Promovendo saúde por meio da música na maternidade: percepções de gestantes e puérperas / Promoting health through music in motherhood: perceptions of pregnant and puerperal women / Promoviendo la salud a través de la música en la maternidad: percepciones de las mujeres embarazadas y puérperas

Objetivo: compreender as percepções de gestantes e puérperas sobre o uso da música como tecnologia de cuidado para promoção da saúde. Método: estudo qualitativo, fundamentado nos pressupostos da promoção da saúde, realizado com sete gestantes e oito puérperas internadas na maternidade de um hospital público de Santa Catarina. Realizou-se entrevistas semiestruturadas, entre setembro de 2021 e fevereiro de 2022, após aprovação do Comitê de Ética em Pesquisa. Os dados foram analisados por meio da análise de conteúdo. Resultados: a música na maternidade diminui o estresse e a tristeza. Alem disso, proporciona distração, alegria, animação, resgate de lembranças, momento especial, gratidão e tranquilidade para as mulheres hospitalizadas e para os seus bebês. Considerações finais: para as gestantes e puérperas, a música tem a capacidade de promover a saúde, sendo uma tecnologia de cuidado que deveria estar presente em todas as maternidades do Brasil(AU)

Objective: to understand the perceptions of pregnant and postpartum women about the use of music as a care technology for health promotion. Method: qualitative research, based on the assumptions of health promotion, carried out with seven pregnant women and eight postpartum women admitted to the maternity ward of a public hospital in Santa Catarina. Semi-structured interviews were carried out between September 2021 and February 2022, after approval by the Research Ethics Committee. Data were analyzed using content analysis. Results: music in the maternity ward reduces stress and sadness. In addition, it provides distraction, joy, animation, recall of memories, a special moment, gratitude and tranquility for hospitalized women and their babies. Final considerations: for pregnant and postpartum women, music has the ability to promote health, being a care technology that should be present in all maternity hospitals in Brazil(AU)

Objetivo: comprender las percepciones de embarazadas y puérperas sobre el uso de la música como tecnología de cuidado para la promoción de la salud. Método: estudio cualitativo, basado en los supuestos de la promoción de la salud, realizado junto a siete mujeres embarazadas y ocho puérperas internadas en la maternidad de un hospital público de Santa Catarina. Las entrevistas semiestructuradas se realizaron entre septiembre de 2021 y febrero de 2022, previa aprobación del Comité de Ética en Investigación. Los datos se analizaron mediante análisis de contenido. Resultados: la música en la sala de maternidad reduce el estrés y la tristeza. Además, brinda distracción, alegría, animación, recuperación de recuerdos, momento especial, gratitud y tranquilidad para las mujeres hospitalizadas y sus bebés. Consideraciones finales: para las mujeres embarazadas y puérperas, la música tiene la capacidad de promover la salud, siendo una tecnología de atención que debe estar presente en todas las maternidades de Brasil(AU)

Biomedical applications of 2D monoelemental materials formed by group VA and VIA: a concise review.

The development of two-dimensional (2D) monoelemental nanomaterials (Xenes) for biomedical applications has generated intensive interest over these years. In this paper, the biomedical applications using Xene-based 2D nanomaterials formed by group VA (e.g., BP, As, Sb, Bi) and VIA (e.g., Se, Te) are elaborated. These 2D Xene-based theranostic nanoplatforms confer some advantages over conventional nanoparticle-based systems, including better photothermal conversion, excellent electrical conductivity, and large surface area. Their versatile and remarkable features allow their implementation for bioimaging and theranostic purposes. This concise review is focused on the current developments in 2D Xenes formed by Group VA and VIA, covering the synthetic methods and various biomedical applications. Lastly, the challenges and future perspectives of 2D Xenes are provided to help us better exploit their excellent performance and use them in practice.

Artificial Intelligence and Health Technology Assessment: Anticipating a New Level of Complexity.

