal physician and based on observations of the following: (1) significant reduction or elimination of palpable signs of inflammation; (2) renormalization of range of motion; (3) reduction or absence of perceived pain as reported to the physician by the patient; (4) renormalization of C-reactive protein (CRP) and erythrocyte sedimentation rate (ESR) values. In addition, the individual's previous steroid or non-steroidal anti-inflamatory medication(s) were reduced or eliminated in a stepwise progressive fashion during the study.


Assuntos
Artrite Juvenil/tratamento farmacológico , Creatina/uso terapêutico , Suplementos Nutricionais , Ácidos Graxos/uso terapêutico , Inflamação/tratamento farmacológico , Dor/tratamento farmacológico , Adolescente , Analgésicos/uso terapêutico , Anti-Inflamatórios/uso terapêutico , Artrite Juvenil/sangue , Artrite Juvenil/complicações , Sedimentação Sanguínea/efeitos dos fármacos , Proteína C-Reativa/metabolismo , Creatina/farmacologia , Ácidos Graxos/farmacologia , Humanos , Inflamação/etiologia , Dor/etiologia , Projetos Piloto , Amplitude de Movimento Articular , Índice de Gravidade de Doença , Resultado do Tratamento
12.
J Environ Pathol Toxicol Oncol ; 32(3): 205-17, 2013.
Artigo em Inglês | MEDLINE | ID: mdl-24266407

RESUMO

The objective of this study was to investigate the modulatory role of Prunus avium fruit extract (PAE) on several blood parameters after exposure to 10-GHz microwaves. Swiss albino mice from an inbred colony were selected and divided into 3 groups. Mice in group I served as the control; they were placed in a Plexiglas cage (without energizing the system) for 2 hours/day for 30 consecutive days. Group II mice were exposed to 10-GHz microwaves for 2 hours/day for 30 consecutive days. Mice in group III received PAE (500 mg/kg/body weight) orally once daily 1 hour before exposure to 10-GHz microwaves (2 hours/day) for 30 consecutive days. After 30 days of treatment, blood samples were collected from mice in all groups and analyzed. Hemoglobin, monocytes, packed cell volume, red blood cells, mean corpuscular hemoglobin concentration declined significantly (P ≤ 0.01), whereas white blood cells, lymphocytes, erythrocyte sedimentation rate, and mean corpuscular volume increased significantly (P ≤ 0.01) compared to the control group (group I). Cholesterol, alkaline phosphatase, and lipid peroxidation also increased significantly (P ≤ 0.01). Depletion in blood sugar, total protein, acid phosphatase, and glutathione levels was noted after microwave exposure compared with levels in the sham-exposed (control) mice. Histopathological alterations in blood cells also were seen. Signs of improvements in the hematological, biochemical, and histopathological parameters were recorded in group III, where PAE was supplemented before exposure. Exposure to microwaves influences hematological parameters, which could be ameliorated by the supplementation of PAE.


Assuntos
Células Sanguíneas/efeitos dos fármacos , Células Sanguíneas/efeitos da radiação , Micro-Ondas/efeitos adversos , Extratos Vegetais/farmacologia , Prunus , Protetores contra Radiação/farmacologia , Fosfatase Alcalina/efeitos dos fármacos , Fosfatase Alcalina/metabolismo , Fosfatase Alcalina/efeitos da radiação , Animais , Sedimentação Sanguínea/efeitos dos fármacos , Sedimentação Sanguínea/efeitos da radiação , Colesterol/metabolismo , Colesterol/efeitos da radiação , Relação Dose-Resposta a Droga , Glutationa/efeitos dos fármacos , Glutationa/metabolismo , Glutationa/efeitos da radiação , Hemoglobinas/efeitos dos fármacos , Hemoglobinas/metabolismo , Hemoglobinas/efeitos da radiação , Peroxidação de Lipídeos/efeitos dos fármacos , Peroxidação de Lipídeos/efeitos da radiação , Masculino , Camundongos , Modelos Animais
13.
Drug Des Devel Ther ; 7: 7-12, 2013.
Artigo em Inglês | MEDLINE | ID: mdl-23326188

