RESUMO
Abstract The endodontic treatment of teeth with incomplete development is always a complex task. Nowadays, biomaterials such as bioceramics offers promising clinical evidence that supports its use. However, the standardization of its use for apexification purpose still needs a deeper understanding of the materials' behavior. The aim of this investigation was to evaluate the marginal adaptability and microleakage by gas permeability of MTA and Biodentine™ apical plugs in an in vitro model. Materials and methods: Twenty- four single rooted human teeth were selected according to previously stablished inclusion criteria. All samples were prepared obtaining standard cylindrical internal canals with a diameter of 1.3 mm. Root canals were gently rinsed using 5.25% sodium hypochlorite and EDTA 17%. The apical 3mm and remaining coronal dental structure were sectioned to obtain 10mm roots. Roots were randomly assigned to 3 different groups as follows: GROUP A: MTA (n=10), GROUP B: Biodentine™ (n=10) and Group C: Control (positive n=1, negative n=3). MTA and Biodentine™ were prepared according to manufacturer's indications, and apical plugs of 4mm were passively placed in the correspondent teeth. All samples were stored in saline solution for 7 days at 37°C before evaluation. Samples were mounted in cylindrical sample-holders using epoxy resin. Microleakage was evaluated with an automatic permeability detector that calculates nitrogen diffusion between the material-root interphase. After microleakage evaluation, the samples were recovered and analyzed by scanning electron microscopy (SEM). Microleakage results were analyzed using Chi-square and adaptation was evaluated with a descriptive analysis. Results: None of the evaluated materials completely avoided the nitrogen microleakage (positive leakage of 10% and 20% of samples for MTA and Biodentine™ respectively); with no statistical significant difference between groups (p=0.527). All apical plugs showed good adaptation under SEM, at 30x, 200x, 1000x and 2500x; with microscopical structures similar to previous reports. Conclusions: Both bioceramics behave similar when used as apical barriers to avoid permeability, with acceptable marginal adaptation. Further in vivo studies are needed to validate these results.
Resumen El tratamiento endodóntico de dientes con desarrollo incompleto es siempre una tarea compleja. Hoy en día, biomateriales como las biocerámicas ofrecen una evidencia clínica prometedora que apoya su uso. Sin embargo, la estandarización de su uso para fines de apexificación todavía necesita una comprensión más profunda del comportamiento de los materiales. El objetivo de esta investigación fue evaluar la adaptabilidad marginal y microfiltración por permeabilidad de gas de los tapones apicales de MTA y Biodentine™ en un modelo in vitro. Materiales y métodos: Veiticuatro dientes humanos uniradiculares fueron seleccionados meticulosamente según criterios de inclusión previamente establecidos. Todas las muestras fueron preparadas con canales cilíndricos internos estandarizados de 1,3 mm de diámetro. Los conductos radiculares fueron gentilmente lavados con hipoclorito de sodio al 5,25% y EDTA al 17%. La estructura dental apical de 3 mm y la coronal restante se seccionó para obtener raíces de 10 mm de longitud. Las raíces se asignaron aleatoriamente a 3 grupos diferentes de la siguiente manera: GRUPO A: MTA (n = 10), GRUPO B: Biodentine™ (n = 10) y Grupo C: Control (n = 1 positivo, n = 3 negativos). El MTA y Biodentine™ se prepararon de acuerdo con las indicaciones de los fabricantes, y se colocaron pasivamente los tapones apicales de 4 mm en los dientes correspondientes. Todas las muestras se almacenaron en solución salina durante 7 días a 37ºC antes de la evaluación. Las muestras se montaron en porta-muestras cilíndricos utilizando resina epóxica. La microfiltración se evaluó con un detector de permeabilidad automática que calcula la difusión de nitrógeno entre la interfase material-raíz. Después de la evaluación de microfiltración, las muestras fueron recuperadas y analizadas por microscopía electrónica de barrido (SEM). Los resultados de microfiltración se analizaron utilizando una prueba estadística de Chi-cuadrado y la adaptación se evaluó con un análisis descriptivo. Resultados: Ninguno de los materiales evaluados evitó completamente la microfiltración de nitrógeno (fuga positiva de 10% y 20% de muestras para MTA y Biodentine™, respectivamente); sin diferencias estadísticamente significativas entre los grupos (p = 0,527). Todos los tapones apicales mostraron una buena adaptación bajo SEM, a 30x, 200x, 1000x y 2500x; con morfologías similares a las previamente reportadas. Conclusiones: ambas biocerámicas se comportan de forma similar cuando se usan como barreras apicales para evitar la permeabilidad de gas, con adaptación marginal aceptable. Se necesitan más estudios in vivo para validar estos resultados.