Artificial intelligence (AI) is seen as a strategic lever to improve access, quality, and efficiency of care and services and to build learning and value-based health systems. Many studies have examined the technical performance of AI within an experimental context. These studies provide limited insights into the issues that its use in a real-world context of care and services raises. To help decision makers address these issues in a systemic and holistic manner, this viewpoint paper relies on the health technology assessment core model to contrast the expectations of the health sector toward the use of AI with the risks that should be mitigated for its responsible deployment. The analysis adopts the perspective of payers (ie, health system organizations and agencies) because of their central role in regulating, financing, and reimbursing novel technologies. This paper suggests that AI-based systems should be seen as a health system transformation lever, rather than a discrete set of technological devices. Their use could bring significant changes and impacts at several levels: technological, clinical, human and cognitive (patient and clinician), professional and organizational, economic, legal, and ethical. The assessment of AI's value proposition should thus go beyond technical performance and cost logic by performing a holistic analysis of its value in a real-world context of care and services. To guide AI development, generate knowledge, and draw lessons that can be translated into action, the right political, regulatory, organizational, clinical, and technological conditions for innovation should be created as a first step.

Biomedical and bioactive engineered nanomaterials for targeted tumor photothermal therapy: A review.

Currently, a lot of efforts have been applied to diagnosis and treat tumors through the fabrication of highly-efficient and multi-functional nanomaterials. Superior to other methods, photothermal therapy (PTT) has been demonstrated as a noninvasive, controllable, and targeted strategy to eliminate tumor cells. The use of functional biomedical and bioactive nanomaterials can enhance the photothermal performances and meanwhile integrate with favorable functions, by taking into account their risk assessments. In this review, novel engineered photothermal nanomaterials, such as noble metal-, carbon-, semiconductor-, and organic molecule-based PTT agents, as well as their targeted biomedical applications were summarized and discussed comprehensively. Particularly, the latest advances of not only the conventional nanomaterials, but also the newly-discovered alternatives, like Au-Ag, graphdiyne, and selenides, were introduced. Besides the benefits, the risks and other implications of novel PTT agents were recorded and evaluated. Moreover, the potential applications of nanomaterials in targeted and multi-functional PTT treatments, which served as foundations and directions for future PTT approaches developments, were stated. Depending on the urgency and boosting demands for tumor treatments, novel engineering advancements of techniques, not limited to PTT and nanomaterials, are prerequisites in the history of medical development.

Accessibility and feasibility of using technology to support mindfulness practice, reduce stress and promote long term mental health.

BACKGROUND AND PURPOSE: We evaluated the feasibility of using an activity monitor to support mindfulness practice, reduce self-reported stress and physiological indicators of stress. MATERIALS AND METHODS: Adult women (N = 19) who previously participated in a mindfulness intervention wore an activity monitor for eight-weeks. The activity monitor notified them when they were stressed (based on standard deviation pulse pressure). Heart rate and pulse pressure were continuously collected via the activity monitor. Mindfulness, stress, depression and trauma symptoms were collected via self-report surveys. RESULTS: There were no significant changes in self-reported stress, depression, post-traumatic stress and mindfulness from baseline to eight-weeks. Pulse pressure and standard deviation of pulse pressure increased over time. Those who were high on the non-judge mindfulness subscale had a lower standard deviation pulse pressure and spent less time stressed. CONCLUSION: Those who are more mindful are less likely to have physiological signs of stress.

Green synthesis of silver nanoparticles using leaf extract of Acalypha hispida and its application in blood compatibility.