RESUMO

BACKGROUND: Hyaluronic acid has been extensively used for treatment of knee osteoarthritis due to its anti-inflammatory properties and its ability to act as a synovial lubricant. Furthermore, it has found application in combination with other drugs in the dermatological field and in pre-clinical studies in animal models of osteoarthritis. Experimental evidence suggests that a combination of this macromolecule with other drugs may act as a slow-release depot. However, to date, to the best of our knowledge, no one has tested local intra-articular delivery of highly cross-linked hyaluronic acid combined with bisphosphonate or nonsteroidal anti-inflammatory drugs for management of knee osteoarthritis pain in the clinical setting. The aim of the present randomized double-blind study was to investigate, for the first time, the effect of a highly cross-linked hyaluronic acid, Variofill(®), alone or in combination with diclofenac sodium or sodium clodronate, for management of bilateral knee osteoarthritis-related pain. METHODS: Sixty-two patients with symptomatic bilateral medial tibiofemoral knee osteoarthritis (Kellgren-Lawrence grade II and III) and pain in both knees corresponding to a daily visual analog scale (VAS) score ≥ 30 in the month before the beginning of the study were included in this investigation. Patients were divided into three groups: group 1, treated with an injection of hyaluronic acid alone (66 mg) into each knee; group 2, treated with an injection of hyaluronic acid (49.5 mg) plus diclofenac sodium (5 mg) into each knee; group 3, treated with an injection of hyaluronic acid (49.5 mg) plus sodium clodronate (5 mg) into each knee. Patients also underwent blood tests for measurement of erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP) immediately before and at 6-month follow-up. RESULTS: Hyaluronic acid alone and in combination with sodium clodronate or diclofenac sodium produced a significant improvement in mean VAS pain score at 3 and 6-month follow-up. At 6-month follow-up, therapy with hyaluronic acid plus sodium clodronate was the most beneficial in terms of percentage improvement in VAS pain score. A significant improvement in ESR and CRP was observed at 6-month follow-up in each treatment group. No significant difference was observed when the percentage change from baseline related to these parameters was compared among the groups. No dropout was observed in any group. No serious adverse events were observed. CONCLUSION: Further studies are necessary to determine the effect of a therapy based on hyaluronic acid combined with diclofenac sodium or sodium clodronate in larger cohorts of patients affected by knee osteoarthritis and in longer-term follow-up.


Assuntos
Ácido Clodrônico/uso terapêutico , Diclofenaco/uso terapêutico , Ácido Hialurônico/uso terapêutico , Osteoartrite do Joelho/tratamento farmacológico , Adjuvantes Imunológicos/administração & dosagem , Adjuvantes Imunológicos/efeitos adversos , Adjuvantes Imunológicos/uso terapêutico , Anti-Inflamatórios não Esteroides/administração & dosagem , Anti-Inflamatórios não Esteroides/efeitos adversos , Anti-Inflamatórios não Esteroides/uso terapêutico , Sedimentação Sanguínea/efeitos dos fármacos , Proteína C-Reativa/metabolismo , Ácido Clodrônico/administração & dosagem , Ácido Clodrônico/efeitos adversos , Reagentes de Ligações Cruzadas/química , Diclofenaco/administração & dosagem , Diclofenaco/efeitos adversos , Método Duplo-Cego , Quimioterapia Combinada , Feminino , Seguimentos , Humanos , Ácido Hialurônico/administração & dosagem , Ácido Hialurônico/efeitos adversos , Masculino , Pessoa de Meia-Idade , Osteoartrite do Joelho/patologia , Dor/tratamento farmacológico , Dor/etiologia , Medição da Dor , Resultado do Tratamento
14.
Inflammation ; 35(4): 1314-21, 2012 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-22395729