Assuntos
Anormalidades Dentárias/diagnóstico , Permeabilidade Dentária/efeitos dos fármacos , Cimentos Dentários/uso terapêutico , Tecido Periapical/patologia , Pemetrexede/uso terapêuticoRESUMO
Una infección endodóncica persistente (IEP) representa un desafío en el tratamiento de conductos radiculares. La remoción de bacterias es complicada cuando una terapia de endodoncia convencional no es efectiva, por lo que estrategias adicionales de desinfección deben aplicarse para obtener un tratamiento exitoso. Este artículo reporta el caso de una IEP en un hombre de 58 años de edad que fue referido al posgrado de endodoncia de la Universidad Autónoma de Nuevo León. Aunque un retratamiento endodóncico fue iniciado, el paciente decidió extraerse el diente con un dentista general; un conducto recurrente y una ramificación apical fueron detectados en el diente extraído
A persistent endodontic infection (PEI) represents a challenge in root canal treatments. The bacterial removal is complicated when a conventional endodontic therapy is ineffective; therefore additional strategies of disinfection should be applied to obtain a successful treatment. This article describes a PEI case of a 58-years-old man who was referred to the Department of Endodontics of Nuevo Leon Autonomous University. Although an endodontic retreatment was initiated, the patient decided to remove his tooth with a general dentist; a recurrent canal and an apical ramification were detected in the extracted tooth
Assuntos
Humanos , Masculino , Pessoa de Meia-Idade , Dente Canino/patologia , Infecções/complicações , Tecido Periapical/patologia , Endodontia/instrumentação , Retratamento/métodos , Técnicas Histológicas/instrumentação , Cavidade Pulpar/patologia , Cavidade Pulpar , Anestesia Local , Ápice Dentário/microbiologia , Tomografia com Microscopia EletrônicaRESUMO
INTRODUCTION: Revascularization treatment is rapidly becoming an accepted treatment alternative for the management of endodontic pathology in immature permanent teeth with necrotic dental pulps. However, the success and timing of clinical resolution of symptoms, and radiographic outcomes of interest, such as continued hard tissue deposition within the root, are largely unknown. METHODS: In this prospective cohort study, 20 teeth were treated with a standardized revascularization treatment protocol and monitored for clinical and radiographic changes for 1 year. Standardized radiographs were collected at regular intervals, and radiographic changes were quantified. RESULTS: All 20 treated teeth survived during the 12-month follow-up period, and all 20 also met the clinical criteria for success at 12 months. As a group, the treated teeth showed a statistically significant increase in radiographic root width and length and a decrease in apical diameter, although the changes in many cases were quite small (such that the clinical significance is unclear). The within-case percent change in apical diameter after 3 months was 16% and had increased to 79% by 12 months, with 55% (11/20) showing complete apical closure. The within-case percent change in root length averaged less than 1% at 3 months and increased to 5% at 12 months. The within-case percent change in root thickness averaged 3% at 3 months and 21% at 12 months. CONCLUSIONS: Although clinical success was highly predictable with this procedure, clinically meaningful radiographic root thickening and lengthening are less predictable after 1-year of follow-up. Apical closure is the most consistent radiographic finding.