The blood compatibility of AgNPs is of great relevance as it has good antifungal, antibacterial and anti-inflammatory properties and the toxicological information of their effects on cells need to be analyzed before using it as drug carriers in the biomedical field. The present study deals with the synthesis of AgNPs from an aqueous solution of silver nitrate using Acalypha hispida leaf extract as the reducing and capping agent. The presence of AgNPs in the reaction mixture was confirmed by visual observation of color change and subsequently identified using UV-Visible Spectroscopy. XRD results revealed the crystalline nature of synthesized AgNPs. The shape and size of particles were characterized by TEM. These results revealed the elemental status of nanopowder. The components present in leaf extract were identified by GC-MS and functional groups present in the sample when treated with silver nitrate were obtained from FT-IR results. The surface of synthesized AgNPs was modified using four different compounds such as CTAB, PEG, PEI, and APTMS to evaluate the blood compatibility. The results showed that 50 µg/mL CTAB coated AgNPs and 50 and 100 µg/mL PEG coated AgNPs had non-hemolytic property and considered as more blood compatible surface modified AgNPs. This investigation gives an idea of using surface modified AgNPs in the field of biomedicine and therapeutic applications.

Visión holística de nuevos desafíos: paradigmas tecnológicos y fundamentos bioéticos en la Medicina futurista / Holistic view of new challenges: technological paradigms and bioethical basis of Futuristic Medicine

Introducción.La medicina del siglo XXI será un punto de fusión de numerosas nuevas tecnologías. Surgirán transformaciones en los paradigmas de la atención médica. Objetivo: Ofrecer una visión de lo que podría ser la atención médica futura. Material y Métodos: Se revisa en la literatura médica las ultimas y nuevas herramientas tecnológicas al servicio de la Medicina, sus posibles transformaciones y aplicación futura a través de la exploración en las principales bases de datos indexadas en los últimos 7 años, que originarán un cambio en el pensamiento científico y una visión predictiva en la atención médica a nivel mundial que realizaran reflexiones sobre enfoques médicos que origina la medicina traslacional. Se analiza el papel de la nanotecnología en la farmacología futurista, así como la genética y robótica, y se establecen comparaciones entre la cantidad de investigaciones por países y el estado actual en la América Latina y cómo influirán los nuevos adelantos científicos en la bioética lo que pudiera dar origen al transhumanismo. Resultados: El influjo de las nuevas tecnologías está ligado con el desarrollo económico y social, por lo que su aplicación no será equitativa, existiendo una diferencia importante en la formulación de patentes, investigaciones indexadas y citaciones entre países desarrollados y subdesarrollados, donde ningún país latinoamericano se encuentra entre los primeros 10 lugares del ranking mundial. Conclusiones: La tecnología actual le da solución a algunos problemas, pero no ha sido capaz de dominar muchas enfermedades. La utilización de la nanotecnología, la genética y la robótica provocarán cambios en los paradigmas de enfrentamiento a las enfermedades. Pudieran ocasionar deshumanización y problemas bioéticos(AU)

Introduction: Medicine in the 21st century will be a fusion point of numerous new technologies. Changes in the paradigms of medical attention will emerge. Objective:To present a view of what future medical attention could be. Material and methods:A review of the last and new technological tools at the service of Medicine is made, and their possible transformations and future implementation are studied through the search of the main databases of the data indexed during the last seven years, which will make a change in the scientific thought and a predictive view of the medical attention worldwide, and make reflections on the medical approaches that arise from translational medicine. The role of nanotechnology in the futuristic pharmacology is analyzed, as well as genetics and robotics; and comparisons are made regarding the amount of research by countries and the current condition in Latin America, and the way the new scientific innovations will influence in the Bioethics, which could give rise to transhumanism. Results:The influence of the new technologies is linked to the economic and social development. Therefore, its implementation will not be equitable, existing an important difference in establishment of patents, indexed research, and quotations between developed and underdeveloped countries, where no Latin American country is among the 10 first places in the world ranking. Conclusions:Current technology gives solution to some problems, but it has not been able to be acquainted with many diseases. The use of nanotechnology, genetics, and robotics will provoke changes in the confrontation paradigms of diseases, which could cause dehumanization and bioethical issues(AU)

Development and Use of Health-Related Technologies in Indigenous Communities: Critical Review.