RESUMO

Trigonella foenum graecum is an Iranian medicinal plant used for the treatment of rheumatoid arthritis and inflammation. The present study was designed to investigate the beneficial outcome of the plant T. foenum graecum on adjuvant-induced arthritis in albino rats. Ethanol extract of T. foenum graecum was tested against Freund's complete adjuvant-induced arthritis in rats. In the present study, paw volume was measured on the 4th, 8th, 14th and 21st day. On day 22, animals were anaesthetized, and blood samples were collected for the estimation of haemoglobin, white blood cells (WBC), differential white blood cells, erythrocyte sedimentation rate (ESR), red blood cells (RBC), interleukins (IL-1α, IL-1ß, IL-2, IL-6) and tumour necrosis factor-α (TNF-α). The animals were sacrificed, and the cartilage tissue was isolated for estimation of lipid peroxidation (LPO), superoxide dismutase (SOD) and glutathione (GSH). Administration with both doses of T. foenum graecum (200 and 400 mg/kg) significantly (P < 0.05) decreased the paw oedema and restored body weight. T. foenum graecum significantly (P < 0.05) reduced the differential WBC count, ESR and WBC (5.833 ± 0.703, 6.989 ± 58.5) content and also showed significant (P < 0.05) increase in RBC and Hb (4.783 ± 0.46, 15.46 ± 0.158) content. T. foenum graecum significantly (P < 0.05) decreased the IL-1α, IL-1ß, IL-2, IL-6 and TNF-α levels. It also significantly decreased the levels of LPO and increased the SOD and GSH levels in cartilage tissue. In this study, T. foenum graecum 400-mg/kg dose showed more prominent results compared to the 200-mg/kg dose of T. foenum graecum. The results obtained in this study suggest that anti-inflammatory and antioxidant activities of T. foenum graecum may be the possible reason behind the observed anti-arthritic activity.


Assuntos
Anti-Inflamatórios/uso terapêutico , Artrite Experimental/tratamento farmacológico , Fitoterapia , Extratos Vegetais/farmacologia , Trigonella , Animais , Sedimentação Sanguínea/efeitos dos fármacos , Edema , Feminino , Adjuvante de Freund , Glutationa/biossíntese , Hemoglobinas/análise , Interleucina-1alfa/sangue , Interleucina-1beta/sangue , Interleucina-2/sangue , Interleucina-6/sangue , Contagem de Leucócitos , Peroxidação de Lipídeos/efeitos dos fármacos , Ratos , Ratos Wistar , Superóxido Dismutase/biossíntese , Fator de Necrose Tumoral alfa/sangue
15.
Immunopharmacol Immunotoxicol ; 34(2): 326-36, 2012 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-21970621

RESUMO

Free radical stress leads to tissue injury and progression of disease conditions such as arthritis, hemorrhagic shock, atherosclerosis, diabetes, hepatic injury, aging and ischemia, reperfusion injury of many tissues, gastritis, tumor promotion, neurodegenerative diseases and carcinogenesis. Safer anti-oxidants suitable for long term use are needed to prevent or stop the progression of free radical mediated disorders. Herbal medicine provides a foundation for various traditional medicine systems worldwide. The Sida species is one of the most important families of medicinal plants in India. Hence, the present study was aimed to investigate the possible anti-oxidant potential of Sida rhombifolia extracts for 30 days on adjuvant induced arthritis in experimental rats. The altered levels of hematological parameters were reverted to near normal levels, especially the elevated rate of erythrocyte sedimentation was significantly reduced by S. rhombifolia extracts in experimental rats. Oral administration of root and stem of S. rhombifolia extracts significantly increased the levels of thiobarbituric acid reactive substances and activities of catalase and glutathione peroxidase and decreased the levels of reduced glutathione and superoxide dismutase activity in arthritis induced rats. The free radical scavenging activity of the plant was further evidenced by histological and transmission electron microscopy observations made on the hind limb tissue.