Assuntos
Apexificação/métodos , Polpa Dentária/lesões , Ápice Dentário/diagnóstico por imagem , Raiz Dentária/diagnóstico por imagem , Antibacterianos/uso terapêutico , Coagulação Sanguínea , Criança , Ciprofloxacina/uso terapêutico , Estudos de Coortes , Exposição da Polpa Dentária/terapia , Necrose da Polpa Dentária/terapia , Teste da Polpa Dentária , Dentina/diagnóstico por imagem , Dentina/patologia , Feminino , Seguimentos , Humanos , Masculino , Metronidazol/uso terapêutico , Minociclina/uso terapêutico , Tecido Periapical/patologia , Estudos Prospectivos , Radiografia , Preparo de Canal Radicular/instrumentação , Preparo de Canal Radicular/métodos , Ápice Dentário/patologia , Raiz Dentária/patologia , Resultado do TratamentoRESUMO
OBJECTIVES: The aim of this study was to compare two different thermoplastic techniques--a core-carrier technique (Thermafil) and warm vertical compaction--in terms of overextension of root canal filling in vivo. MATERIALS AND METHODS: Flaring of 88 teeth was conducted using Pro Files .04 as finishing files, and the teeth were obturated using Thermafil. Flaring of 74 teeth was performed using Pro Files .06 as finishing files, and the teeth were obturated using warm vertical compaction. RESULTS: Seventy (80 %) of the teeth obturated using Thermafil and 31 (42 %) teeth obturated using warm vertical compaction show extruded root canal filling. In contrast to Thermafil, there is a higher rate of extruded root canal filling of teeth with more than one root canal using warm vertical compaction. CONCLUSION: Thermafil demonstrated a higher rate of extruded root canal filling compared to warm vertical compaction. Warm vertical compaction is a more predictable method of filling compared to Thermafil. CLINICAL RELEVANCE: Root canal filling extrusion will cause irritation of the surrounding tissue and impair repair processes. In the present in vivo study, there was a higher rate of root canal filling extrusion using Thermafil compared to warm vertical compaction.
Assuntos
Corpos Estranhos/etiologia , Guta-Percha/uso terapêutico , Tecido Periapical/patologia , Materiais Restauradores do Canal Radicular/uso terapêutico , Obturação do Canal Radicular/métodos , Resinas Compostas/química , Materiais Dentários/química , Cavidade Pulpar/patologia , Restauração Dentária Permanente/métodos , Ácido Edético/uso terapêutico , Resinas Epóxi/uso terapêutico , Corpos Estranhos/diagnóstico por imagem , Guta-Percha/efeitos adversos , Temperatura Alta , Humanos , Tecido Periapical/diagnóstico por imagem , Radiografia , Cimentos de Resina/química , Estudos Retrospectivos , Materiais Restauradores do Canal Radicular/efeitos adversos , Irrigantes do Canal Radicular/uso terapêutico , Preparo de Canal Radicular/instrumentação , Hipoclorito de Sódio/uso terapêutico , Ápice Dentário/patologiaRESUMO
AIM: To investigate the probability of and factors influencing periapical status of teeth following primary (1°RCTx) or secondary (2°RCTx) root canal treatment. METHODOLOGY: This prospective study involved annual clinical and radiographic follow-up of 1°RCTx (1170 roots, 702 teeth and 534 patients) or 2°RCTx (1314 roots, 750 teeth and 559 patients) carried out by Endodontic postgraduate students for 2-4 (50%) years. Pre-, intra- and postoperative data were collected prospectively on customized forms. The proportion of roots with complete periapical healing was estimated, and prognostic factors were investigated using multiple logistic regression models. Clustering effects within patients were adjusted in all models using robust standard error. RESULTS: proportion of roots with complete periapical healing after 1°RCTx (83%; 95% CI: 81%, 85%) or 2°RCTx (80%; 95% CI: 78%, 82%) were similar. Eleven prognostic factors were identified. The conditions that were found to improve periapical healing significantly were: the preoperative absence of a periapical lesion (P = 0.003); in presence of a periapical lesion, the smaller its size (P ≤ 0.001), the better the treatment prognosis; the absence of a preoperative sinus tract (P = 0.001); achievement of patency at the canal terminus (P = 0.001); extension of canal cleaning as close as possible to its apical terminus (P = 0.001); the use of ethylene-diamine-tetra-acetic acid (EDTA) solution as a penultimate wash followed by final rinse with NaOCl solution in 2°RCTx cases (P = 0.002); abstaining from using 2% chlorexidine as an adjunct irrigant to NaOCl solution (P = 0.01); absence of tooth/root perforation (P = 0.06); absence of interappointment flare-up (pain or swelling) (P =0.002); absence of root-filling extrusion (P ≤ 0.001); and presence of a satisfactory coronal restoration (P ≤ 0.001). CONCLUSIONS: Success based on periapical health associated with roots following 1°RCTx (83%) or 2°RCTx (80%) was similar, with 10 factors having a common effect on both, whilst the 11th factor 'EDTA as an additional irrigant' had different effects on the two treatments.