BACKGROUND: Older Indigenous adults encounter multiple challenges as their age intersects with health inequities. Research suggests that a majority of older Indigenous adults prefer to age in place, and they will need culturally safe assistive technologies to do so. OBJECTIVE: The aim of this critical review was to examine literature concerning use, adaptation, and development of assistive technologies for health purposes by Indigenous peoples. METHODS: Working within Indigenous research methodologies and from a decolonizing approach, searches of peer-reviewed academic and gray literature dated to February 2016 were conducted using keywords related to assistive technology and Indigenous peoples. Sources were reviewed and coded thematically. RESULTS: Of the 34 sources captured, only 2 concerned technology specifically for older Indigenous adults. Studies detailing technology with Indigenous populations of all ages originated primarily from Canada (n=12), Australia (n=10), and the United States (n=9) and were coded to four themes: meaningful user involvement and community-based processes in development, the digital divide, Indigenous innovation in technology, and health technology needs as holistic and interdependent. CONCLUSIONS: A key finding is the necessity of meaningful user involvement in technology development, especially in communities struggling with the digital divide. In spite of, or perhaps because of this divide, Indigenous communities are enthusiastically adapting mobile technologies to suit their needs in creative, culturally specific ways. This enthusiasm and creativity, coupled with the extensive experience many Indigenous communities have with telehealth technologies, presents opportunity for meaningful, culturally safe development processes.

Laurus nobilis leaf extract mediated green synthesis of ZnO nanoparticles: Characterization and biomedical applications.

The present study reports the green synthesis of zinc oxide nanoparticles using the aqueous leaf extract of Laurus nobilis (Ln-ZnO NPs) by co-precipitation method. The synthesized Ln-ZnO NPs were characterized by UV-Vis spectroscopy, FTIR, XRD, TEM, SEM and EDX. Ln-ZnO NPs were crystalline in nature, flower like and have hexagonal wurtzite structure with a mean particle size of 47.27nm. The antibacterial activity of Ln-ZnO NPs was greater against Gram positive (Staphylococcus aureus) bacteria than Gram negative (Pseudomonas aeruginosa) bacteria. The zone of inhibition against S. aureus was 11.4, 12.6 and 14.2mm at 25, 50 and 75µgmL-1. The zone of inhibition against P. aeruginosa was 9.8, 10.2 and 11.3mm at 25, 50 and 75µgmL-1. The light and confocal laser scanning microscopic images evidenced that Ln-ZnO NPs effectively inhibited the biofilm growth of S. aureus and P. aeruginosa at 75µgmL-1. The cytotoxicity studies revealed that Ln-ZnO NPs showed no effect on normal murine RAW264.7 macrophage cells. On the other hand, Ln-ZnO NPs were effective in inhibiting the viability of human A549 lung cancer cells at higher concentrations of 80µgmL-1. The morphological changes in the Ln-ZnO NPs treated A549 lung cancer cells were observed under phase contrast microscope.

[Mapping stakeholders' preferences in prioritization criteria for horizon scanning in healthcare technologies]. / Mapeamento das preferências de atores estratégicos sobre os critérios de priorização para o monitoramento do horizonte tecnológico em saúde.

Filtration and prioritization are two basics steps in horizon scanning systems. This article aimed to map stakeholders' preferences in the Brazilian Unified National Health System (SUS) regarding filtration and prioritization criteria. Two filtration criteria (time horizon and innovation) and eight prioritization criteria (relevance to epidemiology, health policies, and clinical practice; potential impact on SUS budget, healthcare providers' costs, and mortality; safety; and legal, ethical, and social aspects) were selected. Multiple correspondence analysis was used to map stakeholders' preferences within and between groups. Two groups were more homogeneous and determinant for selection of prioritization criteria. Stakeholders' professional experience had more influence than institutional affiliations. The approach showed transparent criteria selection and analysis of stakeholders' individual preferences.

Personalized Weight Management Interventions for Cardiovascular Risk Reduction: A Viable Option for African-American Women.

