Feasibility of a school-based mindfulness program for improving inhibitory skills in children with autism spectrum disorder.

BACKGROUND: Executive dysfunction is prevalent in children with autism spectrum disorder (ASD), including prominent difficulties in the two facets of inhibition, as well as with selective attention. School-based mindfulness has been used in typically-developing children to improve executive functioning, though this has not been investigated in children with ASD. Therefore, the purpose of this study was to examine the efficacy of a school-based mindfulness program for improving inhibition (prepotent response inhibition and interference control) and selective attention in children with ASD. METHOD: Using a quasi-experimental, pre-post design, an eight week school-based mindfulness program (Mindful Schools;https://www.mindfulschools.org/), was administered to students with ASD (n = 27) at a private, not-for-profit school for children with special needs. The Walk/Don't Walk test and the Color-Word Interference test were used to evaluate prepotent response inhibition and interference control, respectively. Selective attention was measured using a cancellation test. RESULTS: Significant improvements followed the intervention for prepotent response inhibition and interference control (medium effect sizes), as well as for overall selective attention (large effect size). CONCLUSIONS: The study's findings demonstrate that school-based mindfulness holds promise for increasing specific executive functioning abilities in children with ASD.

How uncommon is tickertaping? Prevalence and characteristics of seeing the words you hear.

Tickertape experience is the subjective phenomenon of routinely visualizing the orthographic appearance of words that one hears, speaks, or thinks, like mental subtitles in the mind's eye. It has been observed in grapheme-color synesthetes, whose letter visualizations are colored, but has been very little studied. We report a survey, among 425 Norwegian adults from varied sub-samples, of the prevalence, character, and associated skills of tickertaping. Our questionnaire was designed to reflect different degrees of automaticity of the experience. While strongly automatic tickertaping appeared rare (n = 6; CI95 = 0.6% to 3.2% of sample), lesser degrees of text visualization were reported by more than half of respondents, indicating a continuity between extreme tickertaping and normal cognition. Tickertaping was not strongly associated with greater awareness of an inner voice while reading silently. We also found no strong evidence that tickertapers are unusually likely to self-report skill in rapidly enumerating heard words, or in backward spelling and backward speaking, despite the fact that these skills have been observed in single-case studies of tickertapers. The qualitative character of tickertaping varied among respondents, and included negative experiences. However visualization of letters was predominantly uncolored, indicating that tickertaping is a phenomenon in its own right and not just a subset of grapheme-color synesthesia. We suggest tickertaping is an explicit expression of the close interconnection between phonemic and graphemic representations of words which, for reasons we do not yet understand, manifests as visual imagery with a varying degree of automaticity.

In search of the disappeared half of it: 35 years of studies on representational neglect.

OBJECTIVE: Representational neglect (RN) is a neuropsychological deficit mostly occurring after right brain damage affecting the mental imagery domain. Patients suffering from RN are unable to represent, describe, or explore the contralesional side of their mental images. Since its first description in 1978, RN has been explored using different theoretical frameworks and experimental paradigms. After 35 years, the nature of its behavioral and anatomical correlates is still unclear. METHOD: We reviewed studies on RN published from 1978-2013 to systematize available knowledge and to shed light on future research directions. RESULTS: The huge variety of tests used to diagnose RN reflects the different clinical features of the deficit, which can compromise space sectors and memory storage, depending on the stimulus to be imagined, even in a dissociated fashion. RN has been frequently described after parietal, temporal, and frontal right brain lesions, even though reliable group studies are scanty. CONCLUSION: A number of priorities concerning RN were identified. Future studies might take into account several aspects of RN that are still poorly explored, starting from a more systematized investigation of RN using larger group studies. RESULTS might add pieces to the puzzle of spatial cognition and its neural basis in mental imagery, paving the way for tailored motor and cognitive rehabilitation programs.

Thalamo-cortical dysfunction in cocaine abusers: implications in attention and perception.

Cocaine affects sensory perception and attention, but little is known about the neural substrates underlying these effects in the human brain. We used functional magnetic resonance imaging (fMRI) and a sustained visuospatial attention task to assess if the visual attention network is dysfunctional in cocaine abusers (n=14) compared to age-, gender-, and education-matched controls (n=14). Compared with controls, cocaine abusers showed (1) hypo-activation of the thalamus, which may reflect noradrenergic and/or dopaminergic deficits; (2) hyper-activation in occipital and prefrontal cortices, which may reflect increased visual cortical processing to compensate for inefficient visual thalamic processing; and (3) larger deactivation of parietal and frontal regions possibly to support the larger hemodynamic supply to the hyper-activated brain regions. These findings provide evidence of abnormalities in thalamo-cortical responses in cocaine abusers that are likely to contribute to the impairments in sensory processing and in attention. The development of therapies that diminish these thalamo-cortical deficits could improve the treatment of cocaine addiction.