Assuntos
Doenças Periapicais/terapia , Tratamento do Canal Radicular/métodos , Adulto , Quelantes/uso terapêutico , Clorexidina , Estudos de Coortes , Contraindicações , Fístula Dentária/patologia , Cavidade Pulpar/lesões , Cavidade Pulpar/patologia , Ácido Edético/uso terapêutico , Feminino , Seguimentos , Guta-Percha/uso terapêutico , Humanos , Masculino , Doenças Periapicais/diagnóstico por imagem , Tecido Periapical/diagnóstico por imagem , Tecido Periapical/patologia , Técnica para Retentor Intrarradicular , Prognóstico , Estudos Prospectivos , Radiografia , Retratamento , Materiais Restauradores do Canal Radicular/uso terapêutico , Irrigantes do Canal Radicular/uso terapêutico , Preparo de Canal Radicular/instrumentação , Preparo de Canal Radicular/métodos , Hipoclorito de Sódio/uso terapêutico , Ápice Dentário/patologia , Odontalgia/prevenção & controle , Resultado do Tratamento , Cicatrização/fisiologia , Cimento de Óxido de Zinco e Eugenol/uso terapêuticoRESUMO
The purpose of this study was to analyze the inflammatory response of dog's periapical tissues to 17% trisodium EDTA salt (pH 8.0) and 1% citric acid (pH 2.0). Saline was used as a control. Six adult dogs were used as the biological model of the study. The experimental units comprised 56 roots of mandibular molars (first and second) and premolars (first, second and third). After coronal opening, pulpectomy and root canal instrumentation were performed using the above-mentioned irrigating solutions. After 24 and 48 hours, the animals were euthanized and the teeth and their supporting tissues were removed and histologically processed. The sections were stained with hematoxylin and eosin and analyzed histopathologically with a light microscope at x100 magnification. The histological analysis focused on the occurrence of acute inflammatory response. The presence of swelling, vasodilatation and inflammatory cells were evaluated and the degree of inflammation was determined for each case. Data were analyzed by Fisher's exact test using the SPSS software with a confidence interval of 95% (p<0.05). 17% EDTA and 1% citric acid caused inflammatory responses in dog's periapical tissues with no significant differences to each other or to saline (control) at either the 24-hour (p=0.482) or 48-hour (p=0.377) periods. It may be concluded that the inflammatory response was of mild intensity for the tested substances.