Obesity is an independent contributor to cardiovascular disease (CVD) and a major driving force behind racial/ethnic and gender disparities in risk. Due to a multitude of interrelating factors (i.e., personal, social, cultural, economic and environmental), African-American (AA) women are disproportionately obese and twice as likely to succumb to CVD, yet they are significantly underrepresented in behavioral weight management interventions. In this selective review we highlight components of the limited interventions shown to enhance weight loss outcomes in this population and make a case for leveraging Web-based technology and artificial intelligence techniques to deliver personalized programs aimed at obesity treatment and CVD risk reduction. Although many of the approaches discussed are generally applicable across populations burdened by disparate rates of obesity and CVD, we specifically focus on AA women due to the disproportionate impact of these non-communicable diseases and the general paucity of interventions targeted to this high-risk group.

Black Phosphorus (BP) Nanodots for Potential Biomedical Applications.

Recently, the appeal of 2D black phosphorus (BP) has been rising due to its unique optical and electronic properties with a tunable band gap (≈0.3-1.5 eV). While numerous research efforts have recently been devoted to nano- and optoelectronic applications of BP, no attention has been paid to promising medical applications. In this article, the preparation of BP-nanodots of a few nm to <20 nm with an average diameter of ≈10 nm and height of ≈8.7 nm is reported by a modified ultrasonication-assisted solution method. Stable formation of nontoxic phosphates and phosphonates from BP crystals with exposure in water or air is observed. As for the BP-nanodot crystals' stability (ionization and persistence of fluorescent intensity) in aqueous solution, after 10 d, ≈80% at 1.5 mg mL(-1) are degraded (i.e., ionized) in phosphate buffered saline. They showed no or little cytotoxic cell-viability effects in vitro involving blue- and green-fluorescence cell imaging. Thus, BP-nanodots can be considered a promising agent for drug delivery or cellular tracking systems.

Utilizing Low-Volume Aqueous Acoustic Transfer with the Echo 525 to Enable Miniaturization of qRT-PCR Assay.

Quantitative reverse transcription PCR (qRT-PCR) is a valuable tool for characterizing the effects of inhibitors on viral replication. The amplification of target viral genes through the use of specifically designed fluorescent probes and primers provides a reliable method for quantifying RNA. Due to reagent costs, use of these assays for compound evaluation is limited. Until recently, the inability to accurately dispense low volumes of qRT-PCR assay reagents precluded the routine use of this PCR assay for compound evaluation in drug discovery. Acoustic dispensing has become an integral part of drug discovery during the past decade; however, acoustic transfer of microliter volumes of aqueous reagents was time consuming. The Labcyte Echo 525 liquid handler was designed to enable rapid aqueous transfers. We compared the accuracy and precision of a qPCR assay using the Labcyte Echo 525 to those of the BioMek FX, a traditional liquid handler, with the goal of reducing the volume and cost of the assay. The data show that the Echo 525 provides higher accuracy and precision compared to the current process using a traditional liquid handler. Comparable data for assay volumes from 500 nL to 12 µL allowed the miniaturization of the assay, resulting in significant cost savings of drug discovery and process streamlining.

Graphene-Alumina Nanocomposites with Improved Mechanical Properties for Biomedical Applications.

This paper presents a study on graphene platelet (GPL)-reinforced alumina (Al2O3) ceramic composites and the relationships between the loading of GPL and both mechanical properties and in vitro biocompatibility. Al2O3 powders with different GPL contents were prepared and sintered using a gas protected pressure-less furnace. The examination of the results shows the density of the composites varying from 99.2% to 95.6% with the loading of GPL from 0.75 to 1.48 vol %. Raman studies show that moderate agglomerations of GPLs occur during the ball milling process and graphitic defects were produced during the high temperature processing. Mechanical properties of the Al2O3 matrix are significantly improved by adding GPLs. A maximum increase of approximately 60% in flexural strength and 70% in fracture toughness are achieved by introducing 0.75 vol % GPLs. In the biocompatibility tests, it was found that cells directly seeding on top of GPL/Al2O3 samples showed better initial attachment (3 h after seeding) and viability (3 days after incubation) than the monolithic Al2O3, indicating that the GPL/Al2O3 composites have comparable or more favorable biocompatibility. The excellent mechanical and biomedical properties of the GPL/Al2O3 composites may enable them to be applied to a wide range of engineering and biomedical applications.