Impaired motor imagery in patients with essential tremor: a case control study.

Motor imagery (MI), which refers to the process of mental representation of movements, has not been studied in patients with essential tremor (ET). We investigated the presence of impaired MI in ET patients compared with healthy controls. A group of drug-naive and nondemented ET patients and age-matched controls were studied using transcranial magnetic stimulation, while they were specifically instructed to try and imagine themselves performing two motor tasks. The various clinical and electrophysiological variables were evaluated and compared. Repeated measures ANOVA demonstrated a significant difference between ET patients and controls with respect to mean motor-evoked potential (MEP) amplitudes (F(1,38) = 31.92, P < 0.005) during MI. The process of MI effectively facilitated MEP amplitude in controls but not in ET patients, regardless of side of stimulation or motor tasks. We provide evidence to demonstrate impairment of MI in a group of ET patients compared with healthy controls. The basis for this novel finding is unclear, and further studies are warranted to determine whether it is related to cerebellar or motor cortical dysfunction.

Spatial visualization, visual imagery, and mathematical problem solving of students with varying abilities.

The purpose of this study was to investigate students' use of visual imagery and its relationship to spatial visualization ability while solving mathematical word problems. Students with learning disabilities (LD), average achievers, and gifted students in sixth grade (N = 66) participated in this study. Students were assessed on measures of mathematical problem solving, visual imagery representation, and spatial visualization ability. The results indicated that gifted students performed better on both spatial visualization measures than students with LD and average-achieving students. Use of visual images was positively correlated with higher mathematical word-problem-solving performance. Furthermore, the use of schematic imagery was significantly and positively correlated with higher performance on each spatial visualization measure; conversely, it was negatively correlated with the use of pictorial images.

Frequency, risk factors, anatomy, and course of unilateral neglect in an acute stroke cohort.

OBJECTIVE: To delineate the frequency, course, risk factors, and neuroanatomy of hemispatial neglect in a large stroke cohort. METHODS: One thousand two hundred eighty-one patients with acute stroke were enrolled in a multicenter trial of an anticoagulant. Presence and severity of neglect were assessed with the NIH Stroke Scale (NIHSS) neglect item, assessing tactile extinction and visuospatial neglect at entry, daily for 1 week, and at 3 months. Head CT scans were obtained on day 7, and infarct location and size were characterized. RESULTS: Neglect was common at presentation, occurring in 43% of right brain-lesioned (RBL) patients and 20% of left brain-lesioned (LBL) patients (p < 0.001). At 3 months, neglect was present in 17% of RBL patients and in 5% of LBL patients (p < 0.001). In RBL patients, neglect was most frequently associated with lesions involving the (in descending order) temporal, parietal, frontal, occipital lobes, basal ganglia, and thalamus. Neglect was more common and persistent with cortical than with subcortical lesions. Increasing age was associated with increased risk of neglect in RBL patients, whereas gender and handedness did not significantly affect neglect frequency. CONCLUSIONS: This series confirms that hemispatial neglect may occur with damage to several supratentorial structures but is most common and persistent with lesions of the right temporoparietal cortex. Increasing age is associated with neglect, particularly after right brain lesions. Gender and handedness do not exert a marked effect on the likelihood of the occurrence of neglect.

Deep arteriovenous malformations of the basal ganglia and thalamus: natural history.

OBJECT: Patients with arteriovenous malformations (AVMs) in a deep location and with deep venous drainage are thought to be at higher risk for hemorrhage than those with AVMs in other locations. Despite this, the natural history of AVMs of the basal ganglia and thalamus has not been well studied. METHODS: The authors retrospectively evaluated a cohort of 96 patients with AVMs in the basal ganglia and thalamus with respect to the tendency of these lesions to hemorrhage between the time of detection and their eventual successful management. The 96 patients studied had a mean age of 22.7 years at diagnosis, and 51% were male. Intracranial hemorrhage (ICH) was the event leading to clinical detection in 69 patients (71.9%), and 85.5% of these patients were left with hemiparesis. After diagnosis, 25 patients bled a total of 49 times. The cumulative clinical follow up after detection but before surgical management was 500.2 patient-years. The risk of hemorrhage after detection of an AVM of the basal ganglia or thalamus was 9.8% per patient-year. CONCLUSIONS: The rate of ICH in patients with AVMs of the basal ganglia or thalamus (9.8%/year) is much higher than the rate in patients with AVMs in other locations (2-4%/year). The risk of incurring a neurological deficit with each hemorrhagic event is high. Treatment of these patients at specialized centers is recommended to prevent neurological injury from a spontaneous ICH.