Assuntos
Materiais Biocompatíveis/uso terapêutico , Ácido Cítrico/uso terapêutico , Ácido Edético/uso terapêutico , Tecido Periapical/efeitos dos fármacos , Irrigantes do Canal Radicular/uso terapêutico , Animais , Dente Pré-Molar/patologia , Cães , Edema/induzido quimicamente , Edema/patologia , Modelos Animais , Dente Molar/patologia , Periodontite Periapical/induzido quimicamente , Periodontite Periapical/patologia , Tecido Periapical/patologia , Pulpectomia/métodos , Preparo de Canal Radicular/instrumentação , Preparo de Canal Radicular/métodos , Fatores de Tempo , Vasodilatação/efeitos dos fármacosRESUMO
The purpose of this study was to analyze the inflammatory response of dog's periapical tissues to 17 percent trisodium EDTA salt (pH 8.0) and 1 percent citric acid (pH 2.0). Saline was used as a control. Six adult dogs were used as the biological model of the study. The experimental units comprised 56 roots of mandibular molars (first and second) and premolars (first, second and third). After coronal opening, pulpectomy and root canal instrumentation were performed using the above-mentioned irrigating solutions. After 24 and 48 hours, the animals were euthanized and the teeth and their supporting tissues were removed and histologically processed. The sections were stained with hematoxylin and eosin and analyzed histopathologically with a light microscope at x100 magnification. The histological analysis focused on the occurrence of acute inflammatory response. The presence of swelling, vasodilatation and inflammatory cells were evaluated and the degree of inflammation was determined for each case. Data were analyzed by Fisher's exact test using the SPSS software with a confidence interval of 95 percent (p<0.05). 17 percent EDTA and 1 percent citric acid caused inflammatory responses in dog's periapical tissues with no significant differences to each other or to saline (control) at either the 24-hour (p=0.482) or 48-hour (p=0.377) periods. It may be concluded that the inflammatory response was of mild intensity for the tested substances.
Assuntos
Animais , Cães , Materiais Biocompatíveis/uso terapêutico , Ácido Cítrico/uso terapêutico , Ácido Edético/uso terapêutico , Tecido Periapical/efeitos dos fármacos , Irrigantes do Canal Radicular/uso terapêutico , Dente Pré-Molar/patologia , Edema/induzido quimicamente , Edema/patologia , Modelos Animais , Dente Molar/patologia , Periodontite Periapical/induzido quimicamente , Periodontite Periapical/patologia , Tecido Periapical/patologia , Pulpectomia/métodos , Preparo de Canal Radicular/instrumentação , Preparo de Canal Radicular/métodos , Fatores de Tempo , Vasodilatação/efeitos dos fármacosRESUMO
The purpose of this study was to evaluate the influence of coronal leakage on the healing of dogs' periapical tissues after root canal filling, post space preparation and protection or not with a temporary sealer plug. Forty root canals of dogs' teeth were instrumented and filled by the lateral condensation technique with gutta-percha points and Endomethasone or CRCS sealers. After post space preparation, the remaining filling material was protected or not with a plug of temporary Coltosol sealer and exposed to the oral environment for 90 days. Thereafter, the animals were sacrificed and the specimens were removed and prepared for histomorphological and histobacteriological analysis. The findings revealed 35% of microbial leakage in the groups without plugs and 15% of leakage in the groups with plugs. Statistical analysis showed that the use of a Coltosol plug improved significantly the histomorphological results regardless of the type of root canal sealer (p=0.05) and that CRCS and Endomethasone sealers showed similar results (p>0.05).
Assuntos
Cavidade Pulpar/patologia , Tecido Periapical/patologia , Técnica para Retentor Intrarradicular , Substâncias Protetoras/uso terapêutico , Obturação do Canal Radicular/métodos , Animais , Hidróxido de Cálcio/uso terapêutico , Sulfato de Cálcio/uso terapêutico , Cemento Dentário/patologia , Infiltração Dentária/microbiologia , Polpa Dentária/patologia , Dentina/patologia , Dexametasona/uso terapêutico , Cães , Combinação de Medicamentos , Formaldeído/uso terapêutico , Bactérias Gram-Negativas/isolamento & purificação , Bactérias Gram-Positivas/isolamento & purificação , Guta-Percha/uso terapêutico , Hidrocortisona/uso terapêutico , Ligamento Periodontal/patologia , Materiais Restauradores do Canal Radicular/uso terapêutico , Preparo de Canal Radicular/instrumentação , Preparo de Canal Radicular/métodos , Timol/análogos & derivados , Timol/uso terapêutico , Ápice Dentário/patologia , Cicatrização/fisiologia , Óxido de Zinco/uso terapêutico , Sulfato de Zinco/uso terapêuticoRESUMO
The purpose of this study was to evaluate the influence of coronal leakage on the healing of dogs' periapical tissues after root canal filling, post space preparation and protection or not with a temporary sealer plug. Forty root canals of dogs' teeth were instrumented and filled by the lateral condensation technique with gutta-percha points and Endomethasone or CRCS sealers. After post space preparation, the remaining filling material was protected or not with a plug of temporary Coltosol sealer and exposed to the oral environment for 90 days. Thereafter, the animals were sacrificed and the specimens were removed and prepared for histomorphological and histobacteriological analysis. The findings revealed 35 percent of microbial leakage in the groups without plugs and 15 percent of leakage in the groups with plugs. Statistical analysis showed that the use of a Coltosol plug improved significantly the histomorphological results regardless of the type of root canal sealer (p=0.05) and that CRCS and Endomethasone sealers showed similar results (p>0.05).