Delivering an Automated and Integrated Approach to Combination Screening Using Acoustic-Droplet Technology.

Drug combination testing in the pharmaceutical industry has typically been driven by late-stage opportunistic strategies rather than by early testing to identify drug combinations for clinical investigation that may deliver improved efficacy. A rationale for combinations exists across a number of diseases in which pathway redundancy or resistance to therapeutics are evident. However, early assays are complicated by the absence of both assay formats representative of disease biology and robust infrastructure to screen drug combinations in a medium-throughput capacity. When applying drug combination testing studies, it may be difficult to translate a study design into the required well contents for assay plates because of the number of compounds and concentrations involved. Dispensing these plates increases in difficulty as the number of compounds and concentration points increase and compounds are subsequently rolled onto additional labware. We describe the development of a software tool, in conjunction with the use of acoustic droplet technology, as part of a compound management platform, which allows the design of an assay incorporating combinations of compounds. These enhancements to infrastructure facilitate the design and ordering of assay-ready compound combination plates and the processing of combinations data from high-content organotypic assays.

Screening Pools of Compounds against Multiple Endogenously Expressed Targets in a Chemoproteomics Binding Assay.

Chemoproteomics-based competition-binding assays allow the screening of compounds against endogenous proteins in cell or tissue extracts, but these assays are hampered by low throughput and high cost. Using compound pools rather than single compounds in a screening campaign holds the promise of increased efficiency and substantial cost reduction. Previous attempts to screen compounds in pools often fell short due to complex data tracking, deconvolution issues, compound interferences, and automation problems. The desire to screen compounds in a high-throughput chemoproteomics format sparked a reassessment of compound pooling. Through the integration of acoustic dispensing, we enabled a flexible pooling process, allowing mixture creation by combining randomized or specific samples to create defined pools. Automation enabled end-to-end tracking, using barcode scan check points and output files to track data and ensure integrity during the mixture creation process. The compound pooling approach proved to be highly compatible with the chemoproteomics assay technology. Pools of 10 compounds in a single well did not show compound interference effects or increased false-positive/negative rates. In the present study, four targets, TBK1, PI3Kδ, PI3Kγ, and mTOR, were screened using a chemoproteomics approach against pools of 10 compounds per well, resulting in robust hit identification.

Acoustic Dispensing Preserves the Potency of Therapeutic Peptides throughout the Entire Drug Discovery Workflow.

Routine peptide structure-activity relationship screening requires the serial dilution of peptides to produce full concentration-response curves. Established tip-based protocols involve multiple tip changes and high exposure to plasticware. In the case of peptides, this becomes a challenge, since peptides can adsorb to plastic, resulting in an observed loss of potency. Various methods can be employed to prevent peptide loss during compound handling, such as the inclusion of bovine serum albumin or solvents in assay buffer and the siliconization of plasticware, yet protein binding remains unpredictable. The degree of variation by which peptides will adhere to plasticware can confuse results and cause inaccuracies in potency predictions. We evaluated acoustic noncontact methods for peptide serial dilution and compared it with traditional tip-based methods, on the effect on potency curves for glucagon-like peptide-1 and glucagon peptide analogues. The current study demonstrates the benefits of noncontact dispensing for high-density microplate assay preparation of peptides using nanoliter droplets across our entire drug discovery workflow, from in vitro high-throughput screening to drug exposure determinations from in vivo samples.

Compound Transfer by Acoustic Droplet Ejection Promotes Quality and Efficiency in Ultra-High-Throughput Screening Campaigns.