Assuntos
Anti-Inflamatórios/uso terapêutico , Antioxidantes/uso terapêutico , Artrite Experimental/tratamento farmacológico , Malvaceae/química , Extratos Vegetais/uso terapêutico , Raízes de Plantas/química , Caules de Planta/química , Animais , Anti-Inflamatórios/isolamento & purificação , Anti-Inflamatórios/farmacologia , Antioxidantes/isolamento & purificação , Antioxidantes/farmacologia , Artrite Experimental/sangue , Artrite Experimental/metabolismo , Artrite Experimental/patologia , Glicemia/metabolismo , Sedimentação Sanguínea/efeitos dos fármacos , Catalase/metabolismo , Creatinina/sangue , Enzimas/sangue , Contagem de Eritrócitos , Pé/patologia , Articulações do Pé/efeitos dos fármacos , Articulações do Pé/patologia , Articulações do Pé/ultraestrutura , Adjuvante de Freund/imunologia , Adjuvante de Freund/farmacologia , Globulinas/metabolismo , Glutationa Peroxidase/metabolismo , Hemoglobinas/metabolismo , Contagem de Leucócitos , Lipídeos/sangue , Fígado/enzimologia , Masculino , Extratos Vegetais/isolamento & purificação , Extratos Vegetais/farmacologia , Contagem de Plaquetas , Ratos , Ratos Wistar , Albumina Sérica/metabolismo , Pele/efeitos dos fármacos , Pele/patologia , Superóxido Dismutase/metabolismo , Membrana Sinovial/efeitos dos fármacos , Membrana Sinovial/patologia , Membrana Sinovial/ultraestrutura , Substâncias Reativas com Ácido Tiobarbitúrico/metabolismo , Ureia/sangue , Ácido Úrico/sangue
16.
Kaohsiung J Med Sci ; 27(7): 251-7, 2011 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-21757141

RESUMO

Systemic lupus erythematosus (SLE) is a chronic systemic autoimmune disease. Prolonged complete remission is rare. Most patients with SLE need long-term treatment with glucocorticoid and immunomodulators. However, side effects because of the above medications are common. We evaluated the effect of adding-on Dan-Chi-Liu-Wei combination (DCLWC) on SLE patients with conventional therapy in tapering steroid and preventing disease flare-up. This was a double-blind and randomized controlled trial. Sixty-six SLE patients were recruited into this study and 53 patients who fulfilled the 1997 revised criteria for the classification of SLE with an SLE disease activity index (SLEDAI) score of 2-12 and a steroid (measured with prednisolone) daily dose of less than 20mg/d were enrolled. The patients were randomized into either an experimental or control group. We checked the urine analysis, hemogram, liver function, renal function, C3, C4, erythrocyte sedimentation rate, and anti-dsDNA, evaluated the SLEDAI score, and recorded the steroid dose at 0 months, 3 months, and 6 months, respectively. After 6 months of study, the C4 and blood urea nitrogen level revealed a statistically significant difference in either group. There was a tendency toward a decreased SLEDAI score in the experimental group (p=0.083) but not in the control group (p=0.867). The steroid dose was not statistically significant in either group. Renal function and liver function revealed no statistically significant statistics changes in either group. Adding-on DCLWC to conventional therapy for the treatment of SLE was safe and might have a borderline effect in decreasing disease activity, but it was not possible to taper the dosage of steroid after 6 months of clinical trial. Therefore, a long-term follow-up and a large-scale study are necessary to confirm the effect of DCLWC.


Assuntos
Quimioterapia Combinada/métodos , Medicamentos de Ervas Chinesas/administração & dosagem , Glucocorticoides/administração & dosagem , Lúpus Eritematoso Sistêmico/tratamento farmacológico , Fitoterapia/métodos , Esteroides/administração & dosagem , Adulto , Anticorpos Antinucleares/sangue , Anticorpos Antinucleares/imunologia , Sedimentação Sanguínea/efeitos dos fármacos , China , Complemento C3/análise , Complemento C3/imunologia , Complemento C4/análise , Complemento C4/imunologia , Método Duplo-Cego , Cálculos da Dosagem de Medicamento , Medicamentos de Ervas Chinesas/uso terapêutico , Feminino , Glucocorticoides/uso terapêutico , Humanos , Lúpus Eritematoso Sistêmico/sangue , Lúpus Eritematoso Sistêmico/imunologia , Masculino , Pessoa de Meia-Idade , Projetos de Pesquisa , Índice de Gravidade de Doença , Esteroides/uso terapêutico , Resultado do Tratamento
17.
Pediatr Pulmonol ; 46(11): 1093-7, 2011 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-21698787