O propósito deste trabalho foi avaliar a influência da infiltração coronária no reparo dos tecidos periapicais após obturação dos canais radiculares, preparo para pino e proteção ou não de um "plug" de cimento temporário. Quarenta canais de dentes de cães foram instrumentados e obturados pela técnica da condensação lateral ativa com cones de guta-percha e os cimentos Endomethasone e CRCS. Após preparo para pino os remanescentes do material obturador foram protegidos ou não com um "plug" do cimento temporário Coltosol e expostos ao meio oral por 90 dias. Decorrido este período, os animais foram mortos e os espécimes foram removidos e preparados para análises histomorfológica e histobacteriológica. Foi observado 35 por cento de casos de infiltração bacteriana nos grupos sem "plug" e 15 por cento nos grupos com "plug". Concluiu-se estatisticamente que o "plug" de Coltosol foi eficiente no controle da infiltração coronária de microorganismos (p=0,05), e que os cimentos CRCS e Endomethasone apresentaram resultados semelhantes (p>0,05).
Assuntos
Animais , Cães , Cavidade Pulpar/patologia , Técnica para Retentor Intrarradicular , Tecido Periapical/patologia , Substâncias Protetoras/uso terapêutico , Obturação do Canal Radicular/métodos , Hidróxido de Cálcio/uso terapêutico , Sulfato de Cálcio/uso terapêutico , Combinação de Medicamentos , Cemento Dentário/patologia , Infiltração Dentária/microbiologia , Polpa Dentária/patologia , Dentina/patologia , Dexametasona/uso terapêutico , Formaldeído/uso terapêutico , Bactérias Gram-Negativas/isolamento & purificação , Bactérias Gram-Positivas/isolamento & purificação , Guta-Percha/uso terapêutico , Hidrocortisona/uso terapêutico , Ligamento Periodontal/patologia , Materiais Restauradores do Canal Radicular/uso terapêutico , Preparo de Canal Radicular/instrumentação , Preparo de Canal Radicular/métodos , Timol/análogos & derivados , Timol/uso terapêutico , Ápice Dentário/patologia , Cicatrização/fisiologia , Óxido de Zinco/uso terapêutico , Sulfato de Zinco/uso terapêuticoRESUMO
Eighty root canals of the premolars of 4 dogs, with vital pulp, were instrumented and filled during the same session with the Sealapex, CRCS, Sealer 26, and Apexit sealers. The animals were sacrificed 180 days after root canal filling and their maxillae and mandibles were removed and fixed in 10% formalin. After routine histologic processing, the sections were stained with hematoxylin-eosin and Mallory trichrome. Histopathologic analysis showed that Sealapex was the sealer that best permitted the deposition of mineralized tissue at the apical level and was the only sealer that provided complete sealing (37.5% of cases). With the use of Sealapex, no inflammatory infiltrate occurred and there was no reabsorption of mineralized tissues. In contrast, partial sealing and a moderate inflammatory infiltrate occurred with the use of CRCS. When Apexit and Sealer 26 were used the absence of sealing was frequent and active reabsorption of mineralized tissues occurred in most cases. The inflammatory infiltrate predominating with the use of Apexit was of the severe type, whereas with the use of Sealer 26 the inflammatory infiltrate was mild or absent.