Acoustic droplet ejection (ADE) as a means of transferring library compounds has had a dramatic impact on the way in which high-throughput screening campaigns are conducted in many laboratories. Two Labcyte Echo ADE liquid handlers form the core of the compound transfer operation in our 1536-well based ultra-high-throughput screening (uHTS) system. Use of these instruments has promoted flexibility in compound formatting in addition to minimizing waste and eliminating compound carryover. We describe the use of ADE for the generation of assay-ready plates for primary screening as well as for follow-up dose-response evaluations. Custom software has enabled us to harness the information generated by the ADE instrumentation. Compound transfer via ADE also contributes to the screening process outside of the uHTS system. A second fully automated ADE-based system has been used to augment the capacity of the uHTS system as well as to permit efficient use of previously picked compound aliquots for secondary assay evaluations. Essential to the utility of ADE in the high-throughput screening process is the high quality of the resulting data. Examples of data generated at various stages of high-throughput screening campaigns are provided. Advantages and disadvantages of the use of ADE in high-throughput screening are discussed.

Mapeamento das preferências de atores estratégicos sobre os critérios de priorização para o monitoramento do horizonte tecnológico em saúde / Mapping stakeholders' preferences in prioritization criteria for horizon scanning in healthcare technologies / Mapeo de las preferencias de actores estratégicos sobre los criterios de priorización en la evaluación de tecnologías emergentes en salud

Resumo: Entre as etapas básicas de um sistema de monitoramento do horizonte de tecnologias emergentes, estão a filtragem e a priorização dessas tecnologias. Este trabalho tem por objetivo mapear as preferências dos atores estratégicos do Sistema Único de Saúde (SUS) quanto aos critérios de filtragem e priorização. Foram selecionados dois critérios de filtragem (horizonte de tempo e inovação) e oito critérios de priorização (relevância: epidemiológica, nas políticas de saúde e na prática clínica; impacto: orçamentário no SUS, no custo para o serviço em saúde e na mortalidade; segurança, e aspectos legais, éticos e sociais). A análise de correspondência múltipla foi aplicada para mapear as preferências dos atores nos grupos e entre grupos. Dois grupos foram mais homogêneos entre si e determinantes para a seleção dos critérios de priorização. A influência da formação profissional foi maior que a institucional. A metodologia permitiu a seleção de critérios de forma transparente e a análise das preferências individuais dos participantes.

Abstract: Filtration and prioritization are two basics steps in horizon scanning systems. This article aimed to map stakeholders' preferences in the Brazilian Unified National Health System (SUS) regarding filtration and prioritization criteria. Two filtration criteria (time horizon and innovation) and eight prioritization criteria (relevance to epidemiology, health policies, and clinical practice; potential impact on SUS budget, healthcare providers' costs, and mortality; safety; and legal, ethical, and social aspects) were selected. Multiple correspondence analysis was used to map stakeholders' preferences within and between groups. Two groups were more homogeneous and determinant for selection of prioritization criteria. Stakeholders' professional experience had more influence than institutional affiliations. The approach showed transparent criteria selection and analysis of stakeholders' individual preferences.

Resumen: Dentro de las etapas básicas de un sistema de evaluación precoz de tecnologías emergentes se encuentran las etapas de filtrado y priorización. Este trabajo tiene por objetivo mapear las preferencias de diferentes actores estratégicos del Sistema Único de Salud brasileño (SUS) para los criterios de filtrado y priorización. Se seleccionaron dos criterios de filtrado (horizonte de tiempo e innovación) y ocho criterios de priorización (relevancia: epidemiológica, en las políticas de salud y en la práctica clínica; impacto: en el presupuesto del SUS, en el costo para el servicio de salud y en la mortalidad; seguridad, aspectos legales, éticos y sociales). Se realizó un análisis de correspondencia múltiple para mapear las preferencias de los actores por grupo y entre grupos. Dos de los grupos fueron más homogéneos entre sí y determinantes para la selección de criterios de priorización. La influencia que tuvo la experiencia profesional fue más decisiva que la influencia institucional. Esta metodología permitió seleccionar criterios de forma transparente y analizar las preferencias individuales.