RESUMO

OBJECTS: To evaluate the efficacy of combined treatment of ciprofloxacin and glucocorticoid for child refractory Mycoplasma pneumoniae (M. pneumoniae) pneumonia. METHODS: Clinical and laboratory characteristics of six pediatric refractory M. pneumoniae pneumonia cases treated with ciprofloxacin and glucocorticoids were reported. RESULTS: Five cases complicated with pleural effusion. The average febrile period prior to admission was 8.5 ± 2.0 days, the average total febrile period was 14.6 ± 7.6 days, and the average febrile period after treatment was 3.3 ± 3.0 days. The average time in hospital for patients was 23.6 ± 4.8 days. The initial mean WBC count was 10,100 ± 2,400/mm(3) . The erythrocyte sedimentation rate (ESR), lactate dehydrogenase (LDH), and C-reactive protein (CRP) in all cases were elevated during the course of illness. After combined therapy, all children clinically improved, with resolution of radiographic findings and normal laboratory items. We analyzed the 23S rRNA gene in four nasopharyngeal secretions, and found mutations in A2063G of domain V in three cases, and mutation in A2064G in the other case. CONCLUSION: Combined treatment of ciprofloxacin and glucocorticoids can significantly ameliorate child refractory M. pneumoniae pneumonia further comparative study is needed to well evaluate the treatment efficacy.


Assuntos
Antibacterianos/uso terapêutico , Ciprofloxacina/uso terapêutico , Glucocorticoides/uso terapêutico , Mycoplasma pneumoniae/efeitos dos fármacos , Pneumonia por Mycoplasma/tratamento farmacológico , Sedimentação Sanguínea/efeitos dos fármacos , Proteína C-Reativa/efeitos dos fármacos , Criança , Pré-Escolar , Quimioterapia Combinada , Feminino , Humanos , L-Lactato Desidrogenase/sangue , Contagem de Leucócitos , Masculino , Mutação , Nasofaringe/metabolismo , Derrame Pleural/sangue , Derrame Pleural/tratamento farmacológico , Derrame Pleural/etiologia , Pneumonia por Mycoplasma/sangue , Pneumonia por Mycoplasma/complicações , RNA Ribossômico 23S/genética , Resultado do Tratamento
19.
J Pediatr Gastroenterol Nutr ; 50(5): 537-44, 2010 May.
Artigo em Inglês | MEDLINE | ID: mdl-20639712

RESUMO

OBJECTIVES: To obtain a balance in the fatty acid (FA) metabolism is important for the inflammatory response and of special importance in cystic fibrosis (CF), which is characterized by impaired FA metabolism, chronic inflammation, and infection in the airways. Nitric oxide (NO) has antimicrobial properties and low nasal (nNO) and exhaled NO (FENO), commonly reported in CF that may affect bacterial status. The present study investigates the effect of different FA blends on nNO and FENO and immunological markers in patients with CF. PATIENTS AND METHODS: Forty-three patients with CF and "severe" mutations were consecutively enrolled in a randomized double-blind placebo-controlled study with 3 FA blends containing mainly n-3 or n-6 FA or saturated FA acting as placebo. FENO, nNO, serum phospholipid concentrations of FA, and biomarkers of inflammation were measured before and after 3 months of supplementation. RESULTS: Thirty-five patients in clinically stable condition completed the study. The serum phospholipid FA pattern changed significantly in all 3 groups. An increase of the n-6 FA, arachidonic acid, was associated with a decrease of FENO and nNO. The inflammatory biomarkers, erythrocyte sedimentation rate, and interleukin-8 decreased after supplementation with n-3 FA and erythrocyte sedimentation rate increased after supplementation with n-6 FA. CONCLUSIONS: This small pilot study indicated that the composition of dietary n-3 and n-6 FA influenced the inflammatory markers in CF. FENO and nNO were influenced by changes in the arachidonic acid concentration, supporting previous studies suggesting that both the lipid abnormality and the colonization with Pseudomonas influenced NO in the airways.