Assuntos
Hidróxido de Cálcio/uso terapêutico , Tecido Periapical/efeitos dos fármacos , Materiais Restauradores do Canal Radicular/uso terapêutico , Tratamento do Canal Radicular , Ápice Dentário/efeitos dos fármacos , Animais , Dente Pré-Molar , Bismuto/uso terapêutico , Cães , Avaliação Pré-Clínica de Medicamentos , Tecido Periapical/patologia , Salicilatos/uso terapêutico , Ápice Dentário/patologia , Óxido de Zinco/uso terapêuticoRESUMO
This study was conducted on six rabbits, six rats and six human permanent teeth to evaluate histologically the effect of resin resorcinol in the periapical areas, the bacteriological aspect of the resin and the penetration of resin in the dentinal tubules. After 12 days period of observation plenty of lymphocytes and macrophages were evident along with granulomas which are suggestive of the tendency of the resin to stay longer. It was observed that the resin penetrate approximately three fourth distance inside the dentinal tubules. In the last phase the resin was found to be effective against the eight commonly found micro organisms. Though the histological results indicated that the periapical tissue would take longer time for complete repair, yet clinically the tooth functions well. Resinifying therapy is effective and economical method in root canal treatment.
Assuntos
Resorcinóis/uso terapêutico , Materiais Restauradores do Canal Radicular/uso terapêutico , Obturação do Canal Radicular , Animais , Bactérias/efeitos dos fármacos , Cavidade Pulpar/efeitos dos fármacos , Cavidade Pulpar/microbiologia , Cavidade Pulpar/patologia , Avaliação Pré-Clínica de Medicamentos , Humanos , Testes de Sensibilidade Microbiana , Tecido Periapical/efeitos dos fármacos , Tecido Periapical/microbiologia , Tecido Periapical/patologia , Coelhos , Ratos , Resorcinóis/farmacologia , Materiais Restauradores do Canal Radicular/farmacologia , Fatores de TempoRESUMO
Pulp stump and periapical tissue reaction to root canal filling with material containing calcium hydroxide and potassium nitrate after subtotal vital extirpation of the pulp was studied in 12 teeth of 6 green monkeys. Use of the material containing potassium nitrate was found to result on the 90th day of the experiment in the formation of a biologic barrier of secondary cement at the dental root apex. Such result was not achieved with calcium hydroxide-containing material. Other advantages of potassium nitrate-containing material were detected, consisting in a more rapid recovery of structural shifts in the pulp stump and periapical tissues.
Assuntos
Compostos de Potássio , Pulpectomia/métodos , Materiais Restauradores do Canal Radicular/farmacologia , Animais , Hidróxido de Cálcio/farmacologia , Chlorocebus aethiops , Polpa Dentária/efeitos dos fármacos , Polpa Dentária/patologia , Avaliação Pré-Clínica de Medicamentos , Nitratos/farmacologia , Tecido Periapical/efeitos dos fármacos , Tecido Periapical/patologia , Periodonto/efeitos dos fármacos , Periodonto/patologia , Fatores de TempoRESUMO
A case of squamous cell carcinoma arising in the gingiva of a 30-year-old nonsmoking woman receiving PUVA therapy for vitiligo is reported. There were no typical predisposing factors for oral cancer in the history, other than the latter therapy. Although there are several previous reports of cutaneous carcinoma developing in patients under PUVA therapy, most of such involve development of tumors on skin surfaces exposed to direct ultraviolet radiation either through sunlight or via therapeutic mode.s In this case, there was no direct ultraviolet exposure at the site of carcinoma. We suggest the possibility that, in this case, PUVA may exerted a carcinogenic influence via systemic distribution of ultraviolet-activated psoralens or its metabolites to the gingiva. The possibility of microbial interaction with substances within gingival inflammatory exudate to produce carcinogenic substances is postulated.