Assuntos
Fibrose Cística/tratamento farmacológico , Ácidos Graxos Ômega-3/farmacologia , Ácidos Graxos Ômega-6/farmacologia , Mediadores da Inflamação/sangue , Óxido Nítrico/metabolismo , Sistema Respiratório/metabolismo , Adolescente , Adulto , Ácido Araquidônico/sangue , Biomarcadores/sangue , Sedimentação Sanguínea/efeitos dos fármacos , Criança , Fibrose Cística/metabolismo , Suplementos Nutricionais , Ácidos Graxos Ômega-3/sangue , Ácidos Graxos Ômega-3/uso terapêutico , Ácidos Graxos Ômega-6/sangue , Ácidos Graxos Ômega-6/uso terapêutico , Feminino , Humanos , Interleucina-8/sangue , Masculino , Mucosa Nasal/metabolismo , Fosfolipídeos/sangue , Projetos Piloto , Adulto Jovem
20.
J Ethnopharmacol ; 126(3): 421-6, 2009 Dec 10.
Artigo em Inglês | MEDLINE | ID: mdl-19818842

RESUMO

AIM OF THE STUDY: The present study was aimed to determine the effects of Viscum album (mistletoe) on red blood cells, packed cell volume, Hb content, absolute haematological values {mean corpuscular volume (MCV), mean corpuscular haemoglobin (MCH), mean corpuscular haemoglobin concentration (MCHC), colour index (CI)}, plasma proteins and ESR in high salt-fed rats. MATERIALS AND METHODS: 24 male albino Wistar rats were divided into 4 groups of 6 rats each. Group 1 received normal rat pellets+drinking water. Group 2 took same as group 1+mistletoe extract (150 mg/kg body weight, orally once daily). Group 3 took high salt (8% NaCl) diet+1% NaCl drinking water. Group 4 took same as group 3+mistletoe extract (150 mg/kg body weight, orally once daily). The feeding regimens lasted for 6 weeks. RESULTS: We observed that the mean RBC, PCV and Hb in the control group were 5.21+/-0.09 x 10(6)cells/mm(3), 43.50+/-1.61%, and 10.88+/-0.21 g/dl respectively. The extract significantly (P<0.05) reduced the RBC (5.72+/-0.08 x 10(6)cells/mm(3)), PCV (54.50+/-2.64%) and Hb (14.33+/-5.78 g/dl) in high salt-fed rats to near control levels. The extract also brought the elevated total plasma protein levels and reduced ESR in the high salt-fed rats (86.77+/-1.08 g/L and 1.83+/-0.31 mm/h respectively) to near control levels (82.23+/-0.91 g/L and 2.83+/-0.31 mm/h respectively), indicating the ability of the extract to prevent marked changes in the blood viscosity. The MCV, MCH, MCHC, and CI were not significantly altered by either extract or salt loading. CONCLUSION: Crude mistletoe extract prevents changes in RBC, PCV, plasma protein levels, and ESR, and indication that the extract prevents changes in blood viscosity a major determinant of arterial blood pressure.


Assuntos
Proteínas Sanguíneas/análise , Sedimentação Sanguínea/efeitos dos fármacos , Eritrócitos/efeitos dos fármacos , Hematócrito , Hemoglobinas/análise , Erva-de-Passarinho/química , Extratos Vegetais/farmacologia , Cloreto de Sódio na Dieta/administração & dosagem , Animais , Masculino , Ratos , Ratos Wistar
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